메뉴 건너뛰기




Volumn 11, Issue 1, 2000, Pages 11-15

The beta cell in autoimmune diabetes: Many mechanisms and pathways of loss

Author keywords

[No Author keywords available]

Indexed keywords

FAS ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 1; PERFORIN; TUMOR NECROSIS FACTOR;

EID: 0034084572     PISSN: 10432760     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1043-2760(99)00210-6     Document Type: Review
Times cited : (61)

References (39)
  • 1
    • 0030828968 scopus 로고    scopus 로고
    • +) T lymphocytes - clarification of their pathogenic roles in diabetes in the NOD mouse
    • +) T lymphocytes - clarification of their pathogenic roles in diabetes in the NOD mouse. Res. Immunol. 148:1997;320-327.
    • (1997) Res. Immunol. , vol.148 , pp. 320-327
    • Kay, T.1
  • 2
    • 0030587871 scopus 로고    scopus 로고
    • RIP-beta 2-microglobulin transgene expression restores insulitis, but not diabetes, in beta 2-microglobulin null nonobese diabetic mice
    • Kay T.W.et al. RIP-beta 2-microglobulin transgene expression restores insulitis, but not diabetes, in beta 2-microglobulin null nonobese diabetic mice. J. Immunol. 157:1996;3688-3693.
    • (1996) J. Immunol. , vol.157 , pp. 3688-3693
    • Kay, T.W.1
  • 3
    • 0032482356 scopus 로고    scopus 로고
    • Help for cytotoxic-T-cell responses is mediated by CD40 signalling
    • Bennett S.R.et al. Help for cytotoxic-T-cell responses is mediated by CD40 signalling. Nature. 393:1998;478-480.
    • (1998) Nature , vol.393 , pp. 478-480
    • Bennett, S.R.1
  • 4
    • 0030937468 scopus 로고    scopus 로고
    • Apoptosis is the mode of beta-cell death responsible for the development of IDDM in the nonobese diabetic (NOD) mouse
    • O'Brien B.A.et al. Apoptosis is the mode of beta-cell death responsible for the development of IDDM in the nonobese diabetic (NOD) mouse. Diabetes. 46:1997;750-757.
    • (1997) Diabetes , vol.46 , pp. 750-757
    • O'Brien, B.A.1
  • 5
    • 0031030653 scopus 로고    scopus 로고
    • Beta cell apoptosis in T-cell-mediated autoimmune diabetes
    • Kurrer M.O.et al. Beta cell apoptosis in T-cell-mediated autoimmune diabetes. Proc. Natl. Acad. Sci. U. S. A. 94:1997;213-218.
    • (1997) Proc. Natl. Acad. Sci. U. S. A. , vol.94 , pp. 213-218
    • Kurrer, M.O.1
  • 6
    • 0031684177 scopus 로고    scopus 로고
    • Beta-cell apoptosis in an accelerated model of autoimmune diabetes
    • Augstein P.et al. Beta-cell apoptosis in an accelerated model of autoimmune diabetes. Mol. Med. 4:1998;495-501.
    • (1998) Mol. Med. , vol.4 , pp. 495-501
    • Augstein, P.1
  • 7
    • 0030731917 scopus 로고    scopus 로고
    • Nitric oxide primes pancreatic beta cells for Fas-mediated destruction in insulin-dependent diabetes mellitus
    • Stassi G.et al. Nitric oxide primes pancreatic beta cells for Fas-mediated destruction in insulin-dependent diabetes mellitus. J. Exp. Med. 186:1997;1193-1200.
    • (1997) J. Exp. Med. , vol.186 , pp. 1193-1200
    • Stassi, G.1
  • 8
    • 0033593572 scopus 로고    scopus 로고
    • Cell death in development
    • Vaux D.L., Korsmeyer S.J. Cell death in development. Cell. 96:1999;245-254.
    • (1999) Cell , vol.96 , pp. 245-254
    • Vaux, D.L.1    Korsmeyer, S.J.2
  • 9
    • 0023216950 scopus 로고
    • The non-obese diabetic (NOD) mouse
    • Leiter E.H.et al. The non-obese diabetic (NOD) mouse. Am. J. Pathol. 128:1987;380-383.
    • (1987) Am. J. Pathol. , vol.128 , pp. 380-383
    • Leiter, E.H.1
  • 10
    • 0022392953 scopus 로고
    • Morphological aspects on pancreatic islets of non-obese diabetic (NOD) mice
    • Fujino-Kurihara H.et al. Morphological aspects on pancreatic islets of non-obese diabetic (NOD) mice. Virchows Arch. B Cell Pathol. Incl. Mol. Pathol. 49:1985;107-120.
