Malonyl-CoA and AMP-activated protein kinase: An expanding partnership

Molecular and Cellular Biochemistry

Volumn 253, Issue 1-2, 2003, Pages 65-70

  Saha, Asish K ^a   Ruderman, Neil B ^a  

^a BOSTON UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Acetyl CoA carboxylase; AMP activated protein kinase; Insulin resistant; Malonyl CoA; Malonyl CoA decarboxylase

Indexed keywords

ACETYL COENZYME A CARBOXYLASE; ADENOSINE PHOSPHATE; CARNITINE PALMITOYLTRANSFERASE; CITRIC ACID; GLUCOSE; INSULIN; LONG CHAIN FATTY ACID; MALONYL COENZYME A; PROTEIN KINASE;

CONCENTRATION (PARAMETERS); CORRELATION ANALYSIS; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME DEGRADATION; ENZYME MECHANISM; ENZYME PHOSPHORYLATION; ENZYME SYNTHESIS; FATTY ACID OXIDATION; HUMAN; IN VIVO STUDY; LIVER; MOLECULAR MECHANICS; NONHUMAN; PROTEIN FUNCTION; RAT; REGULATORY MECHANISM; REVIEW; SIGNAL TRANSDUCTION; SKELETAL MUSCLE;

ACETYL-COA CARBOXYLASE; ANIMALS; CARBOXY-LYASES; CARNITINE O-PALMITOYLTRANSFERASE; DIABETES MELLITUS, TYPE 2; HUMANS; INSULIN RESISTANCE; MITOCHONDRIA, MUSCLE; MULTIENZYME COMPLEXES; MUSCLE, SKELETAL; PROTEIN-SERINE-THREONINE KINASES; RATS;

RODENTIA;

EID: 0142181286     PISSN: 03008177     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1026053302036     Document Type: Review

References (48)

