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Volumn 69, Issue 9, 2009, Pages 4059-4066

Identification of potential driver genes in human liver carcinoma by genomewide screening

Author keywords

[No Author keywords available]

Indexed keywords

DNA; EPIDERMAL GROWTH FACTOR RECEPTOR; MAMMALIAN TARGET OF RAPAMYCIN; SMALL INTERFERING RNA;

EID: 65949098918     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-09-0164     Document Type: Article
Times cited : (89)

References (39)
  • 1
    • 4544273428 scopus 로고    scopus 로고
    • Classification and prediction of survival in hepatocellular carcinoma by gene expression profiling
    • Lee JS. Chu IS. Heo J. et al. Classification and prediction of survival in hepatocellular carcinoma by gene expression profiling. Hepatology 2004; 40: 667-76.
    • (2004) Hepatology , vol.40 , pp. 667-676
    • Lee, J.S.1    Chu, I.S.2    Heo, J.3
  • 2
    • 34247549347 scopus 로고    scopus 로고
    • Genome-wide molecular profiles of HCV-induced dysplasia and hepatocellular carcinoma
    • Wurmbach E. Chen YB. Khitrov G. et al. Genome-wide molecular profiles of HCV-induced dysplasia and hepatocellular carcinoma. Hepatology 2007; 45: 938-47.
    • (2007) Hepatology , vol.45 , pp. 938-947
    • Wurmbach, E.1    Chen, Y.B.2    Khitrov, G.3
  • 3
    • 0037391756 scopus 로고    scopus 로고
    • Predicting hepatitis B virus-positive metastatic hepatocellular carcinomas using gene expression profiling and supervised machine learning
    • Ye QH. Qin LX. Forgues M. et al. Predicting hepatitis B virus-positive metastatic hepatocellular carcinomas using gene expression profiling and supervised machine learning. Nat Med 2003; 9: 416-23.
    • (2003) Nat Med , vol.9 , pp. 416-423
    • Ye, Q.H.1    Qin, L.X.2    Forgues, M.3
  • 4
    • 33645742425 scopus 로고    scopus 로고
    • A novel prognostic subtype of human hepatocellular carcinoma derived from hepatic progenitor cells
    • Lee JS. Heo J. Libbrecht L. et al. A novel prognostic subtype of human hepatocellular carcinoma derived from hepatic progenitor cells. Nat Med 2006; 12: 410-6.
    • (2006) Nat Med , vol.12 , pp. 410-416
    • Lee, J.S.1    Heo, J.2    Libbrecht, L.3
  • 5
    • 3242672465 scopus 로고    scopus 로고
    • Whole genome scanning identifies genotypes associated with recurrence and metastasis in prostate tumors
    • Paris PL. Andaya A. Fridlyand J. et al. Whole genome scanning identifies genotypes associated with recurrence and metastasis in prostate tumors. Hum Mol Genet 2004; 13: 1303-13.
    • (2004) Hum Mol Genet , vol.13 , pp. 1303-1313
    • Paris, P.L.1    Andaya, A.2    Fridlyand, J.3
  • 6
    • 33645769276 scopus 로고    scopus 로고
    • High-resolution genomic profiles define distinct clinico-pathogenetic subgroups of multiple myeloma patients
    • Carrasco DR. Tonon G. Huang Y. et al. High-resolution genomic profiles define distinct clinico-pathogenetic subgroups of multiple myeloma patients. Cancer Cell 2006; 9: 313-25.
    • (2006) Cancer Cell , vol.9 , pp. 313-325
    • Carrasco, D.R.1    Tonon, G.2    Huang, Y.3
  • 7
    • 33749359258 scopus 로고    scopus 로고
    • A tumor progression model for hepatocellular carcinoma: Bioinformatic analysis of genomic data
    • Poon TC. Wong N. Lai PB. Rattray M. Johnson PJ. Sung JJ. A tumor progression model for hepatocellular carcinoma: bioinformatic analysis of genomic data. Gastroenterology 2006; 131: 1262-70.
