Development of insulitis without diabetes in transgenic mice lacking perforin-dependent cytotoxicity

Journal of Experimental Medicine

Volumn 183, Issue 5, 1996, Pages 2143-2152

  Kägi, David ^a,b   Odermatt, Bernhard ^a   Ohashi, Pamela S ^b   Zinkernagel, Rolf M ^a   Hengartner, Hans ^a  

^a UNIVERSITY OF ZURICH   (Switzerland)

^b PRINCESS MARGARET HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOIMMUNITY; CELL DAMAGE; CYTOTOXICITY; DATA ANALYSIS; DIABETES MELLITUS; DISEASE MODEL; IMMUNE RESPONSE; INSULITIS; MAJOR HISTOCOMPATIBILITY COMPLEX; MOUSE; NONHUMAN; OBESITY; PRIORITY JOURNAL; T LYMPHOCYTE SUBPOPULATION; TRANSGENIC MOUSE; VACCINIA VIRUS;

ANIMALS; BASE SEQUENCE; CROSSES, GENETIC; DIABETES MELLITUS, TYPE 1; DNA PRIMERS; FEMALE; ISLETS OF LANGERHANS; LYMPHOCYTIC CHORIOMENINGITIS; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; MALE; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MOLECULAR SEQUENCE DATA; PANCREATIC DISEASES; POLYMERASE CHAIN REACTION; PORE FORMING CYTOTOXIC PROTEINS; RECEPTORS, ANTIGEN, T-CELL; T-LYMPHOCYTES, CYTOTOXIC;

EID: 0029942839     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.183.5.2143     Document Type: Article

References (50)

