Carboxymethylated pyridoindole antioxidants as aldose reductase inhibitors: Synthesis, activity, partitioning, and molecular modeling

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 9, 2008, Pages 4908-4920

  Stefek, Milan ^a   Snirc, Vladimir ^a   Djoubissie, Paul Omer ^a   Majekova, Magdalena ^a   Demopoulos, Vassilis ^b   Rackova, Lucia ^a   Bezakova, Zelmira ^c   Karasu, Cimen ^d   Carbone, Vincenzo ^e   El Kabbani, Ossama ^e  

^a INSTITUTE OF EXPERIMENTAL PHARMACOLOGY AND TOXICOLOGY   (Slovakia)

^b ARISTOTLE UNIVERSITY OF THESSALONIKI   (Greece)

^c Physics and Informatics   (Slovakia)

^d GAZI UNIVERSITY   (Turkey)

^e MONASH UNIVERSITY   (Australia)

Author keywords

Aldose reductase inhibition; Antioxidant; Diabetic complications; Pyridoindole; Zwitterion

Indexed keywords

1,1 DIPHENYL 2 PICRYLHYDRAZYL; 2 BENZYL (4A,9B) 1,2,3,4,4A,9B HEXAHYDRO 1H PYRIDO[4,3 B]INDOL 8 YL ACETIC ACID; 2 BENZYL 2,3,4,5 TETRAHYDRO 1H PYRIDO[4,3 B]INDOL 8 YL ACETIC ACID; 2 METHYL 2,3,4,5 TETRAHYDRO 1H PYRIDO[4,3 B]INDOL 8 YL ACETIC ACID; 2 METHYL(4A,9B) 1,2,3,4,4A,9B HEXAHYDRO 1H PYRIDO[4,3 B]INDOL 8 YL ACETIC ACID; 2 PHENETHYL 2,3,4,5 TETRAHYDRO 1H PYRIDO[4,3 B]INDOL 8 YL ACETIC ACID; ALDEHYDE REDUCTASE; ALDOSE REDUCTASE INHIBITOR; AMPHOLYTE; CARBOLINE DERIVATIVE; DEHYDROSTOBADINE; HEXAHYDROPYRIDOINDOLE DERIVATIVE; OCTANOL; PHOSPHATE BUFFERED SALINE; STOBADINE; TETRAHYDROPYRIDOINDOLE DERIVATIVE; TROLOX C; VALPROIC ACID; ZOPOLRESTAT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIOXIDANT ACTIVITY; ARTICLE; CONFORMATION; CONTROLLED STUDY; DIABETES MELLITUS; DRUG ACTIVITY; DRUG INHIBITION; DRUG POTENCY; DRUG SYNTHESIS; ENZYME INHIBITION; IN VITRO STUDY; LIPOPHILICITY; MALE; NONHUMAN; OXIDATIVE STRESS; PH; RAT; STRUCTURE ACTIVITY RELATION;

ALDEHYDE REDUCTASE; ANIMALS; ANTIOXIDANTS; CARBOLINES; COMPUTER SIMULATION; DRUG EVALUATION, PRECLINICAL; ELECTROSTATICS; ENZYME INHIBITORS; HYDROGEN-ION CONCENTRATION; KINETICS; MALE; METHYLATION; MODELS, MOLECULAR; MOLECULAR STRUCTURE; RATS; RATS, WISTAR; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TIME FACTORS;

RATTUS;

EID: 43049159358     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.03.039     Document Type: Article

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