Chemical reactivity indices and mechanism-based read-across for non-animal based assessment of skin sensitisation potential

Journal of Applied Toxicology

Volumn 28, Issue 4, 2008, Pages 443-454

  Roberts, David W ^a   Aptula, Aynur O ^b   Patlewicz, Grace ^c   Pease, Camilla ^b  

^a LIVERPOOL JOHN MOORES UNIVERSITY   (United Kingdom)

^b UNILEVER RESEARCH   (United Kingdom)

^c JOINT RESEARCH CENTRE   (Italy)

Author keywords

Contact allergy; Electrophiles; Kinetics; Nucleophiles; Protein binding

Indexed keywords

ARTICLE; BIOASSAY; CHEMICAL REACTION; CONTROLLED STUDY; DATA BASE; HYDROPHOBICITY; IN VIVO STUDY; KINETICS; MATHEMATICAL MODEL; MOUSE; NONHUMAN; PRIORITY JOURNAL; SKIN SENSITIZATION; STRUCTURE ACTIVITY RELATION;

ANIMAL TESTING ALTERNATIVES; ANIMALS; BIOLOGICAL ASSAY; CELLS, CULTURED; DATABASES, FACTUAL; HUMANS; HYDROPHOBICITY; IRRITANTS; KINETICS; LOCAL LYMPH NODE ASSAY; MICE; MODELS, BIOLOGICAL; MODELS, CHEMICAL; MOLECULAR STRUCTURE; PROTEIN BINDING; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; RISK ASSESSMENT; SKIN IRRITANCY TESTS;

ANIMALIA; MURINAE;

EID: 44349084840     PISSN: 0260437X     EISSN: 10991263     Source Type: Journal    
DOI: 10.1002/jat.1293     Document Type: Article

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