Genetic disruption of the Plasmodium falciparum digestive vacuole plasmepsins demonstrates their functional redundancy

Journal of Biological Chemistry

Volumn 279, Issue 52, 2004, Pages 54088-54096

  Omara Opyene, A Levi ^a,d   Moura, Pedro A ^b   Sulsona, Carlos R ^a   Bonilla, J Alfredo ^a   Yowell, Charles A ^a   Fujioka, Hisashi ^c   Fidock, David A ^b   Dame, John B ^a  

^a UNIVERSITY OF FLORIDA   (United States)

^b ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^c CASE WESTERN RESERVE UNIVERSITY   (United States)

^d UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; CELLS; ENZYMES; HEMOGLOBIN; MORPHOLOGY;

DRUG DEVELOPMENT; GEL ANALYSES; GENETIC DISRUPTION; HEMOGLOBIN DEGRADATION;

GENES;

ASPARTIC PROTEINASE; PLAMAPEPSIN 4; PLASMEPSIN I; PLASMEPSIN II; UNCLASSIFIED DRUG;

ARTICLE; CATABOLISM; CELL STRUCTURE; CELL VACUOLE; ERYTHROCYTE; GENE CONSTRUCT; GENE DISRUPTION; GENOME; GROWTH RATE; HOMOLOGOUS RECOMBINATION; KNOCKOUT GENE; MITOCHONDRION; NONHUMAN; NORTHERN BLOTTING; NUCLEOTIDE SEQUENCE; PARASITE SURVIVAL; PATHOGENICITY; PHENOTYPE; PLASMODIUM FALCIPARUM; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FAMILY; PROTEIN FUNCTION; PROTEIN TARGETING; SOUTHERN BLOTTING; TWO DIMENSIONAL GEL ELECTROPHORESIS;

ANIMALS; ASPARTIC ENDOPEPTIDASES; BLOTTING, NORTHERN; BLOTTING, SOUTHERN; BLOTTING, WESTERN; CLONING, MOLECULAR; ELECTROPHORESIS, GEL, TWO-DIMENSIONAL; ENZYME INHIBITORS; ERYTHROCYTES; GENETIC ENGINEERING; HEMOGLOBINS; MICROSCOPY, ELECTRON; PLASMODIUM FALCIPARUM; TRANSFECTION; VACUOLES;

PLASMODIUM FALCIPARUM; PROTOZOA;

EID: 11144237489     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M409605200     Document Type: Article

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