The restriction point and control of cell proliferation

Current Opinion in Cell Biology

Volumn 9, Issue 6, 1997, Pages 768-772

  Planas Silva, Maricarmen D ^a   Weinberg, Robert A ^a  

^a WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

RETINOBLASTOMA PROTEIN;

CELL CYCLE; CELL CYCLE G1 PHASE; CELL PROLIFERATION; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; REVIEW; SIGNAL TRANSDUCTION;

EID: 0030657690     PISSN: 09550674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0955-0674(97)80076-2     Document Type: Article

References (63)

1. Pardee AB: G1 events and regulation of cell proliferation. Science 1989, 246:603-608.
2. Zetterberg A, Larsson O, Wiman KG: What is the restriction point? Curr Opin Cell Biol 1995, 7:835-842.
3. Pardee AB: A restriction point for control of normal animal cell proliferation. Proc Natl Acad Sci USA 1974, 71:1286-1290.
4. Polyak K, Kato J, Solomon MJ, Sherr CJ, Massagué J, Roberts JM, Koff A: p27kip, a cyclin-cdk inhibitor, links transforming growth factor-β and contact inhibition to cell cycle arrest Genes Dev 1994, 8:9-22.
5. Geng Y, Weinberg RA: TGF-β effects on expression of G1 cyclins and cdks. Proc Natl Acad Sci USA 1993, 90:10315-10319.
6. Paulovich AG, Toczynski DP, Hartwell LH: When checkpoints fail. Cell 1997, 88:315-321.
7. 1 phase is linked to the pRb pathway.
8. Kip1. Mol Cell Biol 1997, 17:3850-3867.
9. Lloyd AC, Obermüller F, Staddon S, Barth CF, McMahon M, Land H: Cooperating oncogenes converge to regulate cyclin/cdk complexes. Genes Dev 1997, 11:663-677. This study shows that oncogenes that block p53 action are able to cooperate with Raf. These oncogenes prevent p21 induction by Raf, thereby allowing activation of cyclin-dependent kinase 2-cyclin complexes.
10. Weinberg RA: The retinoblastoma protein and cell cycle control. Cell 1995, 81:323-330.
11. Bartek J, Bartkova J, Lukas J: The retinoblastoma protein pathway and the restriction point Curr Opin Cell Biol 1996, 8:805-814. An excellent and thorough review of the restriction point concept and its connections with the retinoblastoma protein.
12. DelSal G, Loda M, Pagano M: Cell cycle and cancer: critical events at the G1 restriction point Crit Rev Oncog 1996, 7:127-142. An excellent review and overview of the interactions of cyclins, cyclin-dependent kinases, and their inhibitors in normal and cancer cells.
13. Kato J, Matsushime H, Hiebert SW, Ewen ME, Sherr CJ: Direct binding of cyclin D to the retinoblastoma gene product (pRb) and pRb phosphorylation by the cyclin D-dependent kinase CDK4. Genes Dev 1993, 7:331-342.
14. Horton LE, Qian Y, Templeton DJ: G1 cyclins control the retinoblastoma gene product growth regulation activity via upstream mechanisms. Cell Growth Differ 1995, 6:395-407.
15. Hatakeyama M, Brill JA, Fink GR, Weinberg RA: Collaboration of G1 cyclins in the functional inactivation of the retinoblastoma protein. Genes Dev 1994, 8:1759-1771.
16. Resnitzky, D, Reed SI: Different roles for cyclins D1 and E in regulation of the G1-to-S transition. Mol Cell Biol 1995, 15:3463-3469.
17. •], characterizes the phosphorylation of the retinoblastoma protein (pRb) by different cyclin-dependent kinase (CDK)-cyclin complexes. Although the site of inactivation of pRb by CDK4-cyclin D1 is distinct in each paper (as is the functional assay used to used to test the site), these studies reach the same conclusions concerning differential pRb phosphorylation by CDK4-cyclin D1 and CDK2-cyclin complexes. In this paper, the authors show that only CDK4-cyclin D1 is able to functionally inactivate pRb as determined by a microinjection-based cell cycle assay. The phosphorylation site required for this effect was mapped to serine 795.
