Aberrant CpG island hypermethylation in dysplastic nodules and early HCC of hepatitis B virus-related human multistep hepatocarcinogenesis

Journal of Hepatology

Volumn 54, Issue 5, 2011, Pages 939-947

  Um, Tae Hee ^a   Kim, Haeryoung ^b   Oh, Bong Kyeong ^c   Kim, Myoung Soo ^d   Kim, Kyung Sik ^d   Jung, Guhung ^e   Park, Young Nyun ^a,d  

^a Yonsei University College of Medicine   (South Korea)

^b Seoul National University Bundang Hospital   (South Korea)

^c Konkuk University   (South Korea)

^d Yonsei University College of Medicine   (South Korea)

^e Seoul National University   (South Korea)

Author keywords

Hepatitis B virus; Hepatocellular carcinoma; Methylation; Multistep hepatocarcinogenesis

Indexed keywords

APC PROTEIN; CYCLOOXYGENASE 2; DEOXYRIBONUCLEOPROTEIN; GNMT PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN P16; RAS ASSOCIATION DOMAIN FAMILY PROTEIN 1A; SPROUTY PROTEIN; SPRY2 PROTEIN; SUPPRESSOR OF CYTOKINE SIGNALING 1; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CANCER GROWTH; CLINICAL FEATURE; CONTROLLED STUDY; CPG ISLAND; DNA DETERMINATION; DNA METHYLATION; DYSPLASIA; FEMALE; HEPATITIS B; HEPATITIS B VIRUS; HUMAN; IMMUNOHISTOCHEMISTRY; LIVER CARCINOGENESIS; LIVER CELL CARCINOMA; LIVER CIRRHOSIS; LIVER NODULE; LIVER RESECTION; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ADENOMATOUS POLYPOSIS COLI PROTEIN; ADULT; AGED; CARCINOMA, HEPATOCELLULAR; CELL TRANSFORMATION, NEOPLASTIC; CELL TRANSFORMATION, VIRAL; CPG ISLANDS; CYCLIN-DEPENDENT KINASE INHIBITOR P16; CYCLOOXYGENASE 2; DNA METHYLATION; FEMALE; HEPATITIS B VIRUS; HEPATITIS B, CHRONIC; HUMANS; LIVER NEOPLASMS; MALE; MIDDLE AGED; SUPPRESSOR OF CYTOKINE SIGNALING PROTEINS; TUMOR SUPPRESSOR PROTEINS;

EID: 79954692738     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhep.2010.08.021     Document Type: Article

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