The cutaneous biochemical redox barrier: A component of the innate immune defenses against sensitization by highly reactive environmental xenobiotics

Journal of Immunology

Volumn 183, Issue 11, 2009, Pages 7576-7584

  Pickard, Chris ^a   Louafi, Fethi ^a   McGuire, Carolann ^a   Lowings, Kelly ^a   Kumar, Pawan ^a   Cooper, Hywel ^a   Dearman, Rebecca J ^b   Cumberbatch, Marie ^b   Kimber, Ian ^b   Healy, Eugene ^a   Friedmann, Peter S ^a  

^a SOUTHAMPTON GENERAL HOSPITAL   (United Kingdom)

^b UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

1 CHLORO 2,4 DINITROBENZENE; 2,4 DINITROPHENYL THIOCYANATE; GLUTATHIONE; NITROBENZENE DERIVATIVE; UNCLASSIFIED DRUG; XENOBIOTIC AGENT; 2,4-DINITROTHIOCYANATOBENZENE; IRRITANT AGENT;

ADULT; ARTICLE; COMPARATIVE STUDY; CONTACT ALLERGY; CONTROLLED STUDY; EPIDERMAL BIOCHEMICAL REDOX BARRIER; EPIDERMIS; FEMALE; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; INNATE IMMUNITY; LANGERHANS CELL; MALE; PRIORITY JOURNAL; SKIN PENETRATION; SKIN SENSITIZATION; STRATUM CORNEUM; CHEMISTRY; CONTACT DERMATITIS; DRUG EFFECT; ENVIRONMENTAL EXPOSURE; IMMUNOLOGY; KERATINOCYTE; OXIDATION REDUCTION REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SKIN; SKIN TEST;

ADULT; DERMATITIS, CONTACT; DINITROBENZENES; DINITROCHLOROBENZENE; ENVIRONMENTAL EXPOSURE; FEMALE; HUMANS; IMMUNITY, INNATE; IRRITANTS; KERATINOCYTES; MALE; OXIDATION-REDUCTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SKIN; SKIN TESTS; XENOBIOTICS;

EID: 73349087840     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.0901064     Document Type: Article

References (20)