    • (2006) Gastroenterology , vol.131 , pp. 1262-1270
    • Poon, T.C.1    Wong, N.2    Lai, P.B.3    Rattray, M.4    Johnson, P.J.5    Sung, J.J.6
  • 8
    • 35648950024 scopus 로고    scopus 로고
    • Genetically distinct and clinically relevant classification of hepatocellular carcinoma: Putative therapeutic targets
    • Katoh H. Ojima H. Kokubu A. et al. Genetically distinct and clinically relevant classification of hepatocellular carcinoma: putative therapeutic targets. Gastroenterology 2007; 133: 1475-86.
    • (2007) Gastroenterology , vol.133 , pp. 1475-1486
    • Katoh, H.1    Ojima, H.2    Kokubu, A.3
  • 9
    • 13844250828 scopus 로고    scopus 로고
    • Microarray analysis reveals a major direct role of DNA copy number alteration in the transcriptional program of human breast tumors
    • Pollack JR. Sorlie T. Perou CM. et al. Microarray analysis reveals a major direct role of DNA copy number alteration in the transcriptional program of human breast tumors. Proc Natl Acad Sci U S A 2002; 99: 12963-8.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 12963-12968
    • Pollack, J.R.1    Sorlie, T.2    Perou, C.M.3
  • 10
    • 20444475795 scopus 로고    scopus 로고
    • An integrated data analysis approach to characterize genes highly expressed in hepatocellular carcinoma
    • Patil MA. Chua MS. Pan KH. et al. An integrated data analysis approach to characterize genes highly expressed in hepatocellular carcinoma. Oncogene 2005; 24: 3737-47.
    • (2005) Oncogene , vol.24 , pp. 3737-3747
    • Patil, M.A.1    Chua, M.S.2    Pan, K.H.3
  • 11
    • 42249098060 scopus 로고    scopus 로고
    • Integration of genomic analysis and in vivo transfection to identify sprouty 2 as a candidate tumor suppressor in liver cancer
    • Lee SA. Ho C. Roy R. et al. Integration of genomic analysis and in vivo transfection to identify sprouty 2 as a candidate tumor suppressor in liver cancer. Hepatology 2008; 47: 1200-10.
    • (2008) Hepatology , vol.47 , pp. 1200-1210
    • Lee, S.A.1    Ho, C.2    Roy, R.3
  • 12
    • 53049086329 scopus 로고    scopus 로고
    • Focal gains of VEGFA and molecular classification of hepatocellular carcinoma
    • Chiang DY. Villanueva A. Hoshida Y. et al. Focal gains of VEGFA and molecular classification of hepatocellular carcinoma. Cancer Res 2008; 68: 6779-88.
    • (2008) Cancer Res , vol.68 , pp. 6779-6788
    • Chiang, D.Y.1    Villanueva, A.2    Hoshida, Y.3
  • 13
    • 33751530055 scopus 로고    scopus 로고
    • Regional copy number-independent deregulation of transcription in cancer
    • Stransky N. Vallot C. Reyal F. et al. Regional copy number-independent deregulation of transcription in cancer. Nat Genet 2006; 38: 1386-96.
    • (2006) Nat Genet , vol.38 , pp. 1386-1396
    • Stransky, N.1    Vallot, C.2    Reyal, F.3
  • 15
    • 34547114031 scopus 로고    scopus 로고
    • Systemic treatment with the antidiabetic drug metformin selectively impairs p53-deficient tumor cell growth
    • Buzzai M. Jones RG. Amaravadi RK. et al. Systemic treatment with the antidiabetic drug metformin selectively impairs p53-deficient tumor cell growth. Cancer Res 2007; 67: 6745-52.