18. •].
19. •].
20. Matsushime H, Roussel MF, Ashmun RA, Sherr CJ: Colony-stimulating factor 1 regulates novel cyclins during the G1 phase of the cell cycle. Cell 1991, 65:701-713.
21. Sewing A, Bürger C, Brüsselbach S, Schalk C, Lucibello FC, Müller R: Human cyclin D1 encodes a labile nuclear protein whose synthesis is directly induced by growth factors and suppressed by cyclic AMP. J Cell Sci 1993, 104:545-655.
22. Hannon GJ, Beach D: p15INK4B is a potential effector of TGF-β-induced cell cycle arrest. Nature 1994, 371:257-261.
23. Reynisdottir I, Polyak K, Iavarone A, Massague J: Kip/Cip and Ink4 Cdk inhibitors cooperate to induce cell cycle arrest in response to TGF-β. Genes Dev 1995, 9:1831-1845.
24. Ewen ME, Sluss HK, Whitehouse LL, Livingston DM: TGF-β inhibition of Cdk4 synthesis is linked to cell cycle arrest. Cell 1993, 74:1009-1020.
25. Iavarone A, Massagué J: Repression of the CDK activator Cdc25A and cell-cycle arrest by cytokine TGF-β in cells lacking the CDK inhibitor p15. Nature 1997, 382:417-422. In this paper it is shown that transforming growth factor is able to cause a downregulation of Cdc25A expression which results in turn in an increased level of tyrosine phosphorylation on cyclin-dependent kinase (CDK) 4 and CDK6 but not on CDK2.
26. Rossow PW, Riddle VG, Pardee AB: Synthesis of labile serum-dependent protein in early G1 controls animal cell growth. Proc Natl Acad Sci USA 1979, 76:4446-4450.
27. PSK-J3/CDK4) for mammalian D-type G1 cyclins. Cell 1992, 71:323-334.
28. 1-S phase protein kinase. Science 1992, 257:1958-1961.
29. 1 to S transition in Drosophila: cyclin E is a limiting downstream target of E2F. Genes Dev 1995, 9:1458-1468.
30. 1 phase of the human cell cycle. Science 1992, 257:1689-1694.
31. Koff A, Ohtsuki M, Polyak K, Roberts JM, Massagué J: Negative regulation of G1 in mammalian cells: inhibition of cyclin E-dependent kinase by TGF-β. Science 1993, 260:536-539.
32. Dou O-P, Levin AH, Zhao S, Pardee AB: Cyclin E and cyclin A as candidates for the restriction point protein. Cancer Res 1993, 53:1493-1497.
33. Lukas J, Herzinger T, Hansen K, Moroni MC, Resnitzky D, Helin K, Reed SI, Bartek J: Cyclin E-induced S phase without activation of the pRb/E2F pathway. Genes Dev 1997, 11:1479-1492. In this study, ectopic expression of cyclin E is shown to overcome the inhibitory effects of p16, a phosphorylation-deficient pRb and a dominant-negative DP1, thereby promoting S-phase entry. Hence, the most important functions of the E2Fs (proteins that are normally inhibited by the pocket proteins mentioned above) in cycling cells may be to turn on cyclin E, which on its own can induce cells to enter S phase.
34. Ohtsubo M, Theodoras AM, Schumacher J, Roberts JM, Pagano M: Human cyclin E, a nuclear protein essential for the G1-to-S phase transition. Mol Cell Biol 1995, 15:2612-2624.
35. Sherr C: G1 phase progression: cyclin on cue. Cell 1994, 79:551-555.
36. Sherr CJ, Roberts JM: Inhibitors of mammalian G1 cyclin-dependent kinases. Genes Dev 1995, 9:1149-1163.
37. Kip1 for restriction point control of the fibroblast cell cycle. Science 1996, 272:877-880. The central role of p27 in enabling cells to exit the cell cycle and in holding cells in Quiescence is demonstrated.
38. Pagano M, Tam SW, Theodoras AM, Beer-Romero P, Del Sal G, Chau V, Yew PR, Draetta GF, Rolfe M: Role of the ubiquitin-proteasome pathway in regulating abundance of the cyclin-dependent kinase inhibitor p27. Science 1995, 269:682-685.
39. IGp1 by platelet-derived growth factor. J Biol Chem 1996, 271:11253-11260.
