메뉴 건너뛰기




Volumn 96, Issue 12, 2011, Pages 1761-1769

Pathways for the regulation of hepcidin expression in anemia of chronic disease and iron deficiency anemia in vivo

Author keywords

Anemia of chronic disease; Bone morphogenetic proteins; Hepcidin; Inflammation; Iron deficiency; SMAD

Indexed keywords

BONE MORPHOGENETIC PROTEIN 6; HEMOJUVELIN; HEPCIDIN; MESSENGER RNA; SMAD1 PROTEIN; SMAD3 PROTEIN; SMAD5 PROTEIN; SMAD8 PROTEIN;

EID: 82855164013     PISSN: 03906078     EISSN: 15928721     Source Type: Journal    
DOI: 10.3324/haematol.2011.048926     Document Type: Article
Times cited : (65)

References (56)
  • 1
    • 14744278436 scopus 로고    scopus 로고
    • Anemia of chronic disease
    • Weiss G, Goodnough LT. Anemia of chronic disease. N Engl J Med. 2005;352(10):1011-1023.
    • (2005) N Engl J Med , vol.352 , Issue.10 , pp. 1011-1023
    • Weiss, G.1    Goodnough, L.T.2
  • 2
    • 0018350898 scopus 로고
    • Prevalence and causes of anemia in elderly hospitalized patients
    • Matzner Y, Levy S, Grossowicz N, Izak G, Hershko C. Prevalence and causes of anemia in elderly hospitalized patients. Gerontology. 1979;25(2):113-119.
    • (1979) Gerontology , vol.25 , Issue.2 , pp. 113-119
    • Matzner, Y.1    Levy, S.2    Grossowicz, N.3    Izak, G.4    Hershko, C.5
  • 3
    • 0141887122 scopus 로고    scopus 로고
    • Recent developments in the anemia of chronic disease
    • Means RT Jr. Recent developments in the anemia of chronic disease. Curr Hematol Rep. 2003;2(2):116-121.
    • (2003) Curr Hematol Rep , vol.2 , Issue.2 , pp. 116-121
    • Means Jr., R.T.1
  • 4
    • 0036728509 scopus 로고    scopus 로고
    • Iron and the anemia of chronic disease
    • Spivak JL. Iron and the anemia of chronic disease. Oncology (Williston Park). 2002;16 (9 Suppl 10):25-33.
    • (2002) Oncology (Williston Park) , vol.16 , Issue.9 SUPPL. 10 , pp. 25-33
    • Spivak, J.L.1
  • 5
    • 0037926880 scopus 로고    scopus 로고
    • Cytokine-mediated regulation of iron transport in human monocytic cells
    • Ludwiczek S, Aigner E, Theurl I, Weiss G. Cytokine-mediated regulation of iron transport in human monocytic cells. Blood. 2003;101(10):4148-4154.
    • (2003) Blood , vol.101 , Issue.10 , pp. 4148-4154
    • Ludwiczek, S.1    Aigner, E.2    Theurl, I.3    Weiss, G.4
  • 6
    • 0037131264 scopus 로고    scopus 로고
    • Regulation of reticuloendothelial iron transporter MTP1 (Slc11a3) by inflammation
    • Yang F, Liu XB, Quinones M, Melby PC, Ghio A, Haile DJ. Regulation of reticuloendothelial iron transporter MTP1 (Slc11a3) by inflammation. J Biol Chem. 2002;277(42): 39786-397891.
    • (2002) J Biol Chem , vol.277 , Issue.42 , pp. 39786-397891
    • Yang, F.1    Liu, X.B.2    Quinones, M.3    Melby, P.C.4    Ghio, A.5    Haile, D.J.6
  • 7
    • 14544298717 scopus 로고    scopus 로고
    • Hepcidin--a regulator of intestinal iron absorption and iron recycling by macrophages
    • Ganz T. Hepcidin--a regulator of intestinal iron absorption and iron recycling by macrophages. Best Pract Res Clin Haematol. 2005;18(2):171-182.
    • (2005) Best Pract Res Clin Haematol , vol.18 , Issue.2 , pp. 171-182
    • Ganz, T.1
  • 8
    • 43049124745 scopus 로고    scopus 로고
    • Iron and inflammation: Crosstalk between pathways regulating hepcidin
    • Fleming RE. Iron and inflammation: crosstalk between pathways regulating hepcidin. J Mol Med. 2008;86(5):491-494.