1. McGarry JD, Mills SE, Long CS, Foster DW: Observations on the affinity for carnitine, and malonyl CoA sensitivity, of carnitine palmitoyltransferase I in animal and human tissues. Demonstration of the presence of malonyl CoA in non-hepatic tissues of the rat. Biochem J 214: 21-28, 1983
2. Saha AK, Kurowski TG, Ruderman NB: A malonyl-CoA fuel sensing mechanism in muscle: Effects of insulin, glucose and denervation. Am J Physiol 269: E283-E289, 1995
3. Winder WW, Arogyasami J, Elayan IM, Cartmill D: Time course of exercise-induced decline in malonyl CoA in different muscle types. Am J Physiol 259: E266-E271, 1990
4. Duan C, Winder WW: Nerve stimulation decreases malonyl-CoA in skeletal muscle. J Appl Physiol 72: 901-904, 1992
5. Vavvas D, Apazidis A, Saha AK, Gamble J, Patel A, Kemp BE, Witters LA, Ruderman NB: Contraction-induced changes in acetyl-CoA carboxylase and 5′-AMP-activated kinase in skeletal muscle. J Biol Chem 272: 13255-13261, 1997
6. Hardie DG, Carling D: The AMP-activated protein kinase. Fuel gauge of the mammalian cell. Eur J Biochem 246: 259-273, 1997
7. Winder WW, Hardie DG: AMP-activated protein kinase, a metabolic master switch: Possible roles in type 2 diabetes. Am J Physiol 277: E1-E10, 1999
8. Saha AK, Schwarsin AJ, Roduit R, Masse F, Kaushik V, Tornheim K, Prentki M, Ruderman NB: Activation of malonyl-CoA decarboxylase in rat skeletal muscle by contraction and the AMP-activated protein kinase activator 5-aminoimidazole-4-carboxamide-1-beta-Dribofuranoside. J Biol Chem 275: 24279-24283, 2000.
9. Saha AK, Kurowski TG, Colca JR, Ruderman NB: Lipid abnormalities in tissues of the KKAy mouse: Effects of pioglitazone on malonyl-CoA and diacylglycerol. Am J Physiol 267: E283-E289, 1994
10. Prenti M, Vischer S, Glennon M, Regazzi R, Deeney J, Corkey B: Malonyl-CoA and long chain acyl-CoA esters as metabolic coupling factors in nutrient-induced insulin secretion. J Biol Chem 267: 5802-5810, 1992
11. Ruderman NB, Saha AK, Vavvas D, Heydrick SJ, Kurowski TG: Lipid abnormalities in muscle of insulin-resistant rodents. The malonyl CoA hypothesis. Ann NY Acad Sci 827: 221-230, 1997
12. Hardie DG: Regulation of fatty acid synthesis via phosphorylation of acetyl CoA carboxylase. Prog Lipid Res 28: 117-146, 1989
13. Kim KH: Regulation of mammalian acetyl-coenzyme A carboxylase. Ann Rev Nutr 17: 77-99, 1997
14. Kim KH, Lopez CF, Bai DH, Luo X, Pape ME: Role of reversible phosphorylation of acetyl-CoA carboxylase in long-chain fatty acid synthesis. FASEB J 3: 2250-2256, 1989
15. Witters LA, Watts TD, Daniels DL, Evans JL: Insulin stimulates the dephosphorylation and activation of acetyl CoA carboxylase. Proc Natl Acad Sci USA 85: 5473-5477, 1988
16. Bianchi A, Evans J, Iverson A, Nordlund A, Watts T, Witters LA: Identification of an isozymic form of acetyl-CoA carboxylase. J Biol Chem 265: 1502-1509, 1990
17. McGarry JD: The mitochondrial carnitine palmitoyltransferase system: Its broadening role in fuel homoeostasis and new insights into its molecular features. Biochem Soc Trans 23: 321-324, 1995
18. Winder WW, MacLean PS, Lucas JC, Fernley JE, Trumble GE: Effect of fasting and refeeding on acetyl-CoA carboxylase in rat hindlimb muscle. J Appl Physiol 78: 578-582, 1995
19. Saha AK, Vavvas D, Kurowski TG, Apazidis A, Witters LA, Shafrir E, Ruderman NB: Malonyl-CoA regulation in skeletal muscle: Its link to cell citrate and the glucose-fatty acid cycle. Am J Physiol 272: E641-E648, 1997
20. Thampy K: Formation of malonyl coenzyme A in rat heart. Identification and purification of an isozyme of A carboxylase from rat heart. J Biol Chem 264: 17631-17634, 1989
21. Ruderman NB, Saha AK, Vavvas D, Witters LA: Malonyl-CoA, fuel sensing, and insulin resistance. Am J Physiol 276: E1-E18, 1999
22. Chien D, Dean D, Saha AK, Flatt JP, Ruderman NB: Malonyl-CoA content and fatty acid oxidation in rat muscle and liver in vivo. Am J Physiol Endocrinol Metab 279: E259-E265, 2000
23. Saha AK, Laybutt DS, Dean D, Vavvas D, Ellis B, Kraegen EW, Shafrir E, Ruderman NB: Increases in cytosolic citrate regulate malonyl CoA levels in rat muscle in vivo. Am J Physiol 276: E1030-E1037, 1999
24. Winder WW, Hardie DG: Inactivation of acetyl-CoA carboxylase and activation of AMP-activated protein kinase in muscle during exercise. Am J Physiol 270: E299-E304, 1996
25. Bavenholm P, Pigon G, Saha AK, Ruderman NB, Efendic S: Fatty acid oxidation in humans is regulated by malonyl CoA in muscle. Diabetologia 49: 1078-1083, 2000
26. Sidossis LS, Stuart CA, Shulman GI, Lopaschuk GD, Wolfe RR: Glucose plus insulin regulate fat oxidation by controlling the rate of fatty acid entry into the mitochondria. J Clin Invest 98: 2244-2250, 1996
