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Volumn 6, Issue 9, 2006, Pages 735-741

Linking oncogenic pathways with therapeutic opportunities

Author keywords

[No Author keywords available]

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; 3 BENZYL 7 CYANO 2,3,4,5 TETRAHYDRO 1 (1H IMIDAZOL 4 YLMETHYL) 4 (2 THIENYLSULFONYL) 1H 1,4 BENZODIAZEPINE; ANASTROZOLE; ANTINEOPLASTIC AGENT; BEVACIZUMAB; BMS 384825; BORTEZOMIB; CETUXIMAB; DASATINIB; ERLOTINIB; EVEROLIMUS; EXEMESTANE; GEFITINIB; IMATINIB; LAPATINIB; NILOTINIB; PANITUMUMAB; SORAFENIB; SUNITINIB; SUNITINIB MALEATE; TAMOXIFEN CITRATE; TEMSIROLIMUS; TIPIFARNIB; TRASTUZUMAB; UNCLASSIFIED DRUG; VANDETANIB; VATALANIB;

EID: 33748093767     PISSN: 1474175X     EISSN: None     Source Type: Journal    
DOI: 10.1038/nrc1976     Document Type: Review
Times cited : (143)

References (82)
  • 1
    • 0036534202 scopus 로고    scopus 로고
    • DNA microarrays in clinical oncology
    • Ramaswamy, S. & Golub, T. R. DNA microarrays in clinical oncology. J. Clin. Oncol. 20, 1932-1941 (2002).
    • (2002) J. Clin. Oncol. , vol.20 , pp. 1932-1941
    • Ramaswamy, S.1    Golub, T.R.2
  • 2
    • 0035931968 scopus 로고    scopus 로고
    • Genome-wide views of cancer
    • Golub, T. R. Genome-wide views of cancer. N. Engl. J. Med. 3, 601-602 (2001).
    • (2001) N. Engl. J. Med. , vol.3 , pp. 601-602
    • Golub, T.R.1
  • 3
    • 0033569406 scopus 로고    scopus 로고
    • Molecular classification of cancer: Class discovery and class prediction by gene expression monitoring
    • Golub, T. R. et al. Molecular classification of cancer: class discovery and class prediction by gene expression monitoring. Science 286, 531-537 (1999).
    • (1999) Science , vol.286 , pp. 531-537
    • Golub, T.R.1
  • 4
    • 0034598746 scopus 로고    scopus 로고
    • Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling
    • Alizadeh, A. A. et al. Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling. Nature 403, 503-511 (2000).
    • (2000) Nature , vol.403 , pp. 503-511
    • Alizadeh, A.A.1
  • 5
    • 0037142053 scopus 로고    scopus 로고
    • The use of molecular profiling to predict survival after chemotherapy for diffuse large-B-cell lymphoma
    • Rosenwald, A. et al. The use of molecular profiling to predict survival after chemotherapy for diffuse large-B-cell lymphoma. N. Engl. J. Med. 346, 1937-1947 (2006).
    • (2006) N. Engl. J. Med. , vol.346 , pp. 1937-1947
    • Rosenwald, A.1
  • 6
    • 0034680102 scopus 로고    scopus 로고
    • Molecular portraits of human breast tumors
    • Perou, C. M. et al. Molecular portraits of human breast tumors. Nature 406, 747-752 (2000).
    • (2000) Nature , vol.406 , pp. 747-752
    • Perou, C.M.1
  • 7
    • 0035845511 scopus 로고    scopus 로고
    • Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications
    • Sorlie, T. et al. Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications. Proc. Natl. Acad. Sci. USA 98, 10869-10874 (2001).
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 10869-10874
    • Sorlie, T.1
  • 8
    • 18244409687 scopus 로고    scopus 로고
    • Gene expression profiling predicts clinical outcome of breast cancer
    • van'T Veer, L. J. et al. Gene expression profiling predicts clinical outcome of breast cancer. Nature 415, 530-536 (2002).
    • (2002) Nature , vol.415 , pp. 530-536
    • Van'T Veer, L.J.1
  • 9
    • 0037137519 scopus 로고    scopus 로고
    • A gene-expression signature as a predictor of survival in breast cancer
    • van de Vijver, M. J. et al. A gene-expression signature as a predictor of survival in breast cancer. N. Engl. J. Med. 347, 1999-2009 (2002).
    • (2002) N. Engl. J. Med. , vol.347 , pp. 1999-2009
    • Van De Vijver, M.J.1
  • 10
    • 19944422061 scopus 로고    scopus 로고
    • A multigene assay to predict recurrence of tamoxifen-treated, node-negative breast cancer
    • Paik, S. et al. A multigene assay to predict recurrence of tamoxifen-treated, node-negative breast cancer. N. Engl. J. Med. 351, 2817-2826 (2004).