    • (1985) Virchows Arch. B Cell Pathol. Incl. Mol. Pathol. , vol.49 , pp. 107-120
    • Fujino-Kurihara, H.1
  • 11
    • 0345161818 scopus 로고    scopus 로고
    • Transfection of human pancreatic islets with an anti-apoptotic gene (bcl-2) protects beta cells from cytokine-induced destruction
    • Rabinovitch A.et al. Transfection of human pancreatic islets with an anti-apoptotic gene (bcl-2) protects beta cells from cytokine-induced destruction. Diabetes. 48:1999;1223-1229.
    • (1999) Diabetes , vol.48 , pp. 1223-1229
    • Rabinovitch, A.1
  • 12
    • 1842289172 scopus 로고    scopus 로고
    • Reduced incidence and delayed onset of diabetes in perforin-deficient nonobese diabetic mice
    • Kagi D.et al. Reduced incidence and delayed onset of diabetes in perforin-deficient nonobese diabetic mice. J. Exp. Med. 186:1997;989-997.
    • (1997) J. Exp. Med. , vol.186 , pp. 989-997
    • Kagi, D.1
  • 13
    • 0030890588 scopus 로고    scopus 로고
    • Cell death mediators in autoimmune diabetes - no shortage of suspects
    • Benoist C., Mathis D. Cell death mediators in autoimmune diabetes - no shortage of suspects. Cell. 89:1997;1-3.
    • (1997) Cell , vol.89 , pp. 1-3
    • Benoist, C.1    Mathis, D.2
  • 14
    • 0030005411 scopus 로고    scopus 로고
    • The harmony of the spheres: Inducible nitric oxide synthase and related genes in pancreatic beta cells
    • Eizirik D.L.et al. The harmony of the spheres: inducible nitric oxide synthase and related genes in pancreatic beta cells. Diabetologia. 39:1996;875-890.
    • (1996) Diabetologia , vol.39 , pp. 875-890
    • Eizirik, D.L.1
  • 15
    • 0029817047 scopus 로고    scopus 로고
    • The role of interleukin-1 in the pathogenesis of IDDM
    • Mandrup-Poulsen T. The role of interleukin-1 in the pathogenesis of IDDM. Diabetologia. 39:1996;1005-1029.
    • (1996) Diabetologia , vol.39 , pp. 1005-1029
    • Mandrup-Poulsen, T.1
  • 16
    • 0033305236 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha-activated cell death pathways in NIT-1 insulinoma cells and primary pancreatic beta cells
    • Stephens L.A.et al. Tumor necrosis factor-alpha-activated cell death pathways in NIT-1 insulinoma cells and primary pancreatic beta cells. Endocrinology. 140:1999;3219-3227.
    • (1999) Endocrinology , vol.140 , pp. 3219-3227
    • Stephens, L.A.1
  • 17
    • 0025130361 scopus 로고
    • Molecular pathology of type 1 diabetes
    • Campbell I.L., Harrison L.C. Molecular pathology of type 1 diabetes. Mol. Biol. Med. 7:1990;299-309.
    • (1990) Mol. Biol. Med. , vol.7 , pp. 299-309
    • Campbell, I.L.1    Harrison, L.C.2
  • 18
    • 0033178741 scopus 로고    scopus 로고
    • Evidence that beta cell death in the non-obese diabetic mouse is Fas-independent
    • Thomas H.E.et al. Evidence that beta cell death in the non-obese diabetic mouse is Fas-independent. J. Immunol. 163:1999;1562-1569.
    • (1999) J. Immunol. , vol.163 , pp. 1562-1569
    • Thomas, H.E.1
  • 19
    • 0025981388 scopus 로고
    • Essential role for interferon-gamma and interleukin-6 in autoimmune insulin-dependent diabetes in NOD/Wehi mice
    • Campbell I.L.et al. Essential role for interferon-gamma and interleukin-6 in autoimmune insulin-dependent diabetes in NOD/Wehi mice. J. Clin. Invest. 87:1991;739-742.
    • (1991) J. Clin. Invest. , vol.87 , pp. 739-742
    • Campbell, I.L.1
  • 20
    • 0031051747 scopus 로고    scopus 로고
    • Interferon-gamma is essential for destruction of beta cells and development of insulin-dependent diabetes mellitus
    • von Herrath M.G., Oldstone M.B. Interferon-gamma is essential for destruction of beta cells and development of insulin-dependent diabetes mellitus. J. Exp. Med. 185:1997;531-539.
    • (1997) J. Exp. Med. , vol.185 , pp. 531-539
