-
1
-
-
0030828968
-
+) T lymphocytes - clarification of their pathogenic roles in diabetes in the NOD mouse
-
+) T lymphocytes - clarification of their pathogenic roles in diabetes in the NOD mouse. Res. Immunol. 148:1997;320-327.
-
(1997)
Res. Immunol.
, vol.148
, pp. 320-327
-
-
Kay, T.1
-
2
-
-
0030587871
-
RIP-beta 2-microglobulin transgene expression restores insulitis, but not diabetes, in beta 2-microglobulin null nonobese diabetic mice
-
Kay T.W.et al. RIP-beta 2-microglobulin transgene expression restores insulitis, but not diabetes, in beta 2-microglobulin null nonobese diabetic mice. J. Immunol. 157:1996;3688-3693.
-
(1996)
J. Immunol.
, vol.157
, pp. 3688-3693
-
-
Kay, T.W.1
-
3
-
-
0032482356
-
Help for cytotoxic-T-cell responses is mediated by CD40 signalling
-
Bennett S.R.et al. Help for cytotoxic-T-cell responses is mediated by CD40 signalling. Nature. 393:1998;478-480.
-
(1998)
Nature
, vol.393
, pp. 478-480
-
-
Bennett, S.R.1
-
4
-
-
0030937468
-
Apoptosis is the mode of beta-cell death responsible for the development of IDDM in the nonobese diabetic (NOD) mouse
-
O'Brien B.A.et al. Apoptosis is the mode of beta-cell death responsible for the development of IDDM in the nonobese diabetic (NOD) mouse. Diabetes. 46:1997;750-757.
-
(1997)
Diabetes
, vol.46
, pp. 750-757
-
-
O'Brien, B.A.1
-
5
-
-
0031030653
-
Beta cell apoptosis in T-cell-mediated autoimmune diabetes
-
Kurrer M.O.et al. Beta cell apoptosis in T-cell-mediated autoimmune diabetes. Proc. Natl. Acad. Sci. U. S. A. 94:1997;213-218.
-
(1997)
Proc. Natl. Acad. Sci. U. S. A.
, vol.94
, pp. 213-218
-
-
Kurrer, M.O.1
-
6
-
-
0031684177
-
Beta-cell apoptosis in an accelerated model of autoimmune diabetes
-
Augstein P.et al. Beta-cell apoptosis in an accelerated model of autoimmune diabetes. Mol. Med. 4:1998;495-501.
-
(1998)
Mol. Med.
, vol.4
, pp. 495-501
-
-
Augstein, P.1
-
7
-
-
0030731917
-
Nitric oxide primes pancreatic beta cells for Fas-mediated destruction in insulin-dependent diabetes mellitus
-
Stassi G.et al. Nitric oxide primes pancreatic beta cells for Fas-mediated destruction in insulin-dependent diabetes mellitus. J. Exp. Med. 186:1997;1193-1200.
-
(1997)
J. Exp. Med.
, vol.186
, pp. 1193-1200
-
-
Stassi, G.1
-
8
-
-
0033593572
-
Cell death in development
-
Vaux D.L., Korsmeyer S.J. Cell death in development. Cell. 96:1999;245-254.
-
(1999)
Cell
, vol.96
, pp. 245-254
-
-
Vaux, D.L.1
Korsmeyer, S.J.2
-
9
-
-
0023216950
-
The non-obese diabetic (NOD) mouse
-
Leiter E.H.et al. The non-obese diabetic (NOD) mouse. Am. J. Pathol. 128:1987;380-383.
-
(1987)
Am. J. Pathol.
, vol.128
, pp. 380-383
-
-
Leiter, E.H.1
-
10
-
-
0022392953
-
Morphological aspects on pancreatic islets of non-obese diabetic (NOD) mice
-
Fujino-Kurihara H.et al. Morphological aspects on pancreatic islets of non-obese diabetic (NOD) mice. Virchows Arch. B Cell Pathol. Incl. Mol. Pathol. 49:1985;107-120.
-
(1985)
Virchows Arch. B Cell Pathol. Incl. Mol. Pathol.