    • (2008) J Mol Med , vol.86 , Issue.5 , pp. 491-494
    • Fleming, R.E.1
  • 9
    • 10844258104 scopus 로고    scopus 로고
    • Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization
    • Nemeth E, Tuttle MS, Powelson J, Vaughn MB, Donovan A, Ward DM, et al. Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science. 2004;306(5704):2090-2093.
    • (2004) Science , vol.306 , Issue.5704 , pp. 2090-2093
    • Nemeth, E.1    Tuttle, M.S.2    Powelson, J.3    Vaughn, M.B.4    Donovan, A.5    Ward, D.M.6
  • 10
    • 0036791486 scopus 로고    scopus 로고
    • The gene encoding the iron regulatory peptide hepcidin is regulatedregulated by anemia, hypoxia, and inflammation
    • Nicolas G, Chauvet C, Viatte L, Danan JL, Bigard X, Devaux I, et al. The gene encoding the iron regulatory peptide hepcidin is regulatedregulated by anemia, hypoxia, and inflammation. J Clin Invest. 2002;110(7):1037-1044.
    • (2002) J Clin Invest , vol.110 , Issue.7 , pp. 1037-1044
    • Nicolas, G.1    Chauvet, C.2    Viatte, L.3    Danan, J.L.4    Bigard, X.5    Devaux, I.6
  • 11
    • 33646427702 scopus 로고    scopus 로고
    • TLR4- dependent hepcidin expression by myeloid cells in response to bacterial pathogens
    • Peyssonnaux C, Zinkernagel AS, Datta V, Lauth X, Johnson RS, Nizet V. TLR4- dependent hepcidin expression by myeloid cells in response to bacterial pathogens. Blood. 2006;107(9):3727-3732.
    • (2006) Blood , vol.107 , Issue.9 , pp. 3727-3732
    • Peyssonnaux, C.1    Zinkernagel, A.S.2    Datta, V.3    Lauth, X.4    Johnson, R.S.5    Nizet, V.6
  • 12
    • 41349106987 scopus 로고    scopus 로고
    • Autocrine formation of hepcidin induces iron retention in human monocytes
    • Theurl I, Theurl M, Seifert M, Mair S, Nairz M, Rumpold H, et al. Autocrine formation of hepcidin induces iron retention in human monocytes. Blood. 2008;111(4):2392-2399.
    • (2008) Blood , vol.111 , Issue.4 , pp. 2392-2399
    • Theurl, I.1    Theurl, M.2    Seifert, M.3    Mair, S.4    Nairz, M.5    Rumpold, H.6
  • 13
    • 67149084949 scopus 로고    scopus 로고
    • Regulation of iron homeostasis in anemia of chronic disease and iron deficiency anemia: Diagnostic and therapeutic implications
    • Theurl I, Aigner E, Theurl M, Nairz M, Seifert M, Schroll A, et al. Regulation of iron homeostasis in anemia of chronic disease and iron deficiency anemia: diagnostic and therapeutic implications. Blood. 2009;113 (21):5277-5286.
    • (2009) Blood , vol.113 , Issue.21 , pp. 5277-5286
    • Theurl, I.1    Aigner, E.2    Theurl, M.3    Nairz, M.4    Seifert, M.5    Schroll, A.6
  • 14
    • 23944502314 scopus 로고    scopus 로고
    • Time-course analysis of hepcidin, serum iron, and plasmacytokine levels in humans injected with LPS
    • Kemna E, Pickkers P, Nemeth E, van der Hoeven H, Swinkels D. Time-course analysis of hepcidin, serum iron, and plasmacytokine levels in humans injected with LPS. Blood. 2005;106(5):1864-1866.
    • (2005) Blood , vol.106 , Issue.5 , pp. 1864-1866
    • Kemna, E.1    Pickkers, P.2    Nemeth, E.3    van der Hoeven, H.4    Swinkels, D.5
  • 15
    • 33646577477 scopus 로고    scopus 로고
    • Dysregulated monocyte iron homeostasis and erythropoeitin formation in patients with anemia of chronic disease
    • Theurl I, Mattle V, Seifert M, Mariani M, Marth C, Weiss G. Dysregulated monocyte iron homeostasis and erythropoeitin formation in patients with anemia of chronic disease. Blood. 2006;107(10):4142-4148.
