메뉴 건너뛰기




Volumn 2012, Issue , 2012, Pages

Autophagy as a therapeutic target in diabetic nephropathy

Author keywords

[No Author keywords available]

Indexed keywords

ADENYLATE KINASE; MAMMALIAN TARGET OF RAPAMYCIN; SIRTUIN 1; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; REACTIVE OXYGEN METABOLITE; SIRT1 PROTEIN, HUMAN; TARGET OF RAPAMYCIN KINASE;

EID: 84855185046     PISSN: 16875214     EISSN: 16875303     Source Type: Journal    
DOI: 10.1155/2012/628978     Document Type: Review
Times cited : (96)

References (122)
  • 1
    • 0031445908 scopus 로고    scopus 로고
    • The rising global burden of diabetes and its complications: Estimates and projections to the year 2010
    • Amos A. F., McCarty D. J., Zimmet P., The rising global burden of diabetes and its complications: estimates and projections to the year 2010 Diabetic Medicine 1997 14, supplement 5 S1 S85
    • (1997) Diabetic Medicine , vol.145
    • Amos, A.F.1    McCarty, D.J.2    Zimmet, P.3
  • 3
    • 0042367765 scopus 로고    scopus 로고
    • Diabetic nephropathy and antihypertensive treatment: What are the lessons from clinical trials?
    • DOI 10.1016/S0895-7061(03)00864-1
    • Lasaridis A. N., Sarafidis P. A., Diabetic nephropathy and antihypertensive treatment: what are the lessons from clinical trials? American Journal of Hypertension 2003 16 8 689 697 (Pubitemid 36900594)
    • (2003) American Journal of Hypertension , vol.16 , Issue.8 , pp. 689-697
    • Lasaridis, A.N.1    Sarafidis, P.A.2
  • 5
    • 0141483457 scopus 로고    scopus 로고
    • The breakdown of preexisting advanced glycation end products is associated with reduced renal fibrosis in experimental diabetes
    • Forbes J. M., Thallas V., Thomas M. C., Founds H. W., Burns W. C., Jerums G., Cooper M. E., The breakdown of preexisting advanced glycation end products is associated with reduced renal fibrosis in experimental diabetes FASEB Journal 2003 17 12 1762 1764
    • (2003) FASEB Journal , vol.17 , Issue.12 , pp. 1762-1764
    • Forbes, J.M.1    Thallas, V.2    Thomas, M.C.3    Founds, H.W.4    Burns, W.C.5    Jerums, G.6    Cooper, M.E.7
  • 6
    • 0030760729 scopus 로고    scopus 로고
    • Characterization of protein kinase C β isoform activation on the gene expression of transforming growth factor-β, extracellular matrix components, and prostanoids in the glomeruli of diabetic rats
    • Koya D., Jirousek M. R., Lin Y. W., Ishii H., Kuboki K., King G. L., Characterization of protein kinase C isoform activation on the gene expression of transforming growth factor-, extracellular matrix components, and prostanoids in the glomeruli of diabetic rats Journal of Clinical Investigation 1997 100 1 115 126 (Pubitemid 27311249)
    • (1997) Journal of Clinical Investigation , vol.100 , Issue.1 , pp. 115-126
    • Koya, D.1    Jirousek, M.R.2    Lin, Y.-W.3    Ishii, H.4    Kuboki, K.5    King, G.L.6
  • 7
    • 0033857113 scopus 로고    scopus 로고
    • Aldose reductase and the role of the polyol pathway in diabetic nephropathy
    • Dunlop M., Aldose reductase and the role of the polyol pathway in diabetic nephropathy Kidney International, Supplement 2000 58 77 S3 S12
    • (2000) Kidney International, Supplement , vol.58 , Issue.77
    • Dunlop, M.1
  • 8
    • 76349122683 scopus 로고    scopus 로고
    • Diabetic nephropathy: A disorder of oxygen metabolism?
