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2at weekly intervals. 48% of patients responded (6% completely) with a median response duration of 11.8 months. This is comparable to results with single-agent chemotherapy. Toxicity was mild (grade 1 and 2) and seen mainly during the first infusion. Only one patient developed a response involving anti-chimeric antibody.
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2at weekly intervals. 48% of patients responded (6% completely) with a median response duration of 11.8 months. This is comparable to results with single-agent chemotherapy. Toxicity was mild (grade 1 and 2) and seen mainly during the first infusion. Only one patient developed a response involving anti-chimeric antibody.
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Nguyen DT, Amess JA, Doughty H, Hendry L, Diamond LW IDEC C2B8 anti-CD20 (Rituximab) immunotherapy in patients with low-grade non-Hodgkin's lymphoma and lymphoproliferative disorder: evaluation of response on 48 patients. Eur J Haem. 62:1999;76-82. In this study, 21% partial remission was achieved overall with no complete remissions. The results suggest that the CD20 density and the type of B cell neoplasia are critical factors in the success of anti-CD20 mAb treatment. Follicular centre cell lymphoma is the most responsive.
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The biology of erbB-2/neu/HER-2 and its role in cancer
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Hynes NE, Stern DF The biology of erbB-2/neu/HER-2 and its role in cancer. Biochim Biophys Acta. 1198:1994;165-184.
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(1994)
Biochim Biophys Acta
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Hynes, N.E.1
Stern, D.F.2
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42
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0026174552
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Characterization of an anti-p185HER2 monoclonal antibody that stimulates receptor function and inhibits tumor-cell growth
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Sarup JC, Johnson RM, King KL, Fendly BM, Lipari MT, Napier MA, Ullrich A, Shepard HM Characterization of an anti-p185HER2 monoclonal antibody that stimulates receptor function and inhibits tumor-cell growth. Growth Regulat. 1:1991;72-82.
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(1991)
Growth Regulat
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Sarup, J.C.1
Johnson, R.M.2
King, K.L.3
Fendly, B.M.4
Lipari, M.T.5
Napier, M.A.6
Ullrich, A.7
Shepard, H.M.8
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43
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0032556948
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The PEA3 Ets transcription factor is a downstream target of the HER2/neu receptor tyrosine kinase
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O'Hagan RC, Hassell JA The PEA3 Ets transcription factor is a downstream target of the HER2/neu receptor tyrosine kinase. Oncogene. 16:1998;301-310.
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(1998)
Oncogene
, vol.16
, pp. 301-310
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O'Hagan, R.C.1
Hassell, J.A.2
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44
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0033559619
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Monoclonal antibody to HER2-neu receptor modulates repair of radiation induced DNA damage and enhances radiosensitivity of human breast cancer cells overexpressing this oncogene
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This is a key study, demonstrating the potent synergistic effects of combining irradiation with anti-Her-2 mAb therapy. This work demonstrated that anti- Her-2 mAbs influence DNA repair and p21WAF1 levels after irradiation, illustrating a possible mechanism whereby potent therapeutic effects are induced.
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Pietras RJ, Poen JC, Gallardo D, Wongvipat PN, Lee HJ, Slamon DJ Monoclonal antibody to HER2-neu receptor modulates repair of radiation induced DNA damage and enhances radiosensitivity of human breast cancer cells overexpressing this oncogene. Cancer Res. 59:1999;1347-1355. This is a key study, demonstrating the potent synergistic effects of combining irradiation with anti-Her-2 mAb therapy. This work demonstrated that anti- Her-2 mAbs influence DNA repair and p21WAF1 levels after irradiation, illustrating a possible mechanism whereby potent therapeutic effects are induced.
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(1999)
Cancer Res
, vol.59
, pp. 1347-1355
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Pietras, R.J.1
Poen, J.C.2
Gallardo, D.3
Wongvipat, P.N.4
Lee, H.J.5
Slamon, D.J.6
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45
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0029041003
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Prevention of breast tumor development in-vivo by down-regulation of the p185 (neu) receptor
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Katsumata M, Okudaira T, Samanta A, Clark DP, Drebin JA, Jolicoeur P, Greene MI Prevention of breast tumor development in-vivo by down-regulation of the p185 (neu) receptor. Nat Med. 1:1995;644-648.
