A tale of two isomerases: Compact versus extended active sites in ketosteroid isomerase and phosphoglucose isomerase

Biochemistry

Volumn 50, Issue 43, 2011, Pages 9283-9295

  Somarowthu, Srinivas ^a   Brodkin, Heather R ^b   DAquino, J Alejandro ^b   Ringe, Dagmar ^b   Ondrechen, Mary Jo ^a   Beuning, Penny J ^a  

^a NORTHEASTERN UNIVERSITY   (United States)

^b BRANDEIS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; CATALYTIC EFFICIENCIES; DIRECT CONTACT; ENZYME CATALYSIS; ISOMERASES; KINETIC ANALYSIS; NEAREST NEIGHBORS; PHOSPHOGLUCOSE ISOMERASE; PSEUDOMONAS PUTIDA; SINGLE-POINT MUTATION; SITE DIRECTED MUTAGENESIS; STRUCTURAL STUDIES; WILD TYPES;

CATALYSIS; CATALYST ACTIVITY; EXPERIMENTS; LAKES;

ENZYMES;

GLUCOSE 6 PHOSPHATE ISOMERASE; STEROID DELTA ISOMERASE;

ARTICLE; CATALYSIS; CONTROLLED STUDY; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME MECHANISM; ENZYME SUBSTRATE; HUMAN; MOUSE; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; PSEUDOMONAS PUTIDA; SITE DIRECTED MUTAGENESIS; WILD TYPE;

CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; GLUCOSE-6-PHOSPHATE ISOMERASE; HUMANS; KETOSTEROIDS; KINETICS; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; PSEUDOMONAS PUTIDA; STEROID ISOMERASES;

PSEUDOMONAS PUTIDA;

EID: 80054974028     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi201089v     Document Type: Article

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