Effect of telmisartan on the expression of cardiac adiponectin and its receptor 1 in type 2 diabetic rats

Journal of Pharmacy and Pharmacology

Volumn 63, Issue 1, 2011, Pages 87-94

  Guo, Zhixin ^a   Zheng, Caihong ^a   Qin, Zhihong ^a   Wei, Ping ^a  

^a SHANXI MEDICAL UNIVERSITY   (China)

Author keywords

adiponectin receptor; cardiomyopathy; telmisartan; type 2 diabetes

Indexed keywords

ADIPONECTIN; ADIPONECTIN RECEPTOR 1; GLUCOSE TRANSPORTER 4; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; MESSENGER RNA; TELMISARTAN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; DRUG EFFECT; ENZYME PHOSPHORYLATION; HEART FUNCTION; HEART WEIGHT; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; RAT; STREPTOZOCIN DIABETES;

ADIPONECTIN; AMP-ACTIVATED PROTEIN KINASES; ANGIOTENSIN II TYPE 1 RECEPTOR BLOCKERS; ANIMALS; BENZIMIDAZOLES; BENZOATES; DIABETES MELLITUS, EXPERIMENTAL; DIABETES MELLITUS, TYPE 2; GENE EXPRESSION REGULATION; GLUCOSE TRANSPORTER TYPE 4; MALE; MYOCARDIUM; PHOSPHORYLATION; RATS; RATS, WISTAR; RECEPTORS, ADIPONECTIN; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; STREPTOZOCIN;

EID: 78650385720     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.2042-7158.2010.01157.x     Document Type: Article

References (34)

1. American Diabetes Association. Economic consequences of diabetes mellitus in the U.S. in 1997. Diabetes Care 1998; 21: 296-309.
2. Lopaschuk GD,. Metabolic abnormalities in the diabetic heart. Heart Fail Rev 2002; 7: 149-159.
3. Trujillo ME, Scherer PE,. Adiponectin-journey from an adipocyte secretory protein to biomarker of the metabolic syndrome. J Intern Med 2005; 257: 167-175.
4. Piñeiro R, et al. Adiponectin is synthesized and secreted by human and murine cardiomyocytes. FEBS Lett 2005; 579: 5163-5169.
5. Yamauchi T, et al. Cloning of adiponectin receptors that mediate antidiabetic metabolic effects. Nature 2003; 423: 762-769.
6. Guo Z, et al. Cardiac expression of adiponectin and its receptors in streptozotocin-induced diabetic rats. Metabolism 2007; 56: 1363-1371.
7. Kurtz TW,. Treating the metabolic syndrome: telmisartan as a peroxisome proliferator-activated receptor-gamma activator. Acta Diabetol 2005; 42 (Suppl. 1): S9-16.
8. Benson SC, et al. Identification of telmisartan as a unique angiotensin II receptor antagonist with selective PPARgamma-modulating activity. Hypertension 2004; 43: 993-1002.
9. Conrady AO, et al. Effect of 24-week treatment with telmisartan on myocardial structure and function: relationship to insertion/deletion polymorphism of the angiotensin-converting enzyme gene. J Int Med Res 2005; 33 (Suppl. 1): 30A-38A.
10. Mori Y, et al. Telmisartan improves lipid metabolism and adiponectin production but does not affect glycemic control in hypertensive patients with type 2 diabetes. Adv Ther 2007; 24: 146-153.
11. Clasen R, et al. PPARgamma-activating angiotensin type-1 receptor blockers induce adiponectin. Hypertension 2005; 46: 137-143.
12. Zhang M, et al. The characterization of high-fat diet and multiple low-dose streptozotocin induced type 2 diabetes rat model. Exp Diabetes Res 2008; 2008: 704045.
13. Goyal BR, et al. Effect of telmisartan on cardiovascular complications associated with streptozotocin diabetic rats. Mol Cell Biochem 2008; 314: 123-131.
14. Bradford MM,. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976; 72: 248-254.
15. Maeda K, et al. cDNA cloning and expression of a novel adipose specific collage-like factor, apM1 (AdiPose Most abundant Gene transcript 1). Biochem Biophys Res Commun 1996; 221: 286-289.
16. Hattori Y, et al. Angiotensin-II-induced oxidative stress elicits hypoadiponectinaemia in rats. Diabetologia 2005; 48: 1066-1074.
17. Sun X, et al. Negative regulation of adiponectin receptor 1 promoter by insulin via a repressive nuclear inhibitory protein element. FEBS Lett 2008; 582: 3401-3407.
18. Shibata R, et al. Adiponectin-mediated modulation of hypertrophic signals in the heart. Nat Med 2004; 10: 1384-1389.
19. Dong F, Ren J,. Adiponectin improve cardiomyocyte contractile function in db/db diabetic obese mice. Obesity (Silver Spring) 2009; 17: 262-268.
20. Tsuchida A, et al. Insulin / Foxo1 pathway regulates expression levels of adiponectin receptors and adiponectin sensitivity. J Biol Chem 2004; 279: 30817-30822.
21. Yamauchi T, et al. Targeted disruption of AdipoR1 and AdipoR2 causes abrogation of adiponectin binding and metabolic actions. Nat Med 2007; 13: 332-339.
22. Iwabu M, et al. Adiponectin and AdipoR1 regulate PGC-1alpha and mitochondria by Ca(2+) and AMPK/SIRT1. Nature 2010; 464: 1313-1319.
23. Yamauchi T, et al. Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase. Nat Med 2002; 8: 1288-1295.
24. Liao Y, et al. Exacerbation of heart failure in adiponectin-deficient mice due to impaired regulation of AMPK and glucose metabolism. Cardiovasc Res 2005; 67: 705-713.
25. Rutter GA, et al. Roles of 5′-AMP-activated protein kinase (AMPK) in mammalian glucose homeostasis. Biochem J 2003; 375: 1-16.
26. Mueckler M,. Family of glucose transporter genes. Implications for glucose homeostasis and diabetes. Diabetes 1990; 39: 6-11.
27. Russell RR, et al. Translocation of myocardial GLUT4 and increased glucose uptake through activation of AMPK by AICAR. Am J Physiol Heart Circ Physiol 1999; 277: H643-H649.
28. Garvey WT, et al. Effects of diabetes on myocardial glucose transport system in rats: implications for diabetic cardiomyopathy. Am J Physiol 1993; 264: H837-H844.
29. Abel ED, et al. Cardiac hypertrophy with preserved contractile function after selective deletion of GLUT4 from the heart. J Clin Invest 1999; 104: 1703-1714.
30. Tsao TS, et al. Prevention of insulin resistance and diabetes in mince heterozygous for GLUT4 ablation by transgenic complementation of GLUT4 in skeletal muscle. Diabetes 1999; 48: 775-782.
31. Maeda N, et al. PPARgamma ligands increase expression and plasma concentrations of adiponectin, an adipose-derived protein. Diabetes 2001; 50: 2094-2099.
32. Chinetti G, et al. Expression of adiponectin receptors in human macrophages and regulation by agonists of the nuclear receptors PPARalpha, PPARgamma, and LXR. Biochem Biophys Res Commun 2004; 314: 151-158.
33. Fujimoto M, et al. An angiotensin II AT1 receptor antagonist, telmisartan augments glucose uptake and GLUT4 protein expression in 3T3-L1 adipocytes. FEBS Lett 2004; 576: 492-497.
34. Ding G, et al. Adiponectin and its receptors are expressed in adult ventricular cardiomyocytes and upregulated by activation of peroxisome proliferator-activated receptor gamma. J Mol Cell Cardiol 2007; 43: 73-84.