Genome-wide screening of Saccharomyces cerevisiae to identify genes required for antibiotic insusceptibility of eukaryotes

Antimicrobial Agents and Chemotherapy

Volumn 47, Issue 2, 2003, Pages 676-681

  Blackburn, Alexandra S ^a   Avery, Simon V ^a  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMOXICILLIN; GENTAMICIN; OXYTETRACYCLINE; PENICILLIN G; RIFAMPICIN; TETRACYCLINE; VANCOMYCIN;

ANTIBIOTIC SENSITIVITY; ARTICLE; CELLULAR DISTRIBUTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; FUNGAL GENE; FUNGAL GENETICS; FUNGUS GROWTH; GENE DELETION; GENETIC ANALYSIS; GOLGI COMPLEX; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE; STRAIN DIFFERENCE;

DRUG RESISTANCE; EUKARYOTIC CELLS; GENOME; GENTAMICINS; MICROBIAL SENSITIVITY TESTS; SACCHAROMYCES CEREVISIAE; TETRACYCLINES;

EID: 0037311417     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.47.2.676-681.2003     Document Type: Article

References (21)

1. Angrave, F. E., and S. V. Avery. 2001. Antioxidant functions required for insusceptibility of Saccharomyces cerevisiae to tetracycline antibiotics. Antimicrob. Agents Chemother. 45:2939-2942.
2. Avery, S. V., S. Malkapuram, C. Mateus, and K. S. Babb. 2000. Cu/Zn superoxide dismutase is required for oxytetracycline resistance of Saccharomyces cerevisiae. J. Bacteriol. 182:76-80.
3. Finch, R. G. 2000. Adverse reactions to antibiotics, p. 200-211. In D. Greenwood (ed.), Antimicrobial chemotherapy, 4th ed. Oxford University Press, Oxford, United Kingdom.
4. Forge, A., and J. Schacht. 2000. Aminoglycoside antibiotics. Audiol. Neurootol. 5:3-22.
5. Foury, F. 1997. Human genetic diseases: a cross-talk between man and yeast. Gene 195:1-10.
6. Giaever, G., D. Shoemaker, T. W. Jones, H. Liang, E. Winzeler, A. Astromoff, and R. Davis. 1999. Genomic profiling of drug sensitivities via induced haploinsufficiency. Nat. Genet. 21:278-283.
7. Higgins, V. J., N. Alic, G. W. Thorpe, M. Breitenbach, V. Larsson, and I. W. Dawes. 2001. Phenotypic analysis of gene deletant strains for sensitivity to oxidative stress. Yeast 19:203-214.
8. Howlett, N. G., and S. V. Avery. 1997. Induction of lipid peroxidation during heavy metal stress in Saccharomyces cerevisiae and influence of plasma membrane fatty acid unsaturation. Appl. Environ. Microbiol. 63:2971-2976.
9. Hughes, T. R., et al. 2000. Functional discovery via a compendium of expression profiles. Cell 102:109-126.
10. Kucers, A., S. M. Crowe, M. L. Grayson, and J. F. Hoy. 1997. The use of antibiotics: a clinical review of antibacterial, antifungal and antiviral drugs, 5th ed. Butterworth-Heinemann, Oxford, United Kingdom.
11. Mingeot-Leclercq, M.-P., and P. M. Tulkens. 1999. Aminoglycosides: nephrotoxicity. Antimicrob. Agents Chemother. 43:1003-1012.
12. Poole, K. 2001. Multidrug resistance in gram-negative bacteria. Curr. Opin. Microbiol. 4:500-508.
13. Prezant, T. R., J. V. Agapian, M. C. Bohlman, X. D. Bu, S. Oztas, W. Q. Qiu, K. S. Arnos, G. A. Cortopassi, L. Jaber, J. I. Rotter, M. Shohat, and N. Fischelghodsian. 1993. Mitochondrial ribosomal-RNA mutation associated with both antibiotic-induced and non-syndromic deafness. Nat. Genet. 4: 289-294.
14. Raamsdonk, L., B. Teusink, D. Broadhurst, N. S. Zhang, A. Hayes, M. Walsh, J. Berden, K. Brindle, D. Kell, J. Rowland, H. Westerhoff, K. van Dam, and S. Oliver. 2001. A functional genomics strategy that uses metabolome data to reveal the phenotype of silent mutations. Nat. Biotechnol. 19:45-50.
15. Rieger, K. J., G. Orlowska, A. Kaniak, J. Y. Coppee, G. Aljinovic, and P. P. Slonimski. 1999. Large-scale phenotypic analysis in microtitre plates of mutants with deleted open reading frames from yeast chromosome III: key-step between genomic sequencing and protein function. Methods Microbiol. 28: 205-227.
16. Ring, H. Z., and D. L. Kroetz. 2002. Candidate gene approach for pharmacogenetic studies. Pharmacogenomics 3:47-56.
17. Sandoval, R., J. Leiser, and B. A. Molitoris. 1998. Aminoglycoside antibiotics traffic to the Golgi complex in LLC-PK1 cells. J. Am. Soc. Nephrol. 9:167-174.
18. Scholar, E. M., and W. B. Pratt. 2000. The Antimicrobial drugs, 2nd ed. Oxford University Press, Oxford, United Kingdom.
19. Silverblatt, F. J., and C. Kuehn. 1979. Autoradiography of gentamicin uptake by the rat proximal tubule cell. Kidney Int. 15:335-345.
20. Slaughter, R. L., and D. M. Cappelletty. 1998. Economic impact of aminoglycoside toxicity and its prevention through therapeutic drug monitoring. Pharmacoeconomics 14:385-394.
21. Winzeler, E., et al. 1999. Functional characterization of the S. cerevisiae genome by gene deletion and parallel analysis. Science 285:901-906.