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Volumn 7, Issue 12, 2010, Pages 669-681

Genome-wide association studies and genetic risk assessment of liver diseases

Author keywords

[No Author keywords available]

Indexed keywords

APOLIPOPROTEIN E; CHEMOKINE RECEPTOR CCR5; INOSINE TRIPHOSPHATE; TRANSFORMING GROWTH FACTOR BETA; WILSON DISEASE PROTEIN; X LINKED INHIBITOR OF APOPTOSIS;

EID: 78649903976     PISSN: 17595045     EISSN: 17595053     Source Type: Journal    
DOI: 10.1038/nrgastro.2010.170     Document Type: Review
Times cited : (72)

References (142)
  • 1
    • 54949117061 scopus 로고    scopus 로고
    • eds Rodés, J., Benhamou, J.-P, Blei, A., Reichen, J. & Rizzetto, M., Blackwell Publishing, Oxford
    • Lammert, F. in Textbook of Hepatology: From Basic Science to Clinical Practice (eds Rodés, J., Benhamou, J.-P, Blei, A., Reichen, J. & Rizzetto, M.) 371-383 (Blackwell Publishing, Oxford, 2007).
    • (2007) Textbook of Hepatology: From Basic Science to Clinical Practice , pp. 371-383
    • Lammert, F.1
  • 2
    • 67349166946 scopus 로고    scopus 로고
    • Detecting gene-gene interactions that underlie human diseases
    • Cordell, H. J. Detecting gene-gene interactions that underlie human diseases. Nat. Rev. Genet. 10, 392-404 (2009).
    • (2009) Nat. Rev. Genet. , vol.10 , pp. 392-404
    • Cordell, H.J.1
  • 4
    • 0004241915 scopus 로고
    • Oxford University Press, London
    • Sheldon, J. H. Haemochromatosis (Oxford University Press, London, 1935).
    • (1935) Haemochromatosis
    • Sheldon, J.H.1
  • 5
    • 85017356077 scopus 로고    scopus 로고
    • The discovery of the new haemochromatosis gene
    • Feder, J. N. et al. The discovery of the new haemochromatosis gene. J. Hepatol. 38, 704-709 (2003).
    • (2003) J. Hepatol. , vol.38 , pp. 704-709
    • Feder, J.N.1
  • 7
    • 9344224529 scopus 로고    scopus 로고
    • A novel MHC class Hike gene is mutated in patients with hereditary haemochromatosis
    • Feder, J. N. et al. A novel MHC class Hike gene is mutated in patients with hereditary haemochromatosis. Nat. Genet. 13, 399-408 (1996).
    • (1996) Nat. Genet. , vol.13 , pp. 399-408
    • Feder, J.N.1
  • 9
    • 77953120762 scopus 로고    scopus 로고
    • EASL clinical practice guidelines for HFE hemochromatosis
    • European Association for the Study of the Liver
    • European Association for the Study of the Liver. EASL clinical practice guidelines for HFE hemochromatosis. J. Hepatol. 53, 3-22 (2010).
    • (2010) J. Hepatol. , vol.53 , pp. 3-22
  • 11
    • 2142768213 scopus 로고    scopus 로고
    • Multigenic control of hepatic iron loading in a murine model of hemochromatosis
    • Bensaid, M. et al. Multigenic control of hepatic iron loading in a murine model of hemochromatosis. Gastroenterology 126, 1400-1408 (2004).
    • (2004) Gastroenterology , vol.126 , pp. 1400-1408
    • Bensaid, M.1
  • 12
    • 77956023046 scopus 로고    scopus 로고
    • Factors influencing disease phenotype and penetrance in HFE haemochromatosis
    • Rochette, J., Le Gac, G., Lassoued, K., Ferec, C. & Robson, K. J. Factors influencing disease phenotype and penetrance in HFE haemochromatosis. Hum. Genet. 128, 233-248 (2010).
    • (2010) Hum. Genet. , vol.128 , pp. 233-248
    • Rochette, J.1    Gac, G.2    Lassoued, K.3    Ferec, C.4    Robson, K.J.5
  • 13
    • 78649906319 scopus 로고    scopus 로고
    • edn eds Killenberg, P G. & Clavien, PA., Blackwell, Maiden, MA
    • rd edn (eds Killenberg, P G. & Clavien, PA.) 172-194 (Blackwell, Maiden, MA, 2006).
    • (2006) rd , pp. 172-194
    • Tendler, D.A.1
  • 16
    • 85047684827 scopus 로고    scopus 로고
    • 1-antitrypsin polymerization and the serpinopathies: Pathobiology and prospects for therapy
    • 1-Antitrypsin polymerization and the serpinopathies: pathobiology and prospects for therapy. J. Clin. Invest. 110, 1585-1590 (2002).
    • (2002) J. Clin. Invest. , vol.110 , pp. 1585-1590
    • Lomas, D.A.1    Mahadeva, R.2
  • 17
    • 24144496018 scopus 로고    scopus 로고
    • Alpha-1-antitrypsin deficiency: A new paradigm for hepatocellular carcinoma in genetic liver disease
    • Rudnick, D. A. & Perlmutter, D. H. Alpha-1-antitrypsin deficiency: a new paradigm for hepatocellular carcinoma in genetic liver disease. Hepatology 42, 514-521 (2005).
    • (2005) Hepatology , vol.42 , pp. 514-521
    • Rudnick, D.A.1    Perlmutter, D.H.2
  • 19
    • 0033652835 scopus 로고    scopus 로고
    • Chronic liver disease in heterozygous αl-antitrypsin deficiency PiZ
    • Fischer, H. P., Ortiz-Pallardó, M. E., Ko, Y., Esch, C. & Zhou, H. Chronic liver disease in heterozygous αl-antitrypsin deficiency PiZ. J. Hepatol. 33, 883-892 (2000).
    • (2000) J. Hepatol. , vol.33 , pp. 883-892
    • Fischer, H.P.1    Ortiz-Pallardó, M.E.2    Ko, Y.3    Esch, C.4    Zhou, H.5
  • 20
    • 70149106634 scopus 로고    scopus 로고
    • Genetic modifiers of liver disease in cystic fibrosis
    • Bartlett, J. R. et al. Genetic modifiers of liver disease in cystic fibrosis. JAMA 302, 1076-1083 (2009).
    • (2009) JAMA , vol.302 , pp. 1076-1083
    • Bartlett, J.R.1
  • 21
    • 16844379095 scopus 로고    scopus 로고
    • Factors associated with advanced liver disease in adults with alphalantitrypsin deficiency
    • Bowlus, C. L. et al. Factors associated with advanced liver disease in adults with alphalantitrypsin deficiency. Clin. Gastroenterol. Hepatol. 3, 390-396 (2005).
    • (2005) Clin. Gastroenterol. Hepatol. , vol.3 , pp. 390-396
    • Bowlus, C.L.1
  • 22
    • 36348964151 scopus 로고    scopus 로고
    • Alpha-1 antitrypsin Z protein (PiZ) increases hepatic fibrosis in a murine model of cholestasis
    • Mencin, A. et al. Alpha-1 antitrypsin Z protein (PiZ) increases hepatic fibrosis in a murine model of cholestasis. Hepatology 46, 1443-1452 (2007).