    • (2006) Blood , vol.107 , Issue.10 , pp. 4142-4148
    • Theurl, I.1    Mattle, V.2    Seifert, M.3    Mariani, M.4    Marth, C.5    Weiss, G.6
  • 16
    • 77951745552 scopus 로고    scopus 로고
    • Anti-hepcidin antibody treatment modulates iron metabolism and is effective in a mouse model of inflammation-induced anemia
    • Sasu BJ, Cooke KS, Arvedson TL, Plewa C, Ellison AR, Sheng J, et al. Anti-hepcidin antibody treatment modulates iron metabolism and is effective in a mouse model of inflammation-induced anemia. Blood. 2010;115 (17):3616-3624.
    • (2010) Blood , vol.115 , Issue.17 , pp. 3616-3624
    • Sasu, B.J.1    Cooke, K.S.2    Arvedson, T.L.3    Plewa, C.4    Ellison, A.R.5    Sheng, J.6
  • 17
    • 0141504266 scopus 로고    scopus 로고
    • Iron deficiency and erythropoiesis: New diagnostic approaches
    • Brugnara C. Iron deficiency and erythropoiesis: new diagnostic approaches. Clin Chem. 2003;49(10):1573-1578.
    • (2003) Clin Chem , vol.49 , Issue.10 , pp. 1573-1578
    • Brugnara, C.1
  • 18
    • 78649753411 scopus 로고    scopus 로고
    • Detection, evaluation, and management of iron-restricted erythropoiesis
    • Goodnough LT, Nemeth E, Ganz T. Detection, evaluation, and management of iron-restricted erythropoiesis. Blood. 2010; 116(23):4754-4761.
    • (2010) Blood , vol.116 , Issue.23 , pp. 4754-4761
    • Goodnough, L.T.1    Nemeth, E.2    Ganz, T.3
  • 19
    • 49949085724 scopus 로고    scopus 로고
    • Phlebotomies or erythropoietin injections allow mobilization of iron stores in a mouse model mimicking intensive care anemia
    • Lasocki S, Millot S, Andrieu V, Letteron P, Pilard N, Muzeau F, et al. Phlebotomies or erythropoietin injections allow mobilization of iron stores in a mouse model mimicking intensive care anemia. Crit Care Med. 2008;36(8):2388-2394.
    • (2008) Crit Care Med , vol.36 , Issue.8 , pp. 2388-2394
    • Lasocki, S.1    Millot, S.2    Andrieu, V.3    Letteron, P.4    Pilard, N.5    Muzeau, F.6
  • 20
    • 33751175421 scopus 로고    scopus 로고
    • Interleukin-6 induces hepcidin expression through STAT3
    • Wrighting DM, Andrews NC. Interleukin-6 induces hepcidin expression through STAT3. Blood. 2006;108(9):3204-3209.
    • (2006) Blood , vol.108 , Issue.9 , pp. 3204-3209
    • Wrighting, D.M.1    Andrews, N.C.2
  • 21
    • 33845985236 scopus 로고    scopus 로고
    • STAT3 mediates hepatic hepcidin expression and its inflammatory stimulation
    • Verga Falzacappa MV, Vujic Spasic M, Kessler R, Stolte J, Hentze MW, Muckenthaler MU. STAT3 mediates hepatic hepcidin expression and its inflammatory stimulation. Blood. 2007;109(1):353-358.
    • (2007) Blood , vol.109 , Issue.1 , pp. 353-358
    • Verga, F.M.V.1    Vujic, S.M.2    Kessler, R.3    Stolte, J.4    Hentze, M.W.5    Muckenthaler, M.U.6
  • 24
    • 33646370235 scopus 로고    scopus 로고
    • Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression
    • Babitt JL, Huang FW, Wrighting DM, Xia Y, Sidis Y, Samad TA, et al. Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression. Nat Genet. 2006;38(5): 531-539.
    • (2006) Nat Genet , vol.38 , Issue.5 , pp. 531-539
    • Babitt, J.L.1    Huang, F.W.2    Wrighting, D.M.3    Xia, Y.4    Sidis, Y.5    Samad, T.A.6
  • 25
    • 44449177930 scopus 로고    scopus 로고
    • The serine protease TMPRSS6 is required to sense iron deficiency
    • Du X, She E, Gelbart T, Truksa J, Lee P, Xia Y, et al. The serine protease TMPRSS6 is required to sense iron deficiency. Science. 2008;320(5879):1088-1092.