    • (2004) N. Engl. J. Med. , vol.351 , pp. 2817-2826
    • Paik, S.1
  • 11
    • 2942534096 scopus 로고    scopus 로고
    • Integrated modeling of clinical and gene expression information for personalized prediction of disease outcomes
    • Pittman, J. et al. Integrated modeling of clinical and gene expression information for personalized prediction of disease outcomes. Proc. Natl. Acad. Sci. USA 101, 8431-8436 (2004).
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 8431-8436
    • Pittman, J.1
  • 12
    • 0038244058 scopus 로고    scopus 로고
    • Gene expression predictors of breast cancer outcomes
    • Huang, E. et al. Gene expression predictors of breast cancer outcomes. Lancet 361, 1590-1596 (2003).
    • (2003) Lancet , vol.361 , pp. 1590-1596
    • Huang, E.1
  • 13
    • 33645279862 scopus 로고    scopus 로고
    • Molecular diagnosis of Burkitt's lymphoma
    • Dave, S. S. et al. Molecular diagnosis of Burkitt's lymphoma. N. Engl. J. Med. 354, 2431-2442 (2006).
    • (2006) N. Engl. J. Med. , vol.354 , pp. 2431-2442
    • Dave, S.S.1
  • 14
    • 8644252736 scopus 로고    scopus 로고
    • Prediction of survival in follicular lymphoma based on molecular features of tumor-infiltrating immune cells
    • Dave, S. S. et al. Prediction of survival in follicular lymphoma based on molecular features of tumor-infiltrating immune cells. N. Engl. J. Med. 351, 2159-2169 (2004).
    • (2004) N. Engl. J. Med. , vol.351 , pp. 2159-2169
    • Dave, S.S.1
  • 15
    • 20044392672 scopus 로고    scopus 로고
    • Mining for regulatory programs in the cancer transcriptome
    • Rhodes, D. R. et al. Mining for regulatory programs in the cancer transcriptome. Nature Genet. 37, 579-583 (2005).
    • (2005) Nature Genet. , vol.37 , pp. 579-583
    • Rhodes, D.R.1
  • 16
    • 3042694117 scopus 로고    scopus 로고
    • Large-scale meta-analysis of cancer microarray data identifies common transcriptional profiles of neoplastic transformation and progression
    • Rhodes, D. R. et al. Large-scale meta-analysis of cancer microarray data identifies common transcriptional profiles of neoplastic transformation and progression. Proc. Natl. Acad. Sci. USA 101, 9309-9314 (2004).
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 9309-9314
    • Rhodes, D.R.1
  • 18
    • 1542399989 scopus 로고    scopus 로고
    • FatiGO: A web tool for finding significant associations of Gene Ontology terms with groups of genes
    • Al-Shahrour, F., Diaz-Uriarte, R. & Dopazo, J. FatiGO: a web tool for finding significant associations of Gene Ontology terms with groups of genes. Bioinformatics 20, 578-580 (2004).
    • (2004) Bioinformatics , vol.20 , pp. 578-580
    • Al-Shahrour, F.1    Diaz-Uriarte, R.2    Dopazo, J.3
  • 19
    • 0037941536 scopus 로고    scopus 로고
    • Gene expression phenotypic models that predict the activity of oncogenic pathways
    • Huang, E. et al. Gene expression phenotypic models that predict the activity of oncogenic pathways. Nature Genet. 34, 226-230 (2003).
    • (2003) Nature Genet. , vol.34 , pp. 226-230
    • Huang, E.1
  • 20
    • 0038756375 scopus 로고    scopus 로고
    • Distinct gene expression phenotypes of cells lacking Rb and Rb family members
    • Black, E. P. et al. Distinct gene expression phenotypes of cells lacking Rb and Rb family members. Cancer Res. 63, 3716-3723 (2003).
    • (2003) Cancer Res. , vol.63 , pp. 3716-3723
    • Black, E.P.1
  • 21
    • 31144459985 scopus 로고    scopus 로고
    • Oncogenic pathway signatures in human cancers as a guide to targeted therapies
    • Bild, A. et al. Oncogenic pathway signatures in human cancers as a guide to targeted therapies. Nature 439, 353-357 (2006).
    • (2006) Nature , vol.439 , pp. 353-357
    • Bild, A.1
  • 22
    • 11244258643 scopus 로고    scopus 로고
    • An oncogenic KRAS2 expression signature identified by cross-species gene expression analysis
    • Sweet-Cordero, A. et al. An oncogenic KRAS2 expression signature identified by cross-species gene expression analysis. Nature Genet. 37, 48-54 (2005).
    • (2005) Nature Genet. , vol.37 , pp. 48-54
    • Sweet-Cordero, A.1
  • 23
    • 33645127077 scopus 로고    scopus 로고
    • Genetic regulators of large-scale transcriptional signatures in cancer
    • Adler, A. S. et al. Genetic regulators of large-scale transcriptional signatures in cancer. Nature Genet. 38, 421-430 (2006).