    • (2007) Hepatology , vol.46 , pp. 1443-1452
    • Mencin, A.1
  • 23
    • 0027452091 scopus 로고
    • The Wilson disease gene is a putative copper transporting P-type ATPase similar to the Menkes gene
    • Bull, P C., Thomas, G. R., Rommens, J. M., Forbes, J. R. & Cox, D. W. The Wilson disease gene is a putative copper transporting P-type ATPase similar to the Menkes gene. Nat. Genet 5, 327-337 (1993).
    • (1993) Nat. Genet. , vol.5 , pp. 327-337
    • Bull, P.C.1    Thomas, G.R.2    Rommens, J.M.3    Forbes, J.R.4    Cox, D.W.5
  • 25
    • 78649903295 scopus 로고    scopus 로고
    • Department of Medical Genetics at the University of Alberta
    • Department of Medical Genetics at the University of Alberta. Wilson Disease Mutation Database [online], http://www.wilsondisease.med.ualberta.ca/ database.asp (2010).
    • (2010) Wilson Disease Mutation Database [online]
  • 26
    • 34247232583 scopus 로고    scopus 로고
    • Late-onset Wilson's disease
    • Ferenci, P. et al. Late-onset Wilson's disease. Gastroenterology 132, 1294-1298 (2007).
    • (2007) Gastroenterology , vol.132 , pp. 1294-1298
    • Ferenci, P.1
  • 27
    • 0034122412 scopus 로고    scopus 로고
    • Diagnosis of Wilson's disease: An experience over three decades
    • Gow, P J. et al. Diagnosis of Wilson's disease: an experience over three decades. Gut 46, 415-419 (2000).
    • (2000) Gut , vol.46 , pp. 415-419
    • Gow, P.J.1
  • 28
    • 46249112793 scopus 로고    scopus 로고
    • Diagnosis and treatment of Wilson disease: An update
    • Roberts, E. A. & Schilsky, M. L. Diagnosis and treatment of Wilson disease: an update. Hepatology 47, 2089-2111 (2008).
    • (2008) Hepatology , vol.47 , pp. 2089-2111
    • Roberts, E.A.1    Schilsky, M.L.2
  • 29
    • 34547455324 scopus 로고    scopus 로고
    • Three atypical cases of Wilson disease: Assessment of the Leipzig scoring system in making a diagnosis
    • Xuan. A., Bookman, I., Cox, D. W. & Heathcote, J. Three atypical cases of Wilson disease: assessment of the Leipzig scoring system in making a diagnosis. J. Hepatol. 47, 428-433 (2007).
    • (2007) J. Hepatol. , vol.47 , pp. 428-433
    • Xuan, A.1    Bookman, I.2    Cox, D.W.3    Heathcote, J.4
  • 30
    • 84897921273 scopus 로고    scopus 로고
    • Genetic analysis of BIRC4/XIAP as a putative modifier gene of Wilson disease
    • doi:10.1007/S10545-010-9123-5
    • Weiss, K. H. et al. Genetic analysis of BIRC4/XIAP as a putative modifier gene of Wilson disease. J. Inherit. Metab. Dis. doi:10.1007/S10545-010-9123-5.
    • J. Inherit. Metab. Dis.
    • Weiss, K.H.1
  • 31
    • 64549148979 scopus 로고    scopus 로고
    • The cost-effectiveness of screening for hereditary hemochromatosis in Germany: A remodeling study
    • Rogowski, W. H. The cost-effectiveness of screening for hereditary hemochromatosis in Germany: a remodeling study. Med. Decis. Making 29, 224-238 (2009).
    • (2009) Med. Decis. Making , vol.29 , pp. 224-238
    • Rogowski, W.H.1
  • 32
    • 0033761666 scopus 로고    scopus 로고
    • Cost-effectiveness of population-based genetic hemochromatosis screening
    • Schofski, O., Schmidtke, J. & Stuhrmann, M. Cost-effectiveness of population-based genetic hemochromatosis screening. Community Genet. 3, 2-11 (2000).
    • (2000) Community Genet. , vol.3 , pp. 2-11
    • Schoffski, O.1    Schmidtke, J.2    Stuhrmann, M.3
  • 33
    • 27144512248 scopus 로고    scopus 로고
    • Genotype-based screening for hereditary hemochromatosis: II. Attitudes toward genetic testing and psychosocial impact-a report from a German pilot study
    • Stuhrmann, M., Hoy, L., Nippert, I. & Schmidtke, J. Genotype-based screening for hereditary hemochromatosis: II. Attitudes toward genetic testing and psychosocial impact-a report from a German pilot study. Genet. Test. 9, 242-254 (2005).
    • (2005) Genet. Test , vol.9 , pp. 242-254
    • Stuhrmann, M.1    Hoy, L.2    Nippert, I.3    Schmidtke, J.4
  • 34
    • 70449637661 scopus 로고    scopus 로고
    • Diagnostic strategies using DNA testing for hereditary haemochromatosis in atrisk populations: A systematic review and economic evaluation
    • Bryant, J. et al. Diagnostic strategies using DNA testing for hereditary haemochromatosis in atrisk populations: a systematic review and economic evaluation. Health Technol. Assess. 13, 1-126 (2009).
    • (2009) Health Technol. Assess , vol.13 , pp. 1-126
    • Bryant, J.1
  • 35
    • 41549144954 scopus 로고    scopus 로고
    • Assessment of the psychological effects of genetic screening for hereditary hemochromatosis
    • Elsass, P., Pedersen, P., Husum, K. & Milman, N. Assessment of the psychological effects of genetic screening for hereditary hemochromatosis. Ann. Hematol. 87, 397-404 (2008).
    • (2008) Ann. Hematol. , vol.87 , pp. 397-404
    • Elsass, P.1    Pedersen, P.2    Husum, K.3    Milman, N.4
  • 36
    • 49849106357 scopus 로고    scopus 로고
    • Hereditary hemochromatosis: Time for targeted screening
    • Phatak, P D., Bonkovsky, H. L. & Kowdley, K. V. Hereditary hemochromatosis: time for targeted screening. Ann. Intern. Med. 149, 270-272 (2008).
    • (2008) Ann. Intern. Med. , vol.149 , pp. 270-272
    • Phatak, P.D.1    Bonkovsky, H.L.2    Kowdley, K.V.3
  • 37
    • 36549053552 scopus 로고    scopus 로고
    • Haemochromatosis
    • Adams, P. C. & Barton, J. C. Haemochromatosis. Lancet 37, 1855-1860 (2007).
    • (2007) Lancet , vol.37 , pp. 1855-1860
    • Adams, P.C.1    Barton, J.C.2
  • 38
    • 77949476499 scopus 로고    scopus 로고
    • Hereditary hemochromatosis: Insights from the Hemochromatosis and Iron Overload Screening (HEIRS) Study
    • McLaren, G. D. & Gordeuk, V. R. Hereditary hemochromatosis: insights from the Hemochromatosis and Iron Overload Screening (HEIRS) Study. Hemato/ogyAm. Soc. Hematol. Educ. Program 2009, 195-206 (2009).