27. Davies SP, Carling D, Munday MR, Hardie DG: Diurinal rhythm of phosphorylation of rat liver acetyl CoA carboxylase by the AMP-activated protein kinase, demonstrated using freeze-clamping. Effects of high fat diets. Eur J Biochem 203: 615-623, 1992
28. Kudo N, Barr A, Barr R, Desai S, Lopaschuk GD: High rates of fatty acid oxidation during reperfusion of ischemic hearts are associated with a decrease in malonyl-CoA levels due to an increase in 5′-AMP-activated protein kinase inhibition of acetyl-CoA carboxylase. J Biol Chem 270: 17513-17520, 1995
29. Saddik M, Gamble J, Witters LA, Lopaschuk GD: Acetyl-CoA carboxylase regulation of fatty acid oxidation in the heart. J Biol Chem 268: 25836-25845, 1993
30. Louis NA, Witters LA: Glucose regulation of acetyl-CoA carboxylase in hepatoma and islet cells. J Biol Chem 267: 2287-2293, 1992
31. Winder WW: Energy-sensing and signaling by AMP-activated protein kinase in skeletal muscle. J Appl Physiol 91: 1017-1028, 2001
32. Holmes BF, Kurth-Kraczek EJ, Winder WW: Chronic activation of 5′-AMP-activated protein kinase increases GLUT-4, hexokinase, and glycogen in muscle. J Appl Physiol 87: 1990-1995, 1999
33. Merrill GF, Kurth EJ, Hardie DG, Winder WW: AICA riboside increases AMP-activated protein kinase, fatty acid oxidation, and glucose uptake in rat muscle. Am J Physiol 273: E1107-E1112, 1997
34. Musi N, Hayashi T, Fujii N, Hirshman MF, Witters LA, Goodyear LJ: AMP-activated protein kinase activity and glucose uptake in rat skeletal muscle. Am J Physiol 280: E677-E684, 2001
35. Hayashi T, Hirshman MF, Kurth EJ, Winder WW, Goodyear LJ: Evidence for 5′ AMP-activated protein kinase mediation of the effect of muscle contraction on glucose transport. Diabetes 47: 1369-1373, 1998
36. Goodwin GW, Taegtmeyer H: Regulation of fatty acid oxidation of the heart by MCD and ACC during contractile stimulation. Am J Physiol 277: E772-E777, 1999
37. Young ME, Goodwin GW, Ying J, Guthrie P, Wilson CR, Laws FA, Taegtmeyer H: Regulation of cardiac and skeletal muscle malonyl-CoA decarboxylase by fatty acids. Am J Physiol 280: E471-E479, 2001
38. Sakamoto J, Barr RL, Kavanagh KM, Lopaschuk GD: Contribution of malonyl-CoA decarboxylase to the high fatty acid oxidation rates seen in the diabetic heart. Am J Physiol 278: H1196-H1204, 2000
39. Dyck JR, Berthiaume LG, Thomas PD, Kantor PF, Barr AJ, Barr R, Singh D, Hopkins TA, Voilley N, Prentki M, Lopaschuk GD: Characterization of rat liver malonyl-CoA decarboxylase and the study of its role in regulating fatty acid metabolism. Biochem J 350: 599-608, 2000
40. Hamilton C, Saggerson ED: Malonyl-CoA metabolism in cardiac myocytes. Biochem J 350: 61-67, 2000
41. Alam N, Saggerson ED: Malonyl-CoA and the regulation of fatty acid oxidation in soleus muscle. Biochem J 334: 233-241, 1998
42. Jang SH, Cheesbrough TM, Kolattukudy PE: Molecular cloning, nucleotide sequence, and tissue distribution of malonyl-CoA decarboxylase. J Biol Chem 264: 3500-3505, 1989
43. Park H, Kaushik V, Constant S, Prentki M, Przybytkowski E, Ruderman NB, Saha AK: Coordinate regulation of malonyl CoA decarboxylase, snglycerol-3-phosphate acyltransferase and acetyl CoA carboxylase by AMP activated protein kinase in rat tissues in response to exercise. J Biol Chem 277: 32571-32577, 2002
44. Prentki M, Corkey BE: Are the beta-cell signaling molecules malonyl-CoA and cystolic long-chain acyl-CoA implicated in multiple tissue defects of obesity and NIDDM? Diabetes 45: 273-283, 1996
45. Laybutt DR, Schmitz-Peiffer SA, Ruderman NB, Chisholm D, Biden T, Kraegen EW: Activation of protein kinase CE may contribute to muscle insulin resistance induced by lipid accumulation during chronic glucose infusion in rats. Diabetes 46: 241A, 1997
46. Oakes ND, Bell KS, Furler SM, Camilleri S, Saha AK, Ruderman NB, Chisholm DJ, Kraegen EW: Diet-induced muscle insulin resistance in rats is ameliorated by acute dietary lipid withdrawal or a single bout of exercise: Parallel relationship between insulin stimulation of glucose uptake and suppression of long chain fatty acyl-CoA. Diabetes 46: 2022-2028, 1997
47. Schmitz-Peiffer C, Browne CL, Oakes ND, Watkinson A, Chisholm DJ, Kraegen EW, Biden TJ: Alterations in the expression and cellular localization of protein kinase C isozymes epsilon and theta are associated with insulin resistance in skeletal muscle of the high-fat-fed rat. Diabetes 46: 169-178, 1997
48. Avignon A, Yamada K, Zhou X, Spencer B, Cardona O, Saba-Siddique S, Galloway L, Standaert ML, Farese RV: Chronic activation of protein kinase C in soleus muscles and other tissues of insulin-resistant type II diabetic Goto-Kakizaki (GK), obese/aged, and obese/Zucker rats. A mechanism for inhibiting glycogen synthesis. Diabetes 45: 1396-1404, 1996