    • (2006) Nature Genet. , vol.38 , pp. 421-430
    • Adler, A.S.1
  • 24
    • 0033981639 scopus 로고    scopus 로고
    • A genome-wide survey of RAS transformation targets
    • Zuber, J. et al. A genome-wide survey of RAS transformation targets. Nature Genet. 24, 144-152 (2000).
    • (2000) Nature Genet. , vol.24 , pp. 144-152
    • Zuber, J.1
  • 25
    • 0033598409 scopus 로고    scopus 로고
    • Gene expression profiling of fibroblasts resistant toward oncogene-mediated transformation reveals preferential transcription of negative growth regulators
    • Tchernitsa, O. I. et al. Gene expression profiling of fibroblasts resistant toward oncogene-mediated transformation reveals preferential transcription of negative growth regulators. Oncogene 18, 5448-5454 (1999).
    • (1999) Oncogene , vol.18 , pp. 5448-5454
    • Tchernitsa, O.I.1
  • 26
    • 2942534604 scopus 로고    scopus 로고
    • Gene expression profiling by DNA microarray analysis in mouse embryonic fibroblasts transformed by rasV12 mutated protein and the E1A oncogene
    • Vasseur, S. et al. Gene expression profiling by DNA microarray analysis in mouse embryonic fibroblasts transformed by rasV12 mutated protein and the E1A oncogene. Mol. Cancer 2, 19 (2003).
    • (2003) Mol. Cancer , vol.2 , pp. 19
    • Vasseur, S.1
  • 27
    • 0042354669 scopus 로고    scopus 로고
    • A mechanism of cyclin D1 action encoded in the patterns of gene expression in human cancer
    • Lamb, J. et al. A mechanism of cyclin D1 action encoded in the patterns of gene expression in human cancer. Cell 114, 323-334 (2003).
    • (2003) Cell , vol.114 , pp. 323-334
    • Lamb, J.1
  • 28
    • 0037076342 scopus 로고    scopus 로고
    • Initiating oncogenic event determines gene-expression patterns of human breast cancer models
    • Desai, K. V. et al. Initiating oncogenic event determines gene-expression patterns of human breast cancer models. Proc. Natl. Acad. Sci. USA 99, 6967-6972 (2002).
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 6967-6972
    • Desai, K.V.1
  • 29
    • 20044388557 scopus 로고    scopus 로고
    • From signatures to models: Understanding cancer using microarrays
    • Segal, E., Friedman, N., Kaminski, N., Regev, A. & Koller, D. From signatures to models: understanding cancer using microarrays. Nature Genet. 37 (Suppl.), S38-S45 (2005).
    • (2005) Nature Genet. , vol.37 , Issue.SUPPL.
    • Segal, E.1    Friedman, N.2    Kaminski, N.3    Regev, A.4    Koller, D.5
  • 30
    • 6944244084 scopus 로고    scopus 로고
    • A module map showing conditional activity of expression modules in cancer
    • Segal, E., Friedman, N., Koller, D. & Regev, A. A module map showing conditional activity of expression modules in cancer. Nature Genet. 36, 1090-1098 (2004).
    • (2004) Nature Genet. , vol.36 , pp. 1090-1098
    • Segal, E.1    Friedman, N.2    Koller, D.3    Regev, A.4
  • 31
    • 0037941585 scopus 로고    scopus 로고
    • Module networks: Identifying regulatory modules and their condition-specific regulators from gene expression data
    • Segal, E. et al. Module networks: identifying regulatory modules and their condition-specific regulators from gene expression data. Nature Genet. 34, 66-176 (2003).
    • (2003) Nature Genet. , vol.34 , pp. 66-176
    • Segal, E.1
  • 32
    • 0141993704 scopus 로고    scopus 로고
    • A gene-coexpression network for global discovery of conserved genetic modules
    • Stuart, J. M., Segal, E., Koller, D. & Kim, S. K. A gene-coexpression network for global discovery of conserved genetic modules. Science 302, 249-255 (2003).
    • (2003) Science , vol.302 , pp. 249-255
    • Stuart, J.M.1    Segal, E.2    Koller, D.3    Kim, S.K.4
  • 33
    • 0842309161 scopus 로고    scopus 로고
    • Discovering molecular pathways from protein interaction and gene expression data
    • Segal, E., Wang, H. & Koller, D. Discovering molecular pathways from protein interaction and gene expression data. Bioinformatics 19 (Suppl. 1), i264-i271 (2003).
    • (2003) Bioinformatics , vol.19 , Issue.1 SUPPL.
    • Segal, E.1    Wang, H.2    Koller, D.3
  • 34
    • 27344435774 scopus 로고    scopus 로고
    • Gene set enrichment analysis: A knowledge-based approach for interpreting genomewide expression profiles
    • Subramanian, A. et al. Gene set enrichment analysis: a knowledge-based approach for interpreting genomewide expression profiles. Proc. Natl. Acad. Sci. USA 102, 15545-15550 (2005).
