Demonstration of an in vivo generated sub-picomolar affinity fully human monoclonal antibody to interleukin-8

Biochemical and Biophysical Research Communications

Volumn 334, Issue 4, 2005, Pages 1004-1013

  Rathanaswami, Palaniswami ^a   Roalstad, Shelly ^b   Roskos, Lorin ^c   Su, Qiaojuan Jane ^c   Lackie, Steve ^b   Babcook, John ^a  

^a Abgenix Biopharma Inc   (Canada)

^b Sapidyne Instruments Incorporated   (United States)

^c Abgenix Inc   (United States)

Author keywords

Affinity ceiling; Affinity maturation; B cells; High affinity; Human antibodies; Interleukin 8 (IL 8); KinExA; SLAM; Sub picomolar affinity; XenoMouse

Indexed keywords

INTERLEUKIN 8; INTERLEUKIN 8 ANTIBODY; MONOCLONAL ANTIBODY; NANOPARTICLE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CELL MATURATION; CONTROLLED STUDY; DRUG POTENCY; EQUILIBRIUM CONSTANT; MATHEMATICAL MODEL; MOUSE; NONHUMAN; PREDICTION; PRIORITY JOURNAL;

ANTIBODIES, MONOCLONAL; ANTIGEN-ANTIBODY COMPLEX; FEASIBILITY STUDIES; HUMANS; IMMUNOASSAY; INTERLEUKIN-8; MICROCHEMISTRY; PROTEIN BINDING;

MUS MUSCULUS;

EID: 23044494423     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbrc.2005.07.002     Document Type: Article

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