    • Miyata T., de Strihou C. V. Y., Diabetic nephropathy: a disorder of oxygen metabolism? Nature Reviews Nephrology 2010 6 2 83 95
    • (2010) Nature Reviews Nephrology , vol.6 , Issue.2 , pp. 83-95
    • Miyata, T.1    De Strihou, C.V.Y.2
  • 9
    • 41349110662 scopus 로고    scopus 로고
    • Mechanisms of Disease: The hypoxic tubular hypothesis of diabetic nephropathy
    • DOI 10.1038/ncpneph0757, PII NCPNEPH0757
    • Singh D. K., Winocour P., Farrington K., Mechanisms of disease: the hypoxic tubular hypothesis of diabetic nephropathy Nature Clinical Practice Nephrology 2008 4 4 216 226 (Pubitemid 351451302)
    • (2008) Nature Clinical Practice Nephrology , vol.4 , Issue.4 , pp. 216-226
    • Singh, D.K.1    Winocour, P.2    Farrington, K.3
  • 11
    • 76049118200 scopus 로고    scopus 로고
    • Role of oxidative stress in diabetic kidney disease
    • Hakim F. A., Pflueger A., Role of oxidative stress in diabetic kidney disease Medical Science Monitor 2010 16 2 RA37 RA48
    • (2010) Medical Science Monitor , vol.16 , Issue.2
    • Hakim, F.A.1    Pflueger, A.2
  • 13
    • 78349297565 scopus 로고    scopus 로고
    • Oxidative stress and diabetic complications
    • Giacco F., Brownlee M., Oxidative stress and diabetic complications Circulation Research 2010 107 9 1058 1070
    • (2010) Circulation Research , vol.107 , Issue.9 , pp. 1058-1070
    • Giacco, F.1    Brownlee, M.2
  • 14
    • 74449085963 scopus 로고    scopus 로고
    • Endoplasmic reticulum stressin proteinuric kidney disease
    • Cybulsky A. V., Endoplasmic reticulum stressin proteinuric kidney disease Kidney International 2010 77 3 187 193
    • (2010) Kidney International , vol.77 , Issue.3 , pp. 187-193
    • Cybulsky, A.V.1
  • 15
    • 79954996508 scopus 로고    scopus 로고
    • Attenuation of diabetic nephropathy in diabetes rats induced by streptozotocin by regulating the endoplasmic reticulum stress inflammatory response
    • Qi W., Mu J., Luo Z. F., Zeng W., Guo Y. H., Pang Q., Ye Z. L., Liu L., Yuan F. H., Feng B., Attenuation of diabetic nephropathy in diabetes rats induced by streptozotocin by regulating the endoplasmic reticulum stress inflammatory response Metabolism 2011 60 5 594 603
    • (2011) Metabolism , vol.60 , Issue.5 , pp. 594-603
    • Qi, W.1    Mu, J.2    Luo, Z.F.3    Zeng, W.4    Guo, Y.H.5    Pang, Q.6    Ye, Z.L.7    Liu, L.8    Yuan, F.H.9    Feng, B.10
  • 16
    • 77952049573 scopus 로고    scopus 로고
    • Induction of diabetes in aged C57B6 mice results in severe nephropathy: An association with oxidative stress, endoplasmic reticulum stress, and inflammation
    • Wu J., Zhang R., Torreggiani M., Ting A., Xiong H., Striker G. E., Vlassara H., Zheng F., Induction of diabetes in aged C57B6 mice results in severe nephropathy: an association with oxidative stress, endoplasmic reticulum stress, and inflammation American Journal of Pathology 2010 176 5 2163 2176
    • (2010) American Journal of Pathology , vol.176 , Issue.5 , pp. 2163-2176
    • Wu, J.1    Zhang, R.2    Torreggiani, M.3    Ting, A.4    Xiong, H.5    Striker, G.E.6    Vlassara, H.7    Zheng, F.8
  • 17
    • 39849109338 scopus 로고    scopus 로고
    • Autophagy fights disease through cellular self-digestion
    • DOI 10.1038/nature06639, PII NATURE06639
    • Mizushima N., Levine B., Cuervo A. M., Klionsky D. J., Autophagy fights disease through cellular self-digestion Nature 2008 451 7182 1069 1075 (Pubitemid 351317450)
    • (2008) Nature , vol.451 , Issue.7182 , pp. 1069-1075
    • Mizushima, N.1    Levine, B.2    Cuervo, A.M.3    Klionsky, D.J.4
  • 20
    • 61649124031 scopus 로고    scopus 로고
    • The role of autophagy in pancreatic -cell and diabetes
    • Fujitani Y., Kawamori R., Watada H., The role of autophagy in pancreatic -cell and diabetes Autophagy 2009 5 2 280 282
    • (2009) Autophagy , vol.5 , Issue.2 , pp. 280-282
    • Fujitani, Y.1    Kawamori, R.2    Watada, H.3
  • 22
    • 0034613294 scopus 로고    scopus 로고
    • Age-related decline in chaperone-mediated autophagy
    • Cuervo A. M., Dice J. F., Age-related decline in chaperone-mediated autophagy Journal of Biological Chemistry 2000 275 40 31505 31513
    • (2000) Journal of Biological Chemistry , vol.275 , Issue.40 , pp. 31505-31513
    • Cuervo, A.M.1    Dice, J.F.2
  • 24
    • 0029560552 scopus 로고
    • The effect of age on formation and elimination of autophagic vacuoles in mouse hepatocytes