    • (2005) Proc. Natl. Acad. Sci. USA , vol.102 , pp. 15545-15550
    • Subramanian, A.1
  • 35
    • 18744389489 scopus 로고    scopus 로고
    • Significance analysis of functional categories in gene expression studies: A structure permutation approach
    • Barry, W. T., Nobel, A. B. & Wright, F. A. Significance analysis of functional categories in gene expression studies: a structure permutation approach. Bioinformatics 21, 1943-1949 (2005).
    • (2005) Bioinformatics , vol.21 , pp. 1943-1949
    • Barry, W.T.1    Nobel, A.B.2    Wright, F.A.3
  • 36
    • 26444608611 scopus 로고    scopus 로고
    • Discovering statistically significant pathways in expression profiling studies
    • Tian, L. et al. Discovering statistically significant pathways in expression profiling studies. Proc. Natl. Acad. Sci. USA 102, 13544-13549 (2005).
    • (2005) Proc. Natl. Acad. Sci. USA , vol.102 , pp. 13544-13549
    • Tian, L.1
  • 37
    • 85142175706 scopus 로고    scopus 로고
    • Analysis of sample set enrichment scores: Assaying the enrichment of sets of genes for individual samples in genome-wide expression profiles
    • in the press
    • Edelman, E. et al. Analysis of sample set enrichment scores: assaying the enrichment of sets of genes for individual samples in genome-wide expression profiles. Bioinformatics (in the press).
    • Bioinformatics
    • Edelman, E.1
  • 38
    • 20444446371 scopus 로고    scopus 로고
    • Identification of a genetic signature of activated signal transducer and activator of transcription 3 in human tumors
    • Alvarez, J. V. et al. Identification of a genetic signature of activated signal transducer and activator of transcription 3 in human tumors. Cancer Res. 65, 5054-5062 (2005).
    • (2005) Cancer Res. , vol.65 , pp. 5054-5062
    • Alvarez, J.V.1
  • 39
    • 19044391072 scopus 로고    scopus 로고
    • Gene expression correlates of clinical prostate cancer behavior
    • Singh, D. et al. Gene expression correlates of clinical prostate cancer behavior. Cancer Cell 1, 203-209 (2002).
    • (2002) Cancer Cell , vol.1 , pp. 203-209
    • Singh, D.1
  • 40
    • 4344623889 scopus 로고    scopus 로고
    • Imatinib as a paradigm of targeted therapies
    • Druker, B. J. Imatinib as a paradigm of targeted therapies. Adv. Cancer Res. 91, 1-30 (2004).
    • (2004) Adv. Cancer Res. , vol.91 , pp. 1-30
    • Druker, B.J.1
  • 41
    • 9244222261 scopus 로고    scopus 로고
    • Targeted cancer therapy
    • Sawyers, C. Targeted cancer therapy. Nature 432, 294-297 (2004).
    • (2004) Nature , vol.432 , pp. 294-297
    • Sawyers, C.1
  • 42
    • 26844536978 scopus 로고    scopus 로고
    • Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancer
    • Romond, E. H. et al. Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancer. N. Engl. J. Med. 353, 1673-1684 (2005).
    • (2005) N. Engl. J. Med. , vol.353 , pp. 1673-1684
    • Romond, E.H.1
  • 43
    • 26844503270 scopus 로고    scopus 로고
    • Trastuzumab after adjuvant chmotherapy in HER2-positive breast cancer
    • Piccart-Gebhart, M. J. et al. Trastuzumab after adjuvant chmotherapy in HER2-positive breast cancer. N. Engl. J. Med. 353, 1659-1672 (2005).
    • (2005) N. Engl. J. Med. , vol.353 , pp. 1659-1672
    • Piccart-Gebhart, M.J.1
  • 44
    • 26844559765 scopus 로고    scopus 로고
    • Trastuzumab in the treatment of breast cancer
    • Hortobagyi, G. N. Trastuzumab in the treatment of breast cancer. N. Engl. J. Med. 353, 17334-1736 (2005).
    • (2005) N. Engl. J. Med. , vol.353 , pp. 17334-1736
    • Hortobagyi, G.N.1
  • 45
    • 0033987746 scopus 로고    scopus 로고
    • Lessons learned from the development of an abl tyrosine kinase inhibitor for chronic myelogenous leukemia
    • Druker, B. J. & Lydon, N. B. Lessons learned from the development of an abl tyrosine kinase inhibitor for chronic myelogenous leukemia. J. Clin. Invest. 105, 3-7 (2000).
    • (2000) J. Clin. Invest. , vol.105 , pp. 3-7
    • Druker, B.J.1    Lydon, N.B.2
  • 46
    • 0025899234 scopus 로고
    • Use of an aqueous soluble tetrazolium/formazan assay for cell growth assays in culture
    • Cory, A. H. Use of an aqueous soluble tetrazolium/formazan assay for cell growth assays in culture. Cancer Commun. 3, 207-212 (1991).