    • (2008) Science , vol.320 , Issue.5879 , pp. 1088-1092
    • Du, X.1    She, E.2    Gelbart, T.3    Truksa, J.4    Lee, P.5    Xia, Y.6
  • 26
    • 56449096622 scopus 로고    scopus 로고
    • The serine protease matriptase-2 (TMPRSS6) inhibits hepcidin activation by cleaving membrane hemojuvelin
    • Silvestri L, Pagani A, Nai A, De Domenico I, Kaplan J, Camaschella C. The serine protease matriptase-2 (TMPRSS6) inhibits hepcidin activation by cleaving membrane hemojuvelin. Cell Metab. 2008;8(6):502-511.
    • (2008) Cell Metab , vol.8 , Issue.6 , pp. 502-511
    • Silvestri, L.1    Pagani, A.2    Nai, A.3    de Domenico, I.4    Kaplan, J.5    Camaschella, C.6
  • 27
    • 77952573858 scopus 로고    scopus 로고
    • Down-regulation of Bmp/Smad signaling by Tmprss6 is required for maintenance of systemic iron homeostasis
    • Finberg KE, Whittlesey RL, Fleming MD, Andrews NC. Down-regulation of Bmp/Smad signaling by Tmprss6 is required for maintenance of systemic iron homeostasis. Blood. 2010;115(18):3817-3826.
    • (2010) Blood , vol.115 , Issue.18 , pp. 3817-3826
    • Finberg, K.E.1    Whittlesey, R.L.2    Fleming, M.D.3    Andrews, N.C.4
  • 28
    • 33745898241 scopus 로고    scopus 로고
    • Bone morphogenetic proteins 2, 4, and 9 stimulate murine hepcidin 1 expression independently of Hfe, transferrin receptor 2 (Tfr2), and IL- 6
    • Truksa J, Peng H, Lee P, Beutler E. Bone morphogenetic proteins 2, 4, and 9 stimulate murine hepcidin 1 expression independently of Hfe, transferrin receptor 2 (Tfr2), and IL- 6. Proc Natl Acad Sci USA. 2006;103(27): 10289-10293.
    • (2006) Proc Natl Acad Sci USA , vol.103 , Issue.27 , pp. 10289-10293
    • Truksa, J.1    Peng, H.2    Lee, P.3    Beutler, E.4
  • 29
    • 34447137331 scopus 로고    scopus 로고
    • Modulation of bone morphogenetic protein signaling in vivo regulatessystemic iron balance
    • Babitt JL, Huang FW, Xia Y, Sidis Y, Andrews NC, Lin HY. Modulation of bone morphogenetic protein signaling in vivo regulatessystemic iron balance. J Clin Invest. 2007;117(7):1933-1939.
    • (2007) J Clin Invest , vol.117 , Issue.7 , pp. 1933-1939
    • Babitt, J.L.1    Huang, F.W.2    Xia, Y.3    Sidis, Y.4    Andrews, N.C.5    Lin, H.Y.6
  • 32
    • 33646337674 scopus 로고    scopus 로고
    • Iron metabolism meets signal transduction
    • Anderson GJ, Frazer DM. Iron metabolism meets signal transduction. Nat Genet. 2006;38(5):503-504.
    • (2006) Nat Genet , vol.38 , Issue.5 , pp. 503-504
    • Anderson, G.J.1    Frazer, D.M.2
  • 33
    • 77954249308 scopus 로고    scopus 로고
    • Two to tango: Regulation of Mammalian iron metabolism
    • Hentze MW, Muckenthaler MU, Galy B, Camaschella C. Two to tango: regulation of Mammalian iron metabolism. Cell. 2010; 142(1):24-38.
    • (2010) Cell , vol.142 , Issue.1 , pp. 24-38
    • Hentze, M.W.1    Muckenthaler, M.U.2    Galy, B.3    Camaschella, C.4
  • 34
    • 77950979752 scopus 로고    scopus 로고
    • SMAD7 controls iron metabolism as a potent inhibitor of hepcidin expression
    • Mleczko-Sanecka K, Casanovas G, Ragab A, Breitkopf K, Muller A, Boutros M, et al. SMAD7 controls iron metabolism as a potent inhibitor of hepcidin expression. Blood. 2009;115(13):2657-2665.