    • (2009) Hemato/ogyAm. Soc. Hematol. Educ. Program , vol.2009 , pp. 195-206
    • McLaren, G.D.1    Gordeuk, V.R.2
  • 39
    • 34249710869 scopus 로고    scopus 로고
    • A genome-wide linkage scan for iron phenotype quantitative trait loci: The HEIRS Family Study
    • Acton, R. T. et al. A genome-wide linkage scan for iron phenotype quantitative trait loci: the HEIRS Family Study. Clin. Genet. 71, 518-529 (2007).
    • (2007) Clin. Genet. , vol.71 , pp. 518-529
    • Acton, R.T.1
  • 40
    • 0742288585 scopus 로고    scopus 로고
    • The complex interplay among factors that influence allelic association
    • Zondervan, K. T. & Cardon, L. R. The complex interplay among factors that influence allelic association. Nat. Rev. Genet. 5, 89-100 (2004).
    • (2004) Nat. Rev. Genet. , vol.5 , pp. 89-100
    • Zondervan, K.T.1    Cardon, L.R.2
  • 41
    • 44349132708 scopus 로고    scopus 로고
    • Common and rare variants in multifactorial susceptibility to common diseases
    • Bodmer, W. & Bonilla, C. Common and rare variants in multifactorial susceptibility to common diseases. Nat. Genet. 40, 695-701 (2008).
    • (2008) Nat. Genet. , vol.40 , pp. 695-701
    • Bodmer, W.1    Bonilla, C.2
  • 42
    • 2542502430 scopus 로고    scopus 로고
    • ApoE genotype accounts for the vast majority of AD risk and AD pathology
    • Raber, J., Huang, Y. & Ashford, J. W. ApoE genotype accounts for the vast majority of AD risk and AD pathology. Neurobiol. Aging 25, 641-650 (2004).
    • (2004) Neurobiol. Aging , vol.25 , pp. 641-650
    • Raber, J.1    Huang, Y.2    Ashford, J.W.3
  • 44
    • 54949138100 scopus 로고    scopus 로고
    • Genetic determinants in hepatic fibrosis: From experimental models to fibrogenic gene signatures in humans
    • Weber, S., Gressner, O. A., Hall, R., Grunhage, F & Lammert, F. Genetic determinants in hepatic fibrosis: from experimental models to fibrogenic gene signatures in humans. Clin. Liver Dis. 12, 747-757 (2008).
    • (2008) Clin. Liver Dis. , vol.12 , pp. 747-757
    • Weber, S.1    Gressner, O.A.2    Hall, R.3    Grunhage, F.4    Lammert, F.5
  • 45
    • 76549102564 scopus 로고    scopus 로고
    • Genome-wide association studies in hepatology [German]
    • Weber, S., Grunhage, F., Hall, R. & Lammert, F Genome-wide association studies in hepatology [German]. Z. Gastroenterol. 48, 56-64 (2010).
    • (2010) Z. Gastroenterol. , vol.48 , pp. 56-64
    • Weber, S.1    Grunhage, F.2    Hall, R.3    Lammert, F.4
  • 46
    • 0037442235 scopus 로고    scopus 로고
    • Genetic associations in large versus small studies: An empirical assessment
    • loannidis, J. P., Trikalinos, T. A., Ntzani, E. E. & Contopoulos-loannidis, D. G. Genetic associations in large versus small studies: an empirical assessment. Lancet 361, 567-571 (2003).
    • (2003) Lancet , vol.361 , pp. 567-571
    • Loannidis, J.P.1    Trikalinos, T.A.2    Ntzani, E.E.3    Contopoulos-Loannidis, D.G.4
  • 47
    • 0037371468 scopus 로고    scopus 로고
    • Genetic polymorphisms and the progression of liver fibrosis: A critical appraisal
    • Bataller, R., North, K. E. & Brenner, D. A. Genetic polymorphisms and the progression of liver fibrosis: a critical appraisal. Hepatology 37, 493-503 (2003).
    • (2003) Hepatology , vol.37 , pp. 493-503
    • Bataller, R.1    North, K.E.2    Brenner, D.A.3
  • 48
    • 55749115971 scopus 로고    scopus 로고
    • TGF-β1 genotypes in cirrhosis: Relationship with the occurrence of liver cancer
    • Falleti, E. et al. TGF-β1 genotypes in cirrhosis: relationship with the occurrence of liver cancer. Cytokine 44, 256-261 (2008).
    • (2008) Cytokine , vol.44 , pp. 256-261
    • Falleti, E.1
  • 49
    • 0036136136 scopus 로고    scopus 로고
    • Association of polymorphisms of the transforming growth factor-β1 gene with the rate of progression of HCV-induced liver fibrosis
    • Gewaltig, J., Mangasser-Stephan, K., Gartung, C., Biesterfeld, S. & Gressner, A. M. Association of polymorphisms of the transforming growth factor-β1 gene with the rate of progression of HCV-induced liver fibrosis. Clin. Chim. Acta 316, 83-94 (2002).
    • (2002) Clin. Chim. Acta , vol.316 , pp. 83-94
    • Gewaltig, J.1    Mangasser-Stephan, K.2    Gartung, C.3    Biesterfeld, S.4    Gressner, A.M.5
  • 50
    • 0034024356 scopus 로고    scopus 로고
    • Host genetic factors influence disease progression in chronic hepatitis C
    • Powell, E. E. et al. Host genetic factors influence disease progression in chronic hepatitis C. Hepatology 31, 828-833 (2000).
    • (2000) Hepatology , vol.31 , pp. 828-833
    • Powell, E.E.1
  • 51
    • 0142164891 scopus 로고    scopus 로고
    • Analysis of the transforming growth factor-β1 (TGF-β1) codon 25 gene polymorphism by LightCycler-analysis in patients with chronic hepatitis C infection
    • Tag, C. G. et al. Analysis of the transforming growth factor-β1 (TGF-β1) codon 25 gene polymorphism by LightCycler-analysis in patients with chronic hepatitis C infection. Cytokine 24, 173-181 (2003).
    • (2003) Cytokine , vol.24 , pp. 173-181
    • Tag, C.G.1
  • 52
    • 17144397601 scopus 로고    scopus 로고
    • Transforming growth factor-beta 1 gene polymorphisms are associated with progression of liver fibrosis in Caucasians with chronic hepatitis C infection
    • Wang, H. et al. Transforming growth factor-beta 1 gene polymorphisms are associated with progression of liver fibrosis in Caucasians with chronic hepatitis C infection. World J. Gastroenterol. 11, 1929-1936 (2005).
    • (2005) World J. Gastroenterol. , vol.11 , pp. 1929-1936
    • Wang, H.1
  • 53
    • 77951487491 scopus 로고    scopus 로고
    • The utility of genome-wide association studies in hepatology
    • Karlsen, T H., Melum, E. & Franke, A. The utility of genome-wide association studies in hepatology. Hepatology 51, 1833-1842 (2010).
    • (2010) Hepatology , vol.51 , pp. 1833-1842
    • Karlsen, T.H.1    Melum, E.2    Franke, A.3
  • 54
    • 55449120805 scopus 로고    scopus 로고
    • Genetic mapping in human disease
    • Altshuler, D., Daly, M. J. & Lander, E. S. Genetic mapping in human disease. Science 322, 881-888 (2008).
