The antimalarial drug quinine disrupts Tat2p-mediated tryptophan transport and causes tryptophan starvation

Journal of Biological Chemistry

Volumn 284, Issue 27, 2009, Pages 17968-17974

  Khozoie, Combiz ^a   Pleass, Richard J ^a   Avery, Simon V ^a  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIMALARIAL DRUG; DATA SETS; HIGH AFFINITY; OVER-EXPRESSION; TOXIC EFFECT; WIDE SCREEN;

BIOCHEMICAL ENGINEERING; BIOCHEMISTRY; STRAIN; TOXICITY;

AMINO ACIDS;

PERMEASE; PHENYLALANINE; QUININE; TRYPTOPHAN; TRYPTOPHAN PERMEASE; TYROSINE; UNCLASSIFIED DRUG;

AMINO ACID METABOLISM; AMINO ACID SYNTHESIS; AMINO ACID TRANSPORT; ANTIBIOTIC RESISTANCE; ANTIPROTOZOAL ACTIVITY; ARTICLE; AUXOTROPHY; BINDING AFFINITY; CONTROLLED STUDY; DRUG SENSITIVITY; DRUG TOXICITY; FUNGAL STRAIN; GENE DELETION; GENE OVEREXPRESSION; GENETIC SCREENING; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPLETION; SACCHAROMYCES CEREVISIAE;

AMINO ACID TRANSPORT SYSTEMS; ANTIMALARIALS; BIOLOGICAL TRANSPORT; DRUG DESIGN; DRUG RESISTANCE, FUNGAL; MUTATION; QUININE; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; TRITIUM; TRYPTOPHAN;

EID: 67650547020     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.005843     Document Type: Article

References (57)