    • (2009) Blood , vol.115 , Issue.13 , pp. 2657-2665
    • Mleczko-Sanecka, K.1    Casanovas, G.2    Ragab, A.3    Breitkopf, K.4    Muller, A.5    Boutros, M.6
  • 36
    • 34948904750 scopus 로고    scopus 로고
    • High levels of GDF15 in thalassemia suppress expression of the iron regulatory protein hepcidin
    • Tanno T, Bhanu NV, Oneal PA, Goh SH, Staker P, Lee YT, et al. High levels of GDF15 in thalassemia suppress expression of the iron regulatory protein hepcidin. Nat Med. 2007;13(9):1096-1101.
    • (2007) Nat Med , vol.13 , Issue.9 , pp. 1096-1101
    • Tanno, T.1    Bhanu, N.V.2    Oneal, P.A.3    Goh, S.H.4    Staker, P.5    Lee, Y.T.6
  • 37
    • 47049116150 scopus 로고    scopus 로고
    • Erythropoietin mediates hepcidin expression in hepatocytes through EPOR signaling and regulation of C/EBPalpha
    • Pinto JP, Ribeiro S, Pontes H, Thowfeequ S, Tosh D, Carvalho F, et al. Erythropoietin mediates hepcidin expression in hepatocytes through EPOR signaling and regulation of C/EBPalpha. Blood. 2008;111(12):5727-5733.
    • (2008) Blood , vol.111 , Issue.12 , pp. 5727-5733
    • Pinto, J.P.1    Ribeiro, S.2    Pontes, H.3    Thowfeequ, S.4    Tosh, D.5    Carvalho, F.6
  • 38
    • 68949220321 scopus 로고    scopus 로고
    • ER stress controls iron metabolism through induction of hepcidin
    • Vecchi C, Montosi G, Zhang K, Lamberti I, Duncan SA, Kaufman RJ, et al. ER stress controls iron metabolism through induction of hepcidin. Science. 2009;325(5942):877-880.
    • (2009) Science , vol.325 , Issue.5942 , pp. 877-880
    • Vecchi, C.1    Montosi, G.2    Zhang, K.3    Lamberti, I.4    Duncan, S.A.5    Kaufman, R.J.6
  • 39
    • 79952162002 scopus 로고    scopus 로고
    • Regulation of cellular iron metabolism
    • Wang J, Pantopoulos K. Regulation of cellular iron metabolism. Biochem J. 2011;434 (3):365-381.
    • (2011) Biochem J , vol.434 , Issue.3 , pp. 365-381
    • Wang, J.1    Pantopoulos, K.2
  • 41
    • 65349173063 scopus 로고    scopus 로고
    • Contribution of STAT3 and SMAD4 pathways to the regulation of hepcidin by opposing stimuli
    • Huang H, Constante M, Layoun A, Santos MM. Contribution of STAT3 and SMAD4 pathways to the regulation of hepcidin by opposing stimuli. Blood. 2009;113(15):3593-3569.
    • (2009) Blood , vol.113 , Issue.15 , pp. 3593-3599
    • Huang, H.1    Constante, M.2    Layoun, A.3    Santos, M.M.4
  • 42
    • 3042745199 scopus 로고    scopus 로고
    • Duodenal HFE expression and hepcidin levels determine body iron homeostasis: Modulation by genetic diversity and dietary iron availability
    • Ludwiczek S, Theurl I, Artner-Dworzak E, Chorney M, Weiss G. Duodenal HFE expression and hepcidin levels determine body iron homeostasis: modulation by genetic diversity and dietary iron availability. J Mol Med. 2004;82(6):373-382.
    • (2004) J Mol Med , vol.82 , Issue.6 , pp. 373-382
    • Ludwiczek, S.1    Theurl, I.2    Artner-Dworzak, E.3    Chorney, M.4    Weiss, G.5
  • 43
    • 33846438680 scopus 로고    scopus 로고
    • Localization of the iron-regulatory proteins hemojuvelin and transferrin receptor 2 to the basolateral membrane domain of hepatocytes
    • Merle U, Theilig F, Fein E, Gehrke S, Kallinowski B, Riedel HD, et al. Localization of the iron-regulatory proteins hemojuvelin and transferrin receptor 2 to the basolateral membrane domain of hepatocytes. Histochem Cell Biol. 2007;127(2):221-226.
