Vitamin E supplementation improves endothelial function in type I diabetes mellitus: A randomized, placebo-controlled study

Journal of the American College of Cardiology

Volumn 36, Issue 1, 2000, Pages 94-102

  Skyrme Jones, R Andrew P ^a   O'Brien, Richard C ^a   Berry, Karen L ^a   Meredith, Ian T ^a  

^a MONASH MEDICAL CENTRE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINE; ALPHA TOCOPHEROL; INSULIN; LOW DENSITY LIPOPROTEIN; NITROPRUSSIDE SODIUM; PLACEBO;

ADULT; AORTA FLOW; ARTERY COMPLIANCE; ARTICLE; BRACHIAL ARTERY; CAROTID ARTERY; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; ECHOGRAPHY; FEMALE; FOREARM BLOOD FLOW; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; MALE; OXIDATIVE STRESS; PATHOGENESIS; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; VASCULAR ENDOTHELIUM; VASCULAR RESISTANCE; VASODILATATION; VITAMIN SUPPLEMENTATION;

ADMINISTRATION, ORAL; ADULT; BLOOD FLOW VELOCITY; BLOOD PRESSURE; BRACHIAL ARTERY; COMPLIANCE; DIABETES MELLITUS, TYPE 1; DIETARY SUPPLEMENTS; DOUBLE-BLIND METHOD; ENDOTHELIUM, VASCULAR; FEMALE; HUMANS; LIPOPROTEINS, LDL; MALE; OXIDATIVE STRESS; PLETHYSMOGRAPHY; TREATMENT OUTCOME; VASCULAR RESISTANCE; VASODILATION; VITAMIN E;

EID: 0033910718     PISSN: 07351097     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0735-1097(00)00720-8     Document Type: Article

References (64)