, vol.49
, pp. 107-120
-
-
Fujino-Kurihara, H.1
-
11
-
-
0345161818
-
Transfection of human pancreatic islets with an anti-apoptotic gene (bcl-2) protects beta cells from cytokine-induced destruction
-
Rabinovitch A.et al. Transfection of human pancreatic islets with an anti-apoptotic gene (bcl-2) protects beta cells from cytokine-induced destruction. Diabetes. 48:1999;1223-1229.
-
(1999)
Diabetes
, vol.48
, pp. 1223-1229
-
-
Rabinovitch, A.1
-
12
-
-
1842289172
-
Reduced incidence and delayed onset of diabetes in perforin-deficient nonobese diabetic mice
-
Kagi D.et al. Reduced incidence and delayed onset of diabetes in perforin-deficient nonobese diabetic mice. J. Exp. Med. 186:1997;989-997.
-
(1997)
J. Exp. Med.
, vol.186
, pp. 989-997
-
-
Kagi, D.1
-
13
-
-
0030890588
-
Cell death mediators in autoimmune diabetes - no shortage of suspects
-
Benoist C., Mathis D. Cell death mediators in autoimmune diabetes - no shortage of suspects. Cell. 89:1997;1-3.
-
(1997)
Cell
, vol.89
, pp. 1-3
-
-
Benoist, C.1
Mathis, D.2
-
14
-
-
0030005411
-
The harmony of the spheres: Inducible nitric oxide synthase and related genes in pancreatic beta cells
-
Eizirik D.L.et al. The harmony of the spheres: inducible nitric oxide synthase and related genes in pancreatic beta cells. Diabetologia. 39:1996;875-890.
-
(1996)
Diabetologia
, vol.39
, pp. 875-890
-
-
Eizirik, D.L.1
-
15
-
-
0029817047
-
The role of interleukin-1 in the pathogenesis of IDDM
-
Mandrup-Poulsen T. The role of interleukin-1 in the pathogenesis of IDDM. Diabetologia. 39:1996;1005-1029.
-
(1996)
Diabetologia
, vol.39
, pp. 1005-1029
-
-
Mandrup-Poulsen, T.1
-
16
-
-
0033305236
-
Tumor necrosis factor-alpha-activated cell death pathways in NIT-1 insulinoma cells and primary pancreatic beta cells
-
Stephens L.A.et al. Tumor necrosis factor-alpha-activated cell death pathways in NIT-1 insulinoma cells and primary pancreatic beta cells. Endocrinology. 140:1999;3219-3227.
-
(1999)
Endocrinology
, vol.140
, pp. 3219-3227
-
-
Stephens, L.A.1
-
17
-
-
0025130361
-
Molecular pathology of type 1 diabetes
-
Campbell I.L., Harrison L.C. Molecular pathology of type 1 diabetes. Mol. Biol. Med. 7:1990;299-309.
-
(1990)
Mol. Biol. Med.
, vol.7
, pp. 299-309
-
-
Campbell, I.L.1
Harrison, L.C.2
-
18
-
-
0033178741
-
Evidence that beta cell death in the non-obese diabetic mouse is Fas-independent
-
Thomas H.E.et al. Evidence that beta cell death in the non-obese diabetic mouse is Fas-independent. J. Immunol. 163:1999;1562-1569.
-
(1999)
J. Immunol.
, vol.163
, pp. 1562-1569
-
-
Thomas, H.E.1
-
19
-
-
0025981388
-
Essential role for interferon-gamma and interleukin-6 in autoimmune insulin-dependent diabetes in NOD/Wehi mice
-
Campbell I.L.et al. Essential role for interferon-gamma and interleukin-6 in autoimmune insulin-dependent diabetes in NOD/Wehi mice. J. Clin. Invest. 87:1991;739-742.
-
(1991)
J. Clin. Invest.
, vol.87
, pp. 739-742
-
-
Campbell, I.L.1
-
20
-
-
0031051747
-
Interferon-gamma is essential for destruction of beta cells and development of insulin-dependent diabetes mellitus
-
von Herrath M.G., Oldstone M.B. Interferon-gamma is essential for destruction of beta cells and development of insulin-dependent diabetes mellitus. J. Exp. Med. 185:1997;531-539.
