Immune mechanisms leading to type 1 Insulin-dependent diabetes mellitus

Hormone Research in Paediatrics

Volumn 48, Issue 4, 1997, Pages 58-63

  Boitard, C ^a   Timsit, J ^a   Larger, E ^a   Dubois, D ^a  

^a HÔPITAL NECKER ENFANTS MALADES   (France)

Author keywords

Autoantigens; Autoimmunity; Insulin dependent diabetes mellitus

Indexed keywords

AUTOANTIGEN; GLUTAMATE DECARBOXYLASE; PROINSULIN;

AUTOIMMUNITY; CELL DESTRUCTION; CELL SPECIFICITY; CONFERENCE PAPER; CONTROLLED STUDY; ETIOLOGY; HUMAN; HUMAN CELL; IMMUNE SYSTEM; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN RELEASE; MARKER GENE; PANCREAS ISLET BETA CELL; PANCREAS ISLET CELL; PRIORITY JOURNAL;

ANIMALS; AUTOANTIBODIES; AUTOANTIGENS; DIABETES MELLITUS, TYPE 1; HUMANS; INSULIN; ISLETS OF LANGERHANS; MAJOR HISTOCOMPATIBILITY COMPLEX; MICE; MICE, INBRED NOD;

EID: 0030720861     PISSN: 16632818     EISSN: 16632826     Source Type: Journal    
DOI: 10.1159/000191316     Document Type: Article

References (33)

