Elimination of •O2-/H2O2 by α-lipoic acid mediates the recovery of basal EDRF/NO availability and the reversal of superoxide dismutase-induced relaxation in diabetic rat aorta

Diabetes, Obesity and Metabolism

Volumn 4, Issue 1, 2002, Pages 69-74

  Kocak G ^a   Karasu, C ^a  

^a ANKARA UNIVERSITY   (Turkey)

Author keywords

Endothelium; Hydrogen peroxide; Nitric oxide; Rat aorta; Streptozotocin diabetes; Superoxide dismutase; lipoic acid

Indexed keywords

AMINOTRIAZOLE; CATALASE; ENDOTHELIUM DERIVED RELAXING FACTOR; ENZYME INHIBITOR; INDOMETACIN; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; OXYGEN RADICAL; PROSTAGLANDIN SYNTHASE INHIBITOR; STREPTOZOCIN; SUPEROXIDE; SUPEROXIDE DISMUTASE; THIOCTIC ACID; AMITROLE; HYDROGEN PEROXIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; DRUG RESPONSE; ENZYME ACTIVITY; ENZYME MECHANISM; ISOLATION PROCEDURE; MALE; MUSCLE ISOMETRIC CONTRACTION; NITROGEN AVAILABILITY; NONHUMAN; RAT; REDUCTION; SMOOTH MUSCLE RELAXATION; STREPTOZOCIN DIABETES; VASCULAR RING; ANIMAL; BODY WEIGHT; COMPARATIVE STUDY; DRUG EFFECT; EXPERIMENTAL DIABETES MELLITUS; GLUCOSE BLOOD LEVEL; METABOLISM; PATHOPHYSIOLOGY; REFERENCE VALUE; THORACIC AORTA; VASODILATATION;

AMITROLE; ANIMALS; AORTA, THORACIC; BLOOD GLUCOSE; BODY WEIGHT; CATALASE; DIABETES MELLITUS, EXPERIMENTAL; ENZYME INHIBITORS; HYDROGEN PEROXIDE; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE; RATS; REFERENCE VALUES; SUPEROXIDE DISMUTASE; SUPEROXIDES; THIOCTIC ACID; VASODILATION;

EID: 0036211948     PISSN: 14628902     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1463-1326.2002.00174.x     Document Type: Article

References (28)

1. The role of endothelial cells on the alterations in vascular reactivity induced by insulin-dependent diabetes mellitus: Effects of insulin treatment
2. The role of endothelium on enhanced contractile response of non-insulin-dependent diabetic rat aortae: Effects of insulin treatment
3. Acute probucol treatment partially restores vasomotor activity and abnormal lipid metabolism whereas morphological changes are not affected in aorta from long-term STZ-diabetic rats
4. Time course of changes in endothelium-dependent and -independent relaxation of chronically diabetic aorta: Role of reactive oxygen species
5. The effects of Type-1 and Type-2 diabetes on endothelium-dependent relaxation in the rat aorta
6. 2 in aorta isolated from chronically streptozotocin-diabetic rats: Effects of antioxidant enzymes and enzyme inhibitors
7. Regulation of spontaneous EDRF release in diabetic rat aorta by oxygen free radicals
8. Antioxidant and triglyceride lowering effects of vitamin E associated with the prevention of abnormalities in the reactivity and morphology of aorta from streptozotocin-diabetic rats
9. Changes in isoprenaline-induced endothelium-dependent and independent relaxations of aorta in long-term STZ-diabetic rats: Reversal effect of dietary vitamin E
10. Effects of α-lipoic acid on oxidative stress markers, blood pressure and impaired integrity of diabetic aorta
11. Alpha-lipoic acid treatment ameliorates metabolic parameters, blood pressure, vascular reactivity and morphology of vessels already damaged by streptozotocin-diabetes
12. Lipoic acid and dihydrolipoic acids as antioxidants. A critical evaluation
13. Thioctic (lipoic) acid: A therapeutic metal-chelating antioxidant?
14. Differential effects of lipoic acid stereoisomers on glucose metabolism in insulin-resistant skeletal muscle
15. Neuroprotection by the metabolic antioxidant α-lipoic acid
16. Possible superoxide-induced alteration of vascular reactivity in aortas from streptozotocin-treated rats
17. Effects of alpha-lipoic acid on neurovascular function in diabetic rats: Interaction with essential fatty acids
18. Effects of diabetes and treatment with the antioxidant alpha-lipoic acid endothelial and neurogenic responses of corpus cavernosum in rats
19. Advenced glycation and product-induced activation of NF-κB is suppressed by α-lipoic acid in cultured endothelial cells
20. α-Lipoic acid as a biological antioxidant
21. Diabetes-induced endothelial dysfunction is prevented by long-term treatment with the modified iron chelators, hydroxymethyl starch conjugated-deferoxamine
22. Chronic treatment in vivo with dimethylthiourea, a hydroxyl radical scavenger, prevents diabetes-induced endothelial dysfunction
23. Effects of DL-α-lipoic acid on peripheral nerve conduction, blood flow, energy metabolism, and oxidative stress in experimental diabetic neuropathy
24. Lipoic acid acutely induces hypoglycemia in fasting nondiabetic and diabetic rats
25. The influence of thioctic acid on metabolism and function of the diabetic heart
26. Diabetes-induced changes in lens antioxidant status, glucose utilization and energy metabolism: Effect of DL-alpha-lipoic acid
27. Modulation of cellular reducing equivalent homeostasis by alphalipoic acid. Mechanisms and implications for diabetes and ischemic injury
28. Restoration of endothelium-dependent relaxation in both hyper-cholesterolemia and diabetes by chronic taurine