메뉴 건너뛰기




Volumn 238, Issue 6, 2009, Pages 1287-1308

Simple vertebrate models for chemical genetics and drug discovery screens: Lessons from zebrafish and Xenopus

Author keywords

Chemical genetics; Chemical library; Chemical screening; Drug development; Drug discovery; Embryo; Embryogenesis; Organogenesis; Tadpole; Xenopus; Zebrafish

Indexed keywords

ANGIOGENESIS; CHEMICAL GENETICS; EMBRYO DEVELOPMENT; LYMPHANGIOGENESIS; NONHUMAN; ORGANOGENESIS; PRIORITY JOURNAL; PROTEIN FUNCTION; REVIEW; XENOPUS; ZEBRA FISH;

EID: 66349117984     PISSN: 10588388     EISSN: 10970177     Source Type: Journal    
DOI: 10.1002/dvdy.21967     Document Type: Review
Times cited : (160)

References (139)
  • 1
    • 33751555418 scopus 로고    scopus 로고
    • Inverse drug screens: A rapid and inexpensive method for implicating molecular targets
    • DOI 10.1002/dvg.20246
    • Adams DS, Levin M. 2006. Inverse drug screens: a rapid and inexpensive method for implicating molecular targets. Genesis 44:530-540. (Pubitemid 44846648)
    • (2006) Genesis , vol.44 , Issue.11 , pp. 530-540
    • Adams, D.S.1    Levin, M.2
  • 2
    • 33744506178 scopus 로고    scopus 로고
    • +-V-ATPase-dependent proton flux is necessary for consistent left-right patterning of non-mammalian vertebrates
    • DOI 10.1242/dev.02341
    • Adams DS, Robinson KR, Fukumoto T, Yuan S, Albertson RC, Yelick P, Kuo L, McSweeney M, Levin M. 2006. Early, H+-V-ATPase-dependent proton flux is necessary for consistent left-right patterning of non-mammalian vertebrates. Development 133:1657-1671. (Pubitemid 43810973)
    • (2006) Development , vol.133 , Issue.9 , pp. 1657-1671
    • Adams, D.S.1    Robinson, K.R.2    Fukumoto, T.3    Yuan, S.4    Albertson, R.C.5    Yelick, P.6    Kuo, L.7    McSweeney, M.8    Levin, M.9
  • 3
    • 34248195467 scopus 로고    scopus 로고
    • + pump-dependent changes in membrane voltage are an early mechanism necessary and sufficient to induce Xenopus tail regeneration
    • DOI 10.1242/dev.02812
    • Adams DS, Masi A, Levin M. 2007. H+ pump-dependent changes in membrane voltage are an early mechanism necessary and sufficient to induce Xenopus tail regeneration. Development 134:1323-1335. (Pubitemid 46706039)
    • (2007) Development , vol.134 , Issue.7 , pp. 1323-1335
    • Adams, D.S.1    Masi, A.2    Levin, M.3
  • 4
    • 35949000935 scopus 로고    scopus 로고
    • Tagged small molecule library approach for facilitated chemical genetics
    • Ahn YH, Chang YT. 2007. Tagged small molecule library approach for facilitated chemical genetics. Acc Chem Res 40:1025-1033.
    • (2007) Acc Chem Res , vol.40 , pp. 1025-1033
    • Ahn, Y.H.1    Chang, Y.T.2
  • 5
    • 30744477450 scopus 로고    scopus 로고
    • Lymphangiogenesis in development and human disease
    • DOI 10.1038/nature04480, PII NATURE04480
    • Alitalo K, Tammela T, Petrova TV. 2005. Lymphangiogenesis in development and human disease. Nature 438:946-953. (Pubitemid 43093960)
    • (2005) Nature , vol.438 , Issue.7070 , pp. 946-953
    • Alitalo, K.1    Tammela, T.2    Petrova, T.V.3
  • 6
    • 33751530490 scopus 로고    scopus 로고
    • Mining the Wnt pathway for cancer therapeutics
    • DOI 10.1038/nrd2154, PII NRD2154
    • Barker N, Clevers H. 2006. Mining the Wnt pathway for cancer therapeutics. Nat Rev Drug Discov 5:997-1014. (Pubitemid 44835127)
    • (2006) Nature Reviews Drug Discovery , vol.5 , Issue.12 , pp. 997-1014
    • Barker, N.1    Clevers, H.2
  • 7
    • 35448968335 scopus 로고    scopus 로고
    • The role of Zebrafish in chemical genetics
    • DOI 10.2174/092986707781745532
    • Berger J, Currie P. 2007. The role of zebrafish in chemical genetics. Curr Med Chem 14:2413-2420. (Pubitemid 47618049)
    • (2007) Current Medicinal Chemistry , vol.14 , Issue.22 , pp. 2413-2420
    • Berger, J.1    Currie, P.2
  • 8
    • 8744282471 scopus 로고    scopus 로고
    • Prospects for the Xenopus embryo model in therapeutics technologies
    • Brändli AW. 2004. Prospects for the Xenopus embryo model in therapeutics technologies. Chimia 58:694-702. (Pubitemid 39523823)
    • (2004) Chimia , vol.58 , Issue.10 , pp. 694-702
    • Brandli, A.W.1
  • 9
    • 2642553258 scopus 로고    scopus 로고
    • Target identification in chemical genetics: The (often) missing link
    • DOI 10.1016/j.chembiol.2004.05.001, PII S1074552104001231
    • Burdine L, Kodadek T. 2004. Target identification in chemical genetics: the (often) missing link. Chem Biol 11:593-597. (Pubitemid 38708828)
    • (2004) Chemistry and Biology , vol.11 , Issue.5 , pp. 593-597
    • Burdine, L.1    Kodadek, T.2
  • 11
    • 0037699955 scopus 로고    scopus 로고
    • Angiogenesis in health and disease
    • DOI 10.1038/nm0603-653
    • Carmeliet P. 2003. Angiogenesis in health and disease. Nat Med 9:653-660. (Pubitemid 36749213)
    • (2003) Nature Medicine , vol.9 , Issue.6 , pp. 653-660
    • Carmeliet, P.1
  • 12
    • 16644394551 scopus 로고    scopus 로고
    • Chemical Approaches to Angiogenesis
    • DOI 10.1016/S0091-679X(04)76021-5, PII S0091679X04760215, The Zebrafish: Cellular and Developmental Biology
    • Chan J, Serluca FC. 2004. Chemical approaches to angiogenesis. Methods Cell Biol 76:475-487. (Pubitemid 39752576)
    • (2004) Methods in Cell Biology , vol.76 , pp. 475-487
    • Chan, J.1    Serluca, F.C.2
  • 13
    • 0036527350 scopus 로고    scopus 로고
    • Dissection of angiogenic signaling in zebrafish using a chemical genetic approach
    • DOI 10.1016/S1535-6108(02)00042-9
    • Chan J, Bayliss PE, Wood JM, Roberts TM. 2002. Dissection of angiogenic signaling in zebrafish using a chemical genetic approach. Cancer Cell 1:257-267. (Pubitemid 41039150)
    • (2002) Cancer Cell , vol.1 , Issue.3 , pp. 257-267
    • Chan, J.1    Bayliss, P.E.2    Wood, J.M.3    Roberts, T.M.4
  • 14
    • 41049102573 scopus 로고    scopus 로고
    • Identification of small molecules rescuing fragile X syndrome phenotypes in Drosophila
    • Chang S, Bray SM, Li Z, Zarnescu DC, He C, Jin P, Warren ST. 2008. Identification of small molecules rescuing fragile X syndrome phenotypes in Drosophila. Nat Chem Biol 4:256-263.
