Dissociation between Fas expression and induction of apoptosis in human islets of Langerhans

Diabetes, Obesity and Metabolism

Volumn 2, Issue 1, 2000, Pages 57-60

  Loweth, A C ^a,b   Watts, K ^a   McBain, S C ^a   Williams, G T ^a   Scarpello, J H B ^a   Morgan, N G ^a  

^a KEELE UNIVERSITY   (United Kingdom)

^b LIVERPOOL JOHN MOORES UNIVERSITY   (United Kingdom)

Author keywords

Apoptosis; Cytokine; Endocrine pancreas; Fas; Insulin secretion; Interleukin 1 ; cell

Indexed keywords

FAS ANTIBODY; FAS ANTIGEN;

APOPTOSIS; ARTICLE; CELL DEATH; CONTROLLED STUDY; DATA BASE; DISSOCIATION; HUMAN; HUMAN CELL; INSULIN DEPENDENT DIABETES MELLITUS; PANCREAS ISLET BETA CELL; PATHOPHYSIOLOGY; PROTEIN EXPRESSION; RECEPTOR UPREGULATION; SERUM;

EID: 0034526127     PISSN: 14628902     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1463-1326.2000.00068.x     Document Type: Article

References (12)

1. Apoptosis and the pathogenesis of IDDM. A question of life and death
2. Apoptosis is the mode of β-cell death responsible for the development of IDDM in the Nonobese Diabetic Mouse
3. β cell apoptosis in T-cell mediated autoimmune disease
4. Cytokines induce deoxynucleic acid strand breaks and apoptosis in human pancreatic islet cells
5. Human islets of Langerhans express Fas Ligand and undergo apoptosis in response to interleukin-1β and Fas ligation
6. The role of Fas in autoimmune diabetes
7. Requirement for Fas for the development of autoimmune diabetes in nonobese diabetic mice
8. Expression of apoptosis-inducing CD95 (Fas/Apo 1) on human β-cells sorted by flow cytometry and cultured in vitro
9. Nitric oxide primes pancreatic β-cells for Fas-mediated destruction in insulin dependent diabetes mellitus
10. β-cell destruction in NOD mice correlates with Fas (CD95) expression on β-cells and proinflammatory cytokine expression in islets
11. Essential role of caspase-3 in apoptosis of mouse β-cells transfected with human Fas
12. Human hepatocytes produce an isoform of Fas that inhibits apoptosis