-
(1997)
J. Exp. Med.
, vol.185
, pp. 531-539
-
-
Von Herrath, M.G.1
Oldstone, M.B.2
-
21
-
-
0029948898
-
Genetic absence of gamma-interferon delays but does not prevent diabetes in NOD mice
-
Hultgren B.et al. Genetic absence of gamma-interferon delays but does not prevent diabetes in NOD mice. Diabetes. 45:1996;812-817.
-
(1996)
Diabetes
, vol.45
, pp. 812-817
-
-
Hultgren, B.1
-
22
-
-
0031456802
-
Interferon-gamma impacts at multiple points during the progression of autoimmune diabetes
-
Wang B.et al. Interferon-gamma impacts at multiple points during the progression of autoimmune diabetes. Proc. Natl. Acad. Sci. U. S. A. 94:1997;13844-13849.
-
(1997)
Proc. Natl. Acad. Sci. U. S. A.
, vol.94
, pp. 13844-13849
-
-
Wang, B.1
-
23
-
-
0032531099
-
IFN-gamma action on pancreatic beta cells causes class I MHC upregulation but not diabetes
-
Thomas H.E.et al. IFN-gamma action on pancreatic beta cells causes class I MHC upregulation but not diabetes. J. Clin. Invest. 102:1998;1249-1257.
-
(1998)
J. Clin. Invest.
, vol.102
, pp. 1249-1257
-
-
Thomas, H.E.1
-
24
-
-
0032214715
-
Local expression of TNF alpha in neonatal NOD mice promotes diabetes by enhancing presentation of islet antigens
-
Green E.A.et al. Local expression of TNF alpha in neonatal NOD mice promotes diabetes by enhancing presentation of islet antigens. Immunity. 9:1998;733-743.
-
(1998)
Immunity
, vol.9
, pp. 733-743
-
-
Green, E.A.1
-
25
-
-
0029834839
-
Local expression of transgene encoded TNF alpha in islets prevents autoimmune diabetes in nonobese diabetic (NOD) mice by preventing the development of auto-reactive islet-specific T cells
-
Grewal I.S.et al. Local expression of transgene encoded TNF alpha in islets prevents autoimmune diabetes in nonobese diabetic (NOD) mice by preventing the development of auto-reactive islet-specific T cells. J. Exp. Med. 184:1996;1963-1974.
-
(1996)
J. Exp. Med.
, vol.184
, pp. 1963-1974
-
-
Grewal, I.S.1
-
26
-
-
0033561630
-
TNF receptor 1-dependent beta cell toxicity as an effector pathway in autoimmune diabetes
-
Kagi D.et al. TNF receptor 1-dependent beta cell toxicity as an effector pathway in autoimmune diabetes. J. Immunol. 162:1999;4598-4605.
-
(1999)
J. Immunol.
, vol.162
, pp. 4598-4605
-
-
Kagi, D.1
-
27
-
-
0033526068
-
In autoimmune diabetes the transition from benign to pernicious insulitis requires an islet cell response to tumor necrosis factor alpha
-
Pakala S.V.et al. In autoimmune diabetes the transition from benign to pernicious insulitis requires an islet cell response to tumor necrosis factor alpha. J. Exp. Med. 189:1999;1053-1062.
-
(1999)
J. Exp. Med.
, vol.189
, pp. 1053-1062
-
-
Pakala, S.V.1
-
28
-
-
0030684124
-
Irreversible inhibition of metabolic function and islet destruction after a 36-hour exposure to interleukin-1beta
-
Scarim A.L.et al. Irreversible inhibition of metabolic function and islet destruction after a 36-hour exposure to interleukin-1beta. Endocrinology. 138:1997;5301-5307.
-
(1997)
Endocrinology
, vol.138
, pp. 5301-5307
-
-
Scarim, A.L.1
-
29
-
-
0030923812
-
Cytokines induce deoxyribonucleic acid strand breaks and apoptosis in human pancreatic islet cells
-
Delaney C.A.et al. Cytokines induce deoxyribonucleic acid strand breaks and apoptosis in human pancreatic islet cells. Endocrinology. 138:1997;2610-2614.
-
(1997)
Endocrinology
, vol.138
, pp. 2610-2614
-
-
Delaney, C.A.1
-
30
-
-
0027934873
-
TNF-alpha and IFN-gamma potentiate the deleterious effects of IL-1 beta on mouse pancreatic islets mainly via generation of nitric oxide
-
Cetkovic-Cvrlje M., Eizirik D.L. TNF-alpha and IFN-gamma potentiate the deleterious effects of IL-1 beta on mouse pancreatic islets mainly via generation of nitric oxide. Cytokine. 6:1994;399-406.