    • (2008) Nat Chem Biol , vol.4 , pp. 256-263
    • Chang, S.1    Bray, S.M.2    Li, Z.3    Zarnescu, D.C.4    He, C.5    Jin, P.6    Warren, S.T.7
  • 15
    • 2942542776 scopus 로고    scopus 로고
    • Retinoic acid signaling is essential for pancreas development and promotes endocrine at the expense of exocrine cell differentiation in Xenopus
    • DOI 10.1016/j.ydbio.2004.03.030, PII S0012160604002428
    • Chen Y, Pan FC, Brandes N, Afelik S, Solter M, Pieler T. 2004. Retinoic acid signaling is essential for pancreas development and promotes endocrine at the expense of exocrine cell differentiation in Xenopus. Dev Biol 271:144-160. (Pubitemid 38757782)
    • (2004) Developmental Biology , vol.271 , Issue.1 , pp. 144-160
    • Chen, Y.1    Pan, F.C.2    Brandes, N.3    Afelik, S.4    Solter, M.5    Pieler, T.6
  • 16
    • 50049109693 scopus 로고    scopus 로고
    • Gene expression analysis defines the proximal tubule as the compartment for endocytic receptor-mediated uptake in the Xenopus pronephric kidney
    • Christensen EI, Raciti D, Reggiani L, Verroust PJ, Brändli AW. 2008. Gene expression analysis defines the proximal tubule as the compartment for endocytic receptor-mediated uptake in the Xenopus pronephric kidney. Pflugers Arch 456:1163-1176.
    • (2008) Pflugers Arch , vol.456 , pp. 1163-1176
    • Christensen, E.I.1    Raciti, D.2    Reggiani, L.3    Verroust, P.J.4    Brändli, A.W.5
  • 17
    • 4444286758 scopus 로고    scopus 로고
    • Screening of FGF target genes in Xenopus by microarray: Temporal dissection of the signalling pathway using a chemical inhibitor
    • DOI 10.1111/j.1356-9597.2004.00761.x
    • Chung HA, Hyodo-Miura J, Kitayama A, Terasaka C, Nagamune T, Ueno N. 2004. Screening of FGF target genes in Xenopus by microarray: temporal dissection of the signalling pathway using a chemical inhibitor. Genes Cells 9:749-761. (Pubitemid 39206614)
    • (2004) Genes to Cells , vol.9 , Issue.8 , pp. 749-761
    • Chung, H.A.1    Hyodo-Miura, J.2    Kitayama, A.3    Terasaka, C.4    Nagamune, T.5    Ueno, N.6
  • 18
    • 3643066630 scopus 로고    scopus 로고
    • VEGF mediates angioblast migration during development of the dorsal aorta in Xenopus
    • Cleaver O, Krieg PA. 1998. VEGF mediates angioblast migration during development of the dorsal aorta in Xenopus. Development 125:3905-3914. (Pubitemid 28488365)
    • (1998) Development , vol.125 , Issue.19 , pp. 3905-3914
    • Cleaver, O.1    Krieg, P.A.2
  • 19
    • 0022262420 scopus 로고
    • Analysis of the activity of DNA, RNA, and protein synthesis inhibitors on Xenopus embryo development
    • DOI 10.1002/tcm.1770050306
    • Courchesne CL, Bantle JA. 1985. Analysis of the activity of DNA, RNA, and protein synthesis inhibitors on Xenopus embryo development. Teratog Carcinog Mutagen 5:177-193. (Pubitemid 15071992)
    • (1985) Teratogenesis Carcinogenesis and Mutagenesis , vol.5 , Issue.3 , pp. 177-193
    • Courchesne, C.L.1    Bantle, J.A.2
  • 20
    • 33745947584 scopus 로고    scopus 로고
    • Apelin, the ligand for the endothelial G-protein-coupled receptor, APJ, is a potent angiogenic factor required for normal vascular development of the frog embryo
    • DOI 10.1016/j.ydbio.2006.04.452, PII S0012160606007482
    • Cox CM, D'Agostino SL, Miller MK, Heimark RL, Krieg PA. 2006. Apelin, the ligand for the endothelial G-protein-coupled receptor, APJ, is a potent angiogenic factor required for normal vascular development of the frog embryo. Dev Biol 296:177-189. (Pubitemid 44061763)
    • (2006) Developmental Biology , vol.296 , Issue.1 , pp. 177-189
    • Cox, C.M.1    D'Agostino, S.L.2    Miller, M.K.3    Heimark, R.L.4    Krieg, P.A.5
  • 21
    • 33748771724 scopus 로고    scopus 로고
    • New insights into the molecular control of the lymphatic vascular system and its role in disease
    • DOI 10.1038/sj.jid.5700464, PII 5700464
    • Cueni LN, Detmar M. 2006. New insights into the molecular control of the lymphatic vascular system and its role in disease. J Invest Dermatol 126:2167-2177. (Pubitemid 44413162)
    • (2006) Journal of Investigative Dermatology , vol.126 , Issue.10 , pp. 2167-2177
    • Cueni, L.N.1    Detmar, M.2
  • 23
    • 0036890399 scopus 로고    scopus 로고
    • The cytochrome P450 superfamily: Biochemistry, evolution and drug metabolism in humans
    • DOI 10.2174/1389200023337054
    • Danielson PB. 2002. The cytochrome P450 superfamily: biochemistry, evolution and drug metabolism in humans. Curr Drug Metab 3:561-597. (Pubitemid 35331660)
    • (2002) Current Drug Metabolism , vol.3 , Issue.6 , pp. 561-597
    • Danielson, P.B.1
  • 24
    • 14944348431 scopus 로고    scopus 로고
    • The immunoglobulin heavy-chain locus in zebrafish: Identification and expression of a previously unknown isotype, immunoglobulin Z
    • Danilova N, Bussmann J, Jekosch K, Steiner LA. 2005. The immunoglobulin heavy-chain locus in zebrafish: identification and expression of a previously unknown isotype, immunoglobulin Z. Nat Immunol 6:295-302.