1. Miyazaki, A., T. Hanafusa, K. Yamada, J. Miyagawa, H. Fujino-Kurihara, H. Nakajima, K. Nonaka, and S. Tarui. 1985. Predominance of T lymphocytes in pancreatic islets and spleen of pre-diabetic non-obese diabetic (NOD) mice: a longitudinal study. Clin. Exp. Immunol. 60:622-630.
2. Wicker, L.S., B.J. Miller, and Y. Mullen. 1986. Transfer of autoimmune diabetes mellitus with splenocytes from non-obese diabetic (NOD) mice. Diabetes. 35:855-860.
3. + T cells in autoimmune diabetes of NOD mice using transfer to NOD athymic nude mice. Eur. J. Immunol. 22: 2387-2393.
4. Harada, M., and S. Makino. 1986. Suppression of overt diabetes in NOD mice by anti-thymocyte serum or anti-Thy 1.2 antibody. Jikken Dobutsu. 35:501-504.
5. - T-lymphocytes in T-lymphocyte depleted mice. Diabetes. 37:204-208.
6. + T cell subsets are required for the transfer of diabetes in nonobese diabetic mice. J. Immunol. 140:52-58.
7. + T cells. J. Exp. Med. 166:823-832.
8. Bradley, B.J., K. Haskins, F.G. La Rosa, and K.J. Lafferty. 1992. CD8 T cells are not required for islet destruction induced by a CD4-positive islet-specific T cell clone. Diabetes. 41:1603-1608.
9. Katz, J.D., and C. Benoist. 1995. T helper cell subsets in insulin-dependent diabetes. Science (Wash. DC). 268:1185-1188.
10. Jarpe, A.J., M.R. Hickman, J.T. Anderson, W.E. Winter, and A.B. Peck. 1991. Flow cytometric enumeration of mononuclear cell populations infiltrating the islets of Langerhans in prediabetic NOD mice: development of a model of autoimmune insulitis for type I diabetes. Reg. Immunol. 3: 305-317.
11. 2-microglobulin-deficient mice do not develop insulitis or diabetes. Diabetes. 43:500-504.
12. 2-microglobulin-deficient non-obese diabetic mice. Int. Immunol. 6:1445-1449.
13. null mice are diabetes and insulitis resistant. Diabetes. 43:505-509.
14. Bendtzen, K., T. Mandrup-Poulsen, J. Nerup, J.H. Nielsen, C.A. Dinarello, and M. Svenson. 1986. Cytotoxicity of human pI 7 interleukin-1 for pancreatic islets of Langerhans. Science (Wash. DC). 232:1545-1547.
15. Corbett, J.A., and M.L. McDaniel. 1992. Perspectives in diabetes: does nitric oxide mediate autoimmune destruction of beta-cells? Possible therapeutic interventions in IDDM. Diabetes. 41:897-903.
16. Kägi, D., B. Ledermann, K. Bürki, P. Seiler, B. Odermatt, K.J. Olsen, E. Podack, R.M. Zinkernagel, and H. Hengartner. 1994. Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice. Nature (Lond.). 369:31-37.
17. + T cell mediated protection against an intracellular bacterium by perforin-dependent cytotoxicity. Eur. J. Immunol. 24:3068-3072.
18. Walsh, C.M., M. Matloubian, C.-C. Liu, R. Ueda, C.G. Kurahara, J.L. Christensen, M.T.F. Huang, J.D.-E. Young, R. Ahmed, and W.R. Clark. 1994. Immune function in mice lacking the perform gene. Proc. Natl. Acad. Sci. USA. 91:10854-10858.
19. Kojima, H., N. Shinohara, S. Hanaoka, Y. Someya-Shirota, Y. Takagaki, H. Ohno, T. Saito, T. Katayama, H. Yagita, K. Okumura et al. 1994. Two distinct pathways of specific killing revealed by perforin mutant cytotoxic T lymphocytes. Immunity. 1:357-364.
20. Lowin, B., F. Beermann, A. Schmidt, and J. Tschopp. 1994. A null mutation in the perforin gene impairs cytolytic T lymphocyte- and natural killer cell-mediated cytotoxicity. Proc. Natl. Acad. Sci. USA. 91:11571-11575.
21. Van den Broek, M.F., D. Kägi, R.M. Zinkernagel, and H. Hengartner. 1995. Natural killer cell-mediated tumour control in vivo is perforin dependent. Eur. J. Immunol. 25:3514-3516.
22. Ohashi, P.S., S. Oehen, K. Bürki, H.P. Pircher, C.T. Ohashi, B. Odermatt, B. Malissen, R. Zinkernagel, and H. Hengartner. 1991. Ablation of "tolerance" and induction of diabetes by virus infection in viral antigen transgenic mice. Cell. 65:305-317.
23. Ohashi, P.S. 1994. Ignorance is bliss. The Immunologist. 2:87-92.
24. Pircher, H.P., K. Bürki, R. Lang, H. Hengartner, and R.M. Zinkernagel. 1989. Tolerance induction in double specific T-cell receptor transgenic mice varies with antigen. Nature (Lond.). 342:559-561.
25. Kyburz, D., P. Aichele, D.E. Speiser, H. Hengartner, R. Zinkernagel, and H. Pircher. 1993. T cell immunity after a viral infection versus T cell tolerance induced by soluble viral peptides. Eur. J. Immunol. 23:1956-1962.
26. Swain, S.L. 1983. T cell subsets and the recognition of MHC Class. Immunol. Rev. 74:129-142.