1. Grabbe, S., M. Steinert, K. Mahnke, A. Schwartz, T. A. Luger, and T. Schwarz. 1996. Dissection of antigenic and irritative effects of epicutaneously applied haptens in mice: evidence that not the antigenic component but nonspecific proinflammatory effects of haptens determine the concentration-dependent elicitation of allergic contact dermatitis. J. Clin. Invest. 98: 1158-1164. (Pubitemid 26299929)
2. Basketter, D. A., R. J. Dearman, J. Hilton, and I. Kimber. 1997. Dinitrohalobenzenes: evaluation of relative skin sensitization potential using the local lymph node assay. Contact Dermatitis 36: 97-100. (Pubitemid 27095634)
3. Sommer, G., D. Parker, and J. L. Turk. 1975. Epicutaneous induction of hyporeactivity in contact sensitization: demonstration of suppressor cells induced by contact with 2,4-dinitrothiocyanatebenzene. Immunology 29: 517-525.
4. Iijima, M., and S. I. Katz. 1983. Specific immunologic tolerance to dinitrofluorobenzene following topical application of dinitrothiocyanobenzene: modulation by suppressor T cells. J. Invest. Dermatol. 81: 325-330. (Pubitemid 13013576)
5. Parker, D., P. V. Long, and J. L. Turk. 1983. A comparison of the conjugation of DNTB and other dinitrobenzenes with free protein radicals and their ability to sensitize or tolerize. J. Invest. Dermatol. 81: 198-201.
6. Kolde, G., and J. Knop. 1987. Different cellular reaction patterns of epidermal Langerhans cells after application of contact sensitizing, toxic, and tolerogenic compounds: a comparative ultrastructural and morphometric time-course analysis. J. Invest. Dermatol. 89: 19-23. (Pubitemid 17084178)
7. Kimber, I., P. A. Botham, N. J. Rattray, and S. T. Walsh. 1986. Contact-sensitizing and tolerogenic properties of 2,4-dinitrothiocyanobenzene. Int. Arch. Allergy Appl. Immunol. 81: 258-264.
8. Kimber, I., and R. J. Dearman. 1991. Investigation of lymph node cell proliferation as a possible immunological correlate of contact sensitizing potential. Food Chem. Toxicol. 29: 125-129.
9. Dearman, R. J., M. Cumberbatch, J. Hilton, I. Fielding, D. A. Basketter, and I. Kimber. 1997. A re-appraisal of the skin-sensitizing activity of 2,4-dinitrothiocyanobenzene. Food Chem. Toxicol. 35: 261-269.
10. Weinlich, G., M. Heine, H. Stossel, M. Zanella, P. Stoitzner, U. Ortner, J. Smolle, F. Koch, N. T. Sepp, G. Schuler, and N. Romani. 1998. Entry into afferent lymphatics and maturation in situ of migrating murine cutaneous dendritic cells. J. Invest. Dermatol. 110: 441-448. (Pubitemid 28158664)
11. Cumberbatch, M., R. J. Dearman, and I. Kimber. 2001. Differential epidermal responses to the skin sensitizing chemicals dinitrochlorobenzene and dinitrothiocyanobenzene. Br. J. Dermatol. 144: 654 (Abstr.).
12. Friedmann, P. S., S. I. White, S. Parker, C. Moss, and J. N. S. Matthews. 1989. Antigenic stimulation during ultraviolet therapy in man does not result in immunological tolerance. Clin. Exp. Immunol. 76: 68-72.
13. Friedmann, P. S., C. Moss, S. Shuster, and J. M. Simpson. 1983. Quantitative relationships between sensitizing dose of DNCB and reactivity in normal subjects. Clin. Exp. Immunol. 53: 709-711.
14. Griffiths, C. E., M. Cumberbatch, S. C. Tucker, R. J. Dearman, S. Andrew, D. R. Headon, and I. Kimber. 2001. Exogenous topical lactoferrin inhibits allergen-induced Langerhans cell migration and cutaneous inflammation in humans. Br. J. Dermatol. 144: 715-725.
15. Cumberbatch, M., C. E. Griffiths, S. C. Tucker, R. J. Dearman, and I. Kimber. 1999. Tumor necrosis factor-α induces Langerhans cell migration in humans. Br. J. Dermatol. 141: 192-200. (Pubitemid 29397983)
16. Cumberbatch, M., R. J. Dearman, C. Antonopoulos, R. W. Groves, and I. Kimber. 2001. Interleukin (IL)-18 induces Langerhans cell migration by a tumor necrosis factor-α- and IL-1β-dependent mechanism. Immunology 102: 323-330. (Pubitemid 32281160)
17. Cumberbatch, M., R. J. Dearman, C. E. Griffiths, and I. Kimber. 2003. Epidermal Langerhans cell migration and sensitization to chemical allergens. APMIS 111: 797-804.
18. Ogawa, H., A. Taneda, Y. Kanaoka, and T. Sekine. 1979. The histochemical distribution of protein bound sulfhydryl groups in human epidermis by the new staining method. J. Histochem. Cytochem. 27: 942-946. (Pubitemid 9196227)
19. Eisen, H. N., and S. Belman. 1953. Studies of hypersensitivity to low molecular weight substances. II. Reactions of some allergenic substituted dinitrobenzenes with cysteine or cystine of skin proteins. J. Exp. Med. 98: 533-549.
20. Degani, C., and Y. Degani. 1980. Further evidence for nonsymmetric subunit association and intersubunit cooperativity in creatine kinase: subunit-selective modifications by 2,4-dinitrophenylthiocyanate. J. Biol. Chem. 255: 8221-8228.