    • (2005) Nat Immunol , vol.6 , pp. 295-302
    • Danilova, N.1    Bussmann, J.2    Jekosch, K.3    Steiner, L.A.4
  • 26
    • 13944274193 scopus 로고    scopus 로고
    • Neural induction in Xenopus requires early FGF signalling in addition to BMP inhibition
    • DOI 10.1242/dev.01582
    • Delaune E, Lemaire P, Kodjabachian L. 2005. Neural induction in Xenopus requires early FGF signalling in addition to BMP inhibition. Development 132:299-310. (Pubitemid 40268280)
    • (2005) Development , vol.132 , Issue.2 , pp. 299-310
    • Delaune, E.1    Lemaire, P.2    Kodjabachian, L.3
  • 32
    • 58949084539 scopus 로고    scopus 로고
    • Adaptive evolution in zinc finger transcription factors
    • Emerson RO, Thomas JH. 2009. Adaptive evolution in zinc finger transcription factors. PLoS Genet 5:e1000325.
    • (2009) PLoS Genet , vol.5
    • Emerson, R.O.1    Thomas, J.H.2
  • 33
    • 0023685999 scopus 로고
    • Development of a metabolic activation system for the frog embryo teratogenesis assay: Xenopus (FETAX)
    • DOI 10.1002/tcm.1770080502
    • Fort DJ, Dawson DA, Bantle JA. 1988. Development of a metabolic activation system for the frog embryo teratogenesis assay: Xenopus (FETAX). Teratog Carcinog Mutagen 8:251-263. (Pubitemid 18274687)
    • (1988) Teratogenesis Carcinogenesis and Mutagenesis , vol.8 , Issue.5 , pp. 251-263
    • Fort, D.J.1    Dawson, D.A.2    Bantle, J.A.3
  • 34
    • 0033985996 scopus 로고    scopus 로고
    • Evaluation of the developmental toxicity of thalidomide using Frog Embryo Teratogenesis Assay - Xenopus (FETAX): Biotransformation and detoxification
    • DOI 10.1002/(SICI)1520-6866(2000)20:1<35::AID-TCM4>3.0.CO;2-I
    • Fort DJ, Stover EL, Bantle JA, Finch RA. 2000. Evaluation of the developmental toxicity of thalidomide using frog embryo teratogenesis assay-xenopus (FETAX): biotransformation and detoxification. Teratog Carcinog Mutagen 20:35-47. (Pubitemid 30036159)
    • (2000) Teratogenesis Carcinogenesis and Mutagenesis , vol.20 , Issue.1 , pp. 35-47
    • Fort, D.J.1    Stover, E.L.2    Bantle, J.A.3    Finch, R.A.4
  • 35
    • 27644571539 scopus 로고    scopus 로고
    • Serotonin transporter function is an early step in left-right patterning in chick and frog embryos
    • DOI 10.1159/000088451
    • Fukumoto T, Blakely R, Levin M. 2005a. Serotonin transporter function is an early step in left-right patterning in chick and frog embryos. Dev Neurosci 27:349-363. (Pubitemid 41567384)
    • (2005) Developmental Neuroscience , vol.27 , Issue.6 , pp. 349-363
    • Fukumoto, T.1    Blakely, R.2    Levin, M.3
  • 36
    • 18844368252 scopus 로고    scopus 로고
    • Serotonin signaling is a very early step in patterning of the left-right axis in chick and frog embryos
    • DOI 10.1016/j.cub.2005.03.044, PII S0960982205003386
    • Fukumoto T, Kema IP, Levin M. 2005b. Serotonin signaling is a very early step in patterning of the left-right axis in chick and frog embryos. Curr Biol 15:794-803. (Pubitemid 40689397)
    • (2005) Current Biology , vol.15 , Issue.9 , pp. 794-803
    • Fukumoto, T.1    Kema, I.P.2    Levin, M.3
  • 37
    • 0032600640 scopus 로고    scopus 로고
    • A knowledge-based approach in designing combinatorial or medicinal chemistry libraries for drug discovery. 1. A qualitative and quantitative characterization of known drug databases
    • Ghose AK, Viswanadhan VN, Wendoloski JJ. 1999. A knowledge-based approach in designing combinatorial or medicinal chemistry libraries for drug discovery. 1. A qualitative and quantitative characterization of known drug databases. J Comb Chem 1:55-68.
    • (1999) J Comb Chem , vol.1 , pp. 55-68
    • Ghose, A.K.1    Viswanadhan, V.N.2    Wendoloski, J.J.3
  • 39
    • 33745698558 scopus 로고    scopus 로고
    • Genetic screens for mutations affecting development of Xenopus tropicalis
    • DOI 10.1371/journal.pgen.0020091
    • Goda T, Abu-Daya A, Carruthers S, Clark MD, Stemple DL, Zimmerman LB. 2006. Genetic screens for mutations affecting development of Xenopus tropicalis. PLoS Genet 2:e91. (Pubitemid 43998835)
    • (2006) PLoS Genetics , vol.2 , Issue.6 , pp. 811-825
    • Goda, T.1    Abu-Daya, A.2    Carruthers, S.3    Clark, M.D.4    Stemple, D.L.5    Zimmerman, L.B.6
  • 40
    • 0034177962 scopus 로고    scopus 로고
    • Dissecting cellular processes using small molecules: Identification of colchicine-like, taxol-like and other small molecules that perturb mitosis
    • DOI 10.1016/S1074-5521(00)00101-0
    • Haggarty SJ, Mayer TU, Miyamoto DT, Fathi R, King RW, Mitchison TJ, Schreiber SL. 2000. Dissecting cellular processes using small molecules: identification of colchicine-like, taxol-like and other small molecules that perturb mitosis. Chem Biol 7:275-286. (Pubitemid 30199616)
    • (2000) Chemistry and Biology , vol.7 , Issue.4 , pp. 275-286
    • Haggarty, S.J.1    Mayer, T.U.2    Miyamoto, D.T.3    Fathi, R.4    King, R.W.5    Mitchison, T.J.6    Schreiber, S.L.7
  • 41
    • 12344324701 scopus 로고    scopus 로고
    • Dissecting cell biology with chemical scalpels
    • DOI 10.1016/j.ceb.2004.12.004, PII S0955067404001723
    • Hathaway NA, King RW. 2005. Dissecting cell biology with chemical scalpels. Curr Opin Cell Biol 17:12-19. (Pubitemid 40138083)
    • (2005) Current Opinion in Cell Biology , vol.17 , Issue.1 , pp. 12-19
    • Hathaway, N.A.1    King, R.W.2
  • 42
    • 0034213262 scopus 로고    scopus 로고
    • Beta-catenin signaling activity dissected in the early Xenopus embryo: A novel antisense approach
    • DOI 10.1006/dbio.2000.9720
    • Heasman J, Kofron M, Wylie C. 2000. Beta-catenin signaling activity dissected in the early Xenopus embryo: a novel anti-sense approach. Dev Biol 222:124-134. (Pubitemid 30387734)
    • (2000) Developmental Biology , vol.222 , Issue.1 , pp. 124-134
    • Heasman, J.1    Kofron, M.2    Wylie, C.3
  • 43
    • 0036846746 scopus 로고    scopus 로고
    • The origin and evolution of model organisms
    • DOI 10.1038/nrg929
    • Hedges SB. 2002. The origin and evolution of model organisms. Nat Rev Genet 3:838-849. (Pubitemid 35303516)
    • (2002) Nature Reviews Genetics , vol.3 , Issue.11 , pp. 838-849
    • Hedges, S.B.1
  • 44
    • 0037162770 scopus 로고    scopus 로고
    • Genomics. Vertebrate genomes compared
    • Hedges SB, Kumar S. 2002. Genomics. Vertebrate genomes compared. Science 297:1283-1285.
