Integrin expression in colon cancer cells is regulated by the cytoplasmic domain of the β6 integrin subunit

International Journal of Cancer

Volumn 99, Issue 4, 2002, Pages 529-537

  Niu, Jun ^a   Dorahy, Douglas J ^a   Gu, Xinhua ^a   Scott, R J ^a   Draganic, Brian ^a   Ahmed, Nuzhat ^b,c   Agrez, Michael V ^a,d  

^a HUNTER MEDICAL RESEARCH INSTITUTE   (Australia)

^b ROYAL WOMEN'S HOSPITAL   (Australia)

^c UNIVERSITY OF MELBOURNE   (Australia)

^d JOHN HUNTER HOSPITAL   (Australia)

Author keywords

Cell density; Colon cancer; Integrins; Kinase signalling

Indexed keywords

INTEGRIN; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE C;

ARTICLE; CANCER CELL CULTURE; CELL ADHESION; CELL DENSITY; COLON CANCER; CYTOPLASM; FLUORESCENCE ACTIVATED CELL SORTING; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION;

AMINO ACID MOTIFS; BINDING SITES; BLOTTING, WESTERN; CELL ADHESION; CELL SEPARATION; COLONIC NEOPLASMS; CYTOPLASM; FLOW CYTOMETRY; GENE DELETION; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; INTEGRIN BETA CHAINS; INTEGRINS; PRECIPITIN TESTS; PROTEIN BINDING; PROTEIN KINASE C; PROTEIN STRUCTURE, TERTIARY; TUMOR CELLS, CULTURED;

EID: 0036605068     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/ijc.10397     Document Type: Article

References (26)

1. Role of integrins in cancer: Survey of expression patterns
2. Integrins and signal transduction
3. Multiple roles of integrins in cell motility
4. Integrins: Versatility, modulation and signaling in cell adhesion
5. Complete amino acid sequence of a novel integrin β subunit (β6) identified in epithelial cells using the polymerase chain reaction
6. Expression of the β6 integrin in development, neoplasia and tissue repair suggests a role in epithelial remodelling
7. Expression of alpha(v) beta 6 integrin in oral leukoplakia
8. Integrins and oral cancer
9. Multiplicity of fibronectin-binding αv integrin receptors in colorectal cancer
10. Integrin expression in non-small cell carcinoma of the lung
11. Significance of α9β1 and αvβ6 integrin expression in breast carcinoma
12. The αvβ6 integrin regulates its own expression with cell crowding: Implications for tumour progression
13. Modulation of human melanoma cell metastasis and adhesion may involve integrin phosphorylation mediated through protein kinase C
14. αv integrin, p38 mitogen-activated protein kinase and urokinase plasminogen activator are functionally linked in invasive breast cancer cells
15. The αvβ6 integrin promotes proliferation of colon carcinoma cells through a unique region of the β6 cytoplasmic domain
16. Integrin-mediated signalling of gelatinase B secretion in colon cancer cells
17. The αvβ6 integrin induces gelatinase B secretion in colon cancer cells
18. Direct integrin αvβ6-ERK binding: Implications for tumour growth
19. Role of the integrin αvβ6 in cell attachment to fibronectin: Heterologous expression of intact and secreted forms of the receptor
20. Effects of β subunit cytoplasmic domain deletions in the recruitment of the integrin αvβ6 to focal contacts
21. A point mutation in the integrin β6 subunit abolishes both αvβ6 binding to fibronectin and receptor localisation to focal contacts
22. Variable β-catenin expression in colorectal cancers indicates tumor progression driven by the tumor environment
23. Vitronectin-driven human keratinocyte locomotion is mediated by the alpha v beta 5 integrin receptor
24. Requirement for protein kinase C theta for cell cycle progression and formation of actin stress fibers and filopodia in vascular endothelial cells
25. Enhancement of endothelial cell migration and in vitro tube formation by TAP20, a novel beta 5 integrin-modulating, PKC theta-dependent protein
26. Tumor cell invasion is promoted by activation of protease activated receptor-1 in cooperation with the αvβ5 integrin