1. Clarkson P., Celermajer D.S., Donald A.E., et al. Impaired vascular reactivity in insulin-dependent diabetes mellitus is related to disease duration and low density lipoprotein cholesterol levels. J Am Coll Cardiol. 28:1996;573-579.
2. Skyrme-Jones R.A.P., Berry K.L., O'Brien R.C., Meredith I.T. Basal and exercise-induced skeletal muscle blood flow is augmented in insulin-dependent diabetes mellitus. Clin Sci. 98:2000;111-120.
3. Johnstone M.T., Creager S.J., Scales K.M., Cusco J.A., Lee B.K., Creager M.A. Impaired endothelium-dependent vasodilation in patients with insulin-dependent diabetes mellitus. Circulation. 88:1993;2510-2516.
4. O'Driscoll G., Green D., Rankin J., Stanton K., Taylor R. Improvement in endothelial function by angiotensin converting enzyme inhibition in insulin-dependent diabetes mellitus. J Clin Invest. 100:1997;678-684.
5. Oxlund H., Rasmussen L.M., Andreassen T.T., Heickendorff L. Increased aortic stiffness in patients with type 1 diabetes mellitus. Diabetologia. 32:1989;748-752.
6. Berry K.L., Skyrme-Jones R.A.P., Cameron J.D., O'Brien R.C., Meredith I.T. Systemic arterial compliance is reduced in young patients with IDDM. Am J Physiol. 276 Heart Circ Physiol:(Suppl 45):1999;H1839-H1845.
7. Laakso M., Lehto S., Penttila I., Pyorala K. Lipids and lipoproteins predicting coronary heart disease mortality and morbidity in patients with non-insulin-dependent diabetes. Circulation. 88:1993;1421-1430.
8. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N Engl J Med. 329:1993;977-986.
9. Despres J.P., Lamarche B., Mauriege P., et al. Hyperinsulinemia as an independent risk factor for ischemic heart disease. N Engl J Med. 334:1996;952-957.
10. Baynes J.W. Role of oxidative stress in development of complications in diabetes. Diabetes. 40:1991;405-412.
11. Williamson J.R., Chang K., Frangos M., et al. Hyperglycemic pseudohypoxia and diabetic complications. Diabetes. 42:1993;801-813.
12. Ishii H., Koya D., King G.L. Protein kinase C activation and its role in the development of vascular complications in diabetes mellitus. J Mol Med. 76:1998;21-31.
13. Esterbauer H, Dieber-Rotheneder M, Striegl G, Waeg G. Role of vitamin E in preventing the oxidation of low-density lipoprotein. Am J Clin Nutr 1991;53 Suppl:314-21S.
14. Kunisaki M., Fumio U., Nawata H., King G.L. Vitamin E normalizes diacylglycerol-protein kinase C activation induced by hyperglycemia in rat vascular tissues. Diabetes. 45:(Suppl 3):1996;S117-S119.
15. Rimm E.B., Stampfer M.J., Ascherio A., Giovannucci E., Colditz G.A., Willett W.C. Vitamin E consumption and the risk of coronary heart disease in men. N Engl J Med. 328:1993;1450-1456.
16. Stampfer M.J., Hennekens C.H., Manson J.E., Colditz G.A., Rosner B., Willett W.C. Vitamin E consumption and the risk of coronary disease in women. N Engl J Med. 328:1993;1444-1449.
17. Regnstrom J., Nilsson J., Moldeus P., et al. Inverse relation between the concentration of low-density-lipoprotein vitamin E and severity of coronary artery disease. Am J Clin Nutr. 63:1996;377-385.
18. Skyrme-Jones R.A.P., Berry K.L., Luo M., O'Brien R.C., Meredith I.T. Impaired endothelial function in insulin-dependent diabetes is related to LDL particle size and LDL vitamin E. J Am Coll Cardiol. 35:2000;292-299.
19. Keegan A., Walbank H., Cotter M.A., Cameron N.E. Chronic vitamin E treatment prevents defective endothelium-dependent relaxation in diabetic rat aorta. Diabetologia. 38:1995;1475-1478.
20. Rosen P., Ballhausen T., Bloch W., Addicks K. Endothelial relaxation is disturbed by oxidative stress in the diabetic rat heart influence of tocopherol as antioxidant . Diabetologia. 38:1995;1157-1168.
21. Matz J., Andersson T.L., Ferns G.A., Anggard E.E. Dietary vitamin E increases the resistance to lipoprotein oxidation and attenuates endothelial dysfunction in the cholesterol-fed rabbit. Atherosclerosis. 110:1994;241-249.
22. Keaney J.F. Jr, Gaziano J.M., Xu A., et al. Low-dose alpha-tocopherol improves and high-dose alpha-tocopherol worsens endothelial vasodilator function in cholesterol-fed rabbits. J Clin Invest. 93:1994;844-851.