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(1995)
Nat Med
, vol.1
, pp. 644-648
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Katsumata, M.1
Okudaira, T.2
Samanta, A.3
Clark, D.P.4
Drebin, J.A.5
Jolicoeur, P.6
Greene, M.I.7
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46
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0033049036
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Tyrosine kinase inhibitor emodin suppresses growth of HER-2/neu-overexpressing breast cancer cells in athymic mice and sensitizes these cells to the inhibitory effect of paclitaxel
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The tyrosine kinase inhibitor emodin mimics the effects of mAbs to the Her-2 molecule on breast cells overexpressing this receptor and demonstrates a similar synergistic therapeutic response in combination with paclitaxel.
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Zhang L, Lau Y-K, Xia W, Hortobagyi GN, Hung M-C Tyrosine kinase inhibitor emodin suppresses growth of HER-2/neu-overexpressing breast cancer cells in athymic mice and sensitizes these cells to the inhibitory effect of paclitaxel. Clin Cancer Res. 5:1999;343-353. The tyrosine kinase inhibitor emodin mimics the effects of mAbs to the Her-2 molecule on breast cells overexpressing this receptor and demonstrates a similar synergistic therapeutic response in combination with paclitaxel.
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(1999)
Clin Cancer Res
, vol.5
, pp. 343-353
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Zhang, L.1
Lau, Y.-K.2
Xia, W.3
Hortobagyi, G.N.4
Hung, M.-C.5
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47
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0029664395
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Regulation of 21/WAF1/CIP1 expression through mitogen-activated protein kinase signaling pathway
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Lui Y, Martindale J, Gorospe M, Holbrook N Regulation of 21/WAF1/CIP1 expression through mitogen-activated protein kinase signaling pathway. Cancer Res. 56:1996;31-35.
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(1996)
Cancer Res
, vol.56
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Lui, Y.1
Martindale, J.2
Gorospe, M.3
Holbrook, N.4
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48
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0030800131
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Chimeric anti-CD20 (IDEC-C2B8) monoclonal antibody sensitizes a B cell lymphoma cell line to cell killing by cytotoxic drugs
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Demiden T, Lam S, Alas S, Hariharan K, Hanna N, Bonavida B Chimeric anti-CD20 (IDEC-C2B8) monoclonal antibody sensitizes a B cell lymphoma cell line to cell killing by cytotoxic drugs. Can Biother Radiopharm. 12:1997;177-186.
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(1997)
Can Biother Radiopharm
, vol.12
, pp. 177-186
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Demiden, T.1
Lam, S.2
Alas, S.3
Hariharan, K.4
Hanna, N.5
Bonavida, B.6
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49
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0344766075
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Treatment of patients with low grade B-cell lymphoma with the combination of chimeric anti-CD20 monoclonal antibody and CHOP chemotherapy
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Czuczman MS, Grillo-Lopez AJ, White CA, Saleh M, Gordon L, Lobuglio AF, Klippenstein D, Dallaire B, Varns C Treatment of patients with low grade B-cell lymphoma with the combination of chimeric anti-CD20 monoclonal antibody and CHOP chemotherapy. J Clin Oncol. 17:1999;268-276.
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(1999)
J Clin Oncol
, vol.17
, pp. 268-276
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Czuczman, M.S.1
Grillo-Lopez, A.J.2
White, C.A.3
Saleh, M.4
Gordon, L.5
Lobuglio, A.F.6
Klippenstein, D.7
Dallaire, B.8
Varns, C.9
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50
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0032127350
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TM) enhances the antitumor activity of paclitaxel and doxirubicin against Her2/neu overexpressing breast cancer xenografts
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A clear demonstration that the humanized anti-Her-2 antibody can potentiate the effects of two standard chemotherapeutic agents. This study illustrates the need to explore the signaling pathways involved, as combinations with paclitaxel were far more effective than those with doxirubicin.
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TM) enhances the antitumor activity of paclitaxel and doxirubicin against Her2/neu overexpressing breast cancer xenografts. Cancer Res. 58:1998;2825-2831. A clear demonstration that the humanized anti-Her-2 antibody can potentiate the effects of two standard chemotherapeutic agents. This study illustrates the need to explore the signaling pathways involved, as combinations with paclitaxel were far more effective than those with doxirubicin.
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(1998)
Cancer Res
, vol.58
, pp. 2825-2831
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Baselga, J.1
Norton, L.2
Albanell, J.3
Kim, Y.-M.4
Mendelsohn, J.5
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51
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0033168299
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Radioimmunotherapy of B-cell lymphoma: The importance of antibody-specificity in determining successful treatment of established disease
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This paper illustrates that the specificity of the mAb is vital in the delivery of radiation through radioimmunotherapy. Signaling mAbs (anti-Id) yield far more impressive therapeutic effects in the treatment of mice late in the course of their disease than nonsignaling mAbs (against MHC class II), despite delivering a lower total radiation dose.