    • (2007) Cancer Res , vol.67 , pp. 6745-6752
    • Buzzai, M.1    Jones, R.G.2    Amaravadi, R.K.3
  • 16
    • 33749335282 scopus 로고    scopus 로고
    • The Connectivity Map: Using gene-expression signatures to connect small molecules, genes, and disease
    • Lamb J. Crawford ED. Peck D. et al. The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease. Science 2006; 313: 1929-35.
    • (2006) Science , vol.313 , pp. 1929-1935
    • Lamb, J.1    Crawford, E.D.2    Peck, D.3
  • 17
    • 84984578427 scopus 로고    scopus 로고
    • HCC: An integrated oncogenomic database of hepatocellular carcinoma revealed aberrant cancer target genes and loci
    • Su WH. Chao CC. Yeh SH. et al. HCC: an integrated oncogenomic database of hepatocellular carcinoma revealed aberrant cancer target genes and loci. Nucleic Acids Res 2007; 35: D727-31.
    • (2007) Nucleic Acids Res , vol.35
    • Su, W.H.1    Chao, C.C.2    Yeh, S.H.3
  • 18
    • 0036699940 scopus 로고    scopus 로고
    • Molecular pathogenesis of human hepatocellular carcinoma
    • Thorgeirsson SS. Grisham JW. Molecular pathogenesis of human hepatocellular carcinoma. Nat Genet 2002; 31: 339-46.
    • (2002) Nat Genet , vol.31 , pp. 339-346
    • Thorgeirsson, S.S.1    Grisham, J.W.2
  • 19
    • 16244373665 scopus 로고    scopus 로고
    • Chromosome alterations in human hepatocellular carcinomas correlate with aetiology and histological grade-results of an explorative CGH meta-analysis
    • Moinzadeh P. Breuhahn K. Stutzer H. Schirmacher P. Chromosome alterations in human hepatocellular carcinomas correlate with aetiology and histological grade-results of an explorative CGH meta-analysis. Br J Cancer 2005; 92: 935-41.
    • (2005) Br J Cancer , vol.92 , pp. 935-941
    • Moinzadeh, P.1    Breuhahn, K.2    Stutzer, H.3    Schirmacher, P.4
  • 21
    • 34247482327 scopus 로고    scopus 로고
    • Multiple regions within 8q24 independently affect risk for prostate cancer
    • Haiman CA. Patterson N. Freedman ML. et al. Multiple regions within 8q24 independently affect risk for prostate cancer. Nat Genet 2007; 39: 638-44.
    • (2007) Nat Genet , vol.39 , pp. 638-644
    • Haiman, C.A.1    Patterson, N.2    Freedman, M.L.3
  • 22
    • 42249087302 scopus 로고    scopus 로고
    • Gene expressionbased recurrence prediction of hepatitis B virus-related human hepatocellular carcinoma
    • Woo HG. Park ES. Cheon JH. et al. Gene expressionbased recurrence prediction of hepatitis B virus-related human hepatocellular carcinoma. Clin Cancer Res 2008; 14: 2056-64.
    • (2008) Clin Cancer Res , vol.14 , pp. 2056-2064
    • Woo, H.G.1    Park, E.S.2    Cheon, J.H.3
  • 23
    • 34347220473 scopus 로고    scopus 로고
    • Defining the role of mTOR in cancer
    • Guertin DA. Sabatini DM. Defining the role of mTOR in cancer. Cancer Cell 2007; 12: 9-22.
    • (2007) Cancer Cell , vol.12 , pp. 9-22
    • Guertin, D.A.1    Sabatini, D.M.2
  • 24
    • 40349108627 scopus 로고    scopus 로고
    • Inhibition of mTOR pathway by everolimus cooperates with EGFR inhibitors in human tumours sensitive and resistant to anti-EGFR drugs
    • Bianco R. Garofalo S. Rosa R. et al. Inhibition of mTOR pathway by everolimus cooperates with EGFR inhibitors in human tumours sensitive and resistant to anti-EGFR drugs. Br J Cancer 2008; 98: 923-30.
