Pancreas biology, pathology, and tissue engineering

Strategies in Regenerative Medicine: Integrating Biology with Materials Design

Volumn , Issue , 2009, Pages 261-281

  MacFarlane, Wendy M ^a   Bone, Adrian J ^a   Harrison, Moira ^a  

^a UNIVERSITY OF BRIGHTON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84555166777     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/978-0-387-74660-9_8     Document Type: Chapter

References (87)

1. Amrani A et al. (2000) IL-1, IL-1 and IFN-mark-cells for Fas-dependent destruction by diabetogenic CD4+ T lymphocytes. J Clin Invest 105:459-468
2. Atkinson MA, Maclaren NK (1994) Mechanisms of Disease - The Pathogenesis of Insulin-Dependent Diabetes-Mellitus. New England Journal of Medicine 331:1428-1436
3. Baeyens L et al. (2006) Ngn3 expression during postnatal in vitro beta cell neogenesis induced by the JAK/STAT pathway. Cell Death Differ 13:1892-1899
4. Blyszczuk P et al. (2003) Expression of Pax4 in embryonic stem cells promotes differentiation of nestin-positive progenitor and insulin-producing cells. Proc Natl Acad Sci USA 100:998-1003
5. Blyszczuk P et al. (2004) Embryonic stem cells differentiate into insulin-producing cells without selection of nestin-expressing cells. Int J Dev Biol 2004 48:1095-1104
6. Boitard C et al. (1997) Immune mechanisms leading to type 1 insulin-dependent diabetes mellitus. Horm Res 48:58-63
7. Bouwens L, De Blay E, (1996) Islet morphogenesis and stem cell markers in rat pancreas. J Histochem Cytochem 44:947-951
8. Bouwens L, Rooman I (2005) Regulation of pancreatic beta-cell mass. Physiol Rev 85:1255-1270
9. Bouwens L, Lu GW, De Krijger R (1997) Proliferation and differentiation in the human fetal endocrine pancreas. Diabetologia 40:398-404
10. Buchanan TA, Xiang AH, Peters RK (2002) Preservation of pancreatic B-cell function and prevention of type 2 diabetes by pharmacological treatment of insulin resistance in highrisk Hispanic women. Diabetes 51:2796-2803
11. Butler AE et al. (2003) Beta-cell deficit and increased beta-cell apoptosis in humans with Type 2 diabetes. Diabetes 52:102-110
12. Chervonsky AV et al. (1997) The role of Fas in autoimmune diabetes. Cell 89:17-24
13. Cnop M et al. (2005) Mechanisms of pancreatic beta-cell death in Type 1 and Type 2 diabetes. Diabetes, Suppl. 2:S97-S107
14. Dabeva MD, Hurston E, Sharitz DA (1995) Transcription factor and liver-specific mRNA expression in facultative epithelial progenitor cells of liver and pancreas. Am J Pathol 147:1633-1648
15. D'Amour KA et al. (2006) Production of pancreatic hormone-expressing endocrine cells from human embryonic stem cells. Nat Biotechnol 24:1392-1401
16. Deramaudt TB et al. (2006) The PDX1 Homeodomain transcription factor negatively regulates the pancreatic ductal cell-specific keratin 19 promoter. J Biol Chem 281:38385-38395
17. Donath MY, Halban PA (2004) Decreased B-cell mass in diabetes: significance, mechanisms and therapeutic implications. Diabetologia 47:581-589
18. Dor Y (2006) β-Cell proliferation is the major source of new pancreatic beta cells. Nat Clin Pract Endocrinol Metab 2:242-243
19. Drucker DJ (1998) Glucagon-like peptides. Diabetes 47:159-169
20. Durbin RJ (2004) Thiazolidinedione therapy in the prevention/delay of type 2 diabetes in patients with impaired glucose tolerance and insulin resistance. Diabetes Obes Metab 6:280-285
21. Edlund H (1998) Transcribing pancreas. Diabetes 47:1817-1823
22. Eizirik DL, Darville MI (2002) Beta cell apoptosis and defense mechanisms: lessons from type 1 diabetes. Diabetes 50:S64-S69
23. Elghazi L et al. (2002) Role for FGFR2IIIb-mediated signals in controlling pancreatic endocrine progenitor cell proliferation. Proc Natl Acad Sci USA 99:3884-3889
24. Farilla L, Lui H, Bertolotto C (2002) Glucagon-like peptide-1 promotes islet cell growth and inhibits apoptosis in Zucker diabetic rats. Endocrinology 143:4397-4408
25. Finegood DT, McArthur MD, Kojwang D (2001) Beta-cell mass dynamics in Zucker diabetic fatty rats. Rosiglitazone prevents the rise in net cell death. Diabetes 50:1021-1029
26. Fodor A et al. (2006) Adult rat liver cells transdifferentiated with lentiviral IPF1 vectors reverse diabetes in mice: an ex vivo gene therapy approach. Diabetologia [Epub ahead of print].
27. Fodor et al (2007) Jan; 50(1):121-30. Epub 2006 Nov. 28