    • (2007) Histochem Cell Biol , vol.127 , Issue.2 , pp. 221-226
    • Merle, U.1    Theilig, F.2    Fein, E.3    Gehrke, S.4    Kallinowski, B.5    Riedel, H.D.6
  • 44
    • 70350494274 scopus 로고    scopus 로고
    • BMP/Smad signaling is not enhanced in Hfedeficient mice despite increased Bmp6 expression
    • Kautz L, Meynard D, Besson-Fournier C, Darnaud V, Al Saati T, Coppin H, et al. BMP/Smad signaling is not enhanced in Hfedeficient mice despite increased Bmp6 expression. Blood. 2009;114(12):2515-2520.
    • (2009) Blood , vol.114 , Issue.12 , pp. 2515-2520
    • Kautz, L.1    Meynard, D.2    Besson-Fournier, C.3    Darnaud, V.4    al Saati, T.5    Coppin, H.6
  • 45
    • 79551629285 scopus 로고    scopus 로고
    • Suppression of hepatic hepcidin expression in response to acute iron deprivation is associated with an increase of matriptase-2 protein
    • Zhang AS, Anderson SA, Wang J, Yang F, DeMaster K, Ahmed R, et al. Suppression of hepatic hepcidin expression in response to acute iron deprivation is associated with an increase of matriptase-2 protein. Blood. 2011;117(5):1687-1699.
    • (2011) Blood , vol.117 , Issue.5 , pp. 1687-1699
    • Zhang, A.S.1    Anderson, S.A.2    Wang, J.3    Yang, F.4    Demaster, K.5    Ahmed, R.6
  • 46
    • 67349204418 scopus 로고    scopus 로고
    • Bone morphogenetic protein (BMP)-responsive elements located in the proximal and distal hepcidin promoter are critical for its response to HJV/BMP/SMAD
    • Casanovas G, Mleczko-Sanecka K, Altamura S, Hentze MW, Muckenthaler MU. Bone morphogenetic protein (BMP)-responsive elements located in the proximal and distal hepcidin promoter are critical for its response to HJV/BMP/SMAD. J Mol Med. 2009;87(5):471-480.
    • (2009) J Mol Med , vol.87 , Issue.5 , pp. 471-480
    • Casanovas, G.1    Mleczko-Sanecka, K.2    Altamura, S.3    Hentze, M.W.4    Muckenthaler, M.U.5
  • 47
    • 51649096725 scopus 로고    scopus 로고
    • Iron regulates phosphorylation of Smad1/5/8 and gene expression of Bmp6, Smad7, Id1, and Atoh8 in the mouse liver
    • Kautz L, Meynard D, Monnier A, Darnaud V, Bouvet R, Wang RH, et al. Iron regulates phosphorylation of Smad1/5/8 and gene expression of Bmp6, Smad7, Id1, and Atoh8 in the mouse liver. Blood. 2008;112(4):1503-1509.
    • (2008) Blood , vol.112 , Issue.4 , pp. 1503-1509
    • Kautz, L.1    Meynard, D.2    Monnier, A.3    Darnaud, V.4    Bouvet, R.5    Wang, R.H.6
  • 48
    • 33644876815 scopus 로고    scopus 로고
    • A role of SMAD4 in iron metabolism through the positive regulation of hepcidin expression
    • Wang RH, Li C, Xu X, Zheng Y, Xiao C, Zerfas P, et al. A role of SMAD4 in iron metabolism through the positive regulation of hepcidin expression. Cell Metab. 2005; 2(6):399-409.
    • (2005) Cell Metab , vol.2 , Issue.6 , pp. 399-409
    • Wang, R.H.1    Li, C.2    Xu, X.3    Zheng, Y.4    Xiao, C.5    Zerfas, P.6
  • 49
    • 70349494083 scopus 로고    scopus 로고
    • Bone orphogenetic protein signaling is impaired in an HFE knockout mouse model of hemochromatosis
    • Corradini E, Garuti C, Montosi G, Ventura P, Andriopoulos B Jr, Lin HY, et al. Bone orphogenetic protein signaling is impaired in an HFE knockout mouse model of hemochromatosis. Gastroenterology. 2009; 137(4):1489-1497.