    • (1991) Cancer Commun. , vol.3 , pp. 207-212
    • Cory, A.H.1
  • 47
    • 0000215699 scopus 로고
    • Comparison of MTT, Xtt, and a novel tetrazolium compound for MTS for in vitro proliferation and chemosensitivity assays
    • Riss, T. L. & A., M. R. Comparison of MTT, Xtt, and a novel tetrazolium compound for MTS for in vitro proliferation and chemosensitivity assays. Mol. Biol. Cell 3, 184a (1993).
    • (1993) Mol. Biol. Cell , vol.3
    • Riss, T.L.1    A, M.R.2
  • 48
    • 0035845531 scopus 로고    scopus 로고
    • Chemosensitivity prediction by transcriptional profiling
    • Staunton, J. E. et al. Chemosensitivity prediction by transcriptional profiling. Proc. Natl. Acad. Sci. USA 98, 10787-19792 (2001).
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 10787-19792
    • Staunton, J.E.1
  • 49
    • 33745086350 scopus 로고    scopus 로고
    • Nilotinib in imatinib-resistant CML and Philadelphia chromosome-positive ALL
    • Kantarjian, H. et al. Nilotinib in imatinib-resistant CML and Philadelphia chromosome-positive ALL. N. Engl. J. Med. 354, 2542-2551 (2006).
    • (2006) N. Engl. J. Med. , vol.354 , pp. 2542-2551
    • Kantarjian, H.1
  • 50
    • 33745114173 scopus 로고    scopus 로고
    • AMN107 (nilotinib): A novel and selective inhibitor of BCR-ABL
    • Weisberg, E. et al. AMN107 (nilotinib): a novel and selective inhibitor of BCR-ABL. Br. J. Cancer 94, 1765-1769 (2006).
    • (2006) Br. J. Cancer , vol.94 , pp. 1765-1769
    • Weisberg, E.1
  • 51
    • 19044371037 scopus 로고    scopus 로고
    • Recent progress in the discovery and development of cyclin-dependent kinase inhibitors
    • Fischer, P. M. & Gianella-Borradori, A. Recent progress in the discovery and development of cyclin-dependent kinase inhibitors. Expert Opin. Investig. Drugs 14, 457-477 (2005).
    • (2005) Expert Opin. Investig. Drugs , vol.14 , pp. 457-477
    • Fischer, P.M.1    Gianella-Borradori, A.2
  • 52
    • 1842637406 scopus 로고    scopus 로고
    • Pharmacokinetic model of R-roscovitine and its metabolite in healthy male subjects
    • de la Motte, S. & Gianella-Borradori, A. Pharmacokinetic model of R-roscovitine and its metabolite in healthy male subjects. Int. J. Clin. Pharmacol. Ther. 42, 232-239 (2004).
    • (2004) Int. J. Clin. Pharmacol. Ther. , vol.42 , pp. 232-239
    • De La Motte, S.1    Gianella-Borradori, A.2
  • 53
    • 1342335029 scopus 로고    scopus 로고
    • Novel small molecular cyclin-dependent kinases modulators in human clinical trials
    • Senderowicz, A. M. Novel small molecular cyclin-dependent kinases modulators in human clinical trials. Cancer Biol. Ther. 2, S84-S95 (2003).
    • (2003) Cancer Biol. Ther. , vol.2
    • Senderowicz, A.M.1
  • 54
    • 21844438498 scopus 로고    scopus 로고
    • Recent results and ongoing trials with panitumumab (ABX-EGF), a fully human antiepidermal growth factor receptor antibody in metastatic colorectal cancer
    • Tyagi, P. Recent results and ongoing trials with panitumumab (ABX-EGF), a fully human antiepidermal growth factor receptor antibody in metastatic colorectal cancer. Clin. Colorectal Cancer 5, 21-23 (2005).
    • (2005) Clin. Colorectal Cancer , vol.5 , pp. 21-23
    • Tyagi, P.1
  • 55
    • 33144481305 scopus 로고    scopus 로고
    • Lapatinib: A novel dual tyrosine kinase inhibitor with activity in solid tumors
    • Nelson, M. H. & Dolder, C. R. Lapatinib: a novel dual tyrosine kinase inhibitor with activity in solid tumors. Ann. Pharmacother. 40, 261-269 (2006).
    • (2006) Ann. Pharmacother. , vol.40 , pp. 261-269
    • Nelson, M.H.1    Dolder, C.R.2
  • 56
    • 23944476155 scopus 로고    scopus 로고
    • Phase II safety, pharmacokinetics, and clinical activity study of lapatinib (GW572016), a reversible dual inhibitor of epidermal growth factor receptor tyrosine kinases, in heavily pretreated patients with metastatic carcinomas
    • Burris, I., H. A. et al. Phase II safety, pharmacokinetics, and clinical activity study of lapatinib (GW572016), a reversible dual inhibitor of epidermal growth factor receptor tyrosine kinases, in heavily pretreated patients with metastatic carcinomas. J. Clin. Oncol. 23, 5305-5313 (2005).