    • (2002) Science , vol.297 , pp. 1283-1285
    • Hedges, S.B.1    Kumar, S.2
  • 45
    • 0033981091 scopus 로고    scopus 로고
    • The receptor tyrosine kinase EphB4 and ephrin-B ligands restrict angiogenic growth of embryonic veins in Xenopus laevis
    • Helbling PM, Saulnier DM, Brändli AW. 2000. The receptor tyrosine kinase EphB4 and ephrin-B ligands restrict angiogenic growth of embryonic veins in Xenopus laevis. Development 127:269-278. (Pubitemid 30087964)
    • (2000) Development , vol.127 , Issue.2 , pp. 269-278
    • Helbling, P.M.1    Saulnier, D.M.E.2    Brandli, A.W.3
  • 46
    • 34548171771 scopus 로고    scopus 로고
    • Accelerated gene evolution and subfunctionalization in the pseudotetraploid frog Xenopus laevis
    • DOI 10.1186/1741-7007-5-31
    • Hellsten U, Khokha MK, Grammer TC, Harland RM, Richardson P, Rokhsar DS. 2007. Accelerated gene evolution and subfunctionalization in the pseudotetraploid frog Xenopus laevis. BMC Biol 5:31. (Pubitemid 47308274)
    • (2007) BMC Biology , vol.5 , pp. 31
    • Hellsten, U.1    Khokha, M.K.2    Grammer, T.C.3    Harland, R.M.4    Richardson, P.5    Rokhsar, D.S.6
  • 47
    • 33745646792 scopus 로고    scopus 로고
    • Artery/Vein Specification Is Governed by Opposing Phosphatidylinositol-3 Kinase and MAP Kinase/ERK Signaling
    • DOI 10.1016/j.cub.2006.05.046, PII S0960982206016290
    • Hong CC, Peterson QP, Hong JY, Peterson RT. 2006. Artery/vein specification is governed by opposing phosphatidylinositol-3 kinase and MAP kinase/ERK signaling. Curr Biol 16:1366-1372. (Pubitemid 43975369)
    • (2006) Current Biology , vol.16 , Issue.13 , pp. 1366-1372
    • Hong, C.C.1    Peterson, Q.P.2    Hong, J.-Y.3    Peterson, R.T.4
  • 48
    • 26644443924 scopus 로고    scopus 로고
    • Identification of the F1F0 mitochondrial ATPase as a target for modulating skin pigmentation by screening a tagged triazine library in zebrafish
    • DOI 10.1039/b417765g
    • Jung DW, Williams D, Khersonsky SM, Kang TW, Heidary N, Chang YT, Orlow SJ. 2005. Identification of the F1F0 mitochondrial ATPase as a target for modulating skin pigmentation by screening a tagged triazine library in zebrafish. Mol Biosyst 1:85-92. (Pubitemid 43349734)
    • (2005) Molecular BioSystems , vol.1 , Issue.1 , pp. 85-92
    • Jung, D.-W.1    Williams, D.2    Khersonsky, S.M.3    Kang, T.-W.4    Heidary, N.5    Chang, Y.-T.6    Orlow, S.J.7
  • 49
    • 34247591454 scopus 로고    scopus 로고
    • Paracrine and autocrine mechanisms of apelin signaling govern embryonic and tumor angiogenesis
    • DOI 10.1016/j.ydbio.2007.03.004, PII S0012160607001832
    • Kälin RE, Kretz MP, Meyer AM, Kispert A, Heppner FL, Brändli AW. 2007. Paracrine and autocrine mechanisms of apelin signaling govern embryonic and tumor angiogenesis. Dev Biol 305:599-614. (Pubitemid 46686624)
    • (2007) Developmental Biology , vol.305 , Issue.2 , pp. 599-614
    • Kalin, R.E.1    Kretz, M.P.2    Meyer, A.M.3    Kispert, A.4    Heppner, F.L.5    Brandli, A.W.6
  • 50
    • 66349132028 scopus 로고    scopus 로고
    • An in vivo chemical screen in Xenopus tadpoles reveals novel pathways involved in angiogenesis and lymphangiogenesis
    • in press
    • Kälin RE, Bänziger-Tobler NE, Detmar M, Brändli AW. 2009. An in vivo chemical screen in Xenopus tadpoles reveals novel pathways involved in angiogenesis and lymphangiogenesis. Blood (in press).
    • (2009) Blood
    • Kälin, R.E.1    Bänziger-Tobler, N.E.2    Detmar, M.3    Brändli, A.W.4
  • 51
    • 0034665737 scopus 로고    scopus 로고
    • Genetic analysis of melanophore development in zebrafish embryos
    • Kelsh RN, Schmid B, Eisen JS. 2000. Genetic analysis of melanophore development in zebrafish embryos. Dev Biol 225:277-293.
    • (2000) Dev Biol , vol.225 , pp. 277-293
    • Kelsh, R.N.1    Schmid, B.2    Eisen, J.S.3
  • 52
    • 0942276434 scopus 로고    scopus 로고
    • Pilot Morpholino Screen in Xenopus tropicalis Identifies a Novel Gene Involved in Head Development
    • DOI 10.1002/dvdy.10440
    • Kenwrick S, Amaya E, Papalopulu N. 2004. Pilot morpholino screen in Xenopus tropicalis identifies a novel gene involved in head development. Dev Dyn 229:289-299. (Pubitemid 38140467)
    • (2004) Developmental Dynamics , vol.229 , Issue.2 , pp. 289-299
    • Kenwrick, S.1    Amaya, E.2    Papalopulu, N.3
  • 55
    • 0042062231 scopus 로고    scopus 로고
    • A restrictive role for Hedgehog signalling during otic specification in Xenopus
    • DOI 10.1016/S0012-1606(03)00242-2
    • Koebernick K, Hollemann T, Pieler T. 2003. A restrictive role for Hedgehog signalling during otic specification in Xenopus. Dev Biol 260:325-338. (Pubitemid 36960082)
    • (2003) Developmental Biology , vol.260 , Issue.2 , pp. 325-338
    • Koebernick, K.1    Hollemann, T.2    Pieler, T.3
  • 56
    • 58149457080 scopus 로고    scopus 로고
    • A novel cell-free screen identifies a potent inhibitor of the Fanconi anemia pathway
    • Landais I, Sobeck A, Stone S, LaChapelle A, Hoatlin ME. 2009. A novel cell-free screen identifies a potent inhibitor of the Fanconi anemia pathway. Int J Cancer 124:783-792.
    • (2009) Int J Cancer , vol.124 , pp. 783-792
    • Landais, I.1    Sobeck, A.2    Stone, S.3    LaChapelle, A.4    Hoatlin, M.E.5
  • 58
    • 0037020041 scopus 로고    scopus 로고
    • Asymmetries in H+/ K+-ATPase and cell membrane potentials comprise a very early step in left-right patterning
    • Levin M, Thorlin T, Robinson KR, Nogi T, Mercola M. 2002. Asymmetries in H+/ K+-ATPase and cell membrane potentials comprise a very early step in left-right patterning. Cell 111:77-89.