23. Jorge P.A., Osaki M.R., de Almeida E., Credidio Neto L., Metze K. Effects of vitamin E on endothelium-dependent coronary flow in hypercholesterolemic dogs. Atherosclerosis. 126:1996;43-51.
24. Gilligan D.M., Sack M.N., Guetta V., et al. Effect of antioxidant vitamins on low density lipoprotein oxidation and impaired endothelium-dependent vasodilation in patients with hypercholesterolemia. J Am Coll Cardiol. 24:1994;1611-1617.
25. Chowienczyk P.J., Kneale B.J., Brett S.E., Paganga G., Jenkins B.S., Ritter J.M. Lack of effect of vitamin E on L-arginine-responsive endothelial dysfunction in patients with mild hypercholesterolaemia and coronary artery disease. Clin Sci. 94:1998;129-134.
26. McDowell I.F., Brennan G.M., McEneny J., et al. The effect of probucol and vitamin E treatment on the oxidation of low-density lipoprotein and forearm vascular responses in humans. Eur J Clin Invest. 24:1994;759-765.
27. Gazis A., White D.J., Page S., Cockcroft J. Effect of oral vitamin E (alpha-tocopherol) supplementation on vascular endothelial function in type II diabetes mellitus. Diabet Med. 16:1999;304-311.
28. Mottram P., Shige H., Nestel P.J. Vitamin E supplementation improves arterial compliance. Atherosclerosis. 145:1999;399-404.
29. Azen S.P., Qian D., Mack W.J., et al. Effect of supplementary antioxidant vitamin intake on carotid arterial wall intima-media thickness in a controlled clinical trial of cholesterol lowering. Circulation. 94:1996;2369-2372.
30. Kinlay S., Fang J.C., Hikita H., et al. Plasma alpha-tocopherol and coronary endothelium-dependent vasodilator function. Circulation. 100:1999;219-221.
31. New G., Timmins K.L., Duffy S.J., et al. Long-term estrogen therapy improves vascular function in male to female transsexuals. J Am Coll Cardiol. 29:1997;1437-1444.
32. Hokanson D.E., Sumner D.S., Strandness D.E. An electrically calibrated plethysmograph for direct measurement of limb blood flow. IEEE Trans Biomed Eng. 22:1975;25-29.
33. Duffy S.J., Tran B.T., New G., et al. Continuous release of vasodilator prostanoids contributes to regulation of resting forearm blood flow in humans. Am J Physiol. 274:(Pt 2):1998;H1174-H1183.
34. Liu Z., Brin K.P., Yin F.C. Estimation of total arterial compliance an improved method and evaluation of current methods . Am J Physiol. 251:(Pt 2):1986;H588-H600.
35. Cameron J.D., Dart A.M. Exercise training increases total systemic arterial compliance in humans. Am J Physiol. 266:(Pt 2):1994;H693-H701.
36. Chung B.H., Segrest J.P., Ray M.J., et al. Single vertical spin density gradient ultracentrifugation. Methods Enzymol. 128:1986;181-209.
37. Krauss R.M., Burke D.J. Identification of multiple subclasses of plasma low density lipoproteins in normal humans. J Lipid Res. 23:1982;97-104.
38. Cuesta Sanz D., Castro Santa-Cruz M. Simultaneous measurement of retinol and alpha-tocopherol in human serum by high-performance liquid chromatography with ultraviolet detection. J Chromatogr. 380:1986;140-144.
39. Esterbauer H., Striegl G., Puhl H., Rotheneder M. Continuous monitoring of in vitro oxidation of human low density lipoprotein. Free Radic Res Commun. 6:1989;67-75.
40. McDowell I.F., McEneny J., Trimble E.R. A rapid method for measurement of the susceptibility to oxidation of low-density lipoprotein. Ann Clin Biochem. 32:(Pt 2):1995;167-174.
41. Timimi F.K., Ting H.H., Haley E.A., Roddy M.A., Ganz P., Creager M.A. Vitamin C improves endothelium-dependent vasodilation in patients with insulin-dependent diabetes mellitus. J Am Coll Cardiol. 31:1998;552-557.
42. Ting H.H., Timimi F.K., Boles K.S., Creager S.J., Ganz P., Creager M.A. Vitamin C improves endothelium-dependent vasodilation in patients with non-insulin-dependent diabetes mellitus. J Clin Invest. 97:1996;22-28.
43. Motoyama T., Kawano H., Kugiyama K., et al. Vitamin E administration improves impairment of endothelium-dependent vasodilation in patients with coronary spastic angina. J Am Coll Cardiol. 32:1998;1672-1679.
44. Heitzer T., Yla-Herttuala S., Wild E., Luoma J., Drexler H. Effect of vitamin E on endothelial vasodilator function in patients with hypercholesterolemia, chronic smoking or both. J Am Coll Cardiol. 33:1999;499-505.