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Illidge TM, Cragg MS, McBride H, French RR, Glennie MJ Radioimmunotherapy of B-cell lymphoma: the importance of antibody-specificity in determining successful treatment of established disease. Blood. 94:1999;233-243. This paper illustrates that the specificity of the mAb is vital in the delivery of radiation through radioimmunotherapy. Signaling mAbs (anti-Id) yield far more impressive therapeutic effects in the treatment of mice late in the course of their disease than nonsignaling mAbs (against MHC class II), despite delivering a lower total radiation dose.
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(1999)
Blood
, vol.94
, pp. 233-243
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Illidge, T.M.1
Cragg, M.S.2
McBride, H.3
French, R.R.4
Glennie, M.J.5
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52
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0031828752
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Iodine-131 anti-B1 antibody for B-cell lymphoma: An update on the Michigan phase I experience
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131I-labeled anti-CD20 mAb B1, using the non-myeloablative approach. This led to a 79% response rate (50% complete) and a median duration of response of 357 days, illustrating the success of this radiolabelled signaling mAb.
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131I-labeled anti-CD20 mAb B1, using the non-myeloablative approach. This led to a 79% response rate (50% complete) and a median duration of response of 357 days, illustrating the success of this radiolabelled signaling mAb.
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(1998)
J Nuc Med
, vol.39
, pp. 21
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Wahl, R.L.1
Zasadny, K.R.2
MacFarlane, D.3
Francis, I.R.4
Ross, C.W.5
Estes, J.6
Fisher, S.7
Regan, D.8
Kroll, S.9
Kaminski, M.S.10
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53
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0031759838
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Follow-up of relapsed B-cell lymphoma patients treated with iodine-131-labeled anti-CD20 antibody and autologous stem-cell rescue
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131I-labelled anti-CD20 mAb B1 in a myeloablative regime with stem cell rescue. Major responses occurred in 86% of cases (79% complete remissions) with remissions lasting 27-87 months, demonstrating the potency of this approach and the durability of the remission.
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131I-labelled anti-CD20 mAb B1 in a myeloablative regime with stem cell rescue. Major responses occurred in 86% of cases (79% complete remissions) with remissions lasting 27-87 months, demonstrating the potency of this approach and the durability of the remission.
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(1998)
J Clin Oncol
, vol.16
, pp. 3270-3278
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Liu, S.Y.1
Eary, J.F.2
Petersdorf, S.H.3
Martin, P.J.4
Maloney, D.G.5
Appelbaum, F.R.6
Matthews, C.7
Bush, S.A.8
Durack, L.D.9
Fisher, D.R.10
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54
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0027316301
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Monoclonal antibody homodimers: Enhanced antitumor activity in nude mice
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Woolf EA, Schreiber GJ, Cosand WL, Raff HV Monoclonal antibody homodimers: enhanced antitumor activity in nude mice. Cancer Res. 53:1993;2560-2565.
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(1993)
Cancer Res
, vol.53
, pp. 2560-2565
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Woolf, E.A.1
Schreiber, G.J.2
Cosand, W.L.3
Raff, H.V.4
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55
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0030806221
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Homodimerization of tumor-reactive monoclonal antibodies markedly increases their ability to induce growth arrest or apoptosis of tumor cells
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Ghetie M-A, Podar EM, Ilgen A, Gordon BE, Uhr JW, Vitetta ES Homodimerization of tumor-reactive monoclonal antibodies markedly increases their ability to induce growth arrest or apoptosis of tumor cells. Proc Natl Acad Sci USA. 94:1998;7509-7514.
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(1998)
Proc Natl Acad Sci USA
, vol.94
, pp. 7509-7514
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Ghetie, M.-A.1
Podar, E.M.2
Ilgen, A.3
Gordon, B.E.4
Uhr, J.W.5
Vitetta, E.S.6
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56
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0028785918
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B-lymphoma cells are activated by peptide ligands of the antigen binding receptor or by anti-idiotype antibody to induce extracellular acidification
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Renschler MF, Wada HG, Fok KS, Levy R B-lymphoma cells are activated by peptide ligands of the antigen binding receptor or by anti-idiotype antibody to induce extracellular acidification. Cancer Res. 55:1995;5642-5647.
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(1995)
Cancer Res
, vol.55
, pp. 5642-5647
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Renschler, M.F.1
Wada, H.G.2
Fok, K.S.3
Levy, R.4
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