    • Terman A., The effect of age on formation and elimination of autophagic vacuoles in mouse hepatocytes Gerontology 1995 41, supplement 2 319 326 (Pubitemid 26019927)
    • (1995) Gerontology , vol.41 , Issue.SUPPL. 2 , pp. 319-326
    • Terman, A.1
  • 28
    • 77749264299 scopus 로고    scopus 로고
    • Autophagy is a renoprotective mechanism during in vitro hypoxia and in vivo ischemia-reperfusion injury
    • Jiang M., Liu K., Luo J., Dong Z., Autophagy is a renoprotective mechanism during in vitro hypoxia and in vivo ischemia-reperfusion injury American Journal of Pathology 2010 176 3 1181 1192
    • (2010) American Journal of Pathology , vol.176 , Issue.3 , pp. 1181-1192
    • Jiang, M.1    Liu, K.2    Luo, J.3    Dong, Z.4
  • 32
    • 29244486472 scopus 로고    scopus 로고
    • Inhibition of mTOR signaling with rapamycin attenuates renal hypertrophy in the early diabetic mice
    • DOI 10.1016/j.bbrc.2005.12.012, PII S0006291X0502752X
    • Sakaguchi M., Isono M., Isshiki K., Sugimoto T., Koya D., Kashiwagi A., Inhibition of mTOR signaling with rapamycin attenuates renal hypertrophy in the early diabetic mice Biochemical and Biophysical Research Communications 2006 340 1 296 301 (Pubitemid 41827680)
    • (2006) Biochemical and Biophysical Research Communications , vol.340 , Issue.1 , pp. 296-301
    • Sakaguchi, M.1    Isono, M.2    Isshiki, K.3    Sugimoto, T.4    Koya, D.5    Kashiwagi, A.6
  • 33
    • 34748880045 scopus 로고    scopus 로고
    • Rapamycin prevents early steps of the development of diabetic nephropathy in rats
    • DOI 10.1159/000106782
    • Yang Y., Wang J., Qin L., Shou Z., Zhao J., Wang H., Chen Y., Chen J., Rapamycin prevents early steps of the development of diabetic nephropathy in rats American Journal of Nephrology 2007 27 5 495 502 (Pubitemid 47482007)
    • (2007) American Journal of Nephrology , vol.27 , Issue.5 , pp. 495-502
    • Yang, Y.1    Wang, J.2    Qin, L.3    Shou, Z.4    Zhao, J.5    Wang, H.6    Chen, Y.7    Chen, J.8
  • 35
    • 55249083264 scopus 로고    scopus 로고
    • Role of TSC-mTOR pathway in diabetic nephropathy
    • Inoki K., Role of TSC-mTOR pathway in diabetic nephropathy Diabetes Research and Clinical Practice 2008 82, supplement 1 S59 S62
    • (2008) Diabetes Research and Clinical Practice , vol.821
    • Inoki, K.1
  • 37
    • 70350560556 scopus 로고    scopus 로고
    • Nutrient stress activates inflammation and reduces glucose metabolism by suppressing AMP-activated protein kinase in the heart
    • Hwi J. K., Zhang Z., Dae Y. J., Jun J. Y., Ma Z., Jones K. E., Chan S. Y., Kim J. K., Nutrient stress activates inflammation and reduces glucose metabolism by suppressing AMP-activated protein kinase in the heart Diabetes 2009 58 11 2536 2546
    • (2009) Diabetes , vol.58 , Issue.11 , pp. 2536-2546
    • Hwi, J.K.1    Zhang, Z.2    Dae, Y.J.3    Jun, J.Y.4    Ma, Z.5    Jones, K.E.6    Chan, S.Y.7    Kim, J.K.8
  • 39
    • 78650385720 scopus 로고    scopus 로고
    • Effect of telmisartan on the expression of cardiac adiponectin and its receptor 1 in type 2 diabetic rats
    • Guo Z., Zheng C., Qin Z., Wei P., Effect of telmisartan on the expression of cardiac adiponectin and its receptor 1 in type 2 diabetic rats Journal of Pharmacy and Pharmacology 2011 63 1 87 94
    • (2011) Journal of Pharmacy and Pharmacology , vol.63 , Issue.1 , pp. 87-94
    • Guo, Z.1    Zheng, C.2    Qin, Z.3    Wei, P.4
  • 42
    • 77950834672 scopus 로고    scopus 로고
    • SIRT1, A calorie restriction mimetic, in a new therapeutic approach for type 2 diabetes mellitus and diabetic vascular complications
    • Kume S., Takashi U., Atsunori K., Daisuke K., SIRT1, A calorie restriction mimetic, in a new therapeutic approach for type 2 diabetes mellitus and diabetic vascular complications Endocrine, Metabolic and Immune DisordersDrug Targets 2010 10 1 16 24
    • (2010) Endocrine, Metabolic and Immune DisordersDrug Targets , vol.10 , Issue.1 , pp. 16-24
    • Kume, S.1    Takashi, U.2    Atsunori, K.3    Daisuke, K.4
  • 44
    • 78649338141 scopus 로고    scopus 로고
    • Autophagy and the integrated stress response
    • Kroemer G., Mario G., Levine B., Autophagy and the integrated stress response Molecular Cell 2010 40 2 280 293
    • (2010) Molecular Cell , vol.40 , Issue.2 , pp. 280-293
    • Kroemer, G.1    Mario, G.2    Levine, B.3
  • 45
    • 14044277429 scopus 로고    scopus 로고