28. Foulis AK et al. (1997) A search for evidence of viral infection in pancreases of newly diagnosed patients with IDDM. Diabetologia 401:53-56
29. Gao R et al. (2005) In vitro neogenesis of human islets reflects the plasticity of differentiated human pancreatic cells. Diabetologia 48:2296-2304
30. Gepts W (1965) Pathologic anatomy of the pancreas in juvenile diabetes mellitus. Diabetes 14:619-633
31. Habener JF, Kemp DM, Thomas MK (2005) Minireview: transcriptional regulation in pancreatic development. Endocrinology 146.
32. Hanke J (2000) Apoptosis and occurrence of Bcl-2, Bak, Bax, Fas and FasL in the developing and adult endocrine pancreas. Anat Embryol 202:303-312
33. Ianus A et al. (2003) In vivo derivation of glucose-competent pancreatic endocrine cells from bone marrow without evidence of cell fusion. J Clin Invest 111:843-850
34. Imagawa A et al. (2001) Pancreatic biopsy as a procedure for detecting in situ autoimmune phenomena in type 1 diabetes: close correlation between serological markers and histological evidence of cellular autoimmunity. Diabetes 50:1269-1273
35. Janson J et al. (1999) The mechanism of islet amyloid polypeptide toxicity is membrane disruption by intermediate-sized toxic amyloid particles. Diabetes 48:491-498
36. Jonsson J et al. (1994) Insulin-promoter-factor 1 is required for pancreas development in mice. Nature 371:606-609
37. Juhl CB, Schmitz O, Pincus S (2000) Short-term treatment with GLP-1 increases pulsatile insulin secretion in type II diabetes with no effect on orderliness. Diabetologia 43:583-588
38. Kagi D et al. (1996) Development of insulitis without diabetes in transgenic mice lacking perforin-dependent toxicity. J Exp Med 183:2143-2152
39. Kahn SE (2003) The relative contributions of insulin resistance and B-cell dysfunction to the pathophysiology of type 2 diabetes. Diabetologia 46:3-19
40. Kahn SE, Andrikopoulos S, Verchere CB (1999) Islet amyloid: A long recognized but underappreciated pathological feature of Type 2 diabetes. Diabetes 48:241-253
41. Kaiser N, Leibowitz G, Nesher R (2003) Glucotoxicity and B-cell failure in Type 2 diabetes mellitus. J Pediatr Endocrinol Metab 16:5-22
42. Kawaguchi Y, et al. (2002) The role of the transcriptional regulator Ptf1a in converting intestinal to pancreatic progenitors. Nat Genet 3. 2:128-134
43. Kay TWH, et al. (2000) The beta cell in autoimmune diabetes: many mechanisms and pathways of loss. Trends Endocrinol Metab 11:11-15
44. Kim S et al. (2006) Analysis of donor and isolation-related factors of successful isolation of human islet of langerhans from human cadaveric donors. Transplantation Proceedings 37:3402-3403
45. Kloppel G et al. (1985) Islet pathology and the pathogenesis of Type 2 diabetes revisted. Surv Synth Pathol Res 4:110-125
46. Koizumi M, et al. (2004) Hepatic regeneration and enforced PDX-1 expression accelerate transdifferentiation in liver. Surgery 136:449-457
47. Kolb H, Mandrup-Poulsen T (2005) An immune origin of type 2 diabetes. Diabetologia 48:1038-1050
48. Kreuwel HT et al. (1999) Comparing the relative role of perforin/granzyme vs Fas/Fas ligand cytotoxic pathways in CD8+ T cell-mediated insulin dependent diabetes mellitus. J Immunol 163:4355-4351
49. Lakey JR, Mirbolooki M, Shapiro AM (2006) Current status of clinical islet cell transplantation. Methods Mol Biol. 2006:47-104
50. Lally FJ, Ratcliffe H, Bone AJ (2001) Apoptosis and disease progression in the spontaneously diabetic BB/S rat. Diabetologia 44:320-324
51. Lechner A et al. (2004) No evidence for significant transdifferentiation of bone marrow into pancreatic beta-cells in vivo. Diabetes 53:616-623
52. Lenzen S et al. (2001) The LEW.1AR1/Ztm-iddm rat: a new model of spontaneous insulindependent diabetes mellitus. Diabetologia 44:1189-1196
53. Loweth AC, et al. (1998) Human islets of Langerhans express Fas-Ligand and undergo apoptosis in response to interleukin-1ß and Fas ligation. Diabetes 47:727-732
54. Loweth AC, et al. (2000) Dissociation between Fas expression and induction of apoptosis in human islets of Langerhans. Diabetes, Obesity and Metabol 2:57-60
55. Lumelsky N, et al. (2001) Differentiation of embryonic stem cells to insulin-secreting structures similar to pancreatic islets. Science 292:1389-1394
56. MacDonald PE, Joseph JW, Rorsman P (2005) Glucose-sensing mechanisms in pancreatic beta-cells. Philos Trans R Soc Lond B Biol Sci 360:2211-2225