1. Atkinson MA, Maclaren NK: Islet cell autoantigens in insulin-dependent diabetes. J Clin Invest 1993;92:1608-1616.
2. Roll U, Christie MR. Fuchtcnbusch M. Payton MA, Hawkes CJ, Ziegler AG: The German multicentrc BABY-D1AB study: Detection of humoral immune responses to islet antigens in early childhood. Diabetes 1996;45:967-973.
3. Haskins K. McDuffie M: Acceleration of diabetes in young NOD mice with a CD4+ islet-specific T cell clone. Science 1990:249:1433-1436.
4. Ohashi PS. Oehen S. Buerki K. Pircher H. Oha-shi CT. Odermatt B. Malissen B. Zinkernagel RM. Hengartner H: Ablation of'tolerance' and induction of diabetes by virus infection in viral antigen transgenic mice. Cell 1991:65:305-317.
5. Oldstone MB, Nerenberg M, Southern P, Price J, Lewicki H: Virus infection triggers insulin-dependent diabetes mellitus in a transgenic model: Role of anti-self (virus) immune response. Cell 1991;65:319-331.
6. Davies JL, Kawaguchi Y, Bennett ST, Cope-man JB, Cordell HJ, Pritchard LE, Reed PW, Gough SC, Jenkins SC, Palmer SM et al: A genome-wide search for human type I diabetes susceptibility genes. Nature 1994:371:130-136.
7. Julier C. Hycr RN, Davies J. Merlin F, Soula-ruc P. Briant L, Cathelineau G. Deschamps I. Rotter JI. Froguel P et al.; Insulin-IGF-II region on chromosome 11 p encodes a gene implicated in HLA-DR4-dcpcndcnt diabetes susceptibility. Nature 1991;354:155-159.
8. Kennedy GC. German MS. Rutter WJ: The minisatellite in the diabetes susceptibility locus 1DDM2 regulates insulin transcription. Nature Genetics 1995:9:293-298.
9. Ghosh S. Palmer SM, Rodrigues NR, Cordell HJ. Hearne CM, Comall RJ. Prins JB, McShane P. Lathrop GM, Peterson LB et al: Polygenic control of autoimmune diabetes in nonobcse diabetic mice. Nature Genetics 1993: 4:404-409.
10. de Gouyon B. Melanitou E. Richard MF. Requarth M, Hahn IH, Guenet JL. Demenais F, Julier C, Lathrop GM, Boitard C et al: Genetic analysis of diabetes and insulitis in an interspecific cross of the nonobese diabetic mouse with Mus spretus. Proc Natl Acad Sci USA 1993:90: 1877-1881.
11. Boitard C. Larger E. Timsit J. Sempc P. Bach JF: An islet or an immune disease? Diabelologia 1994;37:S90-S98.
12. Nagata M, Yokono K, Hayakawa M, Kawase Y, Hatamori N, Ogawa W, Yonezawa K, Shii K, Baba S: Destruction of pancreatic islet cells by cytotoxic T lymphocytes in nonobese diabetic mice. J Immunol 1989:143:1155-1162.
13. Bendelac A, Carnaud C, Boitard C: Syngeneic transfer of autoimmune diabetes from diabetic NOD mice to healthy neonates. Requirement for both L3T4+ and Lyl-2+ T cells. J Exp Med 1987;166:823-832.
14. Miller BJ, Appel MC, O'Neil JJ, Wicker LS: Both the Lyt-2+ and L3T4+ T cell subsets are required for the transfer of diabetes in non-obese diabetic mice. J Immunol 1988; 140:52-58.
15. Christianson SW. Shultz LD. Lcither EH: Adoptive transfer of diabetes into immunode-ficient NOD-SC1D/SC1D mice. Relative contributions of CD4+ and CD8+T cells from diabetic versus prcdiabctic NOD.NON-Thy-la donors. Diabetes 1993;42:44-55.
16. Wang Y, Pontcsilli O, Gill RG, La Rosa FG, Lafferty KJ: The role of CD4+ and CD8+ T cells in the destruction of islet grafts by spontaneously diabetic mice. Proc Natl Acad Sci USA 1991;88:527-531.
17. Sutton R, Gray DW, McShane P, Dallman MJ, Morris PJ: The specificity of rejection and the absence of susceptibility of pancreatic islet beta cells to nonspecific immune destruction in mixed strain islets grafted beneath the renal capsule in the rat. J Exp Med 1989:170:751-762.
18. Laufer TM, von Herrath MG, Grusby MJ, Old-stone MBA, Glimeher LH: Autoimmune diabetes can be induced in transgenic major histocompatibility complex class 11-dcficient mice. J Exp Med 1993:178:589-596.
19. Sibley RK. Sutherland DE. Goetz F. Michael AF: Recurrent diabetes mellitus in the pancreas iso- and allograft. A light and electron microscopic and immunohistochemical analysis of four cases. Lab Invest 1985:53:132-144.
20. Homo-Delarche F. Boitard C: Autoimmune diabetes: The role of the islets of Langerhans. Immunol Today 1996;17:456-459.
21. Atkinson MA, Maclaren NK, Luchetta R: Insulitis and diabetes in NOD mice reduced by pro-phvlactic insulin therapy. Diabetes 1990:39: 933-937.
22. Gotfredsen CF, Buschard K, Frandsen EK: Reduction of diabetes incidence of BB Wistar rats by early prophylactic insulin treatment of diabetes-prone animals. Diabetologia 1985;28: 933-935.
23. Gottlieb PA, Handler ES, Appel MC, Greiner DL, Mordes JP, Rossini AA: Insulin treatment prevents diabetes mellitus but not thyroiditis in RT6-depletcd diabetes resistant BB/Wor rats. Diabetologia 1991:34:296-300.
24. Thivolet CH. Goillot E. Bedossa P. Durand A. Bonnard M. Orgiazzi J: Insulin prevents adoptive cell transfer of diabetes in the autoimmune non-obese diabetic mouse. Diabetologia 1991;34:314-319.
25. Shah SC. Malone JI. Simpson NE: A randomized trial of intensive insulin therapy in newly diagnosed insulin-dependent diabetes mellitus. N Engl J Med 1989;320:550-554.
26. Keller RJ. Eiscnbarth GS. Jackson RA: Insulin prophylaxis in individuals at high risk of type 1 diabetes. Lancet 1993;341:927-928.
27. Palmer JP. Asplin CM, Clemons P. Lyen K. Tatpati O. Raghu PK, Paquette TL: Insulin autoantibodics in insulin-dependent diabetes before insulin treatment. Science 1983:222: 1337-1339.
28. Daniel D. Gill RG. Schloot N. Wegmann D: Epitope specificity, cytokine production profile and diabetogenic activity of insulin-specific T cell clones isolated from NOD mice. Eur J Immunol 1995;25:1056-1062.
29. Muir A, Peck A, Clare-Salzler M, Song YH, Cornelius J, Luchetta R, Krischer J, Maclaren N: Insulin immunization of nonobesc diabetic mice induces a protective insulitis characterized by diminished intraislct inlcrferon-gam-ma transcription. J Clin Invest 1995:95:628- 634.
30. Larger E. Becourt C. Bach JF. Boitard C: Pancreatic islet beta cells drive T cell-immune responses in the nonobesc diabetic mouse model. J Exp Med 1995:181:1635-1642.
31. Adams TE. Alpert S. Hanahan D: Non-tolerance and autoantibodics to a transgenic self antigen expressed in pancreatic β cells. Nature 1987:325:223-228.
32. Tisch R, Yang XD, Singer SM. Liblau RS, Fugger L, McDevitt HO: Immune response to glutamic acid decarboxylase correlates with insulitis in non-obese diabetic mice. Nature 1993: 366:72-75.
33. Kaufman DL, Clare-Salzler M. Tian J, Forsthuber T, Ting GS. Robinson P. Atkinson MA, Sercarz EE. Tobin AJ. Lehmann PV: Spontaneous loss of T-cell tolerance to glutamic acid decarboxylase in murine insulin-dependent diabetes. Nature 1993:366:69-72.