Changes in isoprenaline-induced endothelium-dependent and -independent relaxations of aorta in long-term STZ-diabetic rats: Reversal effect of dietary vitamin E

General Pharmacology

Volumn 29, Issue 4, 1997, Pages 561-567

  Karasu, Çimen ^a   Ozansoy, Gülgün ^a   Bozkurt, Onur ^a   Erdogan, Deniz ^b   Ömeroglu, Suna ^b  

^a ANKARA UNIVERSITY   (Turkey)

^b GAZI UNIVERSITY   (Turkey)

Author keywords

Electron microscopy; Endothelium; Isoprenaline; Lipid peroxidation; Nitric oxide; STZ diabetes; Thoracic aorta; Vitamin E

Indexed keywords

ALPHA TOCOPHEROL; ISOPRENALINE; LIPID PEROXIDE; METHYLENE BLUE; N(G) NITROARGININE METHYL ESTER; PROPRANOLOL; THIOBARBITURIC ACID REACTIVE SUBSTANCE;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD VESSEL REACTIVITY; CONTROLLED STUDY; DIET; DOSE RESPONSE; DRUG SENSITIVITY; ENDOTHELIUM; IN VITRO STUDY; LIPID PEROXIDATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; STREPTOZOCIN DIABETES; THORACIC AORTA; VASODILATATION;

EID: 0030762906     PISSN: 03063623     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0306-3623(96)00577-0     Document Type: Article

References (35)

