Chronic treatment in vivo with dimethylthiourea, a hydroxyl radical scavenger, prevents diabetes-induced endothelial dysfunction

Journal of Cardiovascular Pharmacology

Volumn 28, Issue 6, 1996, Pages 741-745

  Pieper, Galen M ^a,b   Siebeneich, Wolfgang ^a   Roza, Allan M ^a   Jordan, Milan ^a   Adams, Mark B ^a  

^a MEDICAL COLLEGE OF WISCONSIN   (United States)

^b FROEDTERT MEMORIAL LUTHERAN HOSPITAL   (United States)

Author keywords

Diabetes mellitus; Dimethylthiourea; Endothelium; Hydroxyl radicals; Nitric oxide

Indexed keywords

DIMETHYLTHIOUREA; HYDROXYL RADICAL; NITRIC OXIDE;

ANIMAL EXPERIMENT; ARTICLE; DIABETES MELLITUS; DIABETIC ANGIOPATHY; INTRAPERITONEAL DRUG ADMINISTRATION; NONHUMAN; OXIDATIVE STRESS; PATHOPHYSIOLOGY; PRIORITY JOURNAL; RAT; VASCULAR ENDOTHELIUM;

ACETYLCHOLINE; ANIMALS; AORTA; BLOOD GLUCOSE; CALCIMYCIN; CATALASE; DIABETES MELLITUS, EXPERIMENTAL; ENDOTHELIUM, VASCULAR; FREE RADICAL SCAVENGERS; HEMOGLOBIN A, GLYCOSYLATED; INSULIN; MALE; NITROGLYCERIN; RATS; THIOUREA;

EID: 0029798152     PISSN: 01602446     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005344-199612000-00002     Document Type: Article

References (32)

