Relating skin sensitizing potency to chemical reactivity: Reactive Michael acceptors inhibit NF-κB signaling and are less sensitizing than S NAr- and S N2-reactive chemicals

Chemical Research in Toxicology

Volumn 24, Issue 11, 2011, Pages 2018-2027

  Natsch, Andreas ^a   Haupt, Tina ^a   Laue, Heike ^a  

^a GIVAUDAN SCHWEIZ AG   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMICAL AGENT; I KAPPA B KINASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MICHAEL ACCEPTOR; UNCLASSIFIED DRUG;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; CHEMICAL MODEL; CHEMICAL REACTION; HUMAN; HUMAN CELL; IN VITRO STUDY; KINETICS; LOCAL LYMPH NODE ASSAY; REPRODUCIBILITY; SIGNAL TRANSDUCTION; SKIN SENSITIZATION;

ANIMALS; ARNICA; DERMATITIS, ALLERGIC CONTACT; HUMANS; I-KAPPA B KINASE; IMMUNIZATION; KINETICS; LACTONES; LOCAL LYMPH NODE ASSAY; MICE; NF-KAPPA B; PEPTIDES; PICRYL CHLORIDE; PLANT EXTRACTS; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; SESQUITERPENES; SIGNAL TRANSDUCTION; SKIN;

EID: 81755167002     PISSN: 0893228X     EISSN: 15205010     Source Type: Journal    
DOI: 10.1021/tx2003678     Document Type: Article

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