40. Agrawal D, Hauser P, McPherson F, Dong F, Garcia A, Pledger WJ: Repression of p27Kip synthesis by platelet-derived growth factor in Balb/c 3T3 cells. Mol Cell Biol 1996, 16:4327-4336.
41. •].
42. Kip1 accumulation during the cell cycle. Science 1996, 271:1861-1864.
43. Cross FR: Starting the cell cycle: what's the point? Curr Opin Cell Biol 1995, 7:781-789.
44. Geng Y, Eaton E, Picon M, Roberts J, Lundberg A, Gifford A, Sardet C, Weinberg R: Regulation of cyclin E transcription by E2Fs and retinoblastoma protein. Oncogene 1996, 12:1173-1179.
45. Ohtani K, DeGregori J, Nevins JR: Regulation of the cyclin E gene by transcription factor E2F1. Proc Natl Acad Sci USA 1995, 92:12146-12150.
46. 1 restriction point regulation in Rb-deficient fibroblasts. Mol Cell Biol 1996, 16:2402-2407.
47. Kip1. Genes Dev 1997, 11:1464-1478.
48. Lavoie JN, LAllemain G, Brunet A, Muller R, Pouyssegur J: Cyclin D1 expression is regulated positively by the p42/p44 MAPK and negatively by the p38/HOG MAPK pathway. J Biol Chem 1996, 271:20608-20616.
49. Liu JJ, Chao JR, Jiang MC, Ng SY, Yen JJ, Yang YH: Ras transformation results in an elevated level of cyclin D1 and acceleration of G1 progression in NIH3T3 cells. Mol Cell Biol 1995, 15:3654-3663.
50. 1 checkpoint. Mol Cell Biol 1996, 16:6917-6925. Shows that the signals from three classes of receptors and associated signal transduction cascades converge on D-type cyclins and thus on phosphorylation of the retinoblasloma protein.
51. Vadiveloo PK, Vairo G, Novak U, Royston AK, Whitty G, Filonzi EL, Cragoe EJ Jr, Hamilton JA: Differential regulation of cell cycle machinery by various antiproliferative agents is linked to macrophage arrest at distinct G1 checkpoints. Oncogene 1996, 13:599-608.
52. Kip1 by diverse signalling pathways in Swiss 3T3 cells. Oncogene 1997, 14:1759-1766.
53. Muthukkumar S, Sells SF, Crist SA, Rangnekar VM: Interleukin-1 induces growth arrest by hypophosphorylation of the retinoblastoma susceptibility gene product RB. J Biol Chem 1996, 271:5733-5740.
54. Schnier JB, Gadbois DM, Nishi K, Bradbury EM: The kinase Inhibitor staurosporine induces G1 arrest at two points: effect on retinoblastoma protein phosphorylation and cyclin-dependent kinase 2 in normal and transformed cells. Cancer Res 1994, 54:5959-5963.
55. Wilcken NRC, Musgrove EA , Sutherland RL: Different points of action of retinoids and anti-estrogens in G1 phase identified in synchronized T-47D breast cancer cells. Int J Cancer 1997, 70:291-296.
56. Kip1) of cyclin-dependent kinase 4 activation. Cell 1994, 79:487-496.
57. Lalande M: A reversible arrest point in the late G1 phase of the mammalian cell cycle. Exp Cell Res 1990, 186:332-339.
58. L'Allemain G, Lavoie JN, Rivard N, Baldin V, Pouyssegur J: Cyclin D1 expression is a major target of the cAMP-induced inhibition of cell cycle entry in fibroblasts. Oncogene 1997, 14:1981-1990.
59. Goya L. Maiyar AC, Ge Y, Firestone GL: Glucocorticoids induce a G1/G0 cell cycle arrest of Con8 rat mammary tumor cells that is synchronously reversed by steroid withdrawal or addition of transforming growth factor-α Mol Endocrinol 1993, 7:1121-1132.
60. 1 in mammary epithelial cells which correlates with a block in hyperphosphorylation of retinoblastoma. Cell Growth Differ 1996, 7:289-300.
61. 1 phase at which their anchorage is required for cell cycle progression.
62. Fang F, Orend G, Watanabe N, Hunter T, Ruoslahti E: Dependence of cyclin E-CDK2 kinase activity on cell anchorage. Science 1996, 271:499-502.
63. Schulze A, Zerfass-Thome K, Berges J, Middendorp S, Jansen-Dürr P, Henglein B: Anchorage-dependent transcription of the cyclin A gene. Mol Cell Biol 1996, 16:4632-4638.