    • (2008) Science , vol.322 , pp. 881-888
    • Altshuler, D.1    Daly, M.J.2    Lander, E.S.3
  • 55
    • 43049146524 scopus 로고    scopus 로고
    • A HapMap harvest of insights into the genetics of common disease
    • Manolio, T. A., Brooks, L. D. & Collins, F S. A HapMap harvest of insights into the genetics of common disease. J. Clin. Invest. 118, 1590-1605 (2008).
    • (2008) J. Clin. Invest. , vol.118 , pp. 1590-1605
    • Manolio, T.A.1    Brooks, L.D.2    Collins, F.S.3
  • 56
    • 67249117049 scopus 로고    scopus 로고
    • Potential etiologic and functional implications of genome-wide association loci for human diseases and traits
    • Hindorff, L. A. et al. Potential etiologic and functional implications of genome-wide association loci for human diseases and traits. Proc. Natl Acad. Sci. USA 106, 9362-9367 (2009).
    • (2009) Proc. Natl. Acad. Sci. USA , vol.106 , pp. 9362-9367
    • Hindorff, L.A.1
  • 58
    • 27144518494 scopus 로고    scopus 로고
    • Mechanisms of disease: The genetic epidemiology of gallbladder stones
    • Lammert, F & Sauerbruch, T. Mechanisms of disease: the genetic epidemiology of gallbladder stones. Nat. Clin. Pract. Gastroenterol. Hepatol. 2, 423-433 (2005).
    • (2005) Nat. Clin. Pract. Gastroenterol. Hepatol. , vol.2 , pp. 423-433
    • Lammert, F.1    Sauerbruch, T.2
  • 59
    • 17144408092 scopus 로고    scopus 로고
    • Genetic and environmental influences on symptomatic gallstone disease: A Swedish study of 43, 141 twin pairs
    • Katsika, D. et al. Genetic and environmental influences on symptomatic gallstone disease: a Swedish study of 43, 141 twin pairs. Hepatology 41, 1138-1143 (2005).
    • (2005) Hepatology , vol.41 , pp. 1138-1143
    • Katsika, D.1
  • 60
    • 34547546458 scopus 로고    scopus 로고
    • A genome-wide association scan identifies the hepatic cholesterol transporter ABCG8 as a susceptibility factor for human gallstone disease
    • Buch, S. et al. A genome-wide association scan identifies the hepatic cholesterol transporter ABCG8 as a susceptibility factor for human gallstone disease. Nat. Genet. 39, 995-999 (2007).
    • (2007) Nat. Genet. , vol.39 , pp. 995-999
    • Buch, S.1
  • 61
    • 0036733630 scopus 로고    scopus 로고
    • Overexpression of ABCG5 and ABCG8 promotes biliary cholesterol secretion and reduces fractional absorption of dietary cholesterol
    • Yu, L. et al. Overexpression of ABCG5 and ABCG8 promotes biliary cholesterol secretion and reduces fractional absorption of dietary cholesterol. J. Clin. Invest. 110, 671-680 (2002).
    • (2002) J. Clin. Invest. , vol.110 , pp. 671-680
    • Yu, L.1
  • 62
    • 66349121963 scopus 로고    scopus 로고
    • Biliary lipids and cholesterol gallstone disease
    • Wang, D. Q., Cohen, D. E. & Carey, M. C. Biliary lipids and cholesterol gallstone disease. J. Lipid Res. 50 (Suppl.), S406-S411 (2009).
    • (2009) J. Lipid Res. , vol.50 , Issue.SUPPL.
    • Wang, D.Q.1    Cohen, D.E.2    Carey, M.C.3
  • 63
    • 0035170811 scopus 로고    scopus 로고
    • Chromosomal organization of candidate genes involved in cholesterol gallstone formation: A murine gallstone map
    • Lammert, F., Carey, M. C. & Paigen, B. Chromosomal organization of candidate genes involved in cholesterol gallstone formation: a murine gallstone map. Gastroenterology 120, 221-238 (2001).
    • (2001) Gastroenterology , vol.120 , pp. 221-238
    • Lammert, F.1    Carey, M.C.2    Paigen, B.3
  • 64
    • 33845660031 scopus 로고    scopus 로고
    • Cholesterol gallstone susceptibility loci: A mouse map, candidate gene evaluation, and guide to human LITH genes
    • Lyons, M. A. & Wittenburg, H. Cholesterol gallstone susceptibility loci: a mouse map, candidate gene evaluation, and guide to human LITH genes. Gastroenterology 131, 1943-1970 (2006).
    • (2006) Gastroenterology , vol.131 , pp. 1943-1970
    • Lyons, M.A.1    Wittenburg, H.2
  • 65
    • 33645962479 scopus 로고    scopus 로고
    • Coinheritance of Gilbert syndrome-associated UGT1A1 mutation increases gallstone risk in cystic fibrosis
    • Wasmuth, H. E. et al. Coinheritance of Gilbert syndrome-associated UGT1A1 mutation increases gallstone risk in cystic fibrosis. Hepatology 43, 738-741 (2006).
    • (2006) Hepatology , vol.43 , pp. 738-741
    • Wasmuth, H.E.1
  • 66
    • 78649705083 scopus 로고    scopus 로고
    • Loci from a genome-wide analysis of bilirubin levels are associated with gallstone risk and composition
    • doi:10.1053/j.gastro.2010.09.003
    • Buch, S. et al. Loci from a genome-wide analysis of bilirubin levels are associated with gallstone risk and composition. Gastroenterology doi:10.1053/j.gastro.2010.09.003.
    • Gastroenterology
    • Buch, S.1
  • 67
    • 67649851008 scopus 로고    scopus 로고
    • Common variants in the SLC01B3 locus are associated with bilirubin levels and unconjugated hyperbilirubinemia
    • Sanna. S. et al. Common variants in the SLC01B3 locus are associated with bilirubin levels and unconjugated hyperbilirubinemia. Hum. Mol. Genet. 18, 2711-2718 (2009).
    • (2009) Hum. Mol. Genet. , vol.18 , pp. 2711-2718
    • Sanna, S.1
  • 68
    • 67649838598 scopus 로고    scopus 로고
    • Genome-wide association meta-analysis for total serum bilirubin levels
    • Johnson, A. D. et al. Genome-wide association meta-analysis for total serum bilirubin levels. Hum. Mol. Genet. 18, 2700-2710 (2009).
    • (2009) Hum. Mol. Genet. , vol.18 , pp. 2700-2710
    • Johnson, A.D.1
  • 69
    • 68949200960 scopus 로고    scopus 로고
    • Conditional linkage and genomewide association studies identify UGT1A1 as a major gene for anti-atherogenic serum bilirubin levels-the Framingham Heart Study
    • Lin, J. P. et al. Conditional linkage and genomewide association studies identify UGT1A1 as a major gene for anti-atherogenic serum bilirubin levels-the Framingham Heart Study. Atherosc/erosis 206, 228-233 (2009).