1. Alkadi, H. O. (2007) Chemotherapy 53, 385-391
2. Taylor, W. R., and White, N. J. (2004) Drug Safety 27, 25-61
3. Bell, D. J., and Molyneux, M. E. (2007) Expert Rev. Anti-Infective Ther. 5, 141-152
4. Huston, M., and Levinson, M. (2006) J. Emerg. Med. 31, 395-401
5. Holland, S., Lodwig, E., Sideri, T., Reader, T., Clarke, I., Gkargkas, K., Hoyle, D. C., Delneri, D., Oliver, S. G., and Avery, S. V. (2007) Genome Biol. 8, R268
6. Ruotolo, R., Marchini, G., and Ottonello, S. (2008) Genome Biol. 9, R67
7. Thorpe, G. W., Fong, C. S., Alic, N., Higgins, V. J., and Dawes, I. W. (2004) Proc. Natl. Acad. Sci. U. S. A. 101, 6564-6569
8. Dobson, P. D., Lanthaler, K., Oliver, S. G., and Kell, D. B. (2009) Curr. Top. Med. Chem. 9, 163-181
9. Ericson, E., Gebbia, M., Heisler, L. E., Wildenhain, J., Tyers, M., Giaever, G., and Nislow, C. (2008) PLoS Genet. 4, e1000151
10. Giaever, G., Flaherty, P., Kumm, J., Proctor, M., Nislow, C., Jaramillo, D. F., Chu, A. M., Jordan, M. I., Arkin, A. P., and Davis, R. W. (2004) Proc. Natl. Acad. Sci. U.S.A. 101, 793-798
11. Lum, P. Y., Armour, C. D., Stepaniants, S. B., Cavet, G., Wolf, M. K., Butler, J. S., Hinshaw, J. C., Garnier, P., Prestwich, G. D., Leonardson, A., Garrett-Engele, P., Rush, C. M., Bard, M., Schimmack, G., Phillips, J. W., Roberts, C. J., and Shoemaker, D. D. (2004) Cell 116, 121-137
12. Blackburn, A. S., and Avery, S. V. (2003) Antimicrob. Agents Chemother. 47, 676-681
13. Morton, C. O., Hayes, A., Wilson, M., Rash, B. M., Oliver, S. G., and Coote, P. (2007) Antimicrob. Agents Chemother. 51, 3948-3959
14. Foury, F. (1997) Gene 195, 1-10
15. Zhang, N., Osborn, M., Gitsham, P., Yen, K., Miller, J. R., and Oliver, S. G. (2003) Gene 303, 121-129
16. Daily, J. P., Scanfeld, D., Pochet, N., Le Roch, K., Plouffe, D., Kamal, M., Sarr, O., Mboup, S., Ndir, O., Wypij, D., Levasseur, K., Thomas, E., Tamayo, P., Dong, C., Zhou, Y., Lander, E. S., Ndiaye, D., Wirth, D., Winzeler, E. A., Mesirov, J. P., and Reger, A. (2007) Nature 450, 1091-1095
17. Li, W., Mo, W. K., Shen, D., Sun, L. B., Wang, J., Lu, S., Gitschier, J. M., and Zhou, B. (2005) PLoS Genet. 1, 329-334
18. Lovegrove, F. E., Peña-Castillo, L., Liles, W. C., Hughes, T. R., and Kain, K. C. (2008) Trends Parasitol. 24, 288-291
19. Suthram, S., Sittler, T., and Ideker, T. (2005) Nature 438, 108-112
20. Avery, S. V., Malkapuram, S., Mateus, C., and Babb, K. S. (2000) J. Bacteriol. 182, 76-80
21. Rojas, M., Wright, C. W., Piña, B., and Portugal, J. (2008) Antimicrob. Agents Chemother. 52, 3844-3850
22. Garí, E., Piedrafita, L., Aldea, M., and Herrero, E. (1997) Yeast 13, 837-848
23. Gietz, R. D., and Woods, R. A. (2002) Methods Enzymol. 350, 87-96
24. Ausubel, F. M., Brent, R., Kingston, R. E., Moore, D. D., Seidman, J. G., and Struhl, K. (2007) Current Protocols in Molecular Biology, John Wiley and Sons, New York
25. Tucker, C. L., and Fields, S. (2004) Comp. Funct. Genomics 5, 216-224
26. Bishop, A. L., Rab, F. A., Sumner, E. R., and Avery, S. V. (2007) Mol. Microbiol. 63, 507-520
27. Ruepp, A. Zollner, A., Maier, D., Albermann, K., Hani, J., Mokrejs, M., Tetko, I., Gürdener, U., Mannhaupt, G., Münsterkötter, M., and Mewes, H. W. (2004) Nucleic Acids Res. 32, 5539-5545
28. Beck, T., Schmidt, A., and Hall, M. N. (1999) J. Cell Biol. 146, 1227-1238
29. Morales, F. J., Acar, O. C., Serpen, A., Arribas-Lorenzo, G., and Gokmen, V. (2007) J. Agric. Food Chem. 55, 6793-6797
30. Bisswanger, H. (2008) Enzyme Kinetics-Principles and Methods, Wiley-VCH, Weinheim
31. Kakkar, T., Boxenbaum, H., and Mayersohn, M. (1999) Drug Metab. Dispos. 27, 756-762
32. Greasham, R. L., and Moat, A. G. (1973) J. Bacteriol. 115, 975-981
33. Smith, M. C., Sumner, E. R., and Avery, S. V. (2007) Mol. Microbiol. 66, 699-712
34. Schmidt, A., Hall, M. N., and Koller, A. (1994) Mol. Cell. Biol. 14, 6597-6606
35. Alván, G., Karlsson, K. K., Hellgren, U., and Villén, T. (1991) Br. J. Clin. Pharmacol. 31, 409-412
36. Wolf, L. R., Otten, E. J., and Spadafora, M. P. (1992) J. Emergency Med. 10, 295-301
37. Eriksson, T., and Lidberg, L. (1997) Psychol. Med. 27, 477-481
38. Peet, M., Moody, J. P., Worrall, E. P., Walker, P., and Naylor, G. J. (1976) Br. J. Psychiatry 128, 255-258
39. Hall, A. P., Williams, S. C., Rajkumar, K. N., and Galloway, N. R. (1997) Br. J. Ophthalmol. 81, 1029-1029
40. Regenberg, B., Düring-Olsen, L., Kielland-Brandt, M. C., and Holmberg, S. (1999) Curr. Genet. 36, 317-328
41. Abe, F., and Iida, H. (2003) Mol. Cell. Biol. 23, 7566-7584
42. Welsch, C. A., Hagiwara, S., Goetschy, J. F., and Movva, N. R. (2003) J. Biol. Chem. 278, 26976-26982
43. Abe, F. (2007) in The Interdisciplinary Conference on Tryptophan and Related Substances: Chemistry, Biology and Medicine. Proceedings of the Eleventh Triannual Meeting of the International Study Group for Tryptophan Research: 2006 (Takai, K., ed) pp. 75-84, Elsevier, University of Tokyo
44. Leete, E. (1969) Accounts Chem. Res. 2, 59-64
45. O'Connor, S. E., and Maresh, J. J. (2006) Natural Product Rep. 23, 532-547
46. Craig, C. L., and Weber, R. S. (1998) Mol. Biol. Evolution 15, 774-776
47. Raiford, D. W., Heizer, E. M., Jr., Miller, R. V., Akashi, H., Raymer, M. L., and Krane, D. E. (2008) J. Mol. Evolution 67, 621-630
48. Liu, J., Istvan, E. S., Gluzman, I. Y., Gross, J., and Goldberg, D. E. (2006) Proc. Natl. Acad. Sci. U.S.A. 103, 8840-8845
49. Seymour, R. L., Ganapathy, V., Mellor, A. L., and Munn, D. H. (2006) J. Leukocyte Biol. 80, 1320-1327
50. Booij, L., Swenne, C. A., Brosschot, J. F., Haffmans, P. M., Thayer, J. F., and Van der Does, A. J. (2006) Biol. Psychiatry 60, 507-514
51. Porter, R. J., Mulder, R. T., Joyce, P. R., Miller, A. L., and Kennedy, M. (2008) J. Affective Disord. 109, 209-212
52. van der Veen, F. M., Mies, G. W., van der Molen, M. W., and Evers, E. A. (2008) Psychopharmacology 199, 255-263
53. Simpson, J. J., and Davies, W. E. (2000) Hearing Res. 145, 1-7
54. Tetsutani, K., To, H., Torii, M., Hisaeda, H., and Himeno, K. (2007) Parasitology 134, 923-930
55. Krogstad, D. J., Schlesinger, P. H., and Gluzman, I. Y. (1985) J. Cell Biol. 101, 2302-2309
56. Sullivan, D. J. (2002) Int. J. Parasitol. 32, 1645-1653
57. Ferreira, P. E., Cavaco, I., and Gil, J. P. (2008) Personalized Med. 5, 627-639