    • The molecular machinery of autophagy: Unanswered questions
    • DOI 10.1242/jcs.01620
    • Klionsky D. J., The molecular machinery of autophagy: unanswered questions Journal of Cell Science 2005 118, part 1 7 18 (Pubitemid 40277100)
    • (2005) Journal of Cell Science , vol.118 , Issue.1 , pp. 7-18
    • Klionsky, D.J.1
  • 46
    • 33745023775 scopus 로고    scopus 로고
    • Chaperone-Mediated Autophagy in Aging and Disease
    • DOI 10.1016/S0070-2153(05)73007-6, PII S0070215305730076
    • Massey A. C., Zhang C., Cuervo A. M., Chaperone-mediated autophagy in aging and disease Current Topics in Developmental Biology 2006 73 205 235 (Pubitemid 43878134)
    • (2006) Current Topics in Developmental Biology , vol.73 , pp. 205-235
    • Massey, A.C.1    Zhang, C.2    Cuervo, A.M.3
  • 48
    • 71649112895 scopus 로고    scopus 로고
    • 3D tomography reveals connections between the phagophore and endoplasmic reticulum
    • Yl-Anttila P., Vihinen H., Jokitalo E., Eskelinen E. L., 3D tomography reveals connections between the phagophore and endoplasmic reticulum Autophagy 2009 5 8 1180 1185
    • (2009) Autophagy , vol.5 , Issue.8 , pp. 1180-1185
    • Yl-Anttila, P.1    Vihinen, H.2    Jokitalo, E.3    Eskelinen, E.L.4
  • 49
    • 50249084987 scopus 로고    scopus 로고
    • Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum
    • Axe E. L., Walker S. A., Manifava M., Chandra P., Roderick H. L., Habermann A., Griffiths G., Ktistakis N. T., Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum Journal of Cell Biology 2008 182 4 685 701
    • (2008) Journal of Cell Biology , vol.182 , Issue.4 , pp. 685-701
    • Axe, E.L.1    Walker, S.A.2    Manifava, M.3    Chandra, P.4    Roderick, H.L.5    Habermann, A.6    Griffiths, G.7    Ktistakis, N.T.8
  • 51
  • 52
    • 66449083078 scopus 로고    scopus 로고
    • ULK1 ATG13 FIP200 complex mediates mTOR signaling and is essential for autophagy
    • Ganley I. G., Lam D. H., Wang J., Ding X., Chen S., Jiang X., ULK1 ATG13 FIP200 complex mediates mTOR signaling and is essential for autophagy Journal of Biological Chemistry 2009 284 18 12297 12305
    • (2009) Journal of Biological Chemistry , vol.284 , Issue.18 , pp. 12297-12305
    • Ganley, I.G.1    Lam, D.H.2    Wang, J.3    Ding, X.4    Chen, S.5    Jiang, X.6
  • 55
    • 0000906170 scopus 로고    scopus 로고
    • Induction of autophagy and inhibition of tumorigenesis by beclin 1
    • Liang X. H., Jackson S., Seaman M., Brown K., Kempkes B., Hibshoosh H., Levine B., Induction of autophagy and inhibition of tumorigenesis by beclin 1 Nature 1999 402 6762 672 676 (Pubitemid 129516338)
    • (1999) Nature , vol.402 , Issue.6762 , pp. 672-676
    • Liang, X.H.1    Jackson, S.2    Seaman, M.3    Brown, K.4    Kempkes, B.5    Hibshoosh, H.6    Levine, B.7
  • 56
    • 38749136302 scopus 로고    scopus 로고
    • Regulation of macroautophagy by mTOR and Beclin 1 complexes
    • DOI 10.1016/j.biochi.2007.08.014, PII S0300908407002283
    • Pattingre S., Espert L., Biard-Piechaczyk M., Codogno P., Regulation of macroautophagy by mTOR and beclin 1 complexes Biochimie 2008 90 2 313 323 (Pubitemid 351181247)
    • (2008) Biochimie , vol.90 , Issue.2 , pp. 313-323
    • Pattingre, S.1    Espert, L.2    Biard-Piechaczyk, M.3    Codogno, P.4
  • 59
    • 75749122303 scopus 로고    scopus 로고
    • Methods in mammalian autophagy research
    • Mizushima N., Yoshimori T., Levine B., Methods in mammalian autophagy research Cell 2010 140 3 313 326
    • (2010) Cell , vol.140 , Issue.3 , pp. 313-326
    • Mizushima, N.1    Yoshimori, T.2    Levine, B.3
  • 60
    • 77956416339 scopus 로고    scopus 로고
    • Autophagy in mammalian development and differentiation
    • Mizushima N., Levine B., Autophagy in mammalian development and differentiation Nature Cell Biology 2010 12 9 823 830
    • (2010) Nature Cell Biology , vol.12 , Issue.9 , pp. 823-830
    • Mizushima, N.1    Levine, B.2
  • 63
    • 27944504351 scopus 로고    scopus 로고
    • P62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death
    • DOI 10.1083/jcb.200507002
    • Bjrky G., Lamark T., Brech A., Outzen H., Perander M., vervatn A., Stenmark H., Johansen T., p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death Journal of Cell Biology 2005 171 4 603 614 (Pubitemid 41668720)
    • (2005) Journal of Cell Biology , vol.171 , Issue.4 , pp. 603-614
