Down-regulation of Bmp/Smad signaling by Tmprss6 is required for maintenance of systemic iron homeostasis

Blood

Volumn 115, Issue 18, 2010, Pages 3817-3826

  Finberg, Karin E ^a   Whittlesey, Rebecca L ^b   Fleming, Mark D ^c,d   Andrews, Nancy C ^b  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c BOSTON CHILDREN S HOSPITAL   (United States)

^d HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BONE MORPHOGENETIC PROTEIN; BONE MORPHOGENETIC PROTEIN 6; HEMOJUVELIN; HEPCIDIN; MESSENGER RNA; SERINE PROTEINASE; SMAD PROTEIN; TMPRSS6 PROTEIN; UNCLASSIFIED DRUG; ANTIMICROBIAL CATIONIC PEPTIDE; HFE2 PROTEIN, MOUSE; INHIBITOR OF DIFFERENTIATION 1; IRON; MATRIPTASE 2; MEMBRANE PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; DOWN REGULATION; FEMALE; HOMEOSTASIS; HUMAN; IRON DEFICIENCY ANEMIA; IRON OVERLOAD; IRON STORAGE; LIVER; LIVER CELL; LOSS OF FUNCTION MUTATION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; ANIMAL; C57BL MOUSE; GENETICS; METABOLISM; MOUSE MUTANT; PATHOLOGY; PHYSIOLOGY; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

ANEMIA, IRON-DEFICIENCY; ANIMALS; ANTIMICROBIAL CATIONIC PEPTIDES; BLOTTING, WESTERN; BONE MORPHOGENETIC PROTEINS; DOWN-REGULATION; FEMALE; HEPATOCYTES; HOMEOSTASIS; INHIBITOR OF DIFFERENTIATION PROTEIN 1; IRON; LIVER; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SERINE ENDOPEPTIDASES; SIGNAL TRANSDUCTION; SMAD PROTEINS;

EID: 77952573858     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2009-05-224808     Document Type: Article

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