27. Pircher, H.P., D. Moskophidis, U. Rohrer, K. Bürki, H. Hengartner, and R.M. Zinkernagel. 1990. Viral escape by selection of cytotoxic T cell-resistant virus variants in vivo. Nature. 346:629-633.
28. Whitton, J.L., J.R. Gebhard, H. Lewicki, A. Tishon, and M.B. Oldstone. 1988. Molecular definition of a major cytotoxic T-lymphocyte epitope in the glycoprotein of lymphocytic choriomeningitis virus. J. Virol. 62:687-695.
29. Hany, M., S. Oehen, M. Schulz, H. Hengartner, M. Mackett, D.H. L. Bishop, and R.M. Zinkernagel. 1989. Anti-viral protection and prevention of lymphocytic choriomeningitis or of the local footpad swelling reaction in mice by immunisation with vaccinia-recombinant virus expressing LCMV-WE nucleoprotein or glycoprotein. Eur. J. Immunol. 19:417-424.
30. Cobbold, S.P., A. Jayasuriya, A. Nash, T.D. Prospero, and H. Waldmann. 1984. Therapy with monoclonal antibodies by elimination of T cell subsets in vivo. Nature (Lond.). 312: 548-551.
31. Austyn, J.M., and S. Gordon. 1981. F4/80, a monoclonal antibody directed specifically against the mouse macrophage. Eur. J. Immunol. 11:805-815.
32. a-encoded antigens. Nature (Lond.). 332:40-45.
33. a (Mtv-7). J. Exp. Med. 175: 1623-1633.
34. Kägi, D., F. Vignaux, B. Ledermann, K. Bürki, V. Depraetere, S. Nagata, H. Hengartner, and P. Golstein. 1994. Fas and perform pathways as major mechanisms of T cell-mediated cytotoxicity. Science (Wash. DC). 265:528-530.
35. Kägi, D., B. Ledermann, K. Bürki, R.M. Zinkernagel, and H. Hengartner. 1995. Lymphocyte-mediated cytotoxicity in vitro and in vivo: mechanisms and significance. Immunol. Rev. 146:95-115.
36. 2+-independent T cell mediated cytotoxicity. J. Exp. Med. 177:195-200.
37. Lowin, U., M. Hahne, G. Mattmann, and J. Tschopp. 1994. Cytolytic T-cell cytotoxicity is mediated through perform and Fas lytic pathways. Nature (Lond.). 370:650-652.
38. Suda, T., T. Takahashi, P. Golstein, and S. Nagata. 1993. Molecular cloning and expression of the Fas ligand, a novel member of the tumor necrosis factor family. Cell. 75:1169-1178.
39. Kägi, D., P. Seiler, J. Pavlovic, B. Ledermann, K. Bürki, R.M. Zinkernagel, and H. Hengartner. 1995. The roles of perforin- and Fas-dependent cytotoxicity in protection against cytopathic and noncytopathic viruses. Eur. J. Immunol. 25: 3256-3262.
40. Shehadeh, N.N., and K.J. Lafferty. 1993. The role of T-cells in the development of autoimmune diabetes. Diabetes Rev. 1: 141-151.
41. Leithäuser, F., J. Dhein, G. Mechtersheimer, K. Koretz, S. Brüderlein, C. Henne, A. Schmidt, K.-M. Debatin, P.H. Krammer, and P. Möller. 1993. Constitutive and induced expression of APO-1, a new member of the nerve growth factor/tumor necrosis factor receptor superfamily, in normal and neoplastic cells. Lab. Invest. 69:415-429.
42. Pukel, H., H. Baquerizo, and A. Rabinovitch. 1988. Destruction of rat islet cell monolayers by cytokines. Synergistic interactions of interferon-gamma, tumour necrosis factor, lymphotoxin and interleukin 1. Diabetes. 37:133-136.
43. Guidotti, L.G., T. Ishikawa, M.V. Hobbs, B. Matzke, R. Schreiber, and F.V. Chisari. 1996. Intracellular inactivation of the hepatitis B virus by cytotoxic T lymphocytes. Immunity. 4:25-36.
44. Ogasawara, J., R. Watanabe-Fukunaga, M. Adachi, A. Matsuzawa, T. Kasugai, Y. Kitamura, N. Itoh, T. Suda, and S. Nagata. 1993. Lethal effect of the anti-Fas antibody in mice. Nature (Lond.). 364:806-809.
45. Ohashi, P.S., S. Oehen, P. Aichele, H. Pircher, B. Odermatt, P. Herrera, Y. Higuchi, K. buerki, H. Hengartner, and R.M. Zinkernagel. 1993. Induction of diabetes is influenced by the infectious virus and local expression of MHC class I and TNF-a. J. Immunol. 150:5185-5194.
46. + lymphocytes in autoimmune disease. Studies on spontaneous and adoptively transferred diabetes in nonobese diabetic mice. J. Immunol. 143:3994-3999.
47. + T cell-mediated cytotoxicity. J. Immunol. 152:1127-1233.
48. Bottazzo, G.F., B.M. Dean, J.M. McNally, E.H. MacKay, P.G.F. Swift, and D.R. Gamble. 1985. In situ characterization of autoimmune phenomena and expression of HLA molecules in the pancreas in diabetic insulitis. N. Engl. J. Med. 313:353-360.
49. a donors. Diabetes. 42:44-55.
50. Sibley, R.K. 1985. Recurrent diabetes mellitus in the pancreas iso- and allograft: a light and electron microscopic analysis of four cases. Lab. Invest. 53:132-144.