    • Von Herrath, M.G.1    Oldstone, M.B.2
  • 21
    • 0029948898 scopus 로고    scopus 로고
    • Genetic absence of gamma-interferon delays but does not prevent diabetes in NOD mice
    • Hultgren B.et al. Genetic absence of gamma-interferon delays but does not prevent diabetes in NOD mice. Diabetes. 45:1996;812-817.
    • (1996) Diabetes , vol.45 , pp. 812-817
    • Hultgren, B.1
  • 22
    • 0031456802 scopus 로고    scopus 로고
    • Interferon-gamma impacts at multiple points during the progression of autoimmune diabetes
    • Wang B.et al. Interferon-gamma impacts at multiple points during the progression of autoimmune diabetes. Proc. Natl. Acad. Sci. U. S. A. 94:1997;13844-13849.
    • (1997) Proc. Natl. Acad. Sci. U. S. A. , vol.94 , pp. 13844-13849
    • Wang, B.1
  • 23
    • 0032531099 scopus 로고    scopus 로고
    • IFN-gamma action on pancreatic beta cells causes class I MHC upregulation but not diabetes
    • Thomas H.E.et al. IFN-gamma action on pancreatic beta cells causes class I MHC upregulation but not diabetes. J. Clin. Invest. 102:1998;1249-1257.
    • (1998) J. Clin. Invest. , vol.102 , pp. 1249-1257
    • Thomas, H.E.1
  • 24
    • 0032214715 scopus 로고    scopus 로고
    • Local expression of TNF alpha in neonatal NOD mice promotes diabetes by enhancing presentation of islet antigens
    • Green E.A.et al. Local expression of TNF alpha in neonatal NOD mice promotes diabetes by enhancing presentation of islet antigens. Immunity. 9:1998;733-743.
    • (1998) Immunity , vol.9 , pp. 733-743
    • Green, E.A.1
  • 25
    • 0029834839 scopus 로고    scopus 로고
    • Local expression of transgene encoded TNF alpha in islets prevents autoimmune diabetes in nonobese diabetic (NOD) mice by preventing the development of auto-reactive islet-specific T cells
    • Grewal I.S.et al. Local expression of transgene encoded TNF alpha in islets prevents autoimmune diabetes in nonobese diabetic (NOD) mice by preventing the development of auto-reactive islet-specific T cells. J. Exp. Med. 184:1996;1963-1974.
    • (1996) J. Exp. Med. , vol.184 , pp. 1963-1974
    • Grewal, I.S.1
  • 26
    • 0033561630 scopus 로고    scopus 로고
    • TNF receptor 1-dependent beta cell toxicity as an effector pathway in autoimmune diabetes
    • Kagi D.et al. TNF receptor 1-dependent beta cell toxicity as an effector pathway in autoimmune diabetes. J. Immunol. 162:1999;4598-4605.
    • (1999) J. Immunol. , vol.162 , pp. 4598-4605
    • Kagi, D.1
  • 27
    • 0033526068 scopus 로고    scopus 로고
    • In autoimmune diabetes the transition from benign to pernicious insulitis requires an islet cell response to tumor necrosis factor alpha
    • Pakala S.V.et al. In autoimmune diabetes the transition from benign to pernicious insulitis requires an islet cell response to tumor necrosis factor alpha. J. Exp. Med. 189:1999;1053-1062.
    • (1999) J. Exp. Med. , vol.189 , pp. 1053-1062
    • Pakala, S.V.1
  • 28
    • 0030684124 scopus 로고    scopus 로고
    • Irreversible inhibition of metabolic function and islet destruction after a 36-hour exposure to interleukin-1beta
    • Scarim A.L.et al. Irreversible inhibition of metabolic function and islet destruction after a 36-hour exposure to interleukin-1beta. Endocrinology. 138:1997;5301-5307.
    • (1997) Endocrinology , vol.138 , pp. 5301-5307
    • Scarim, A.L.1
  • 29
    • 0030923812 scopus 로고    scopus 로고
    • Cytokines induce deoxyribonucleic acid strand breaks and apoptosis in human pancreatic islet cells
    • Delaney C.A.et al. Cytokines induce deoxyribonucleic acid strand breaks and apoptosis in human pancreatic islet cells. Endocrinology. 138:1997;2610-2614.
    • (1997) Endocrinology , vol.138 , pp. 2610-2614
    • Delaney, C.A.1
  • 30
    • 0027934873 scopus 로고