    • Bjorkoy, G.1    Lamark, T.2    Brech, A.3    Outzen, H.4    Perander, M.5    Overvatn, A.6    Stenmark, H.7    Johansen, T.8
  • 65
    • 23944491271 scopus 로고    scopus 로고
    • Role of mammalian target of rapamycin signaling in compensatory renal hypertrophy
    • DOI 10.1681/ASN.2004100894
    • Chen J. K., Chen J., Neilson E. G., Harris R. C., Role of mammalian target of rapamycin signaling in compensatory renal hypertrophy Journal of the American Society of Nephrology 2005 16 5 1384 1391 (Pubitemid 41716522)
    • (2005) Journal of the American Society of Nephrology , vol.16 , Issue.5 , pp. 1384-1391
    • Chen, J.-K.1    Chen, J.2    Neilson, E.G.3    Harris, R.C.4
  • 68
    • 79957881425 scopus 로고    scopus 로고
    • Role of mTOR in podocyte function and diabetic nephropathy in humans and mice
    • Gdel M., Hartleben B., Herbach N., Role of mTOR in podocyte function and diabetic nephropathy in humans and mice Journal of Clinical Investigation 2011 121 6 2197 2209
    • (2011) Journal of Clinical Investigation , vol.121 , Issue.6 , pp. 2197-2209
    • Gdel, M.1    Hartleben, B.2    Herbach, N.3
  • 69
    • 79957927211 scopus 로고    scopus 로고
    • MTORC1 activation in podocytes is a critical step in the development of diabetic nephropathy in mice
    • Inoki K., Mori H., Wang J., mTORC1 activation in podocytes is a critical step in the development of diabetic nephropathy in mice Journal of Clinical Investigation 2011 121 6 2181 2196
    • (2011) Journal of Clinical Investigation , vol.121 , Issue.6 , pp. 2181-2196
    • Inoki, K.1    Mori, H.2    Wang, J.3
  • 70
    • 77955708390 scopus 로고    scopus 로고
    • Overview of macroautophagy regulation in mammalian cells
    • Mehrpour M., Esclatine A., Beau I., Codogno P., Overview of macroautophagy regulation in mammalian cells Cell Research 2010 20 7 748 762
    • (2010) Cell Research , vol.20 , Issue.7 , pp. 748-762
    • Mehrpour, M.1    Esclatine, A.2    Beau, I.3    Codogno, P.4
  • 71
    • 27544500981 scopus 로고    scopus 로고
    • Growing roles for the mTOR pathway
    • DOI 10.1016/j.ceb.2005.09.009, PII S0955067405001481
    • Sarbassov D. D., Ali S. M., Sabatini D. M., Growing roles for the mTOR pathway Current Opinion in Cell Biology 2005 17 6 596 603 (Pubitemid 41540408)
    • (2005) Current Opinion in Cell Biology , vol.17 , Issue.6 , pp. 596-603
    • Sarbassov, D.D.1    Ali, S.M.2    Sabatini, D.M.3
  • 73
    • 34547907805 scopus 로고    scopus 로고
    • Expanding mTOR signaling
    • DOI 10.1038/cr.2007.64, PII CR200764
    • Yang Q., Guan K. L., Expanding mTOR signaling Cell Research 2007 17 8 666 681 (Pubitemid 47255937)
    • (2007) Cell Research , vol.17 , Issue.8 , pp. 666-681
    • Yang, Q.1    Guan, K.-L.2
  • 75
    • 3342895823 scopus 로고    scopus 로고
    • Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton
    • DOI 10.1016/j.cub.2004.06.054, PII S0960982204004713
    • Dos D. S., Ali S. M., Kim D. H., Guertin D. A., Latek R. R., Erdjument-Bromage H., Tempst P., Sabatini D. M., Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton Current Biology 2004 14 14 1296 1302 (Pubitemid 38991819)
    • (2004) Current Biology , vol.14 , Issue.14 , pp. 1296-1302
    • Dos D. Sarbassov1    Ali, S.M.2    Kim, D.-H.3    Guertin, D.A.4    Latek, R.R.5    Erdjument-Bromage, H.6    Tempst, P.7    Sabatini, D.M.8
  • 76
    • 77951221542 scopus 로고    scopus 로고
    • The role of the Atg1/ULK1 complex in autophagy regulation
    • Mizushima N., The role of the Atg1/ULK1 complex in autophagy regulation Current Opinion in Cell Biology 2010 22 2 132 139
    • (2010) Current Opinion in Cell Biology , vol.22 , Issue.2 , pp. 132-139
    • Mizushima, N.1
  • 77
    • 7944235758 scopus 로고    scopus 로고
    • Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive
    • DOI 10.1038/ncb1183
    • Jacinto E., Loewith R., Schmidt A., Lin S., Regg M. A., Hall A., Hall M. N., Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive Nature Cell Biology 2004 6 11 1122 1128 (Pubitemid 39468014)
    • (2004) Nature Cell Biology , vol.6 , Issue.11 , pp. 1122-1128
    • Jacinto, E.1    Loewith, R.2    Schmidt, A.3    Lin, S.4    Ruegg, M.A.5    Hall, A.6    Hall, M.N.7
  • 78
    • 0034687688 scopus 로고    scopus 로고
    • Cytoplasmic-nuclear shuttling of FKBP12-rapamycin-associated protein is involved in rapamycin-sensitive signaling and translation initiation
    • DOI 10.1073/pnas.011511898
