The use of surfactants to enhance the permeability of peptides through caco-2 cells by inhibition of an apically polarized efflux system

Pharmaceutical Research

Volumn 13, Issue 4, 1996, Pages 528-534

  Nerurkar, Manoj M ^a   Burton, Philip S ^b   Borchardt, Ronald T ^a  

^a UNIVERSITY OF KANSAS   (United States)

^b PFIZER INC   (United States)

Author keywords

Caco 2; Cremophor EL; P glycoprotein; Polarized efflux system; Polysorbate 80

Indexed keywords

CREMOPHOR; GLYCOPROTEIN P; MANNITOL; PEPTIDE; POLYSORBATE 80; SURFACTANT;

ARTICLE; CELL CULTURE; CELL MEMBRANE PERMEABILITY; COLON CARCINOMA; CONTROLLED STUDY; DRUG PENETRATION; DRUG TRANSPORT; HUMAN; HUMAN CELL; INTESTINE ABSORPTION; INTESTINE MUCOSA; PRIORITY JOURNAL;

BIOLOGICAL TRANSPORT; CACO-2 CELLS; CELL MEMBRANE PERMEABILITY; DIALYSIS; ELECTRIC IMPEDANCE; HUMANS; INTESTINAL MUCOSA; MANNITOL; PEPTIDES; POLYETHYLENE GLYCOLS; POLYSORBATES; SURFACE-ACTIVE AGENTS; VEHICLES;

EID: 0029875543     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1016033702220     Document Type: Article

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