Minichromosome maintenance proteins 2 and 5 expression in muscle-invasive urothelial cancer: A multivariate survival study including proliferation markers and cell cycle regulators

Human Pathology

Volumn 36, Issue 8, 2005, Pages 899-907

  Korkolopoulou, Penelope ^a   Givalos, Nikolaos ^a   Saetta, Angelica ^a   Goudopoulou, Athina ^a   Gakiopoulou, Hariklia ^a   Thymara, Irene ^a   Thomas Tsagli, Euphemia ^b   Patsouris, Efstratios ^a  

^a UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

^b Asklepeion Voula Hospital   (Greece)

Author keywords

Cell cycle regulators; Minichromosome maintenance proteins; Muscle invasive urothelial cancer

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 1; CYCLIN DEPENDENT KINASE INHIBITOR 1B; KI 67 ANTIGEN; MINICHROMOSOME MAINTENANCE PROTEIN 2; MINICHROMOSOME MAINTENANCE PROTEIN 5; PROTEIN; PROTEIN P53; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; BLADDER CARCINOMA; CANCER GROWTH; CANCER INVASION; CANCER SURVIVAL; CELL CYCLE; CELL CYCLE G1 PHASE; DETRUSOR MUSCLE; FEMALE; HUMAN; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MALE; PROTEIN EXPRESSION; UROGENITAL TRACT TUMOR;

ADULT; AGED; AGED, 80 AND OVER; CARCINOMA, TRANSITIONAL CELL; CELL CYCLE PROTEINS; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLIN-DEPENDENT KINASE INHIBITOR P27; DNA-BINDING PROTEINS; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; KI-67 ANTIGEN; MALE; MIDDLE AGED; MUSCLE NEOPLASMS; PROGNOSIS; RETROSPECTIVE STUDIES; SCHIZOSACCHAROMYCES POMBE PROTEINS; SURVIVAL ANALYSIS; SURVIVAL RATE; TUMOR MARKERS, BIOLOGICAL; TUMOR SUPPRESSOR PROTEIN P53; TUMOR SUPPRESSOR PROTEINS; URINARY BLADDER NEOPLASMS; UROTHELIUM;

EID: 23944515316     PISSN: 00468177     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.humpath.2005.06.008     Document Type: Article

References (35)

