In vivo inhibition of serine protease processing requires a high fractional inhibition of cathepsin C

Molecular Pharmacology

Volumn 73, Issue 6, 2008, Pages 1857-1865

  Méthot, Nathalie ^a   Guay, Daniel ^a   Rubin, Joel ^a   Ethier, Diane ^a   Ortega, Karen ^a   Wong, Simon ^a   Normandin, Denis ^a   Beaulieu, Christian ^a   Reddy, T Jagadeeswar ^a   Riendeau, Denis ^a   Percival, M David ^a  

^a MERCK FROSST CENTRE FOR THERAPEUTIC RESEARCH   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CATHEPSIN G; CYSTEINE PROTEINASE INHIBITOR; DIPEPTIDYL PEPTIDASE I; GRANZYME B; LEUKOCYTE ELASTASE; MYELOBLASTIN; SERINE PROTEINASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BONE MARROW; CELL ASSAY; CELL STRAIN U937; ENZYME ACTIVE SITE; ENZYME ACTIVITY; HUMAN; HUMAN CELL; IN VIVO STUDY; ISOTOPE LABELING; LEUKOCYTE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEINASE INHIBITION; RAT; RECEPTOR OCCUPANCY; WILD TYPE;

ANIMALS; DIPEPTIDYL PEPTIDASE I; HUMANS; MALE; PROTEASE INHIBITORS; RATS; RATS, SPRAGUE-DAWLEY; SERINE ENDOPEPTIDASES; U937 CELLS;

EID: 44249115565     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.108.045682     Document Type: Article

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