    • (2002) Cell , vol.111 , pp. 77-89
    • Levin, M.1    Thorlin, T.2    Robinson, K.R.3    Nogi, T.4    Mercola, M.5
  • 59
    • 34247186766 scopus 로고    scopus 로고
    • Animal models of human disease: Zebrafish swim into view
    • DOI 10.1038/nrg2091, PII NRG2091
    • Lieschke GJ, Currie PD. 2007. Animal models of human disease: zebrafish swim into view. Nat Rev Genet 8:353-367. (Pubitemid 46625809)
    • (2007) Nature Reviews Genetics , vol.8 , Issue.5 , pp. 353-367
    • Lieschke, G.J.1    Currie, P.D.2
  • 60
    • 0034461768 scopus 로고    scopus 로고
    • Drug-like properties and the causes of poor solubility and poor permeability
    • DOI 10.1016/S1056-8719(00)00107-6, PII S1056871900001076
    • Lipinski CA. 2000. Drug-like properties and the causes of poor solubility and poor permeability. J Pharmacol Toxicol Methods 44:235-249. (Pubitemid 32239479)
    • (2000) Journal of Pharmacological and Toxicological Methods , vol.44 , Issue.1 , pp. 235-249
    • Lipinski, C.A.1
  • 61
    • 0035289779 scopus 로고    scopus 로고
    • Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings
    • Lipinski CA, Lombardo F, Dominy BW, Feeney PJ. 2001. Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. Adv Drug Deliv Rev 46:3-26.
    • (2001) Adv Drug Deliv Rev , vol.46 , pp. 3-26
    • Lipinski, C.A.1    Lombardo, F.2    Dominy, B.W.3    Feeney, P.J.4
  • 64
    • 48949116218 scopus 로고    scopus 로고
    • Investigations of the effects of the antimalarial drug dihydroartemisinin (DHA) using the Frog Embryo Teratogenesis Assay-Xenopus (FETAX)
    • Longo M, Zanoncelli S, Della Torre P, Rosa F, Giusti A, Colombo P, Brughera M, Mazue G, Olliaro P. 2008. Investigations of the effects of the antimalarial drug dihydroartemisinin (DHA) using the Frog Embryo Teratogenesis Assay-Xenopus (FETAX). Reprod Toxicol 25:433-441.
    • (2008) Reprod Toxicol , vol.25 , pp. 433-441
    • Longo, M.1    Zanoncelli, S.2    Della Torre, P.3    Rosa, F.4    Giusti, A.5    Colombo, P.6    Brughera, M.7    Mazue, G.8    Olliaro, P.9
  • 65
    • 2342503825 scopus 로고    scopus 로고
    • Overcoming the gridlock in discovery research
    • DOI 10.1038/nbt0504-522
    • Margolis J, Plowman GD. 2004. Overcoming the gridlock in discovery research. Nat Biotechnol 22:522-524. (Pubitemid 38585901)
    • (2004) Nature Biotechnology , vol.22 , Issue.5 , pp. 522-524
    • Margolis, J.1    Plowman, G.D.2
  • 66
    • 0036337492 scopus 로고    scopus 로고
    • Fgf3 and Fgf8 are required together for formation of the otic placode and vesicle
    • Maroon H, Walshe J, Mahmood R, Kiefer P, Dickson C, Mason I. 2002. Fgf3 and Fgf8 are required together for formation of the otic placode and vesicle. Development 129:2099-2108.
    • (2002) Development , vol.129 , pp. 2099-2108
    • Maroon, H.1    Walshe, J.2    Mahmood, R.3    Kiefer, P.4    Dickson, C.5    Mason, I.6
  • 69
    • 44949162060 scopus 로고    scopus 로고
    • Targeted gene inactivation in zebrafish using engineered zinc-finger nucleases
    • Meng X, Noyes MB, Zhu LJ, Lawson ND, Wolfe SA. 2008. Targeted gene inactivation in zebrafish using engineered zinc-finger nucleases. Nat Biotechnol 26:695-701.
    • (2008) Nat Biotechnol , vol.26 , pp. 695-701
    • Meng, X.1    Noyes, M.B.2    Zhu, L.J.3    Lawson, N.D.4    Wolfe, S.A.5
  • 70
    • 0031731989 scopus 로고    scopus 로고
    • Genetics of programmed cell death in C. elegans: Past, present and future
    • DOI 10.1016/S0168-9525(98)01573-X
    • Metzstein MM, Stanfield GM, Horvitz HR. 1998. Genetics of programmed cell death in C. elegans: past, present and future. Trends Genet 14:410-416. (Pubitemid 28505585)
    • (1998) Trends in Genetics , vol.14 , Issue.10 , pp. 410-416
    • Metzstein, M.M.1    Stanfield, G.M.2    Horvitz, H.R.3
  • 71
    • 0037453021 scopus 로고    scopus 로고
    • Drugs that induce repolarization abnormalities cause bradycardia in zebrafish
    • DOI 10.1161/01.CIR.0000061912.88753.87
    • Milan DJ, Peterson TA, Ruskin JN, Peterson RT, MacRae CA. 2003. Drugs that induce repolarization abnormalities cause bradycardia in zebrafish. Circulation 107:1355-1358. (Pubitemid 36350731)
    • (2003) Circulation , vol.107 , Issue.10 , pp. 1355-1358
    • Milan, D.J.1    Peterson, T.A.2    Ruskin, J.N.3    Peterson, R.T.4    MacRae, C.A.5
  • 75
  • 77
    • 33747040085 scopus 로고    scopus 로고
    • Small molecule screening in the zebrafish
    • DOI 10.1016/j.ymeth.2005.09.019, PII S1046202306000673
    • Murphey RD, Zon LI. 2006. Small molecule screening in the zebrafish. Methods 39:255-261. (Pubitemid 44209329)
    • (2006) Methods , vol.39 , Issue.3 , pp. 255-261
    • Murphey, R.D.1    Zon, L.I.2
  • 78
    • 33751032262 scopus 로고    scopus 로고
    • A chemical genetic screen for cell cycle inhibitors in zebrafish embryos
    • DOI 10.1111/j.1747-0285.2006.00439.x
    • Murphey RD, Stern HM, Straub CT, Zon LI. 2006. A chemical genetic screen for cell cycle inhibitors in zebrafish embryos. Chem Biol Drug Des 68:213-219. (Pubitemid 44760246)
    • (2006) Chemical Biology and Drug Design , vol.68 , Issue.4 , pp. 213-219
    • Murphey, R.D.1    Stern, H.M.2    Straub, C.T.3    Zon, L.I.4
  • 79
    • 34250628806 scopus 로고    scopus 로고
    • Identification of novel pigmentation modulators by chemical genetic screening
    • DOI 10.1038/sj.jid.5700852, PII 5700852
    • Ni-Komatsu L, Orlow SJ. 2007. Identification of novel pigmentation modulators by chemical genetic screening. J Invest Dermatol 127:1585-1592. (Pubitemid 46933418)
    • (2007) Journal of Investigative Dermatology , vol.127 , Issue.7 , pp. 1585-1592
    • Ni-Komatsu, L.1    Orlow, S.J.2
  • 81
    • 0019133661 scopus 로고
    • Mutations affecting segment number and polarity in Drosophila
    • DOI 10.1038/287795a0
    • Nusslein-Volhard C, Wieschaus E. 1980. Mutations affecting segment number and polarity in Drosophila. Nature 287:795-801. (Pubitemid 11214475)
    • (1980) Nature , vol.287 , Issue.5785 , pp. 795-801
    • Nusslein-Volhard, C.1    Wieschaus, E.2
  • 84
    • 33847195428 scopus 로고    scopus 로고
    • Matrix metalloproteinases and the regulation of tissue remodelling
    • DOI 10.1038/nrm2125, PII NRM2125
    • Page-McCaw A, Ewald AJ, Werb Z. 2007. Matrix metalloproteinases and the regulation of tissue remodelling. Nat Rev Mol Cell Biol 8:221-233. (Pubitemid 46310551)
    • (2007) Nature Reviews Molecular Cell Biology , vol.8 , Issue.3 , pp. 221-233
    • Page-McCaw, A.1    Ewald, A.J.2    Werb, Z.3
  • 85
    • 33646073413 scopus 로고    scopus 로고
    • Biochemical suppression of small-molecule inhibitors: A strategy to identify inhibitor targets and signaling pathway components
    • Peterson JR, Lebensohn AM, Pelish HE, Kirschner MW. 2006. Biochemical suppression of small-molecule inhibitors: a strategy to identify inhibitor targets and signaling pathway components. Chem Biol 13:443-452.