    • (2005) J. Clin. Oncol. , vol.23 , pp. 5305-5313
    • Burris, I.1    A, H.2
  • 57
    • 33644815892 scopus 로고    scopus 로고
    • Tailoring Ras-pathway-inhibitor combinations for cancer therapy
    • Blum, R. & Kloog, Y. Tailoring Ras-pathway-inhibitor combinations for cancer therapy. Drug Resist. Update 8, 369-380 (2005).
    • (2005) Drug Resist. Update , vol.8 , pp. 369-380
    • Blum, R.1    Kloog, Y.2
  • 58
    • 33746015951 scopus 로고    scopus 로고
    • Targeted inhibition of farnesyltransferase in locally advanced breast cancer: A phase I and II trial of tipifarnib plus dose-dense doxorubicin and cyclophosphamide
    • Sparano, J. A. et al. Targeted inhibition of farnesyltransferase in locally advanced breast cancer: a phase I and II trial of tipifarnib plus dose-dense doxorubicin and cyclophosphamide. J. Clin. Oncol. 24, 3013-3018 (2006).
    • (2006) J. Clin. Oncol. , vol.24 , pp. 3013-3018
    • Sparano, J.A.1
  • 59
    • 27944480502 scopus 로고    scopus 로고
    • Phase I and pharmacological study of the farnesyltransferase inhibitor tipifarnib (Zarnestra, R117555) in combination with gemcitabine and cisplatin in patients with advanced solid tumours
    • Siegel-Lakhai, W. S. et al. Phase I and pharmacological study of the farnesyltransferase inhibitor tipifarnib (Zarnestra, R117555) in combination with gemcitabine and cisplatin in patients with advanced solid tumours. Br. J. Cancer 93, 1222-1229 (2005).
    • (2005) Br. J. Cancer , vol.93 , pp. 1222-1229
    • Siegel-Lakhai, W.S.1
  • 60
    • 27744507024 scopus 로고    scopus 로고
    • mTOR, a new therapeutic target in acute myeloid leukemia
    • Racher, C., Dos Santos, C., Demur, C. & Payrastre, B. mTOR, a new therapeutic target in acute myeloid leukemia. Cell Cycle 4, 1540-1549 (2005).
    • (2005) Cell Cycle , vol.4 , pp. 1540-1549
    • Racher, C.1    Dos Santos, C.2    Demur, C.3    Payrastre, B.4
  • 61
    • 0041802820 scopus 로고    scopus 로고
    • Targeting mTOR signaling for cancer therapy
    • Huang, S. & Houghton, P. J. Targeting mTOR signaling for cancer therapy. Curr. Opin. Pharmacol. 3, 371-377 (2003).
    • (2003) Curr. Opin. Pharmacol. , vol.3 , pp. 371-377
    • Huang, S.1    Houghton, P.J.2
  • 62
    • 21044431575 scopus 로고    scopus 로고
    • Phase II study of CCI-779 in patients with recurrent glioblastoma multiforme
    • North American Brain Tumor Consortium and the National Cancer Institute
    • Chang, S. M. et al. North American Brain Tumor Consortium and the National Cancer Institute. Phase II study of CCI-779 in patients with recurrent glioblastoma multiforme. Invest. New Drugs 23, 357-361 (2005).
    • (2005) Invest. New Drugs , vol.23 , pp. 357-361
    • Chang, S.M.1
  • 63
    • 23944453425 scopus 로고    scopus 로고
    • Phase II trail of temsirolimus (CCI-779) in recurrent glioblastoma multiforme: A North Central Cancer Treatment Group Study
    • North Central Cancer Treatment Group
    • Galanis, E. et al. North Central Cancer Treatment Group. Phase II trail of temsirolimus (CCI-779) in recurrent glioblastoma multiforme: a North Central Cancer Treatment Group Study. J. Clin. Oncol. 23, 5294-5304 (2005).
    • (2005) J. Clin. Oncol. , vol.23 , pp. 5294-5304
    • Galanis, E.1
  • 64
    • 23944481410 scopus 로고    scopus 로고
    • Phase II trial of single-agent temsirolimus (CCI-779) for relapsed mantle cell lymphoma
    • Witzig, T. E. et al. Phase II trial of single-agent temsirolimus (CCI-779) for relapsed mantle cell lymphoma. J. Clin. Oncol. 23, 5357-5356 (2005).