    • (2008) Br J Cancer , vol.98 , pp. 923-930
    • Bianco, R.1    Garofalo, S.2    Rosa, R.3
  • 25
    • 33747620519 scopus 로고    scopus 로고
    • Systems biology and combination therapy in the quest for clinical efficacy
    • Fitzgerald JB. Schoeberl B. Nielsen UB. Sorger PK. Systems biology and combination therapy in the quest for clinical efficacy. Nat Chem Biol 2006; 2: 458-66.
    • (2006) Nat Chem Biol , vol.2 , pp. 458-466
    • Fitzgerald, J.B.1    Schoeberl, B.2    Nielsen, U.B.3    Sorger, P.K.4
  • 26
    • 34347369749 scopus 로고    scopus 로고
    • Notch signals positively regulate activity of the mTOR pathway in T-cell acute lymphoblastic leukemia
    • Chan SM. Weng AP. Tibshirani R. Aster JC. Utz PJ. Notch signals positively regulate activity of the mTOR pathway in T-cell acute lymphoblastic leukemia. Blood 2007; 110: 278-86.
    • (2007) Blood , vol.110 , pp. 278-286
    • Chan, S.M.1    Weng, A.P.2    Tibshirani, R.3    Aster, J.C.4    Utz, P.J.5
  • 27
    • 34447309737 scopus 로고    scopus 로고
    • Human scribble accumulates in colorectal neoplasia in association with an altered distribution of β-catenin
    • Kamei Y. Kito K. Takeuchi T. et al. Human scribble accumulates in colorectal neoplasia in association with an altered distribution of β-catenin. Hum Pathol 2007; 38: 1273-81.
    • (2007) Hum Pathol , vol.38 , pp. 1273-1281
    • Kamei, Y.1    Kito, K.2    Takeuchi, T.3
  • 28
    • 34548658230 scopus 로고    scopus 로고
    • Heat shock factor 1 is a powerful multifaceted modifier of carcinogenesis
    • Dai C. Whitesell L. Rogers AB. Lindquist S. Heat shock factor 1 is a powerful multifaceted modifier of carcinogenesis. Cell 2007; 130: 1005-18.
    • (2007) Cell , vol.130 , pp. 1005-1018
    • Dai, C.1    Whitesell, L.2    Rogers, A.B.3    Lindquist, S.4
  • 29
    • 33749433916 scopus 로고    scopus 로고
    • Gene expression signature-based chemical genomic prediction identifies a novel class of HSP90 pathway modulators
    • Hieronymus H. Lamb J. Ross KN. et al. Gene expression signature-based chemical genomic prediction identifies a novel class of HSP90 pathway modulators. Cancer Cell 2006; 10: 321-30.
    • (2006) Cancer Cell , vol.10 , pp. 321-330
    • Hieronymus, H.1    Lamb, J.2    Ross, K.N.3
  • 30
    • 33749443714 scopus 로고    scopus 로고
    • Gene expressionbased chemical genomics identifies rapamycin as a modulator of MCL1 and glucocorticoid resistance
    • Wei G. Twomey D. Lamb J. et al. Gene expressionbased chemical genomics identifies rapamycin as a modulator of MCL1 and glucocorticoid resistance. Cancer Cell 2006; 10: 331-42.
    • (2006) Cancer Cell , vol.10 , pp. 331-342
    • Wei, G.1    Twomey, D.2    Lamb, J.3
  • 31
    • 3042514191 scopus 로고    scopus 로고
    • Coexpression analysis of human genes across many microarray data sets
    • Lee HK. Hsu AK. Sajdak J. Qin J. Pavlidis P. Coexpression analysis of human genes across many microarray data sets. Genome Res 2004; 14: 1085-94.