    • (2006) Chem Biol , vol.13 , pp. 443-452
    • Peterson, J.R.1    Lebensohn, A.M.2    Pelish, H.E.3    Kirschner, M.W.4
  • 86
    • 16644375807 scopus 로고    scopus 로고
    • Discovery and Use of Small Molecules for Probing Biological Processes in Zebrafish
    • DOI 10.1016/S0091-679X(04)76026-4, PII S0091679X04760264, The Zebrafish: Cellular and Developmental Biology
    • Peterson RT, Fishman MC. 2004. Discovery and use of small molecules for probing biological processes in zebrafish. Methods Cell Biol 76:569-591. (Pubitemid 39752581)
    • (2004) Methods in Cell Biology , vol.76 , pp. 569-591
    • Peterson, R.T.1    Fishman, M.C.2
  • 87
    • 0034700166 scopus 로고    scopus 로고
    • Small molecule developmental screens reveal the logic and timing of vertebrate development
    • Peterson RT, Link BA, Dowling JE, Schreiber SL. 2000. Small molecule developmental screens reveal the logic and timing of vertebrate development. Proc Natl Acad Sci USA 97:12965-12969.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 12965-12969
    • Peterson, R.T.1    Link, B.A.2    Dowling, J.E.3    Schreiber, S.L.4
  • 88
    • 0035797939 scopus 로고    scopus 로고
    • Convergence of distinct pathways to heart patterning revealed by the small molecule concentramide and the mutation heart-and-soul
    • DOI 10.1016/S0960-9822(01)00482-1
    • Peterson RT, Mably JD, Chen JN, Fishman MC. 2001. Convergence of distinct pathways to heart patterning revealed by the small molecule concentramide and the mutation heart-and-soul. Curr Biol 11:1481-1491. (Pubitemid 32931009)
    • (2001) Current Biology , vol.11 , Issue.19 , pp. 1481-1491
    • Peterson, R.T.1    Mably, J.D.2    Chen, J.-N.3    Fishman, M.C.4
  • 93
    • 0034880203 scopus 로고    scopus 로고
    • Tight transcriptional control of the ETS domain factors Erm and Pea3 by Fgf signaling during early zebrafish development
    • PII S0925477301004567
    • Raible F, Brand M. 2001. Tight transcriptional control of the ETS domain factors Erm and Pea3 by Fgf signaling during early zebrafish development. Mech Dev 107:105-117. (Pubitemid 32755809)
    • (2001) Mechanisms of Development , vol.107 , Issue.1-2 , pp. 105-117
    • Raible, F.1    Brand, M.2
  • 94
    • 33751359804 scopus 로고    scopus 로고
    • Defining synphenotype groups in Xenopus tropicalis by use of antisense morpholino oligonucleotides
    • DOI 10.1371/journal.pgen.0020193
    • Rana AA, Collart C, Gilchrist MJ, Smith JC. 2006. Defining synphenotype groups in Xenopus tropicalis by use of antisense morpholino oligonucleotides. PLoS Genet 2:e193. (Pubitemid 44813574)
    • (2006) PLoS Genetics , vol.2 , Issue.11 , pp. 1751-1772
    • Rana, A.A.1    Collart, C.2    Gilchrist, M.J.3    Smith, J.C.4
  • 95
    • 17244376814 scopus 로고    scopus 로고
    • Wnt signalling in stem cells and cancer
    • DOI 10.1038/nature03319
    • Reya T, Clevers H. 2005. Wnt signalling in stem cells and cancer. Nature 434:843-850. (Pubitemid 40558990)
    • (2005) Nature , vol.434 , Issue.7035 , pp. 843-850
    • Reya, T.1    Clevers, H.2
  • 96
    • 33751095609 scopus 로고    scopus 로고
    • A toxicity and hazard assessment of fourteen pharmaceuticals to Xenopus laevis larvae
    • DOI 10.1007/s10646-006-0102-4
    • Richards SM, Cole SE. 2006. A toxicity and hazard assessment of fourteen pharmaceuticals to Xenopus laevis larvae. Ecotoxicology 15:647-656. (Pubitemid 44764295)
    • (2006) Ecotoxicology , vol.15 , Issue.8 , pp. 647-656
    • Richards, S.M.1    Cole, S.E.2
  • 98
    • 0141521869 scopus 로고    scopus 로고
    • Biological mechanism profiling using an annotated compound library
    • DOI 10.1016/j.chembiol.2003.08.009
    • Root DE, Flaherty SP, Kelley BP, Stockwell BR. 2003. Biological mechanism profiling using an annotated compound library. Chem Biol 10:881-892. (Pubitemid 37171905)
    • (2003) Chemistry and Biology , vol.10 , Issue.9 , pp. 881-892
    • Root, D.E.1    Flaherty, S.P.2    Kelley, B.P.3    Stockwell, B.R.4
  • 100
    • 44849098437 scopus 로고    scopus 로고
    • Identification of a novel retinoid by small molecule screening with zebrafish embryos
    • Sachidanandan C, Yeh JR, Peterson QP, Peterson RT. 2008. Identification of a novel retinoid by small molecule screening with zebrafish embryos. PLoS ONE 3:e1947.