    • (2005) J. Clin. Oncol. , vol.23 , pp. 5357-5356
    • Witzig, T.E.1
  • 65
    • 23944439945 scopus 로고    scopus 로고
    • Phase II study of temsirolimus (CCI-779), a novel inhibitor of mTOR, in heavily pretreated patients with locally advanced or metastatic breast cancer
    • Chan, S. et al. Phase II study of temsirolimus (CCI-779), a novel inhibitor of mTOR, in heavily pretreated patients with locally advanced or metastatic breast cancer. J. Clin. Oncol. 23, 5314-5322 (2005).
    • (2005) J. Clin. Oncol. , vol.23 , pp. 5314-5322
    • Chan, S.1
  • 66
    • 24944522719 scopus 로고    scopus 로고
    • Inhibition of the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin pathway but not the MEK-ERK pathway attenuates laminin-mediated small cell lung cancer cellular survival and resistance to imatinib mesylate or chemotherapy
    • Tsurutani, J., West, K. A., Sayyah, J., Gills, J. J. & Dennis, P. A. Inhibition of the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin pathway but not the MEK-ERK pathway attenuates laminin-mediated small cell lung cancer cellular survival and resistance to imatinib mesylate or chemotherapy. Cancer Res. 65, 8423-8432 (2005).
    • (2005) Cancer Res. , vol.65 , pp. 8423-8432
    • Tsurutani, J.1    West, K.A.2    Sayyah, J.3    Gills, J.J.4    Dennis, P.A.5
  • 67
    • 10744230387 scopus 로고    scopus 로고
    • Linking molecular diagnostics to molecular therapeutics: Targeting the PI3K pathway in breast cancer
    • Mills, G. B. et al. Linking molecular diagnostics to molecular therapeutics: targeting the PI3K pathway in breast cancer. Semin. Oncol. 30, 93-104 (2003).
    • (2003) Semin. Oncol. , vol.30 , pp. 93-104
    • Mills, G.B.1
  • 68
    • 33745102555 scopus 로고    scopus 로고
    • Dasatinib in imatinib-resistant Philadelphia chromosome-positive leukemias
    • Talpaz, M. et al. Dasatinib in imatinib-resistant Philadelphia chromosome-positive leukemias. N. Engl. J. Med. 354, 2531-2541 (2006).
    • (2006) N. Engl. J. Med. , vol.354 , pp. 2531-2541
    • Talpaz, M.1
  • 69
    • 33645687784 scopus 로고    scopus 로고
    • Dasatinib (BMS-354825) inhibits KITD816V, an imatinib-resistant activating mutation that triggers neoplastic growth in most patients with systemic mastocytosis
    • Shah, N. P. et al. Dasatinib (BMS-354825) inhibits KITD816V, an imatinib-resistant activating mutation that triggers neoplastic growth in most patients with systemic mastocytosis. Blood 108, 286-291 (2006).
    • (2006) Blood , vol.108 , pp. 286-291
    • Shah, N.P.1
  • 70
    • 25844467877 scopus 로고    scopus 로고
    • Inhibitors of growth factor signalling
    • Wakeling, A. E. Inhibitors of growth factor signalling. Endocr. Relat. Cancer (12 Suppl. 1), S183-S187 (2005).
    • (2005) Endocr. Relat. Cancer , vol.12 , Issue.1 SUPPL.
    • Wakeling, A.E.1
  • 71
    • 32044467693 scopus 로고    scopus 로고
    • Phase II data with ZD6474, a small-molecule kinase inhibitor of epidermal growth factor receptor and vascular endothelial growth factor receptor, in previously treated advanced non-small-cell lung cancer
    • Lee, D. Phase II data with ZD6474, a small-molecule kinase inhibitor of epidermal growth factor receptor and vascular endothelial growth factor receptor, in previously treated advanced non-small-cell lung cancer. Clin. Lung Cancer 7, 89-91 (2005).
    • (2005) Clin. Lung Cancer , vol.7 , pp. 89-91
    • Lee, D.1
  • 72
    • 85082027058 scopus 로고    scopus 로고
    • A phase II study of ZD6474 (Zactimatrade mark), a selective inhibitor of VEGFR and EGFR tyrosine kinase in patients with relapsed multiple myeloma-NCIC CTG IND. 145
    • in the press
    • Kovacs, M. J. et al. A phase II study of ZD6474 (Zactimatrade mark), a selective inhibitor of VEGFR and EGFR tyrosine kinase in patients with relapsed multiple myeloma-NCIC CTG IND. 145. Invest. New Drugs (in the press).
    • Invest. New Drugs
    • Kovacs, M.J.1
  • 73
    • 33744954585 scopus 로고    scopus 로고
    • Sunitinib in patients with metastatic renal cell carcinoma
    • Motzer, R. J. et al. Sunitinib in patients with metastatic renal cell carcinoma. JAMA 295, 2516-2524 (2006).
    • (2006) JAMA , vol.295 , pp. 2516-2524
    • Motzer, R.J.1
  • 74
    • 33644935244 scopus 로고    scopus 로고
    • SU11248 and AG013736: Current data and future trials in renal call carcinoma
    • Rini, B. I. SU11248 and AG013736: current data and future trials in renal call carcinoma. Clin. Genitourin. Cancer 4, 175-180 (2005).