    • (2009) Gastroenterology , vol.137 , Issue.4 , pp. 1489-1497
    • Corradini, E.1    Garuti, C.2    Montosi, G.3    Ventura, P.4    Andriopoulos Jr., B.5    Lin, H.Y.6
  • 50
    • 72249109128 scopus 로고    scopus 로고
    • Iron-induced expression of bone morphogenic protein 6 in intestinal cells is the main regulator of hepatic hepcidin expression in vivo
    • Arndt S, Maegdefrau U, Dorn C, Schardt K, Hellerbrand C, Bosserhoff AK. Iron-induced expression of bone morphogenic protein 6 in intestinal cells is the main regulator of hepatic hepcidin expression in vivo. Gastroenterology. 2010;138(1):372-382.
    • (2010) Gastroenterology , vol.138 , Issue.1 , pp. 372-382
    • Arndt, S.1    Maegdefrau, U.2    Dorn, C.3    Schardt, K.4    Hellerbrand, C.5    Bosserhoff, A.K.6
  • 51
    • 25444530350 scopus 로고    scopus 로고
    • Hepatic expression of hemochromatosis genes in two mouse strains after phlebotomy and iron overload
    • Bondi A, Valentino P, Daraio F, Porporato P, Gramaglia E, Carturan S, et al. Hepatic expression of hemochromatosis genes in two mouse strains after phlebotomy and iron overload. Haematologica. 2005;90(9): 1161-1167.
    • (2005) Haematologica , vol.90 , Issue.9 , pp. 1161-1167
    • Bondi, A.1    Valentino, P.2    Daraio, F.3    Porporato, P.4    Gramaglia, E.5    Carturan, S.6
  • 52
    • 66749183353 scopus 로고    scopus 로고
    • Crosstalk between the mitogen activated protein kinase and bone morphogenetic protein/hemojuvelin pathways is required for the induction of hepcidin by holotransferrin in primary mouse hepatocytes
    • Ramey G, Deschemin JC, Vaulont S. Crosstalk between the mitogen activated protein kinase and bone morphogenetic protein/hemojuvelin pathways is required for the induction of hepcidin by holotransferrin in primary mouse hepatocytes. Haematologica. 2009;94(6):765-772.
    • (2009) Haematologica , vol.94 , Issue.6 , pp. 765-772
    • Ramey, G.1    Deschemin, J.C.2    Vaulont, S.3
  • 53
    • 27744485015 scopus 로고    scopus 로고
    • Post-transcriptional regulation of Smad7 in the gut of patients with inflammatory bowel disease
    • Monteleone G, Del Vecchio Blanco G, Monteleone I, Fina D, Caruso R, Gioia V, et al. Post-transcriptional regulation of Smad7 in the gut of patients with inflammatory bowel disease. Gastroenterology. 2005;129 (5):1420-1429.
    • (2005) Gastroenterology , vol.129 , Issue.5 , pp. 1420-1429
    • Monteleone, G.1    del Vecchio, B.G.2    Monteleone, I.3    Fina, D.4    Caruso, R.5    Gioia, V.6
  • 54
    • 79251556820 scopus 로고    scopus 로고
    • Smad7: Not only a regulator, but also a cross-talk mediator of TGFbeta signalling
    • Yan X, Chen YG. Smad7: not only a regulator, but also a cross-talk mediator of TGFbeta signalling. Biochem J. 2011;434(1):1-10.
    • (2011) Biochem J , vol.434 , Issue.1 , pp. 1-10
    • Yan, X.1    Chen, Y.G.2
  • 55
    • 0037071383 scopus 로고    scopus 로고
    • Transcriptional regulation of erythropoiesis: An affair involving multiple partners
    • Cantor AB, Orkin SH. Transcriptional regulation of erythropoiesis: an affair involving multiple partners. Oncogene. 2002;21(21): 3368-3376.
    • (2002) Oncogene , vol.21 , Issue.21 , pp. 3368-3376
    • Cantor, A.B.1    Orkin, S.H.2
  • 56
    • 33747181698 scopus 로고    scopus 로고
    • Histone acetyltransferase p300 regulates the transcription of human erythroidspecific 5-aminolevulinate synthase gene
    • Han L, Lu J, Pan L, Wang X, Shao Y, Han S, et al. Histone acetyltransferase p300 regulates the transcription of human erythroidspecific 5-aminolevulinate synthase gene. Biochem Biophys Res Commun. 2006;348 (3):799-806.
    • (2006) Biochem Biophys Res Commun , vol.348 , Issue.3 , pp. 799-806
    • Han, L.1    Lu, J.2    Pan, L.3    Wang, X.4    Shao, Y.5    Han, S.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.