Ranking the selectivity of PubChem screening hits by activity-based protein profiling: MMP13 as a case study

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 3, 2009, Pages 1101-1108

  Nakai, Ryuichiro ^a   Salisbury, Cleo M ^a   Rosen, Hugh ^a   Cravatt, Benjamin F ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Activity based profiling; Enzymes; High throughput screening; Inhibitors; Metalloproteinase

Indexed keywords

COLLAGENASE 3; COLLAGENASE 3 INHIBITOR; COLLAGENASE INHIBITOR; UNCLASSIFIED DRUG;

ACTIVITY BASED PROTEIN PROFILING; ARTICLE; ASSAY; DRUG SCREENING; DRUG SELECTIVITY; ENZYME ACTIVITY; HIGH THROUGHPUT SCREENING; HUMAN; TECHNIQUE;

COMBINATORIAL CHEMISTRY TECHNIQUES; DATABASES, FACTUAL; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; MATRIX METALLOPROTEINASE 13; MATRIX METALLOPROTEINASES, SECRETED; PILOT PROJECTS; PROTEASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 58949084056     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.03.018     Document Type: Article

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