    • (2009) Atherosc/erosis , vol.206 , pp. 228-233
    • Lin, J.P.1
  • 70
    • 0025087247 scopus 로고
    • Unconjugated bilirubin and cholesterol gallstone formation
    • Ostrow, J. D. Unconjugated bilirubin and cholesterol gallstone formation. Hepatology 12, 219S-226S (1990).
    • (1990) Hepatology , vol.12
    • Ostrow, J.D.1
  • 71
    • 56749096610 scopus 로고    scopus 로고
    • Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease
    • Romeo, S. et al. Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease. Nat. Genet. 40, 1461-1465 (2008).
    • (2008) Nat. Genet. , vol.40 , pp. 1461-1465
    • Romeo, S.1
  • 72
    • 77949895032 scopus 로고    scopus 로고
    • A sequence variation (I148M) in PNPLA3 associated with nonalcoholic fatty liver disease disrupts triglyceride hydrolysis
    • He, S. et al. A sequence variation (I148M) in PNPLA3 associated with nonalcoholic fatty liver disease disrupts triglyceride hydrolysis. J. Biol. Chem. 285, 6706-6715 (2010).
    • (2010) J. Biol. Chem. , vol.285 , pp. 6706-6715
    • He, S.1
  • 73
    • 0035157380 scopus 로고    scopus 로고
    • Evidence for a substantial genetic influence on biochemical liver function tests: Results from a population-based Danish twin study
    • Bathum, L. et al. Evidence for a substantial genetic influence on biochemical liver function tests: results from a population-based Danish twin study. Clin. Chem. 47, 81-87 (2001).
    • (2001) Clin. Chem. , vol.47 , pp. 81-87
    • Bathum, L.1
  • 74
    • 0036720992 scopus 로고    scopus 로고
    • Genetic covariation between serum gamma-glutamyl transferase activity and cardiovascular risk factors
    • Whitfield, J. B., Zhu, G., Nestler, J. E., Heath, A. C. & Martin, N. G. Genetic covariation between serum gamma-glutamyl transferase activity and cardiovascular risk factors. Clin. Chem. 48, 1426-1431 (2002).
    • (2002) Clin. Chem. , vol.48 , pp. 1426-1431
    • Whitfield, J.B.1    Zhu, G.2    Nestler, J.E.3    Heath, A.C.4    Martin, N.G.5
  • 76
    • 20044374023 scopus 로고    scopus 로고
    • Design and validation of a histological scoring system for nonalcoholic fatty liver disease
    • Kleiner, D. E. et al. Design and validation of a histological scoring system for nonalcoholic fatty liver disease. Hepatology 41, 1313-1321 (2005).
    • (2005) Hepatology , vol.41 , pp. 1313-1321
    • Kleiner, D.E.1
  • 77
    • 78049457761 scopus 로고    scopus 로고
    • Genome-wide association study identifies variants associated with histologic features of nonalcoholic fatty liver disease
    • doi:10.1053/j.gastro.2010.07.057
    • Chalasani, N. et al. Genome-wide association study identifies variants associated with histologic features of nonalcoholic fatty liver disease. Gastroenterology doi:10.1053/j.gastro.2010.07.057.
    • Gastroenterology
    • Chalasani, N.1
  • 78
    • 67149095289 scopus 로고    scopus 로고
    • Primary biliary cirrhosis associated with HLA, IL12A, and IL12RB2 variants
    • Hirschfield, G. M. et al. Primary biliary cirrhosis associated with HLA, IL12A, and IL12RB2 variants. N. Engl. J. Med. 360, 2544-2555 (2009).
    • (2009) N. Engl. J. Med. , vol.360 , pp. 2544-2555
    • Hirschfield, G.M.1
  • 79
    • 77955088582 scopus 로고    scopus 로고
    • Genome-wide meta-analyses identify three loci associated with primary biliary cirrhosis
    • Liu, X. et al. Genome-wide meta-analyses identify three loci associated with primary biliary cirrhosis. Nat Genet 42, 658-660 (2010).
    • (2010) Nat. Genet. , vol.42 , pp. 658-660
    • Liu, X.1
  • 80
    • 77249164222 scopus 로고    scopus 로고
    • Genome-wide association analysis in primary sclerosing cholangitis
    • Karlsen. T. H. et al. Genome-wide association analysis in primary sclerosing cholangitis. Gastroenterology 138, 1102-1111 (2010).
    • (2010) Gastroenterology , vol.138 , pp. 1102-1111
    • Karlsen, T.H.1
  • 82
    • 70349292099 scopus 로고    scopus 로고
    • Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance
    • Ge, D. et al. Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance. Nature 461, 399-401 (2009).
    • (2009) Nature , vol.461 , pp. 399-401
    • Ge, D.1
  • 83
    • 70349548852 scopus 로고    scopus 로고
    • IL28B is associated with response to chronic hepatitis C interferon-a and ribavirin therapy
    • Suppiah, V. et al. IL28B is associated with response to chronic hepatitis C interferon-a and ribavirin therapy. Nat Genet 41, 1100-1104 (2009).
    • (2009) Nat. Genet. , vol.41 , pp. 1100-1104
    • Suppiah, V.1
  • 84
    • 70349533037 scopus 로고    scopus 로고
    • Genome-wide association of IL28B with response to pegylated interferon-a and ribavirin therapy for chronic hepatitis C
    • Tanaka, Y. et al. Genome-wide association of IL28B with response to pegylated interferon-a and ribavirin therapy for chronic hepatitis C. Nat Genet 41, 1105-1109 (2009).
    • (2009) Nat. Genet. , vol.41 , pp. 1105-1109
    • Tanaka, Y.1
  • 85
    • 70349966196 scopus 로고    scopus 로고
    • Genetic variation in IL28B and spontaneous clearance of hepatitis C virus
    • Thomas, D. L. et al. Genetic variation in IL28B and spontaneous clearance of hepatitis C virus. Nature 461, 798-801 (2009).
    • (2009) Nature , vol.461 , pp. 798-801
    • Thomas, D.L.1
  • 86
    • 77949831342 scopus 로고    scopus 로고
    • Genetic variation in IL28B is associated with chronic hepatitis C and treatment failure: A genome-wide association study
    • Rauch, A. et al. Genetic variation in IL28B is associated with chronic hepatitis C and treatment failure: a genome-wide association study. Gastroenterology 138, 1338-1345 (2010).
    • (2010) Gastroenterology , vol.138 , pp. 1338-1345
    • Rauch, A.1
  • 87
    • 77949773445 scopus 로고    scopus 로고
    • ITPA gene variants protect against anaemia in patients treated for chronic hepatitis C
    • Fellay, J. et al. ITPA gene variants protect against anaemia in patients treated for chronic hepatitis C. Nature 464, 405-408 (2010).
    • (2010) Nature , vol.464 , pp. 405-408
    • Fellay, J.1
  • 88
    • 67349160018 scopus 로고    scopus 로고
    • A genome-wide association study identifies variants in the HLA-DP locus associated with chronic hepatitis B in Asians
    • Kamatani, Y. et al. A genome-wide association study identifies variants in the HLA-DP locus associated with chronic hepatitis B in Asians. Nat Genet 41, 591-595 (2009).