45. Kugiyama K., Motoyama T., Doi H., et al. Improvement of endothelial vasomotor dysfunction by treatment with alpha-tocopherol in patients with high remnant lipoprotein levels. J Am Coll Cardiol. 33:1999;1512-1518.
46. Kugiyama K., Kerns S.A., Morrisett J.D., Roberts R., Henry P.D. Impairment of endothelium-dependent arterial relaxation by lysolecithin in modified low-density lipoproteins. Nature. 344:1990;160-162.
47. Galle J., Mulsch A., Busse R., Bassenge E. Effects of native and oxidized low density lipoproteins on formation and inactivation of endothelium-derived relaxing factor. Arterioscler Thromb. 11:1991;198-203.
48. Chin J.H., Azhar S., Hoffman B.B. Inactivation of endothelial derived relaxing factor by oxidized lipoproteins. J Clin Invest. 89:1992;10-18.
49. Xia P., Inoguchi T., Kern T.S., Engerman R.L., Oates P.J., King G.L. Characterization of the mechanism for the chronic activation of diacylglycerol-protein kinase C pathway in diabetes and hypergalactosemia. Diabetes. 43:1994;1122-1129.
50. Keaney J.F. Jr, Guo Y., Cunningham D., Shwaery G.T., Xu A., Vita J.A. Vascular incorporation of alpha-tocopherol prevents endothelial dysfunction due to oxidized LDL by inhibiting protein kinase C stimulation. J Clin Invest. 98:1996;386-394.
51. Ohara Y., Sayegh H.S., Harrison D.G. Regulation of endothelial constitutive nitric oxide synthase by protein kinase C. Hypertension. 25:1995;415-420.
52. Paolisso G., D'Amore A., Giugliano D., Ceriello A., Varricchio M., D'Onofrio F. Pharmacologic doses of vitamin E improve insulin action in healthy subjects and non-insulin-dependent diabetic patients. Am J Clin Nutr. 57:1993;650-656.
53. Faruqi R., de la Motte C., DiCorleto P.E. Alpha-tocopherol inhibits agonist-induced monocytic cell adhesion to cultured human endothelial cells. J Clin Invest. 94:1994;592-600.
54. Cominacini L., Garbin U., Pasini A.F., et al. Antioxidants inhibit the expression of intercellular cell adhesion molecule-1 and vascular cell adhesion molecule-1 induced by oxidized LDL on human umbilical vein endothelial cells. Free Rad Biol Med. 22:1997;117-127.
55. Navab M., Hama S.Y., Nguyen T.B., Fogelman A.M. Monocyte adhesion and transmigration in atherosclerosis. Coron Artery Dis. 5:1994;198-204.
56. Stephens N.G., Parsons A., Schofield P.M., Kelly F., Cheeseman K., Mitchinson M.J. Randomised controlled trial of vitamin E in patients with coronary disease Cambridge Heart Antioxidant Study (CHAOS) . Lancet. 347:1996;781-786.
57. Neunteufl T., Kostner K., Katzenschlager R., Zehetgruber M., Maurer G., Weidinger F. Additional benefit of vitamin E supplementation to simvastatin therapy on vasoreactivity of the brachial artery of hypercholesterolemic men. J Am Coll Cardiol. 32:1998;711-716.
58. Feener E.P., King G.L. Vascular dysfunction in diabetes mellitus. Lancet. 350:(Suppl I):1997;9-13.
59. Wilkinson I.B., Cockcroft J.R., Webb D.J. Pulse wave analysis and arterial stiffness. J Cardiovasc Pharmacol. 32:(Suppl 3):1998;S33-S37.
60. Kunisaki M., Bursell S.E., Umeda F., Nawata H., King G.L. Normalization of diacylglycerol-protein kinase C activation by vitamin E in aorta of diabetic rats and cultured rat smooth muscle cells exposed to elevated glucose levels. Diabetes. 43:1994;1372-1377.
61. Boscoboinik D., Szewczyk A., Azzi A. Alpha-tocopherol (vitamin E) regulates vascular smooth muscle cell proliferation and protein kinase C activity. Arch Biochem Biophys. 286:1991;264-269.
62. Green D., O'Driscoll G., Rankin J.M., Maiorana A.J., Taylor R. Beneficial effect of vitamin E administration on nitric oxide function in subjects with hypercholesterolaemia. Clin Sci. 95:1998;361-367.
63. Green D., O'Driscoll G., Blanksby B., Taylor R. Lack of effect of vitamin E administration on basal nitric oxide function in male smokers and non-smokers. Clin Sci (Colch). 89:1995;343-348.
64. Stocker R., Bowry V.W., Frei B. Ubiquinol-10 protects human low density lipoprotein more efficiently against lipid peroxidation than does alpha-tocopherol. Proc Natl Acad Sci USA. 88:1991;1646-1650.