Design and in vivo evaluation of solid-in-oil suspension for oral delivery of human growth hormone

Biochemical Engineering Journal

Volumn 41, Issue 2, 2008, Pages 106-110

  Yoshiura, Hiromu ^a   Tahara, Yoshiro ^a   Hashida, Masakazu ^a   Kamiya, Noriho ^a,b   Hirata, Akihiko ^c   Fujii, Takeru ^c   Goto, Masahiro ^a,b  

^a Grad Sch Eng   (Japan)

^b KYUSHU UNIVERSITY   (Japan)

^c ASPION Corporation   (Japan)

Author keywords

Amphiphilic materials; Biomedical; Drug delivery system; Microcarriers; Oral protein delivery; Protein

Indexed keywords

BIOCHEMISTRY; OPTIMIZATION; PHYSIOLOGICAL MODELS; QUALITY ASSURANCE; RELIABILITY; SURFACE ACTIVE AGENTS; SUSPENSIONS (COMPONENTS); SUSPENSIONS (FLUIDS);

(E ,3E) PROCESS; BIOLOGICAL ACTIVITIES; DATA COLLECTED; ELSEVIER (CO); HORSE RADISH PEROXIDASE (HRP); HUMAN GROWTH HORMONE (HGH); IN VIVO EVALUATION; NEW ZEALAND RABBITS; OIL SUSPENSIONS; OPTIMIZED CONDITIONS; ORAL ADMINISTRATION; ORAL DELIVERY; PHYSIOLOGICAL CONDITIONS; PROTEIN RELEASE; SOYBEAN OIL (SBO); SPECIFIC ACTIVITY; SYSTEMIC CIRCULATION;

PROJECT MANAGEMENT;

DRUG CARRIER; HORSERADISH PEROXIDASE; HUMAN GROWTH HORMONE; SOYBEAN OIL; SURFACTANT; TREHALOSE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG DELIVERY SYSTEM; DRUG DESIGN; DRUG FORMULATION; DRUG SCREENING; ENZYME ACTIVITY; IN VIVO STUDY; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN SECRETION; RABBIT; SOLUBILIZATION; SUSPENSION;

ARMORACIA RUSTICANA; GLYCINE MAX; ORYCTOLAGUS CUNICULUS;

EID: 47849089487     PISSN: 1369703X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bej.2008.04.001     Document Type: Article

References (16)

1. Pearlman R., and Bewley T.A. Stability and characterization of human growth hormone. Pharm. Biotechnol. 5 (1993) 1-58
2. Cheng Y.H., Dyer A.M., Jabbal-Gill I., Hhinchcliffe M., Nankerris R., Smith A., and Watts P. Intranasal delivery of recombinant human growth hormone (somatropin) in sheep using chitosan-based powder formulations. Eur. J. Pharm. Sci. 26 1 (2005) 9-15
3. Hamman J.H., Enslin G.M., and Kotze A.F. Oral delivery of peptide drugs-barriers and developments. Biodrugs 19 3 (2005) 165-177
4. Sood A., and Panchagnula R. Peroral route: an opportunity for protein and peptide drug delivery. Chem. Rev. 101 11 (2001) 3275-3303
5. Trenktrog Y., Muller B.W., Specht F.M., and Seifert J. Enteric coated insulin pellets: development, drug release and in vivo evaluation. Eur. J. Pharm. Sci. 4 6 (1995) 323-329
6. Lin Y.H., Mi F.L., Chen C.T., Chang W.C., Peng S.F., Liang H.F., and Sung H.W. Preparation and Characterization of Nanoparticles Shelled with Chitosan for Oral Insulin Delivery. Biomacromolecules 8 1 (2007) 146-152
7. Morishita M., Goto T., Nakamura K., Lowman A.M., Takayama K., and Peppas N.A. Novel oral insulin delivery systems based on complexation polymer hydrogels: Single and multiple administration studies in types 1 and 2 diabetic rats. J. Control. Release 110 3 (2006) 587-594
8. Degim I.T., Gumusel B., Degim Z., Ozceliday T., Tay A., and Guner S. Oral administration of liposomal insulin. J. Nanosci. Nanotechnol. 6 9-10 (2006) 2945-2949
9. Piao H., Kamiya N., Watanabe J., Yokoyama H., Hirata A., Fujii T., Shimizu I., Ito S., and Goto M. Oral delivery of diclofenac sodium using a novel solid-in-oil suspension. Int. J. Pharm. 313 1-2 (2006) 159-162
10. Toorisaka E., Ono H., Arimori K., Kamiya N., and Goto M. Hypoglycemic effect of surfactant-coated insulin solubilized in a novel solid-in-oil-in-water (S/O/W) emulsion. Int. J. Pharm. 252 1/2 (2003) 271-274
11. Ozaki S.-i., and Ortiz de Montellano P.R. Molecular engineering of horseradish peroxidase: thioether sulfoxidation and stylene epoxidation by Phe-41 leucine and threonine mutants. J. Am. Chem. Soc. 117 (1995) 7056-7064
12. Yoshiura H., Hashida M., Kamiya N., and Goto M. Factors affecting protein release behavior from surfactant-protein complexes under physiological conditions. Int. J. Pharm. 338 1/2 (2007) 174-179
13. Pikal M.J., Shah S., Roy M.L., and Putman R. The secondary drying stage of freeze drying: drying kinetics as a function of temperature and chamber pressure. Int. J. Pharm. 60 3 (1990) 203-217
14. Zdzieblo A., and Synowiecki J. Physiological functions and unusual possibilities of trehalose applications. Med. Weter 61 1 (2005) 31-34
15. Camilo C., Shevanti S., Madan T., Stephen P., and Bruce R. Extraordinary stability of enzymes dried in trehalose: simplified molecular biology. Nat. Biotechnol. 10 9 (1992) 1007-1011
16. Vermehren C., Hansen H.S., and Thomsen M.K. Time dependent effects of two absorption enhancers on the nasal absorption of growth hormone in rabbits. Int. J. Pharm. 128 1/2 (1996) 239-250