    • (2009) Nat. Genet. , vol.41 , pp. 591-595
    • Kamatani, Y.1
  • 89
    • 33745134040 scopus 로고    scopus 로고
    • Class II cytokine receptor gene cluster is a major locus for hepatitis B persistence
    • Frodsham, A. J. et al. Class II cytokine receptor gene cluster is a major locus for hepatitis B persistence. Proc. Natl Acad. Sci. USA 103, 9148-9153 (2006).
    • (2006) Proc. Natl. Acad. Sci. USA , vol.103 , pp. 9148-9153
    • Frodsham, A.J.1
  • 90
    • 77956628160 scopus 로고    scopus 로고
    • Genome-wide association study identifies 1p36.22 as a new susceptibility locus for hepatocellular carcinoma in chronic hepatitis B virus carriers
    • Zhang, H. et al. Genome-wide association study identifies 1p36.22 as a new susceptibility locus for hepatocellular carcinoma in chronic hepatitis B virus carriers. Nat Genet 42, 755-758 (2010).
    • (2010) Nat. Genet. , vol.42 , pp. 755-758
    • Zhang, H.1
  • 91
    • 67649859295 scopus 로고    scopus 로고
    • *5701 genotype is a major determinant of drug-induced liver injury due to flucloxacillin
    • *5701 genotype is a major determinant of drug-induced liver injury due to flucloxacillin. Nat Genet 41, 816-819 (2009).
    • (2009) Nat. Genet. , vol.41 , pp. 816-819
    • Daly, A.K.1
  • 92
    • 77955082302 scopus 로고    scopus 로고
    • A genome-wide study identifies HLA alleles associated with lumiracoxib-related liver injury
    • Singer, J. B. et al. A genome-wide study identifies HLA alleles associated with lumiracoxib-related liver injury. Nat Genet 42, 711-714 (2010).
    • (2010) Nat. Genet. , vol.42 , pp. 711-714
    • Singer, J.B.1
  • 93
    • 44049102035 scopus 로고    scopus 로고
    • Genome-wide pharmacogenetic investigation of a hepatic adverse event without clinical signs of immunopathology suggests an underlying immune pathogenesis
    • Kindmark, A. et al. Genome-wide pharmacogenetic investigation of a hepatic adverse event without clinical signs of immunopathology suggests an underlying immune pathogenesis. Pharmacogenoinics J. 8, 186-195 (2008).
    • (2008) Pharmacogenoinics J , vol.8 , pp. 186-195
    • Kindmark, A.1
  • 94
    • 23044477984 scopus 로고    scopus 로고
    • Complement factor 5 is a quantitative trait gene that modifies liver fibrogenesis in mice and humans
    • Hillebrandt, S. et al. Complement factor 5 is a quantitative trait gene that modifies liver fibrogenesis in mice and humans. Nat Genet 37, 835-843 (2005).
    • (2005) Nat. Genet. , vol.37 , pp. 835-843
    • Hillebrandt, S.1
  • 95
    • 0036892365 scopus 로고    scopus 로고
    • Genome-wide analysis of hepatic fibrosis in inbred mice identifies the susceptibility locus Hfibl on chromosome 15
    • Hillebrandt, S., Goos, C., Matern, S. & Lammert, F. Genome-wide analysis of hepatic fibrosis in inbred mice identifies the susceptibility locus Hfibl on chromosome 15. Gastroenterology 123, 2041-2051 (2002).
    • (2002) Gastroenterology , vol.123 , pp. 2041-2051
    • Hillebrandt, S.1    Goos, C.2    Matern, S.3    Lammert, F.4
  • 96
    • 77957860297 scopus 로고    scopus 로고
    • Genetics of the hippocampal transcriptome in mouse: A systematic survey and online neurogenomics resource
    • Overall, R. W. et al. Genetics of the hippocampal transcriptome in mouse: a systematic survey and online neurogenomics resource. Front Neurosci. 3, 55 (2009).
    • (2009) Front Neurosci. , vol.3 , pp. 55
    • Overall, R.W.1
  • 97
    • 34548321205 scopus 로고    scopus 로고
    • Genome-level analysis of genetic regulation of liver gene expression networks
    • Gatti, D. et al. Genome-level analysis of genetic regulation of liver gene expression networks. Hepatology 46, 548-557 (2007).
    • (2007) Hepatology , vol.46 , pp. 548-557
    • Gatti, D.1
  • 98
    • 77956895712 scopus 로고    scopus 로고
    • SYSGEN ET: A meeting report from a new European network for systems genetics
    • Schughart, K. et al. SYSGEN ET: a meeting report from a new European network for systems genetics. Mamm. Genome 21, 331-336 (2010).
    • (2010) Mamm. Genome , vol.21 , pp. 331-336
    • Schughart, K.1
  • 99
    • 14644441018 scopus 로고    scopus 로고
    • The Collaborative Cross, a community resource for the genetic analysis of complex traits
    • Churchill, G. A. et al. The Collaborative Cross, a community resource for the genetic analysis of complex traits. Nat Genet. 36, 1133-1137 (2004).
    • (2004) Nat. Genet. , vol.36 , pp. 1133-1137
    • Churchill, G.A.1
  • 100
    • 57649128465 scopus 로고    scopus 로고
    • Applying mouse complex-trait resources to behavioural genetics
    • Flint, J. & Mott, R. Applying mouse complex-trait resources to behavioural genetics. Nature 456, 724-727 (2008).
    • (2008) Nature , vol.456 , pp. 724-727
    • Flint, J.1    Mott, R.2
  • 101
    • 57649124192 scopus 로고    scopus 로고
    • Reverse engineering the genotype-phenotype map with natural genetic variation
    • Rockman, M. V. Reverse engineering the genotype-phenotype map with natural genetic variation. Nature 456, 738-744 (2008).
    • (2008) Nature , vol.456 , pp. 738-744
    • Rockman, M.V.1
  • 102
    • 40749105508 scopus 로고    scopus 로고
    • Variations in DNA elucidate molecular networks that cause disease
    • Chen, y et al. Variations in DNA elucidate molecular networks that cause disease. Nature 452, 429-435 (2008).
    • (2008) Nature , vol.452 , pp. 429-435
    • Chen, Y.1
  • 103
    • 33644877806 scopus 로고    scopus 로고
    • Mouse phenogenomics: The fast track to "systems metabolism"
    • Argmann, C. A., Chambon, R & Auwerx, J. Mouse phenogenomics: the fast track to "systems metabolism". Cell Metab. 2, 349-360 (2005).
    • (2005) Cell. Metab. , vol.2 , pp. 349-360
    • Argmann, C.A.1    Chambon, R.2    Auwerx, J.3
  • 104
    • 33845732301 scopus 로고    scopus 로고
    • The mouse as a model for human biology: A resource guide for complex trait analysis
    • Peters, L. L. et al. The mouse as a model for human biology: a resource guide for complex trait analysis. Nat Rev. Genet 8, 58-69 (2007).
    • (2007) Nat. Rev. Genet. , vol.8 , pp. 58-69
    • Peters, L.L.1
  • 105
    • 73249149539 scopus 로고    scopus 로고
    • An experimental assessment of in silico haplotype association mapping in laboratory mice
    • Burgess-Herbert, S. L. et al. An experimental assessment of in silico haplotype association mapping in laboratory mice. BMC Genet. 10, 81 (2009).