    • (2005) Clin. Genitourin. Cancer , vol.4 , pp. 175-180
    • Rini, B.I.1
  • 75
    • 30944446883 scopus 로고    scopus 로고
    • Lessons from phase III clinical trials on anti-VEGF therapy for cancer
    • Jain, R. K., Duda, D. G., Clark, J. W. & Loeffler, J. S. Lessons from phase III clinical trials on anti-VEGF therapy for cancer. Nature Clin. Pract. Oncol. 3, 24-40 (2006).
    • (2006) Nature Clin. Pract. Oncol. , vol.3 , pp. 24-40
    • Jain, R.K.1    Duda, D.G.2    Clark, J.W.3    Loeffler, J.S.4
  • 76
    • 20444473802 scopus 로고    scopus 로고
    • Phase I clinical and pharmacokinetic study of PTK/ZK, a multiple VEGF receptor inhibitor, in patients with liver metastases from solid tumours
    • Mross, K. et al. Phase I clinical and pharmacokinetic study of PTK/ZK, a multiple VEGF receptor inhibitor, in patients with liver metastases from solid tumours. Eur. J. Cancer 41, 1291-1299 (2005).
    • (2005) Eur. J. Cancer , vol.41 , pp. 1291-1299
    • Mross, K.1
  • 77
    • 21844464600 scopus 로고    scopus 로고
    • Vatalanib (PTK787/ZK 222584) in combination with FOLFOX4 versus FOLFOX4 alone as first-line treatment for colorectal cancer: Preliminary results from the CONFIRM-1 trial
    • Tyagi, P. Vatalanib (PTK787/ZK 222584) in combination with FOLFOX4 versus FOLFOX4 alone as first-line treatment for colorectal cancer: preliminary results from the CONFIRM-1 trial. Clin. Colorectal Cancer 5, 24-26 (2005).
    • (2005) Clin. Colorectal Cancer , vol.5 , pp. 24-26
    • Tyagi, P.1
  • 78
    • 27544503230 scopus 로고    scopus 로고
    • Gefitinib plus best supportive care in previously treated patients with refractory advanced non-small-cell lung cancer: Results from a randomised, placebo-controlled, multicentre study (Iressa Survival Evaluation in Lung Cancer)
    • Thatcher, N. et al. Gefitinib plus best supportive care in previously treated patients with refractory advanced non-small-cell lung cancer: results from a randomised, placebo-controlled, multicentre study (Iressa Survival Evaluation in Lung Cancer). Lancet 366, 1527-1537 (2005).
    • (2005) Lancet , vol.366 , pp. 1527-1537
    • Thatcher, N.1
  • 79
    • 33746862936 scopus 로고    scopus 로고
    • Epidermal growth factor receptor inhibitors in development for the treatment of non-small cell lung cancer
    • Heymach, J. V., Nilsson, M., Blumenschein, G., Papadimitrakopoulou, V. & Herbst, R. Epidermal growth factor receptor inhibitors in development for the treatment of non-small cell lung cancer. Clin. Cancer Res. 12, 4441s-4445s (2006).
    • (2006) Clin. Cancer Res. , vol.12
    • Heymach, J.V.1    Nilsson, M.2    Blumenschein, G.3    Papadimitrakopoulou, V.4    Herbst, R.5
  • 80
    • 33646888233 scopus 로고    scopus 로고
    • Where next for gefitinib in patients with lung cancer?
    • Blackhall, F., Ranson, M. & Thatcher, N. Where next for gefitinib in patients with lung cancer? Lancet Oncol. 7, 499-507 (2006).
    • (2006) Lancet Oncol. , vol.7 , pp. 499-507
    • Blackhall, F.1    Ranson, M.2    Thatcher, N.3
  • 81
    • 33646381931 scopus 로고    scopus 로고
    • Gefitinib therapy in advanced bronchiolaolveolar carcinoma: Southwest Oncology Group Study S0126
    • West, H. L. et al. Gefitinib therapy in advanced bronchiolaolveolar carcinoma: Southwest Oncology Group Study S0126. J. Clin. Oncol. 24, 1807-1813 (2006).
    • (2006) J. Clin. Oncol. , vol.24 , pp. 1807-1813
    • West, H.L.1
  • 82
    • 32044461557 scopus 로고    scopus 로고
    • Second-line treatment options in non-small cell lung cancer: A comparison of cytotoxic agents and targeted therapies
    • de marinis, F., De Santis, S. & De Petris, L. Second-line treatment options in non-small cell lung cancer: a comparison of cytotoxic agents and targeted therapies. Semin. Oncol. 33, S17-S24 (2006).
    • (2006) Semin. Oncol. , vol.33
    • De Marinis, F.1    De Santis, S.2    De Petris, L.3


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