    • (2008) PLoS ONE , vol.3
    • Sachidanandan, C.1    Yeh, J.R.2    Peterson, Q.P.3    Peterson, R.T.4
  • 101
    • 0034678033 scopus 로고    scopus 로고
    • Target-oriented and diversity-oriented organic synthesis in drug discovery
    • DOI 10.1126/science.287.5460.1964
    • Schreiber SL. 2000. Target-oriented and diversity-oriented organic synthesis in drug discovery. Science 287:1964-1969. (Pubitemid 30158663)
    • (2000) Science , vol.287 , Issue.5460 , pp. 1964-1969
    • Schreiber, S.L.1
  • 102
    • 34248598584 scopus 로고    scopus 로고
    • Invertebrate animal models of diseases as screening tools in drug discovery
    • DOI 10.1021/cb700009m
    • Segalat L. 2007. Invertebrate animal models of diseases as screening tools in drug discovery. ACS Chem Biol 2:231-236. (Pubitemid 47629209)
    • (2007) ACS Chemical Biology , vol.2 , Issue.4 , pp. 231-236
    • Segalat, L.1
  • 103
    • 0000905788 scopus 로고    scopus 로고
    • Zebrafish angiogenesis: A new model for drug screening
    • Serbedzija GN, Flynn E, Willett CE. 1999. Zebrafish angiogenesis: a new model for drug screening. Angiogenesis 3:353-359. (Pubitemid 129643978)
    • (1999) Angiogenesis , vol.3 , Issue.4 , pp. 353-359
    • Serbedzija, G.N.1    Flynn, E.2    Willett, C.E.3
  • 104
    • 7944229549 scopus 로고    scopus 로고
    • Induction of reversible hemolytic anemia in living zebrafish using a novel small molecule
    • DOI 10.1016/j.cca.2004.05.003, PII S1532045604000948, Aquatic Animal Models of Human Disease
    • Shafizadeh E, Peterson RT, Lin S. 2004. Induction of reversible hemolytic anemia in living zebrafish using a novel small molecule. Comp Biochem Physiol C Toxicol Pharmacol 138:245-249. (Pubitemid 39469059)
    • (2004) Comparative Biochemistry and Physiology - C Toxicology and Pharmacology , vol.138 , Issue.3 , pp. 245-249
    • Shafizadeh, E.1    Peterson, R.T.2    Lin, S.3
  • 105
    • 28244496603 scopus 로고    scopus 로고
    • Identification of a specific inhibitor of the Dishevelled PDZ domain
    • DOI 10.1021/bi0512602
    • Shan J, Shi DL, Wang J, Zheng J. 2005. Identification of a specific inhibitor of the dishevelled PDZ domain. Biochemistry 44:15495-15503. (Pubitemid 41706133)
    • (2005) Biochemistry , vol.44 , Issue.47 , pp. 15495-15503
    • Shan, J.1    Shi, D.-L.2    Wang, J.3    Zheng, J.4
  • 107
    • 0035170549 scopus 로고    scopus 로고
    • Fgf signalling through MAPK cascade is required for development of the subpallial telencephalon in zebrafish embryos
    • Shinya M, Koshida S, Sawada A, Kuroiwa A, Takeda H. 2001. Fgf signalling through MAPK cascade is required for development of the subpallial telencephalon in zebrafish embryos. Development 128:4153-4164. (Pubitemid 33077028)
    • (2001) Development , vol.128 , Issue.21 , pp. 4153-4164
    • Shinya, M.1    Koshida, S.2    Sawada, A.3    Kuroiwa, A.4    Takeda, H.5
  • 108
    • 0037138650 scopus 로고    scopus 로고
    • Diversity-oriented synthesis of biaryl-containing medium rings using a one bead/one stock solution platform
    • DOI 10.1021/ja017248o
    • Spring DR, Krishnan S, Blackwell HE, Schreiber SL. 2002. Diversity-oriented synthesis of biaryl-containing medium rings using a one bead/one stock solution platform. J Am Chem Soc 124:1354-1363. (Pubitemid 34169142)
    • (2002) Journal of the American Chemical Society , vol.124 , Issue.7 , pp. 1354-1363
    • Spring, D.R.1    Krishnan, S.2    Blackwell, H.E.3    Schreiber, S.L.4
  • 109
    • 0035221107 scopus 로고    scopus 로고
    • Zebrafish genetics and vertebrate heart formation
    • DOI 10.1038/35047564
    • Stainier DY. 2001. Zebrafish genetics and vertebrate heart formation. Nat Rev Genet 2:39-48. (Pubitemid 33674768)
    • (2001) Nature Reviews Genetics , vol.2 , Issue.1 , pp. 39-48
    • Stainier, D.Y.R.1
  • 110
    • 0742323536 scopus 로고    scopus 로고
    • TILLING - A high-throughput harvest for functional genomics
    • DOI 10.1038/nrg1273
    • Stemple DL. 2004. TILLING: a high-throughput harvest for functional genomics. Nat Rev Genet 5:145-150. (Pubitemid 38160281)
    • (2004) Nature Reviews Genetics , vol.5 , Issue.2 , pp. 145-150
    • Stemple, D.L.1
  • 112
    • 0035961490 scopus 로고    scopus 로고
    • Split - Pool synthesis of 1,3-dioxanes leading to arrayed stock solutions of single compounds sufficient for multiple phenotypic and protein-binding assays
    • DOI 10.1021/ja0036108
    • Sternson SM, Louca JB, Wong JC, Schreiber SL. 2001. Split-pool synthesis of 1,3-dioxanes leading to arrayed stock solutions of single compounds sufficient for multiple phenotypic and protein-binding assays. J Am Chem Soc 123:1740-1747. (Pubitemid 32179424)
    • (2001) Journal of the American Chemical Society , vol.123 , Issue.8 , pp. 1740-1747
    • Sternson, S.M.1    Louca, J.B.2    Wong, J.C.3    Schreiber, S.L.4
  • 113
    • 0034331004 scopus 로고    scopus 로고
    • Chemical genetics: Ligand-based discovery of gene function
    • Stockwell BR. 2000. Chemical genetics: ligand-based discovery of gene function. Nat Rev Genet 1:116-125.
    • (2000) Nat Rev Genet , vol.1 , pp. 116-125
    • Stockwell, B.R.1
  • 114
    • 11144298973 scopus 로고    scopus 로고
    • Exploring biology with small organic molecules
    • DOI 10.1038/nature03196
    • Stockwell BR. 2004. Exploring biology with small organic molecules. Nature 432:846-854. (Pubitemid 40037140)
    • (2004) Nature , vol.432 , Issue.7019 , pp. 846-854
    • Stockwell, B.R.1
  • 115
    • 63149157274 scopus 로고    scopus 로고
    • Molecular genetics of human pigmentation diversity
    • Sturm RA. 2009. Molecular genetics of human pigmentation diversity. Hum Mol Genet 18:R9-17.