    • Kim J. E., Chen J., Cytoplasmic-nuclear shuttling of FKBP12-rapamycin- associated protein is involved in rapamycin-sensitive signaling and translation initiation Proceedings of the National Academy of Sciences of the United States of America 2000 97 26 14340 14345 (Pubitemid 32016577)
    • (2000) Proceedings of the National Academy of Sciences of the United States of America , vol.97 , Issue.26 , pp. 14340-14345
    • Kim, J.E.1    Chen, J.2
  • 79
    • 32044465506 scopus 로고    scopus 로고
    • TOR signaling in growth and metabolism
    • DOI 10.1016/j.cell.2006.01.016, PII S0092867406001085
    • Wullschleger S., Loewith R., Hall M. N., TOR signaling in growth and metabolism Cell 2006 124 3 471 484 (Pubitemid 43199434)
    • (2006) Cell , vol.124 , Issue.3 , pp. 471-484
    • Wullschleger, S.1    Loewith, R.2    Hall, M.N.3
  • 81
  • 82
    • 79551601710 scopus 로고    scopus 로고
    • Resveratrol improves oxidative stress and protects against diabetic nephropathy through normalization of Mn-SOD dysfunction in AMPK/SIRT1- independent pathway
    • Kitada M., Kume S., Imaizumi N., Koya D., Resveratrol improves oxidative stress and protects against diabetic nephropathy through normalization of Mn-SOD dysfunction in AMPK/SIRT1- independent pathway Diabetes 2011 60 2 634 643
    • (2011) Diabetes , vol.60 , Issue.2 , pp. 634-643
    • Kitada, M.1    Kume, S.2    Imaizumi, N.3    Koya, D.4
  • 85
    • 79959442302 scopus 로고    scopus 로고
    • Resveratrol retards progression of diabetic nephropathy through modulations of oxidative stress, proinflammatory cytokines, and AMP-activated protein kinase
    • Chang C. C., Chang C. Y., Wu Y. T., Huang J. P., Yen T. H., Hung L. M., Resveratrol retards progression of diabetic nephropathy through modulations of oxidative stress, proinflammatory cytokines, and AMP-activated protein kinase Journal of Biomedical Science 2011 18 1 47
    • (2011) Journal of Biomedical Science , vol.18 , Issue.1 , pp. 47
    • Chang, C.C.1    Chang, C.Y.2    Wu, Y.T.3    Huang, J.P.4    Yen, T.H.5    Hung, L.M.6
  • 89
    • 25444465657 scopus 로고    scopus 로고
    • Diet-induced obesity in C57BL/6J mice causes increased renal lipid accumulation and glomerulosclerosis via a sterol regulatory element-binding protein-1c-dependent pathway
    • DOI 10.1074/jbc.M500801200
    • Jiang T., Wang Z., Proctor G., Moskowitz S., Liebman S. E., Rogers T., Lucia M. S., Li J., Levi M., Diet-induced obesity in C57BL/6J mice causes increased renal lipid accumulation and glomerulosclerosis via a sterol regulatory element-binding protein-1c-dependent pathway Journal of Biological Chemistry 2005 280 37 32317 32325 (Pubitemid 41361841)
    • (2005) Journal of Biological Chemistry , vol.280 , Issue.37 , pp. 32317-32325
    • Jiang, T.1    Wang, Z.2    Proctor, G.3    Moskowitz, S.4    Liebman, S.E.5    Rogers, T.6    Lucia, M.S.7    Li, J.8    Levi, M.9
  • 90
    • 23644438916 scopus 로고    scopus 로고
    • db/db mice with type 2 diabetes
    • DOI 10.2337/diabetes.54.8.2328
    • Wang Z., Jiang T., Li J., Proctor G., McManaman J. L., Lucia S., Chua S., Levi M., Regulation of renal lipid metabolism, lipid accumulation, and glomerulosclerosis in FVBdb/db mice with type 2 diabetes Diabetes 2005 54 8 2328 2335 (Pubitemid 41134259)
    • (2005) Diabetes , vol.54 , Issue.8 , pp. 2328-2335
    • Wang, Z.1    Jiang, T.2    Li, J.3    Proctor, G.4    McManaman, J.L.5    Lucia, S.6    Chua, S.7    Levi, M.8
  • 91
    • 0142181286 scopus 로고    scopus 로고
    • Malonyl-CoA and AMP-activated protein kinase: An expanding partnership
    • DOI 10.1023/A:1026053302036
    • Saha A. K., Ruderman N. B., Malonyl-CoA and AMP-activated protein kinase: an expanding partnership Molecular and Cellular Biochemistry 2003 253 1-2 65 70 (Pubitemid 37321713)
    • (2003) Molecular and Cellular Biochemistry , vol.253 , Issue.1-2 , pp. 65-70
    • Saha, A.K.1    Ruderman, N.B.2
  • 92
    • 77957349477 scopus 로고    scopus 로고
    • AMP-activated protein kinase and its downstream transcriptional pathways
    • Cant C., Auwerx J., AMP-activated protein kinase and its downstream transcriptional pathways Cellular and Molecular Life Sciences 2010 67 20 3407 3423
    • (2010) Cellular and Molecular Life Sciences , vol.67 , Issue.20 , pp. 3407-3423
    • Cant, C.1    Auwerx, J.2
  • 94
    • 78149476877 scopus 로고    scopus 로고
