Compound prioritization methods increase rates of chemical probe discovery in model organisms

Chemistry and Biology

Volumn 18, Issue 10, 2011, Pages 1273-1283

  Wallace, Iain M ^a,b   Urbanus, Malene L ^a,b   Luciani, Genna M ^a   Burns, Andrew R ^a   Han, Mitchell K L ^b   Wang, Hao ^c   Arora, Kriti ^a   Heisler, Lawrence E ^a,b   Proctor, Michael ^d   St Onge, Robert P ^d   Roemer, Terry ^c   Roy, Peter J ^a   Cummins, Carolyn L ^b   Bader, Gary D ^a,b   Nislow, Corey ^a,b   Giaever, Guri ^a,b  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c MERCK RESEARCH LABORATORIES   (United States)

^d STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACYL COENZYME A DESATURASE; BENZOFURAN DERIVATIVE; DELTA 9 FATTY ACID DESATURASE; DELTA-9 FATTY ACID DESATURASE; ENZYME INHIBITOR; ERG7.153; LANOSTEROL SYNTHASE; MUTASE; PIPERAZINE DERIVATIVE;

ARTICLE; BACILLUS SUBTILIS; BAYES THEOREM; BIOLOGICAL MODEL; CANDIDA ALBICANS; CHEMISTRY; COMPUTER SIMULATION; DRUG ANTAGONISM; DRUG EFFECT; ESCHERICHIA COLI; GROWTH, DEVELOPMENT AND AGING; HELA CELL; HUMAN; METABOLISM; MOLECULAR LIBRARY; PHENOTYPE; SACCHAROMYCES CEREVISIAE;

BACILLUS SUBTILIS; BAYES THEOREM; BENZOFURANS; CANDIDA ALBICANS; COMPUTER SIMULATION; ENZYME INHIBITORS; ESCHERICHIA COLI; FATTY ACID DESATURASES; HELA CELLS; HUMANS; INTRAMOLECULAR TRANSFERASES; MODELS, BIOLOGICAL; PHENOTYPE; PIPERAZINES; SACCHAROMYCES CEREVISIAE; SMALL MOLECULE LIBRARIES;

SACCHAROMYCES CEREVISIAE;

EID: 80055075327     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chembiol.2011.07.018     Document Type: Article

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