    • (2009) Hum Mol Genet , vol.18
    • Sturm, R.A.1
  • 117
    • 26644435056 scopus 로고    scopus 로고
    • Xenopus as a model organism in developmental chemical genetic screens
    • DOI 10.1039/b506103b
    • Tomlinson M, Field RA, Wheeler GN. 2005. Xenopus as a model organism in developmental chemical genetic screens. Molecular BioSystems 1:223-228. (Pubitemid 41442432)
    • (2005) Molecular BioSystems , vol.1 , Issue.3 , pp. 223-228
    • Tomlinson, M.L.1    Field, R.A.2    Wheeler, G.N.3
  • 118
    • 58849103612 scopus 로고    scopus 로고
    • A chemical genomic approach identifies matrix metalloproteinases as playing an essential and specific role in Xenopus melanophore migration
    • Tomlinson ML, Guan P, Morris RJ, Fidock MD, Rejzek M, Garcia-Morales C, Field RA, Wheeler GN. 2009a. A chemical genomic approach identifies matrix metalloproteinases as playing an essential and specific role in Xenopus melanophore migration. Chem Biol 16:93-104.
    • (2009) Chem Biol , vol.16 , pp. 93-104
    • Tomlinson, M.L.1    Guan, P.2    Morris, R.J.3    Fidock, M.D.4    Rejzek, M.5    Garcia-Morales, C.6    Field, R.A.7    Wheeler, G.N.8
  • 119
    • 62949098600 scopus 로고    scopus 로고
    • Chemical genomics identifies compounds affecting Xenopus laevis pigment cell development
    • Tomlinson ML, Rejzek M, Fidock M, Field RA, Wheeler GN. 2009b. Chemical genomics identifies compounds affecting Xenopus laevis pigment cell development Molecular BioSystems 5:376-384.
    • (2009) Molecular BioSystems , vol.5 , pp. 376-384
    • Tomlinson, M.L.1    Rejzek, M.2    Fidock, M.3    Field, R.A.4    Wheeler, G.N.5
  • 120
    • 0028876086 scopus 로고
    • Gridlock: A model for coarctation of the aorta?
    • Towbin JA, McQuinn TC. 1995. Gridlock: a model for coarctation of the aorta? Nat Med 1:1141-1142.
    • (1995) Nat Med , vol.1 , pp. 1141-1142
    • Towbin, J.A.1    McQuinn, T.C.2
  • 123
    • 0037380723 scopus 로고    scopus 로고
    • Comparative genomics: Genome-wide analysis in metazoan eukaryotes
    • DOI 10.1038/nrg1043
    • Ureta-Vidal A, Ettwiller L, Birney E. 2003. Comparative genomics: genome-wide analysis in metazoan eukaryotes. Nat Rev Genet 4:251-262. (Pubitemid 36389530)
    • (2003) Nature Reviews Genetics , vol.4 , Issue.4 , pp. 251-262
    • Ureta-Vidal, A.1    Ettwiller, L.2    Birney, E.3
  • 124
    • 0036781709 scopus 로고    scopus 로고
    • MMP9 potentiates pulmonary metastasis formation
    • DOI 10.1016/S1535-6108(02)00157-5
    • van Kempen LC, Coussens LM. 2002. MMP9 potentiates pulmonary metastasis formation. Cancer Cell 2:251-252. (Pubitemid 41043957)
    • (2002) Cancer Cell , vol.2 , Issue.4 , pp. 251-252
    • Van Kempen, L.C.L.1    Coussens, L.M.2
  • 125
    • 16844386134 scopus 로고    scopus 로고
    • Wnt/Frizzled signaling during vertebrate retinal development
    • DOI 10.1159/000082277
    • Van Raay TJ, Vetter ML. 2004. Wnt/frizzled signaling during vertebrate retinal development. Dev Neurosci 26:352-358. (Pubitemid 40663243)
    • (2004) Developmental Neuroscience , vol.26 , Issue.5-6 , pp. 352-358
    • Van Raay, T.J.1    Vetter, M.L.2
  • 127
    • 34447250515 scopus 로고    scopus 로고
    • 1 embryotoxicity using the frog embryo teratogenesis assay-Xenopus and bio-activation with microsome activation systems
    • DOI 10.1002/bdrb.20113
    • Vismara C, Caloni F. 2007. Evaluation of aflatoxin B1 embryotoxicity using the frog embryo teratogenesis assay-Xenopus and bio-activation with microsome activation systems. Birth Defects Res B Dev Reprod Toxicol 80:183-187. (Pubitemid 47047367)
    • (2007) Birth Defects Research Part B - Developmental and Reproductive Toxicology , vol.80 , Issue.3 , pp. 183-187
    • Vismara, C.1    Caloni, F.2
  • 128
    • 33847298936 scopus 로고    scopus 로고
    • Xenopus as a model system for vertebrate heart development
    • DOI 10.1016/j.semcdb.2006.11.010, PII S108495210600125X
    • Warkman AS, Krieg PA. 2007. Xenopus as a model system for vertebrate heart development. Semin Cell Dev Biol 18:46-53. (Pubitemid 46330842)
    • (2007) Seminars in Cell and Developmental Biology , vol.18 , Issue.1 , pp. 46-53
    • Warkman, A.S.1    Krieg, P.A.2
  • 129
    • 50849127845 scopus 로고    scopus 로고
    • Melanocytes in development, regeneration, and cancer
    • White RM, Zon LI. 2008. Melanocytes in development, regeneration, and cancer. Cell Stem Cell 3:242-252.
    • (2008) Cell Stem Cell , vol.3 , pp. 242-252
    • White, R.M.1    Zon, L.I.2
  • 133
    • 4644273636 scopus 로고    scopus 로고
    • Modular synthesis and preliminary biological evaluation of stereochemically diverse 1,3-dioxanes
    • DOI 10.1016/j.chembiol.2004.07.012, PII S1074552104002261
    • Wong JC, Sternson SM, Louca JB, Hong R, Schreiber SL. 2004. Modular synthesis and preliminary biological evaluation of stereochemically diverse 1,3-dioxanes. Chem Biol 11:1279-1291. (Pubitemid 39282802)
    • (2004) Chemistry and Biology , vol.11 , Issue.9 , pp. 1279-1291
    • Wong, J.C.1    Sternson, S.M.2    Louca, J.B.3    Hong, R.4    Schreiber, S.L.5
  • 137
    • 0034629325 scopus 로고    scopus 로고
    • Gridlock, an HLH gene required for assembly of the aorta in zebrafish
    • DOI 10.1126/science.287.5459.1820
    • Zhong TP, Rosenberg M, Mohideen MA, Weinstein B, Fishman MC. 2000. gridlock, an HLH gene required for assembly of the aorta in zebrafish. Science 287:1820-1824. (Pubitemid 30143966)
    • (2000) Science , vol.287 , Issue.5459 , pp. 1820-1824
    • Fishman, M.C.1
  • 139
    • 12144273121 scopus 로고    scopus 로고
    • In vivo drug discovery in the zebrafish
    • Zon LI, Peterson RT. 2005. In vivo drug discovery in the zebrafish. Nat Rev Drug Discov 4:35-44.
    • (2005) Nat Rev Drug Discov , vol.4 , pp. 35-44
    • Zon, L.I.1    Peterson, R.T.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.