    • The association of AMPK with ULK1 regulates autophagy
    • Lee J. W., Park S., Takahashi Y., Wang H. G., The association of AMPK with ULK1 regulates autophagy PLoS ONE 2010 5 11
    • (2010) PLoS ONE , vol.5 , Issue.11
    • Lee, J.W.1    Park, S.2    Takahashi, Y.3    Wang, H.G.4
  • 95
    • 77954237882 scopus 로고    scopus 로고
    • Network organization of the human autophagy system
    • Behrends C., Sowa M. E., Gygi S. P., Harper J. W., Network organization of the human autophagy system Nature 2010 466 7302 68 76
    • (2010) Nature , vol.466 , Issue.7302 , pp. 68-76
    • Behrends, C.1    Sowa, M.E.2    Gygi, S.P.3    Harper, J.W.4
  • 96
    • 77952547233 scopus 로고    scopus 로고
    • Ten years of NAD-dependent SIR2 family deacetylases: Implications for metabolic diseases
    • Imai S. I., Guarente L., Ten years of NAD-dependent SIR2 family deacetylases: implications for metabolic diseases Trends in Pharmacological Sciences 2010 31 5 212 220
    • (2010) Trends in Pharmacological Sciences , vol.31 , Issue.5 , pp. 212-220
    • Imai, S.I.1    Guarente, L.2
  • 97
    • 77949887506 scopus 로고    scopus 로고
    • Mammalian sirtuins: Biological insights and disease relevance
    • Haigis M. C., Sinclair D. A., Mammalian sirtuins: biological insights and disease relevance Annual Review of Pathology 2010 5 253 295
    • (2010) Annual Review of Pathology , vol.5 , pp. 253-295
    • Haigis, M.C.1    Sinclair, D.A.2
  • 99
    • 33847091642 scopus 로고    scopus 로고
    • Intermittent fasting prevents the progression of type I diabetic nephropathy in rats and changes the expression of Sir2 and p53
    • DOI 10.1016/j.febslet.2007.02.006, PII S001457930700155X
    • Tikoo K., Tripathi D. N., Kabra D. G., Sharma V., Gaikwad A. B., Intermittent fasting prevents the progression of type I diabetic nephropathy in rats and changes the expression of Sir2 and p53 FEBS Letters 2007 581 5 1071 1078 (Pubitemid 46282743)
    • (2007) FEBS Letters , vol.581 , Issue.5 , pp. 1071-1078
    • Tikoo, K.1    Tripathi, D.N.2    Kabra, D.G.3    Sharma, V.4    Gaikwad, A.B.5
  • 100
    • 48849086013 scopus 로고    scopus 로고
    • Change in histone H3 phosphorylation, MAP kinase p38, SIR 2 and p53 expression by resveratrol in preventing streptozotocin induced type i diabetic nephropathy
    • Tikoo K., Singh K., Kabra D., Sharma V., Gaikwad A., Change in histone H3 phosphorylation, MAP kinase p38, SIR 2 and p53 expression by resveratrol in preventing streptozotocin induced type I diabetic nephropathy Free Radical Research 2008 42 4 397 404
    • (2008) Free Radical Research , vol.42 , Issue.4 , pp. 397-404
    • Tikoo, K.1    Singh, K.2    Kabra, D.3    Sharma, V.4    Gaikwad, A.5
  • 104
    • 81555225308 scopus 로고    scopus 로고
    • Dietary restriction ameliorates diabetic nephropathy through anti-inflammatory effects and regulation of the autophagy via restoration of Sirt1 in Diabetic Wistar fatty (fa/fa) rats, a model of type 2 diabetes
    • Kitada M., Takeda A., Nagai T., Dietary restriction ameliorates diabetic nephropathy through anti-inflammatory effects and regulation of the autophagy via restoration of Sirt1 in Diabetic Wistar fatty (fa/fa) rats, a model of type 2 diabetes Experimental Diabetes Research 2011 2011 11
    • (2011) Experimental Diabetes Research , vol.2011 , pp. 11
    • Kitada, M.1    Takeda, A.2    Nagai, T.3
  • 105
    • 34249934085 scopus 로고    scopus 로고
    • Selective degradation of mitochondria by mitophagy
    • DOI 10.1016/j.abb.2007.03.034, PII S0003986107001622, Highlight Issue: Pro- and antiapoptotic Signalling
    • Kim I., Rodriguez-Enriquez S., Lemasters J. J., Selective degradation of mitochondria by mitophagy Archives of Biochemistry and Biophysics 2007 462 2 245 253 (Pubitemid 46876640)
    • (2007) Archives of Biochemistry and Biophysics , vol.462 , Issue.2 , pp. 245-253
    • Kim, I.1    Rodriguez-Enriquez, S.2    Lemasters, J.J.3
  • 106
    • 57649221592 scopus 로고    scopus 로고
    • Hypoxic reactive oxygen species regulate the integrated stress response and cell survival
    • Liu L., Wise D. R., Diehl J. A., Simon M. C., Hypoxic reactive oxygen species regulate the integrated stress response and cell survival Journal of Biological Chemistry 2008 283 45 31153 31162
    • (2008) Journal of Biological Chemistry , vol.283 , Issue.45 , pp. 31153-31162
    • Liu, L.1    Wise, D.R.2    Diehl, J.A.3    Simon, M.C.4
  • 107
