Skin sensitizers induce antioxidant response element dependent genes: Application to the in vitro testing of the sensitization potential of chemicals

Toxicological Sciences

Volumn 102, Issue 1, 2008, Pages 110-119

  Natsch, Andreas ^a   Emter, Roger ^a  

^a GIVAUDAN SCHWEIZ AG   (Switzerland)

Author keywords

Antioxidant response element; In vitro testing; Skin sensitization

Indexed keywords

1 CHLORO 2,4 DINITROBENZENE; 1 NAPHTHOL; 1,4 BENZOQUINONE; 2 AMINOPHENOL; 2,3 BUTANEDIOL; 3 AMINOPHENOL; 4 VINYLPYRIDINE; ANETHOLE; BENZOCAINE; BENZYL BENZOATE; BENZYLIDENEACETONE; CINNAMALDEHYDE; CITRAL; DIETHYL SULFATE; DIPHENCYPRONE; ESTRAGOLE; EUGENOL; FLUORESCEIN ISOTHIOCYANATE; FORMALDEHYDE; GALLIC ACID PROPYL ESTER; GLUTARALDEHYDE; ISOEUGENOL; LINALOOL; LUCIFERASE; MALEIC ACID DIETHYL ESTER; MYRISTIC ACID ISOPROPYL ESTER; OXAZOLONE; PHTHALIC ANHYDRIDE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE); SALICYLIC ACID BENZYL ESTER;

ALLERGY TEST; AMINO ACID SEQUENCE; ANTIOXIDANT RESPONSIVE ELEMENT; ARTICLE; CANCER CELL CULTURE; CHEMOSENSITIZATION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INDUCTION; HUMAN; HUMAN CELL; IN VITRO STUDY; RISK ASSESSMENT; SENSITIVITY AND SPECIFICITY; SIGNAL TRANSDUCTION; SKIN SENSITIZATION;

ALLERGENS; ANIMAL USE ALTERNATIVES; ANIMALS; ANTIOXIDANTS; CELL LINE, TUMOR; DERMATITIS, CONTACT; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INDUCTION; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, REPORTER; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LUCIFERASES; NAD(P)H DEHYDROGENASE (QUINONE); PROMOTER REGIONS (GENETICS); REPRODUCIBILITY OF RESULTS; RISK ASSESSMENT; SKIN TESTS; TRANSCRIPTION FACTORS; TRANSFECTION;

ANIMALIA;

EID: 39149086011     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfm259     Document Type: Article

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