57. Maedler K et al. (2001) Glucose induces ß-cell apoptosis via upregulation of the Fas receptor in human islets. Diabetes 50:1683-1690
58. Mathis D, Benoist C (2006) Beta cell death during progression to diabetes. Nature 414:792-798
59. Meier JJ, et al. (2005) Sustained beta cell apoptosis in patients with long-standing type 1 diabetes: indirect evidence for islet regeneration? Diabetologia 48:2221-2228
60. Meier JJ, et al. (2006) Increased vulnerability of newly forming beta cells to cytokine-induced cell death. Diabetologia 49:83-89
61. Mest H, Mentlein R (2005) Dipeptidyl peptidase inhibitors as new drugs for the treatment of type 2 diabetes. Diabetologia 48:616-620
62. Moriwaki M, et al. (1999) Fas and Fas ligand expression in inflamed islets in pancreas sections of patients with recent-onset Type 1 diabetes mellitus. Diabetologia 42:1332-1340
63. Ogata T, et al. (2004) Reversal of streptozotocin-induced hyperglycemia by transplantation of pseudoislets consisting of beta cells derived from ductal cells. Endocr J. 51:381-386
64. Paraskevas S, et al. (2000) Cell loss in isolated human islets occurs by apoptosis. Pancreas 20:270-276
65. Paty BW, et al. (2006) Assessment of glycemic control after islet transplantation using the continuous glucose monitor in insulin-independent versus insulin-requiring type 1 diabetes subjects. Diabetes Technol Ther. 8:165-173
66. Perfetti R (2004) The role of GLP-1 in the regulation of islet cell mass. Medscape Diabetes & Endocrinology 6 (2)
67. Rao MS, et al. (1996) Expression of transcription factors and stem cell factor precedes hepatocyte differentiation in rat pancreas. Gene Expr 6:15-22
68. Ratner RE (2005) Therapeutic roleof incretin mimetics. Medscape Diabetes & Endocrinology 7 (1)
69. Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus (2003) Diabetes Care 26:S5-20S
70. Ridgway WM (2003) The non obese diabetic (NOD) mouse: a unique model for understanding the interaction between genetics and T cell response. Rev Endocr Metab Disord 4:263-269
71. Rolletschek A, Kania G, Wobus AM (2006) Generation of pancreatic insulin-producing cells from embryonic stem cells - 'Proof of principle', but questions still unanswered. Diabetologia 49:2541-2545
72. Rooman I, et al. (2000) Modulation of rat pancreatic acinoductal transdifferentiation and expression of PDX-1 in vitro. Diabetologia 43:907-914
73. Scharfmann R (2000) Control of early development of the pancreas in rodents and humans: implications of signals from the mesenchyme. Diabetologia 43:1083-1092
74. Servitja JM, Ferrer J (2004) Transcriptional networks controlling pancreatic development and beta cell function. Diabetologia 47:597-613
75. Shapiro AM, et al. (2000) Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen. N Engl J Med 343:230-238
76. Shen CN et al. (2003) Transdifferentiation of pancreas to liver. Mech Dev 120:107-116
77. Stassi G et al. (1997) Nitric oxide primes pancreatic-cells for Fas-mediated destruction in insulin-dependent diabetes mellitus. J Exp Med 186:1193-1200
78. Stojkovic M et al. (2004a) Derivation of human embryonic stem cells from day-8 blastocysts recovered after three-step in vitro culture. Stem Cells 22:790-797
79. Stojkovic M et al. (2004b) Derivation, growth and applications of human embryonic stem cells Reproduction 128:259-267
80. Suarez-Pinzon W et al. (1999) ß-cell destruction in NOD mice correlates with Fas (CD95) expression on ß-cells and proinflammatory cytokine expression in islets. Diabetes 48:21-28
81. Sun J et al. (2006) Expression of Pdx-1 in bone marrow mesenchymal stem cells promotes differentiation of islet-like cells in vitro. Sci China C Life Sci 49:480-489
82. Tayaramma T et al. (2006) Chromatin-remodeling factors allow differentiation of bone marrow cells into insulin-producing cells. Stem Cells 24:2858-2867
83. Tisch R, McDevitt H (1996) Insulin-dependent diabetes mellitus. Cell 85:291-297
84. Tuch BE (2006) Stem cells-a clinical update. Aust Fam Physician 35:719-721
85. Uwaifo GI, Ratner RE (2005) Novel pharmacologic agents for type 2 diabetes. Endocrinol Metab Clin North Am. 34:155-197
86. Wolf HK et al. (1990) Exocrine pancreatic tissue in human liver: a metaplastic process? Am J Surg Pathol 14:590-595
87. Yoon JW, Jun. H-S, Santamaria P (1998) Cellular and molecular mechanisms for the initiation and progression of -cell dstruction resulting from the collaboration between macrophages and T cells. Autoimmunity 27:109-122