-
(1994)
Cytokine
, vol.6
, pp. 399-406
-
-
Cetkovic-Cvrlje, M.1
Eizirik, D.L.2
-
31
-
-
0030667121
-
Evidence for the presence of type I IL-1 receptors on beta-cells of islets of Langerhans
-
Scarim A.L.et al. Evidence for the presence of type I IL-1 receptors on beta-cells of islets of Langerhans. Biochim. Biophys. Acta. 1361:1997;313-320.
-
(1997)
Biochim. Biophys. Acta
, vol.1361
, pp. 313-320
-
-
Scarim, A.L.1
-
32
-
-
0032579373
-
Transgenic mice overexpressing type 2 nitric-oxide synthase in pancreatic beta cells develop insulin-dependent diabetes without insulitis
-
Takamura T.et al. Transgenic mice overexpressing type 2 nitric-oxide synthase in pancreatic beta cells develop insulin-dependent diabetes without insulitis. J. Biol. Chem. 273:1998;2493-2496.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 2493-2496
-
-
Takamura, T.1
-
33
-
-
0028900805
-
Intraislet release of interleukin 1 inhibits beta cell function by inducing beta cell expression of inducible nitric oxide synthase
-
Corbett J.A., McDaniel M.L. Intraislet release of interleukin 1 inhibits beta cell function by inducing beta cell expression of inducible nitric oxide synthase. J. Exp. Med. 181:1995;559-568.
-
(1995)
J. Exp. Med.
, vol.181
, pp. 559-568
-
-
Corbett, J.A.1
McDaniel, M.L.2
-
34
-
-
0030890721
-
The role of Fas in autoimmune diabetes
-
Chervonsky A.V.et al. The role of Fas in autoimmune diabetes. Cell. 89:1997;17-24.
-
(1997)
Cell
, vol.89
, pp. 17-24
-
-
Chervonsky, A.V.1
-
35
-
-
0030800122
-
Requirement of Fas for the development of autoimmune diabetes in nonobese diabetic mice
-
Itoh N.et al. Requirement of Fas for the development of autoimmune diabetes in nonobese diabetic mice. J. Exp. Med. 186:1997;613-618.
-
(1997)
J. Exp. Med.
, vol.186
, pp. 613-618
-
-
Itoh, N.1
-
36
-
-
0029856723
-
Mouse islet cell lysis mediated by interleukin-1-induced Fas
-
Yamada K.et al. Mouse islet cell lysis mediated by interleukin-1-induced Fas. Diabetologia. 39:1996;1306-1312.
-
(1996)
Diabetologia
, vol.39
, pp. 1306-1312
-
-
Yamada, K.1
-
37
-
-
0032506224
-
Mechanisms of beta cell death in diabetes: A minor role for CD95
-
Allison J., Strasser A. Mechanisms of beta cell death in diabetes: a minor role for CD95. Proc. Natl. Acad. Sci. U. S. A. 95:1998;13818-13822.
-
(1998)
Proc. Natl. Acad. Sci. U. S. A.
, vol.95
, pp. 13818-13822
-
-
Allison, J.1
Strasser, A.2
-
38
-
-
0032586826
-
Apoptosis of pancreatic beta cells detected in accelerated diabetes of NOD mice: No role of Fas-Fas ligand interaction in autoimmune diabetes
-
Kim Y-H.et al. Apoptosis of pancreatic beta cells detected in accelerated diabetes of NOD mice: no role of Fas-Fas ligand interaction in autoimmune diabetes. Eur. J. Immunol. 29:1999;455-465.
-
(1999)
Eur. J. Immunol.
, vol.29
, pp. 455-465
-
-
Kim, Y.-H.1
-
39
-
-
0033560930
-
+ T lymphocytes in transgenic nonobese diabetic mice
-
+ T lymphocytes in transgenic nonobese diabetic mice. J. Clin. Invest. 103:1999;1201-1209.
-
(1999)
J. Clin. Invest.
, vol.103
, pp. 1201-1209
-
-
Amrani, A.1
|