    • (2009) BMC Genet. , vol.10 , pp. 81
    • Burgess-Herbert, S.L.1
  • 107
    • 70450223891 scopus 로고    scopus 로고
    • Common disorders are quantitative traits
    • Plomin, R., Haworth, C. M. & Davis, O. S. Common disorders are quantitative traits. Nat. Rev. Genet 10, 872-878 (2009).
    • (2009) Nat. Rev. Genet. , vol.10 , pp. 872-878
    • Plomin, R.1    Haworth, C.M.2    Davis, O.S.3
  • 108
    • 30544436224 scopus 로고    scopus 로고
    • A combination of genetic polymorphisms increases the risk of progressive disease in chronic hepatitis C
    • Richardson, M. M. et al. A combination of genetic polymorphisms increases the risk of progressive disease in chronic hepatitis C. J. Med. Genet 42, e45 (2005).
    • (2005) J. Med. Genet. , vol.42
    • Richardson, M.M.1
  • 109
    • 34548301514 scopus 로고    scopus 로고
    • A 7 gene signature identifies the risk of developing cirrhosis in patients with chronic hepatitis C
    • Huang, H. et al. A 7 gene signature identifies the risk of developing cirrhosis in patients with chronic hepatitis C. Hepatology 46, 297-306 (2007).
    • (2007) Hepatology , vol.46 , pp. 297-306
    • Huang, H.1
  • 110
    • 63349103768 scopus 로고    scopus 로고
    • Functional linkage of cirrhosispredictive single nucleotide polymorphisms of Toll-like receptor 4 to hepatic stellate cell responses
    • Guo, J. et al. Functional linkage of cirrhosispredictive single nucleotide polymorphisms of Toll-like receptor 4 to hepatic stellate cell responses. Hepatology 49, 960-968 (2009).
    • (2009) Hepatology , vol.49 , pp. 960-968
    • Guo, J.1
  • 111
    • 69949156901 scopus 로고    scopus 로고
    • Multiple variants in toll-like receptor 4 gene modulate risk of liver fibrosis in Caucasians with chronic hepatitis C infection
    • Li, y et al. Multiple variants in toll-like receptor 4 gene modulate risk of liver fibrosis in Caucasians with chronic hepatitis C infection. J. Hepatol. 51, 750-757 (2009).
    • (2009) J. Hepatol. , vol.51 , pp. 750-757
    • Li, Y.1
  • 112
    • 70350054801 scopus 로고    scopus 로고
    • A seven-gene signature (cirrhosis risk score) predicts liver fibrosis progression in patients with initially mild chronic hepatitis C
    • Marcolongo, M. et al. A seven-gene signature (cirrhosis risk score) predicts liver fibrosis progression in patients with initially mild chronic hepatitis C. Hepatology 50, 1038-1044 (2009).
    • (2009) Hepatology , vol.50 , pp. 1038-1044
    • Marcolongo, M.1
  • 113
    • 73449108399 scopus 로고    scopus 로고
    • The cirrhosis risk score predicts liver fibrosis progression in patients with initially mild chronic hepatitis C
    • Pradat, R et al. The cirrhosis risk score predicts liver fibrosis progression in patients with initially mild chronic hepatitis C. Hepatology 51, 356-357 (2010).
    • (2010) Hepatology , vol.51 , pp. 356-357
    • Pradat, R.1
  • 114
    • 73449129712 scopus 로고    scopus 로고
    • From disease association to risk assessment: An optimistic view from genomewide association studies on type 1 diabetes
    • Wei, Z. et al. From disease association to risk assessment: an optimistic view from genomewide association studies on type 1 diabetes. PLoS Genet. 5, el000678 (2009).
    • (2009) PLoS Genet. , vol.5
    • Wei, Z.1
  • 115
    • 69249087403 scopus 로고    scopus 로고
    • Prediction of non-alcoholic fatty liver disease and liver fat using metabolic and genetic factors
    • Kotronen, A. et al. Prediction of non-alcoholic fatty liver disease and liver fat using metabolic and genetic factors. Gastroenterology 137, 865-872 (2009).
    • (2009) Gastroenterology , vol.137 , pp. 865-872
    • Kotronen, A.1
  • 116
    • 77949538156 scopus 로고    scopus 로고
    • How many genetic variants remain to be discovered?
    • Pawitan, Y., Seng, K. C. & Magnusson, P K. How many genetic variants remain to be discovered? PLoS ONE 4, e7969 (2009).
    • (2009) PLoS ONE , vol.4
    • Pawitan, Y.1    Seng, K.C.2    Magnusson, P.K.3
  • 117
    • 65949099120 scopus 로고    scopus 로고
    • Genetic risk predictionare we there yet?
    • Kraft, R & Hunter, D. J. Genetic risk predictionare we there yet? N. Engl. J. Med. 360, 1701-1703 (2007).
    • (2007) N. Engl. J. Med. , vol.360 , pp. 1701-1703
    • Kraft, R.1    Hunter, D.J.2
  • 118
    • 77954136357 scopus 로고    scopus 로고
    • Hints of hidden heritability in GWAS
    • Gibson, G. Hints of hidden heritability in GWAS. Nat Genet 42, 558-560 (2010).
    • (2010) Nat. Genet. , vol.42 , pp. 558-560
    • Gibson, G.1
  • 119
    • 34948877698 scopus 로고    scopus 로고
    • Prediction of individual genetic risk to disease from genome-wide association studies
    • Wray, N. R., Goddard, M. E. & Visscher, R M. Prediction of individual genetic risk to disease from genome-wide association studies. Genome Res. 17, 1520-1528 (2007).
    • (2007) Genome Res. , vol.17 , pp. 1520-1528
    • Wray, N.R.1    Goddard, M.E.2    Visscher, R.M.3
  • 120
    • 77649209124 scopus 로고    scopus 로고
    • The genetic interpretation of area under the ROC curve in genomic profiling
    • Wray, N. R., Yang, J., Goddard, M. E. & Visscher, R M. The genetic interpretation of area under the ROC curve in genomic profiling. PLoS Genet. 6, el000864 (2010).
    • (2010) PLoS Genet. , vol.6
    • Wray, N.R.1    Yang, J.2    Goddard, M.E.3    Visscher, R.M.4
  • 121
    • 69449098701 scopus 로고    scopus 로고
    • Estimation of absolute risk for prostate cancer using genetic markers and family history
    • Xu, J. et al. Estimation of absolute risk for prostate cancer using genetic markers and family history. Prostate 69, 1565-1572 (2009).
    • (2009) Prostate , vol.69 , pp. 1565-1572
    • Xu, J.1
  • 122
    • 70349956433 scopus 로고    scopus 로고
    • Finding the missing heritability of complex diseases
    • Manolio, T. A. et al. Finding the missing heritability of complex diseases. Nature 461, 747-753 (2009).
    • (2009) Nature , vol.461 , pp. 747-753
    • Manolio, T.A.1
  • 123
    • 75349100756 scopus 로고    scopus 로고
    • Lower copy numbers of the chemokine CCL3L1 gene in patients with chronic hepatitis C
    • Grunhage, F. et al. Lower copy numbers of the chemokine CCL3L1 gene in patients with chronic hepatitis C. J. Hepatol. 52, 153-159 (2010).