    • TNF-alpha and IFN-gamma potentiate the deleterious effects of IL-1 beta on mouse pancreatic islets mainly via generation of nitric oxide
    • Cetkovic-Cvrlje M., Eizirik D.L. TNF-alpha and IFN-gamma potentiate the deleterious effects of IL-1 beta on mouse pancreatic islets mainly via generation of nitric oxide. Cytokine. 6:1994;399-406.
    • (1994) Cytokine , vol.6 , pp. 399-406
    • Cetkovic-Cvrlje, M.1    Eizirik, D.L.2
  • 31
    • 0030667121 scopus 로고    scopus 로고
    • Evidence for the presence of type I IL-1 receptors on beta-cells of islets of Langerhans
    • Scarim A.L.et al. Evidence for the presence of type I IL-1 receptors on beta-cells of islets of Langerhans. Biochim. Biophys. Acta. 1361:1997;313-320.
    • (1997) Biochim. Biophys. Acta , vol.1361 , pp. 313-320
    • Scarim, A.L.1
  • 32
    • 0032579373 scopus 로고    scopus 로고
    • Transgenic mice overexpressing type 2 nitric-oxide synthase in pancreatic beta cells develop insulin-dependent diabetes without insulitis
    • Takamura T.et al. Transgenic mice overexpressing type 2 nitric-oxide synthase in pancreatic beta cells develop insulin-dependent diabetes without insulitis. J. Biol. Chem. 273:1998;2493-2496.
    • (1998) J. Biol. Chem. , vol.273 , pp. 2493-2496
    • Takamura, T.1
  • 33
    • 0028900805 scopus 로고
    • Intraislet release of interleukin 1 inhibits beta cell function by inducing beta cell expression of inducible nitric oxide synthase
    • Corbett J.A., McDaniel M.L. Intraislet release of interleukin 1 inhibits beta cell function by inducing beta cell expression of inducible nitric oxide synthase. J. Exp. Med. 181:1995;559-568.
    • (1995) J. Exp. Med. , vol.181 , pp. 559-568
    • Corbett, J.A.1    McDaniel, M.L.2
  • 34
    • 0030890721 scopus 로고    scopus 로고
    • The role of Fas in autoimmune diabetes
    • Chervonsky A.V.et al. The role of Fas in autoimmune diabetes. Cell. 89:1997;17-24.
    • (1997) Cell , vol.89 , pp. 17-24
    • Chervonsky, A.V.1
  • 35
    • 0030800122 scopus 로고    scopus 로고
    • Requirement of Fas for the development of autoimmune diabetes in nonobese diabetic mice
    • Itoh N.et al. Requirement of Fas for the development of autoimmune diabetes in nonobese diabetic mice. J. Exp. Med. 186:1997;613-618.
    • (1997) J. Exp. Med. , vol.186 , pp. 613-618
    • Itoh, N.1
  • 36
    • 0029856723 scopus 로고    scopus 로고
    • Mouse islet cell lysis mediated by interleukin-1-induced Fas
    • Yamada K.et al. Mouse islet cell lysis mediated by interleukin-1-induced Fas. Diabetologia. 39:1996;1306-1312.
    • (1996) Diabetologia , vol.39 , pp. 1306-1312
    • Yamada, K.1
  • 37
    • 0032506224 scopus 로고    scopus 로고
    • Mechanisms of beta cell death in diabetes: A minor role for CD95
    • Allison J., Strasser A. Mechanisms of beta cell death in diabetes: a minor role for CD95. Proc. Natl. Acad. Sci. U. S. A. 95:1998;13818-13822.
    • (1998) Proc. Natl. Acad. Sci. U. S. A. , vol.95 , pp. 13818-13822
    • Allison, J.1    Strasser, A.2
  • 38
    • 0032586826 scopus 로고    scopus 로고
    • Apoptosis of pancreatic beta cells detected in accelerated diabetes of NOD mice: No role of Fas-Fas ligand interaction in autoimmune diabetes
    • Kim Y-H.et al. Apoptosis of pancreatic beta cells detected in accelerated diabetes of NOD mice: no role of Fas-Fas ligand interaction in autoimmune diabetes. Eur. J. Immunol. 29:1999;455-465.
    • (1999) Eur. J. Immunol. , vol.29 , pp. 455-465
    • Kim, Y.-H.1
  • 39
    • 0033560930 scopus 로고    scopus 로고
    • + T lymphocytes in transgenic nonobese diabetic mice
    • + T lymphocytes in transgenic nonobese diabetic mice. J. Clin. Invest. 103:1999;1201-1209.
    • (1999) J. Clin. Invest. , vol.103 , pp. 1201-1209
    • Amrani, A.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.