    • 0017614419 scopus 로고
    • Reversible hematologic sequelae of diabetes mellitus
    • Peterson C. M., Jones R. L., Koenig R. J., Reversible hematologic sequelae of diabetes mellitus Annals of Internal Medicine 1977 86 4 425 429 (Pubitemid 8078951)
    • (1977) Annals of Internal Medicine , vol.86 , Issue.4 , pp. 425-429
    • Peterson, C.M.1    Jones, R.L.2    Koenig, R.J.3
  • 108
    • 0019471680 scopus 로고
    • Hematologic alterations in diabetes mellitus
    • DOI 10.1016/0002-9343(81)90771-3
    • Jones R. L., Peterson C. M., Hematologic alterations in diabetes mellitus American Journal of Medicine 1981 70 2 339 352 (Pubitemid 11146020)
    • (1981) American Journal of Medicine , vol.70 , Issue.2 , pp. 339-352
    • Jones, R.L.1    Peterson, C.M.2
  • 109
    • 33646358954 scopus 로고    scopus 로고
    • High glucose blunts vascular endothelial growth factor response to hypoxia via the oxidative stress-regulated hypoxia-inducible factor/hypoxia-responsible element pathway
    • DOI 10.1681/ASN.2005090918
    • Katavetin P., Miyata T., Inagi R., Tanaka T., Sassa R., Ingelfinger J. R., Fujita T., Nangaku M., High glucose blunts vascular endothelial growth factor response to hypoxia via the oxidative stress-regulated hypoxia-inducible factor/hypoxia-responsible element pathway Journal of the American Society of Nephrology 2006 17 5 1405 1413 (Pubitemid 43673421)
    • (2006) Journal of the American Society of Nephrology , vol.17 , Issue.5 , pp. 1405-1413
    • Katavetin, P.1    Miyata, T.2    Inagi, R.3    Tanaka, T.4    Sassa, R.5    Ingelfinger, J.R.6    Fujita, T.7    Nangaku, M.8
  • 110
    • 78649364332 scopus 로고    scopus 로고
    • Hypoxia-inducible factors and the response to hypoxic stress
    • Majmundar A. J., Wong W. J., Simon M. C., Hypoxia-inducible factors and the response to hypoxic stress Molecular Cell 2010 40 2 294 309
    • (2010) Molecular Cell , vol.40 , Issue.2 , pp. 294-309
    • Majmundar, A.J.1    Wong, W.J.2    Simon, M.C.3
  • 111
    • 77951228508 scopus 로고    scopus 로고
    • Hypoxia-induced autophagy: Cell death or cell survival?
    • Mazure N. M., Pouysségur J., Hypoxia-induced autophagy: cell death or cell survival? Current Opinion in Cell Biology 2010 22 2 177 180
    • (2010) Current Opinion in Cell Biology , vol.22 , Issue.2 , pp. 177-180
    • Mazure, N.M.1    Pouysségur, J.2
  • 112
    • 66349121718 scopus 로고    scopus 로고
    • Hypoxia-induced autophagy is mediated through hypoxia-inducible factor induction of BNIP3 and BNIP3L via their BH3 domains
    • Bellot G., Garcia-Medina R., Gounon P., Chiche J., Roux D., Pouysségur J., Mazure N. M., Hypoxia-induced autophagy is mediated through hypoxia-inducible factor induction of BNIP3 and BNIP3L via their BH3 domains Molecular and Cellular Biology 2009 29 10 2570 2581
    • (2009) Molecular and Cellular Biology , vol.29 , Issue.10 , pp. 2570-2581
    • Bellot, G.1    Garcia-Medina, R.2    Gounon, P.3    Chiche, J.4    Roux, D.5    Pouysségur, J.6    Mazure, N.M.7
  • 116
    • 77957078371 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress and inflammation in obesity and diabetes
    • Hummasti S., Hotamisligil G. S., Endoplasmic reticulum stress and inflammation in obesity and diabetes Circulation Research 2010 107 5 579 591
    • (2010) Circulation Research , vol.107 , Issue.5 , pp. 579-591
    • Hummasti, S.1    Hotamisligil, G.S.2
  • 117
    • 34250899722 scopus 로고    scopus 로고
    • Signal integration in the endoplasmic reticulum unfolded protein response
    • DOI 10.1038/nrm2199, PII NRM2199
    • Ron D., Walter P., Signal integration in the endoplasmic reticulum unfolded protein response Nature Reviews Molecular Cell Biology 2007 8 7 519 529 (Pubitemid 46985379)
    • (2007) Nature Reviews Molecular Cell Biology , vol.8 , Issue.7 , pp. 519-529
    • Ron, D.1    Walter, P.2
  • 118
    • 35348827324 scopus 로고    scopus 로고
    • That which does not kill me makes me stronger: Adapting to chronic ER stress
    • DOI 10.1016/j.tibs.2007.09.003, PII S0968000407002137
    • Rutkowski D. T., Kaufman R. J., That which does not kill me makes me stronger: adapting to chronic ER stress Trends in Biochemical Sciences 2007 32 10 469 476 (Pubitemid 47588945)
    • (2007) Trends in Biochemical Sciences , vol.32 , Issue.10 , pp. 469-476
    • Rutkowski, D.T.1    Kaufman, R.J.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.