    • (2004) Genome Res , vol.14 , pp. 1085-1094
    • Lee, H.K.1    Hsu, A.K.2    Sajdak, J.3    Qin, J.4    Pavlidis, P.5
  • 33
    • 34249304441 scopus 로고    scopus 로고
    • Mammalian target of rapamycin activation impairs hepatocytic differentiation and targets genes moderating lipid homeostasis and hepatocellular growth
    • Parent R. Kolippakkam D. Booth G. Beretta L. Mammalian target of rapamycin activation impairs hepatocytic differentiation and targets genes moderating lipid homeostasis and hepatocellular growth. Cancer Res 2007; 67: 4337-45.
    • (2007) Cancer Res , vol.67 , pp. 4337-4345
    • Parent, R.1    Kolippakkam, D.2    Booth, G.3    Beretta, L.4
  • 34
    • 57349087153 scopus 로고    scopus 로고
    • Pivotal role of mTOR signaling in hepatocellular carcinoma
    • Villanueva A. Chiang DY. Newell P. et al. Pivotal role of mTOR signaling in hepatocellular carcinoma. Gastroenterology 2008; 135: 1972-83.
    • (2008) Gastroenterology , vol.135 , pp. 1972-1983
    • Villanueva, A.1    Chiang, D.Y.2    Newell, P.3
  • 35
    • 27244447373 scopus 로고    scopus 로고
    • Phase II study of erlotinib (OSI-774) in patients with advanced hepatocellular cancer
    • Philip PA. Mahoney MR. Allmer C. et al. Phase II study of erlotinib (OSI-774) in patients with advanced hepatocellular cancer. J Clin Oncol 2005; 23: 6657-63.
    • (2005) J Clin Oncol , vol.23 , pp. 6657-6663
    • Philip, P.A.1    Mahoney, M.R.2    Allmer, C.3
  • 36
    • 34548150925 scopus 로고    scopus 로고
    • Phase 2 study of erlotinib in patients with unresectable hepatocellular carcinoma
    • Thomas MB. Chadha R. Glover K. et al. Phase 2 study of erlotinib in patients with unresectable hepatocellular carcinoma. Cancer 2007; 110: 1059-67.
    • (2007) Cancer , vol.110 , pp. 1059-1067
    • Thomas, M.B.1    Chadha, R.2    Glover, K.3
  • 37
    • 33751284806 scopus 로고    scopus 로고
    • Metformin is an AMP kinase-dependent growth inhibitor for breast cancer cells
    • Zakikhani M. Dowling R. Fantus IG. Sonenberg N. Pollak M. Metformin is an AMP kinase-dependent growth inhibitor for breast cancer cells. Cancer Res 2006; 66: 10269-73.
    • (2006) Cancer Res , vol.66 , pp. 10269-10273
    • Zakikhani, M.1    Dowling, R.2    Fantus, I.G.3    Sonenberg, N.4    Pollak, M.5
  • 38
    • 44849099894 scopus 로고    scopus 로고
    • The antidiabetic drug metformin exerts an antitumoral effect in vitro and in vivo through a decrease of cyclin D1 level
    • Ben Sahra I. Laurent K. Loubat A. et al. The antidiabetic drug metformin exerts an antitumoral effect in vitro and in vivo through a decrease of cyclin D1 level. Oncogene 2008; 27: 3576-86.
    • (2008) Oncogene , vol.27 , pp. 3576-3586
    • Ben Sahra, I.1    Laurent, K.2    Loubat, A.3
  • 39
    • 33746651189 scopus 로고    scopus 로고
    • Heat shock transcription factor (HSF1) plays a critical role in cell migration via maintaining MAP kinase signaling
    • O'Callaghan-Sunol C. Sherman MY. Heat shock transcription factor (HSF1) plays a critical role in cell migration via maintaining MAP kinase signaling. Cell Cycle 2006; 5: 1431-7.
    • (2006) Cell Cycle , vol.5 , pp. 1431-1437
    • O'Callaghan-Sunol, C.1    Sherman, M.Y.2


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