1. Pieper GM, Gross GJ. Endothelial dysfunction in diabetes. In: Rubanyi GM, ed. Cardiovascular significance of endothelium-derived vasoactive factors. Mount Kisco, NY: Futura, 1991;223-49.
2. Cohen RA. Dysfunction of vascular endothelium in diabetes mellitus. Circulation 1993;87(suppl V):V-67-76.
3. Kamata K, Miyata N, Abiru T, Kasuya Y. Functional changes in vascular smooth muscle and endothelium of arteries during diabetes mellitus. Life Sci 1992;50:1379-87.
4. Johnstone MT, Creager SJ, Scales KM, Cusco JA, Lee BK, Creger MA. Impaired endothelium-dependent vasodilation in patients with insulin-dependent diabetes mellitus. Circulation 1993;88:2510-6.
5. McNally PG, Watt PAC, Rimmer T, Burden AC, Hearnshaw JR, Thurston H. Impaired contraction and endothelium-dependent relaxation in isolated resistance vessels from patients with endothelium-dependent diabetes mellitus. Clin Sci 1994;87:313-36.
6. McVeigh GE, Brennan GM, Johnston GD, et al. Impaired endothelium-dependent and independent vasodilation in patients with type 2 (non-insulin-dependent) diabetes mellitus. Diabetologia 1992;35:771-6.
7. Tesfamariam B, Jakubowski JA, Cohen RA. Contraction of diabetic rabbit aorta caused by endothelium-derived PGH2-TxA2. Am J Physiol 1989;51(Heart Circ Physiol 26):H1327-33.
8. Mayhan WG. Impairment of endothelium-dependent dilatation of cerebral arterioles during diabetes mellitus. Am J Physiol 1989;256(Heart Circ Physiol 25):H621-5.
9. Pelligrino DA, Koenig HM, Wang Q, Albrecht RF. Protein kinase C suppresses receptor-mediated pial arteriolar relaxation in the diabetic rat. Neuroreport 1994;%;417-20.
10. Pieper GM, Peltier BA. Amelioration by L-arginine of a dysfunctional arginine/nitric oxide pathway in diabetic endothelium. J Cardiovasc Pharmacol 1995;25:397-403.
11. Pieper GM, Jordan M, Adams MB, Roza AM. Syngeneic pancreatic islet transplantation reverses endothelial dysfunction in experimental diabetes. Diabetes 1995;44:1106-13.
12. Pieper GM. Acute amelioration of diabetic endothelial dysfunction with a derivative of the nitric oxide synthase cofactor, tetrahydro-biopterin. J Cardiovasc Pharmacol (in press).
13. Bucala R, Tracey KJ, Cerami A. Advanced glycosylation products quench nitric oxide and mediate defective endothelium-dependent vasodilatation in experimental diabetes. J Clin Invest 1991;87:432-8.
14. Langenstroer P, Pieper GM. Regulation of spontaneous EDRF release in diabetic rat aorta by oxygen free radicals. Am J Physiol 1992;263(Heart Circ Physiol 32):H257-65.
15. Pieper GM, Mei DA, Langenstroer P, O'Rourke ST. Bioassay of en- dothelium-derived relaxing factor in diabetic rat aorta. Am J Physiol 1992;263(Heart Circ Physiol 32):H676-80.
16. Diederich D, Skopec J, Diederich A, Dai FX. Endothelial dysfunction in mesenteric resistance arteries of diabetic rats: role of free radicals. Am J Physiol 1994;266(Heart Circ Physiol 35):H1153-61.
17. Pieper GM, Moore-Hilton G, Roza AM. Evaluation of the mechanism of endothelial dysfunction in the genetically-diabetic BB rat. Life Sci 1996;58:PL147-52.
18. Tesfamariam B, Cohen RA. Free radicals mediate endothelial cell dysfunction caused by elevated glucose. Am J Physiol 1992;263(Heart Circ Physiol 32):H321-6.
19. Cameron NE, Cotter MA. Impaired contraction and relaxation in aorta from streptozolocin-diabetic rats: role of polyol pathway. Diabetologia 1992;35:1011-9.
20. Tesfamariam B, Palacino JJ, Weisbrod RM, Cohen RA. Aldose reductase inhibition restores endothelial cell function in diabetic rabbit aorta. J Cardiovasc Pharmacol 1993;21:205-11.
21. Pieper GM, Jordan M, Dondlinger LA, Adams MB, Roza AM. Peroxidative stress in diabetic blood vessels: reversal by pancreatic islet transplantation. Diabetes 1995;44:884-9.
22. Wasil M, Halliweell B, Grootevel M, Moorhouse CP, Hutchison DCS, Baum H. The specificity of thiourea, dimethylthiourea and dimethylsulfoxide as scavengers of hydroxyl radical. Biochem J 1987;243:867-70.
23. Roza AM, Pieper G, Moore-Hilton G, Johnson CP, Adams MB. Free radicals in pancreatic and cardiac rejection. Transplant Proc 1994;26:544-5.
24. Aebi H. Catalase in vitro. Methods Enzymol 1984;105:121-6.
25. Sato Y, Hotta N, Sakomoto N, Mutsuoka S, Ohishi N, Yagi K. Lipid peroxides in plasma of diabetic patients. Biochem Med 1979;21:104-7.
26. Gallou G, Ruelland A, Legras B, Maugendre D, Allannic A, Clourec L. Plasma malondialdehyde in type 1 and type 2 diabetic patients. Clin Chim Acta 1993;214:227-34.
27. Pieper GM, Gross GJ. Selective impairment of endothelium-dependent relaxation by oxygen-derived free radicals: distinction between receptor versus nonreceptor mediators. Blood Vessels 1989;26:44-7.
28. Pieper GM, Gross GJ. Priming by platelet-activating factor of neutrophil-induced impairment of endothelium-dependent relaxation. J Vasc Med Biol 1990;2:56-61.
29. Pieper GM, Langenstroer P, Gross GJ. Hydroxyl radicals mediate injury to endothelium-dependent relaxation in diabetic rat. Mol Cell Biochem 1993;122:139-45.
30. Keegan A, Walbank H, Cotter MA, Cameron NE. Chronic vitamin E treatment prevents defective endothelium-dependent relaxation in diabetic rat aorta. Diabetologia 1995;38:1475-8.
31. Ohkuwa T, Sato Y, Naoi M. Hydroxyl radical formation in diabetic rats induced by streptozotocin. Life Sci 1995;56:1789-98.
32. Pieper GM, Dondlinger L. Mechanism for elevated glucose-induced alteration in intracellular calcium signals to bradykinin in cultured endothelial cells [Abstract]. Circulation 1995;92:I-67.