1. Abiru T., Kamata K., Miyata N., Kasuya Y. Differences in vascular responses to vasoactive agents of basilar artery and aorta from rabbits with alloxan-induced diabetes. Can. J. Physiol. Pharmac. 68:1990;882-888.
2. Baynes J. W. Role of oxidative stress in development of complications in diabetes. Diabetes. 40:1992;405-412.
3. Cohen R. A. Dysfunction of vascular endothelium in diabetes mellitus. Circulation. 87(Suppl. 5):1993;V67-V76.
4. Chisolm G. M., Irwin K. C., Penn M. S. Lipoprotein oxidation and lipoprotein induced cell injury in diabetes. Diabetes. 41(Suppl. 2):1992;61-66.
5. Ebersole B. J., Molinoff P. B. Inhibition of binding of PN200-110 to membrane from rat brain and heart by ascorbate is mediated by lipid peroxidation. J. Pharmac. Exp. Ther. 259:1991;337-344.
6. Esterbauer H., Rotheneder M. D., Striegl G., Weag G. Role of vitamin E in preventing the oxidation of low-density lipoprotein. Am. J. Clin. Nutr. 53:1991;314S.
7. Freeman B. A., Rosen G. M., Barber M. J. Superoxide pertubation of the organization of vascular endothelial cell membranes. J. Biol. Chem. 261:1986;6590-6593.
8. Furchgott R. F., Vanhoutte P. M. Endothelium-derived relaxing and constricting factors. FASEB. 3:1989;2007-2018.
9. G-nitro-L-arginine methyl ester on vasodilator responses to acetylcholine, 5′-N-ethylcarboxamidoadenosine or salbutamol in conscious rats. Br. J. Pharmac. 103:1991;1725-1732.
10. Giugliano D., Ceriello A., Paolisso G. Diabetes mellitus, hypertension, and cardiovascular disease. which role for oxidative stress? Metabolism. 44:1995;363-368.
11. Grace G. C., MacDonalds P. S., Dusting G. J. Cyclic nucleotide interactions involved in endothelium-dependent dilatation in rat aortic rings. Eur. J. Pharmac. 148:1988;17-24.
12. Graves J., Poston L. Beta-adrenoceptor agonist mediated relaxation of rat isolated resistance arteries. a role for the endothelium and nitric oxide Br. J. Pharmac. 108:1993;631-637.
13. Gray D. V., Marshall I. Isoprenalin relaxation of rat thoracic aorta is endothelium-dependent, releases nitric oxide and raises cyclic GMP and cyclic AMP. Br. J. Pharmac. 102:1991;125P.
14. Gray D., Marshall I. Noval signal transduction pathway mediating endothelium-dependent beta-adrenoceptor vasorelaxation in rat thoracic aorta. Br. J. Pharmac. 107:1992;684-690.
15. Heeson B. J., De Mey J. G. R. Effect of cyclic AMP-affecting agents on contractile reactivity of isolated mesenteric and renal resistance arteries of the rat. Br. J. Pharmac. 101:1990;859-864.
16. Henning B., Chow C. K. Lipid peroxidation and endothelial cell injury. implications in atherosclerosis Free Radical Biol. Med. 4:1988;99-106.
17. Jain S. K., Levine S. N. Elevated lipid peroxidation and vitamin E-quinone levels in heart ventricles of streptozotocin-treated diabetic rats. Free Radical Biol. Med. 18:1995;337-341.
18. Kamata K., Miyata N., Kasuya Y. Involvement of endothelial cells in relaxation and contraction responses to isoproterenol in naive and STZ-induced diabetic rats. J. Pharmac. Exp. Ther. 249:1989;890-894.
19. Karasu Ç, Altan V. M. The role of endothelial cells on the alterations in vascular reactivity induced by insulin-dependent diabetes mellitus. effects of insulin treatment Gen. Pharmac. 24:1993;743-757.
20. Karasu Ç, Altan V. M. The role of the endothelium on enhanced contractile response of non-insulin-dependent diabetic rat aortae. effects of insulin treatment Gen. Pharmac. 25:1994;795-802.
21. Karasu Ç, Dewhurst M., Stevens E. J., Tomlinson D. R. Effects of anti-oxidant treatment on sciatic nerve dysfunction in streptozotocin- diabetic rats. comparison with essential fatty acids Diabetologia. 38:1995;129-134.
22. Karasu Ç., Ozansoy G., Bozkurt O., Erdogan D. and Ömeroglu S. (1997) Antioxidant and triglyceride lowering properties of dietary vitamin E associate with its preventive effects on abnormal reactivity and morphology of aorta from STZ-diabetic rats. Metabolism (in press).
23. Kukovetz W. R., Poch G., Holzmann S. Cyclic nucleotides and relaxation of vascular smooth muscle. Vanhoutte P. M., Leuzen I. Vasodilatation. 1981;339-353 Raven Press, New York.
24. Kunisaki M., Umeda F., Noguchi T., Watanabe J., Nawata H. Effects of vitamin E administration in diabetes mellitus. Diabetes Res. 14:1990;37-42.
25. Langenstroer P. and Pieper G. M. (1992) Regulation of spontaneus EDRF release in diabetic rat aorta by oxygen free radicals. Am. J. Physiol. 263, (Heart Circ. Physiol. 32), H257-H265.
26. Langenstroer P. and Pieper G. M. (1992) Regulation of spontaneus EDRF release in diabetic rat aorta by oxygen free radicals. Am. J. Physiol. 263, (Heart Circ. Physiol. 32), H257-H265.
27. MacLeod K. M., McNeill J. H. The influence of chronic experimental diabetes on contractile responses of rat isolated blood vessels. Can. J. Physiol. Pharmac. 63:1985;52-60.
28. Martin W., Villani G. M., Jothianandan D., Furchgott R. F. Selective blockade of endothelium-dependent and glyceryl trinitrate- induced relaxation by hemoglobin and by methylene blue in the rabbit aorta. J. Pharmac. Exp. Ther. 232:1985;708-716.
29. Moncada S., Rees D. D., Schultz R., Palmer R. M. F. Development and mechanisms of a specific supersensitivity to nitrovasodilators after inhibition of vascular nitric oxide synthesis in vivo. Proc. Natl. Acad. Sci. USA. 88:1991;2166-2170.
30. Morel D. W., Chisolm G. M. Antioxidant treatment of diabetic rats inhibits lipoprotein oxidation and cytotoxicity. J. Lipid Res. 30:1989;1827-1834.
31. Nishigaki I., Hagihara M., Tsunekawa H. T., Maseki M., Yagi K. Lipid peroxide levels of serum lipoprotein fractions of diabetic patients. Biochem. Med. 25:1981;373-378.
32. Rubanyi G., Vanhoutte P. M. Endothelium-removal decreases relaxations of canine coronary arteries caused by β-adrenergic agonists and adenosine. J. Cardiovasc. Pharmac. 7:1985;139-144.
33. Rubino A., Loesch A., Gross-Sampson M. A., Milla P., Burnstock G. Effects of vitamin E deficiency on vasomotor activity and ultrastructural organisation of rat thoracic aorta. Br. J. Pharmac. 115:1995;415-420.
34. Tasfamariam B. Free radicals in diabetic endothelial cell dysfunction. Free Radical Biol. Med. 16:1994;383-391.
35. Urano S., Yano K., Matsuo M. Membrane-stabilizing effect of vitamin E. effect of alpha-tocopherol and its model compounds on fluidity of lecithin liposomes Biochem. Biophys. Res. Commun. 150:1988;469-475.