1. Zlotta AR, Schulman CC. Biological markers in superficial bladder tumours and their prognostic significance. Urol Clin North Am 2000;27:179-189, xi-xii.
2. B.K. Tye MCM proteins in DNA replication Annu Rev Biochem 68 1999 649 686
3. M. Ritzi, and R. Knippers Initiation of genome replication: assembly and disassembly of replication-competent chromatin Gene 245 2000 13 20
4. K. Labib, and J.F. Diffley Is the MCM2-7 complex the eukaryotic DNA replication fork helicase? Curr Opin Genet Dev 11 2001 64 70
5. M. Lei, and B.K. Tye Initiating DNA synthesis: from recruiting to activating the MCM complex J Cell Sci 114 2001 1447 1454
6. Z. Yu, D. Feng, and C. Liang Pairwise interactions of the six human MCM protein subunits J Mol Biol 340 2004 1197 1206
7. K. Stoeber, T.D. Tlsty, L. Happerfield, G.A. Thomas, S. Romanov, and L. Bohrow DNA replication licensing and human cell proliferation J Cell Sci 114 2001 2027 2041
8. G.H. Williams, P. Romanowski, L. Morris, M. Madine, A.D. Mills, and K. Stoeber Improved cervical smear assessment using antibodies against proteins that regulate DNA replication Proc Natl Acad Sci U S A 95 1998 14932 14937
9. S. Krüger, C. Thorns, W. Stöcker, E. Müller-Kunert, A. Böhle, and A. Feller Prognostic value of MCM2 immunoreactivity in stage T1 transitional cell carcinoma of the bladder Eur Urol 43 2003 138 145
10. K. Stoeber, I. Halsall, A. Freeman, R. Swinn, A. Doble, and L. Morris Immunoassay for urothelial cancers that detects DNA replication protein MCM5 in urine Lancet 354 1999 1524 1525
11. F.L. Greene, D.L. Page, I.D. Fleming, A.G. Fritz, C.M. Balch, and D.G. Haller AJCC cancer staging manual 2002 Springer-Verlag New York
12. N. Eble, G. Sauter, J.I. Epstein, and A. Sesterhenn The World Health Organization classification of tumours. Pathology and genetics. Tumours of the urinary system and male genital organs 2004 AIRC Press Lyon 90
13. P. Korkolopoulou, P. Christodoulou, A. Lazaris, E. Thomas-Tsagli, P. Kapralos, and A. Papanikolaou Prognostic implications of aberrations in p16/pRb pathway in urothelial bladder carcinomas: a multivariate analysis including p53 expression and proliferation markers Eur Urol 39 2001 167 177
14. S.B. Wharton, K.K. Chan, J.R. Anderson, K. Stoeber, and G.H. Williams Replicative Mcm2 protein as a novel proliferation marker in oligodendrogliomas and its relationship to Ki67 labeling index, histological grade and prognosis Neuropathol Appl Neurobiol 27 2001 305 313
15. K. Rodins, K. Cheale, N. Coleman, and S.B. Fox Minichromosome maintenance protein 2 expression in normal kidney and renal cell carcinomas: relationship to tumor dormancy and potential clinical utility Clin Cancer Res 8 2002 1075 1081
16. D.P.J. Hunt, A. Freeman, L.S. Morris, N.G. Burnet, K. Bird, and T.W. Davies Early recurrence of benign meningioma correlates with expression of mini-chromosome maintenance-2 protein Br J Neurosurg 58 1993 51 56
17. P. Korkolopoulou, P. Christodoulou, A.-E. Konstantinidou, E. Thomas-Tsagli, P. Kapralos, and P. Davaris Cell cycle regulators in bladder cancer: a multivariate survival study with emphasis on p27Kip1 Hum Pathol 31 2000 751 760
18. P. Korkolopoulou, A.-E. Konstantinidou, E. Thomas-Tsagli, P. Christodoulou, P. Kapralos, and P. Davaris WAF1/p21 expression is an independent prognostic indicator in superficial and invasive bladder cancer Appl Immunohistochem Mol Morphol 8 2000 285 292
19. P. Korkolopoulou, P. Christodoulou, and P. Kapralos The role of p53, MDM2 and c-erbB2 oncoproteins, epidermal growth factor receptor and proliferation markers in the prognosis of urinary bladder cancer Pathol Res Pract 193 1998 767 775
20. M.V. Meng, G.D. Grossfeld, G.H. Williams, S. Dilworth, K. Stoeber, and T.W. Mulley Minichromosome maintenance protein 2 expression in prostate: characterization and association with outcome after therapy for cancer Clin Cancer Res 7 2001 2712 2718
21. H.J. Heidebrecht, F. Buck, E. Endl, M.L. Kruse, S. Adam-Klages, and K. Andersen Ki-Mcm6, a new monoclonal antibody specific to Mcm6: comparison of the distribution profile of Mcm6 and the Ki-67 antigen Lab Invest 81 2001 1163 1165
22. J.J. Going, W.N. Keith, L. Neilson, K. Stoeber, R.C. Stuart, and G.H. Williams Aberrant expression of minichromosome maintenance proteins 2 and 5, and Ki-67 in dysplastic squamous oesophageal epithelium and Barrett's mucosa Gut 50 2002 373 377
23. I. Kodan, K. Shomori, M. Osaki, I. Kuratate, K. Ryoke, and H. Ito Expression of minichromosome maintenance 2 (MCM2), Ki-67 and cell cycle-related molecules, and apoptosis in the normal-dysplasia-carcinoma sequence of the oral mucosa Pathobiology 69 2001 150 158
24. I.T. Todorov, B.A. Werness, H.Q. Wang, L.N. Buddharaju, P.D. Todorova, and H.K. Slocum HsMCM2/BM28: a novel proliferation marker for human tumors and normal tissues Lab Invest 78 1998 73 78
25. A. Freeman, L.S. Morris, and A.D. Mills Minichromosome maintenance proteins as biological markers of dysplasia and malignancy Clin Cancer Res 5 1999 2121 2132
26. M. Osaki, M. Osaki, H. Yamashita, K. Shomori, H. Yoshida, and H. Ito Expression of minichromosome maintenance-2 in human malignant fibrous histiocytomas: correlations with Ki-67 and p53 expression, and apoptosis Int J Mol Med 10 2002 161 168
27. T. Scholzen, and J. Gerdes The Ki-67 protein: from the known and the unknown J Cell Physiol 182 2000 311 322
28. D.E. MacCallum, and P.E. Hall The location of pKi67 in the outer dense fibrillary compartment of the nucleolus points to a role in ribosome biogenesis during the cell division cycle J Pathol 190 2000 537 544
29. I.T. Todorov, R. Pepperkok, R.N. Philipova, S.E. Kearsey, W. Ansorge, and D. Werner A human nuclear protein with sequence homology to a family of early S phase proteins is required for entry into S phase and for cell division J Cell Sci 107 1994 253 265
30. R.N. Philipova, A.P. Vassilev, and R.P. Kaneva Expression of the nuclear protein mitotin in differentiating in vitro HL60 cells Biol Cell 72 1991 47 50
31. M.R. Alison, T. Hunt, and S.J. Forbes Minichromosome maintenance (MCM) proteins may be pre-cancer markers Gut 50 2002 290 291
32. M.A. Gonzalez, S.E. Pinder, G. Callagy, S.L. Vowler, L.S. Morris, and K. Bird Minichromosome maintenance protein 2 is a strong independent prognostic marker in breast cancer J Clin Oncol 21 2003 4306 4313
33. N. Ramnath, F.J. Hernandez, D.-F. Tan, J.A. Huberman, N. Natarajan, and A.F. Beck MCM2 is an independent predictor of survival in patients with non-small-cell lung cancer J Clin Oncol 22 2001 4259 4266
34. G.H. Williams, R. Swinn, A.T. Prevost, P. De Clive-Lowe, I. Halsall, and J.J. Going Diagnosis of oesophageal cancer by detection of minichromosome maintenance 5 protein in gastric aspirates Br J Cancer 91 2004 714 719
35. D. Esrig, D. Elmajian, S. Groshen, J.A. Freeman, J.P. Stein, and S.-C. Chen Accumulation of nuclear p53 and tumor progression in bladder cancer N Engl J Med 331 1994 1259 1264