    • (2010) J. Hepatol. , vol.52 , pp. 153-159
    • Grunhage, F.1
  • 124
    • 77949772292 scopus 로고    scopus 로고
    • Gene-environment-wide association studies: Emerging approaches
    • Thomas, D. Gene-environment-wide association studies: emerging approaches. Nat Rev. Genet 11, 259-272 (2010).
    • (2010) Nat. Rev. Genet. , vol.11 , pp. 259-272
    • Thomas, D.1
  • 125
    • 77951589703 scopus 로고    scopus 로고
    • Clinical assessment incorporating a personal genome
    • Ashley, E. A. et al. Clinical assessment incorporating a personal genome. Lancet 375, 1525-1535 (2010).
    • (2010) Lancet , vol.375 , pp. 1525-1535
    • Ashley, E.A.1
  • 126
    • 77952101271 scopus 로고    scopus 로고
    • Challenges in the clinical application of whole-genome sequencing
    • Ormond, K. E. et al. Challenges in the clinical application of whole-genome sequencing. Lancet 375, 1749-1751 (2010).
    • (2010) Lancet , vol.375 , pp. 1749-1751
    • Ormond, K.E.1
  • 127
    • 52949089274 scopus 로고    scopus 로고
    • The current landscape for direct-to-consumer genetic testing: Legal, ethical, and policy issues
    • Hogarth, S., Javitt, G. & Melzer, D. The current landscape for direct-to-consumer genetic testing: legal, ethical, and policy issues. Annu. Rev. Genomics Hum. Genet 9, 161-182 (2008).
    • (2008) Annu. Rev. Genomics Hum. Genet. , vol.9 , pp. 161-182
    • Hogarth, S.1    Javitt, G.2    Melzer, D.3
  • 128
    • 48249118775 scopus 로고    scopus 로고
    • Putting science over supposition in the arena of personalized genomics
    • McBride, C. M. et al. Putting science over supposition in the arena of personalized genomics. Nat Genet 40, 939-942 (2008).
    • (2008) Nat. Genet. , vol.40 , pp. 939-942
    • McBride, C.M.1
  • 129
    • 74049131900 scopus 로고    scopus 로고
    • Genetic risk information for common diseases may indeed be already useful for prevention and early detection
    • Gulcher, J. & Stefansson, K. Genetic risk information for common diseases may indeed be already useful for prevention and early detection. Eur. J. Clin. Invest 40, 56-63 (2010).
    • (2010) Eur. J. Clin. Invest. , vol.40 , pp. 56-63
    • Gulcher, J.1    Stefansson, K.2
  • 130
    • 38549148724 scopus 로고    scopus 로고
    • NASH may be trash
    • Cassiman, D. & Jaeken, J. NASH may be trash. Gut 57, 141-144 (2008).
    • (2008) Gut , vol.57 , pp. 141-144
    • Cassiman, D.1    Jaeken, J.2
  • 131
    • 38649103116 scopus 로고    scopus 로고
    • Positively disruptive
    • No authors listed
    • [No authors listed] Positively disruptive. Nat. Genet 40, 119 (2008).
    • (2008) Nat. Genet. , vol.40 , pp. 119
  • 132
    • 78649906637 scopus 로고    scopus 로고
    • Direct-to-consumer genetic testing
    • Office of Science Policy, National Institutes of Health
    • Office of Science Policy, National Institutes of Health. Direct-to-consumer genetic testing. Report of the Secretary's Advisory Committee on Genetics, Health, and Society [online], http://oba.od.nih.gov/oba/sacghs/ reports/SACGHSPTCReport2010.pdf (2010).
    • (2010) Report of the Secretary's Advisory Committee on Genetics, Health, and Society [online]
  • 134
    • 33746921634 scopus 로고    scopus 로고
    • The personal genome project
    • Church, G. M. The personal genome project. Mol. Syst Biol. 1, 2005.0030 (2005).
    • (2005) Mol. Syst. Biol. , vol.1 , pp. 20050030
    • Church, G.M.1
  • 135
    • 78649909315 scopus 로고    scopus 로고
    • Centers for Disease Control and Prevention
    • Centers for Disease Control and Prevention. Genomic Translation [online], http://www.cdc.gov/genomics/gtesting/ACCE/index.htm (2010).
    • (2010) Genomic Translation [online]
  • 136
    • 74049101159 scopus 로고    scopus 로고
    • Personal genomics: Information can be harmful
    • Ransohoff, D. F. & Khoury, M. J. Personal genomics: information can be harmful. Eur. J. Clin. Invest 40, 64-68 (2010).
    • (2010) Eur. J. Clin. Invest. , vol.40 , pp. 64-68
    • Ransohoff, D.F.1    Khoury, M.J.2
  • 138
    • 42349112088 scopus 로고    scopus 로고
    • Genome-wide association studies for complex traits: Consensus, uncertainty and challenges
    • McCarthy, M. I. et al. Genome-wide association studies for complex traits: consensus, uncertainty and challenges. Nat. Rev. Genet 9, 356-369 (2008).
    • (2008) Nat. Rev. Genet. , vol.9 , pp. 356-369
    • McCarthy, M.I.1
  • 139
    • 33646351020 scopus 로고    scopus 로고
    • Identification of two gene variants associated with risk of advanced fibrosis in patients with chronic hepatitis C
    • Huang, H. et al. Identification of two gene variants associated with risk of advanced fibrosis in patients with chronic hepatitis C. Gastroenterology 130, 1679-1687 (2006).
    • (2006) Gastroenterology , vol.130 , pp. 1679-1687
    • Huang, H.1
  • 140
    • 53049090077 scopus 로고    scopus 로고
    • Population-based genome-wide association studies reveal six loci influencing plasma levels of liver enzymes
    • Yuan, X. et al. Population-based genome-wide association studies reveal six loci influencing plasma levels of liver enzymes. Am J. Hum. Genet. 83, 520-528 (2008).
    • (2008) Am. J. Hum. Genet. , vol.83 , pp. 520-528
    • Yuan, X.1
  • 141
    • 44949201115 scopus 로고    scopus 로고
    • A genome-wide association study identifies protein quantitative trait loci (pQTLs)
    • Melzer, D. et al. A genome-wide association study identifies protein quantitative trait loci (pQTLs). PLoS Genet. 4, el000072 (2008).
    • (2008) PLoS Genet. , vol.4
    • Melzer, D.1
  • 142
    • 77957346513 scopus 로고    scopus 로고
    • Inosine triphosphate pyrophophatase polymorphism affects ribavirininduced anemia and outcome of therapy-a genome-wide study of Japanese hepatitis C virus patients
    • Ochi, H. et al. Inosine triphosphate pyrophophatase polymorphism affects ribavirininduced anemia and outcome of therapy-a genome-wide study of Japanese hepatitis C virus patients. Gastroenterology 139, 1190-1197 (2010).
    • (2010) Gastroenterology , vol.139 , pp. 1190-1197
    • Ochi, H.1


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