Chemistry-based risk assessment for skin sensitization: Quantitative mechanistic modeling for the S NAr domain

Chemical Research in Toxicology

Volumn 24, Issue 7, 2011, Pages 1003-1011

  Roberts, D W ^a   Aptula, A O ^b   Patlewicz, G Y ^c  

^a LIVERPOOL JOHN MOORES UNIVERSITY   (United Kingdom)

^b UNILEVER RESEARCH   (United Kingdom)

^c DUPONT COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 CHLORO 2,4 DINITROBENZENE; 2,4 DICHLOROPYRIMIDINE; ELECTROPHILE; PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANALYTICAL PARAMETERS; ARTICLE; CHEMICAL REACTION; HYDROPHOBICITY; LOCAL LYMPH NODE ASSAY; PREDICTION; QUANTITATIVE ANALYSIS; QUANTITATIVE MECHANISTIC MODEL; QUANTITATIVE STRUCTURE ACTIVITY RELATION; RISK ASSESSMENT; SKIN SENSITIZATION;

ANIMALS; DERMATITIS, ALLERGIC CONTACT; HUMANS; HYDROGEN-ION CONCENTRATION; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; LOCAL LYMPH NODE ASSAY; MICE; MODELS, CHEMICAL; PYRIMIDINES; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; RISK ASSESSMENT; SKIN; SKIN TESTS; TOXICITY TESTS;

CAVIA; MURINAE;

EID: 79960541330     PISSN: 0893228X     EISSN: 15205010     Source Type: Journal    
DOI: 10.1021/tx100420w     Document Type: Article

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