Evaluation of the in-vitro digestion profiles of long and medium chain glycerides and the phase behaviour of their lipolytic products

Journal of Pharmacy and Pharmacology

Volumn 54, Issue 1, 2002, Pages 29-41

  Sek, Leab ^a   Porter, Christopher J H ^a   Kaukonen, Ann Marie ^a   Charman, William N ^a  

^a MONASH UNIVERSITY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ACYLGLYCEROL; BILE SALT; C18 MONOGLYCERIDE DIGLYCERIDE LIPID MIXTURE; C8 C10 MONOGLYCERIDE DIGLYCERIDE LIPID MIXTURE; CAPMUL MCM; DIACYLGLYCEROL; FATTY ACID; LIPID; LONG CHAIN FATTY ACID; LONG CHAIN LIPID; LONG CHAIN TRIACYLGLYCEROL; MAISINE 35 1; MEDIUM CHAIN LIPID; MEDIUM CHAIN TRIACYLGLYCEROL; MIGLYOL; MONOACYLGLYCEROL; OCTANOIN; SOYBEAN OIL; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ARTICLE; BIOLOGICAL MODEL; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DIGESTION; DRUG ABSORPTION; DRUG ADMINISTRATION ROUTE; DRUG FORMULATION; EXPERIMENTATION; HIGH PERFORMANCE THIN LAYER CHROMATOGRAPHY; IN VITRO STUDY; INTESTINE FUNCTION; KINETICS; LIQUID; PHASE SEPARATION; PHYSICAL CHEMISTRY; PHYSICAL PHASE; POSTPRANDIAL STATE; TITRIMETRY; ULTRACENTRIFUGATION;

CHROMATOGRAPHY, THIN LAYER; DIGESTION; GLYCERIDES; LIPOLYSIS; MODELS, BIOLOGICAL; SOYBEAN OIL; STRUCTURE-ACTIVITY RELATIONSHIP; TRIGLYCERIDES;

EID: 0036159895     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1211/0022357021771896     Document Type: Article

References (37)

1. The role of calcium ions and bile salts on the pancreatic lipase- catalyzed hydrolysis of triglyceride emulsions stabilized with lecithin
2. Physiocochemical characteristics of emulsions during fat digestion in human stomach and duodenum
3. Solubilities of normal aliphatic acids, alcohols and alkanes in water
4. On the mechanism of pancreatic lipolysis of glycerides
5. Binding of bile salts to pancreatic colipase and lipase
6. Pancreatic lipase and colipase: Interactions and effects of bile salts and other detergents
7. Lipid digestion and absorption
8. Physicochemical and physiological mechanisms for the effects of food on drug absorption: The role of lipids and pH
9. Ionization and phase behavior of fatty acids in water: Application of the Gibbs Phase Rule
10. Lipid microemulsions for improving drug dissolution and oral absorption: Physical and biopharmaceutical aspects
11. Duodenal bile acids after a test meal
12. Physical-chemical behavior of dietary and biliary lipids during intestinal digestion and absorption. 2. Phase analysis and aggregation states of luminal lipids during duodenal fat digestion in healthy adult human beings
13. The behavior and solubility of monoglycerides in dilute, micellar bile-salt solution
14. Hydrolysis of long-chain monoglycerides in micellar solution by pancreatic lipase
15. Physicochemical properties of bile acids and their relationship to biological properties: An overview of the problem
16. Lipid-based vehicles for the oral delivery of poorly water soluble drugs
17. Formulation design and bioavailability assessment of lipidic self-emulsifying formulations of halofantrine
18. Polycyclic hydrocarbon and polychlorinated biphenyl solubilization in aqueous solutions of mixed micelles
19. Effect of phosphatidylcholine and free fatty acids on the activity of pancreatic lipase-colipase
20. Pancreatic lipase assays with triglycerides as substrate: Contribution of each sequential reaction to product formation
21. Kinetics of the two-step hydrolysis of triaglycerol by pancreatic lipases
22. Combined effect of a lecithin and a bile salt on pancreatic lipase activity
23. Influence of lipolysis on drug absorption from the gastrointestinal tract
24. The digestion and absorption of triglycerides
25. Watching fat digestion
26. Inhibition of human pancreatic lipase-colipase activity by mixed bile salt-phospholipid micelles
27. The light microscopy of triglyceride digestion
28. Intestinal lipid absorption and transport
29. Isolation of the aqueous phase of human intestinal contents during the digestion of a fatty meal
30. Study of the oil and micellar phases during fat digestion in the normal child
31. Formation of lithogenic bile in man
32. Characterisation and quantification of medium chain and long chain triglycerides and their in vitro digestion products, by HPTLC coupled with in situ densitometric analysis
33. The ionic behaviour of fatty acids solubilized by bile salts
34. Physical-chemical behavior of dietary and biliary lipids during intestinal digestion and absorption. 1. Phase behavior and aggregation states of model lipid systems patterned after aqueous duodenal contents of healthy adult human beings
35. Competitive inhibitory effect exerted by bile salt micelles on the hydrolysis of tributyrin by pancreatic lipase
36. Coassimilation of dietary fat and benzo(a)pyrene in the small intestine: An absorption model using the killifish