How enzymes work

Science

Volumn 320, Issue 5882, 2008, Pages 1428-1429

  Ringe, Dagmar ^a   Petsko, Gregory A ^a  

^a BRANDEIS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYME; OLIGOSACCHARIDE; PEPTIDOGLYCAN; LYSOZYME;

CATALYSIS; ENZYME; MECHANICS; RESEARCH;

CATALYSIS; CATALYST; CRYSTAL STRUCTURE; ELECTRICITY; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME SUBSTRATE; MACROMOLECULE; PRIORITY JOURNAL; QUANTUM MECHANICS; SHORT SURVEY; SITE DIRECTED MUTAGENESIS; THREE DIMENSIONAL IMAGING; X RAY CRYSTALLOGRAPHY; ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; ENZYME SPECIFICITY; METABOLISM; PROTEIN CONFORMATION;

CATALYSIS; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; ENZYMES; MODELS, MOLECULAR; MURAMIDASE; PROTEIN CONFORMATION; SUBSTRATE SPECIFICITY;

EID: 45849108388     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1159747     Document Type: Short Survey

References (21)

1. J. B. Sumner, J. Biol. Chem. 69, 435 (1926).
2. D. E. Koshland Jr., Nature 432, 447 (2004).
3. C. Lad, N. H. Williams, R. V. Wolfenden, Proc. Natl. Acad. Sci. U.S.A. 100, 5607 (2003).
4. C. C. Blake et al., Proc. R. Soc. London B 167, 378 (1967).
5. D. J. Vocadlo, G. J. Davies, R. Laine, S. G. Withers, Nature 412, 835 (2001).
6. T. A. Steitz, R. Harrison, I. T. Weber, M. Leahy, Ciba Found. Symp. 93, 25 (1983).
7. D. L. Pompliano, A. Peyman, J. R. Knowles, Biochemistry 29, 3186 (1990).
8. S. D. Lahiri, G. Zhang, D. Dunaway-Mariano, K. N. Allen, Science 299, 2067 (2003).
9. A. Warshel et al., Chem. Rev. 106, 3210 (2006).
10. R. A. Lerner, C. F. Barbas III, K. D. Janda, Harvey Lect. 92, 1 (1996-1997).
11. J. R. Knowles, Nature 350, 121 (1991).
12. T. C. Bruice, S. J. Benkovic, Biochemistry 39, 6267 (2000);
13. D. A. Kraut, K. S. Carroll, D. Herschlag, Annu. Rev. Biochem. 72, 517 (2003).
14. I. Schlichting et al., Science 287, 1615 (2000).
15. Z. D. Nagel, J. P. Klinman, Chem. Rev. 106, 3095 (2006).
16. W. W. Cleland, P. A. Frey, J. A. Gerlt, J. Biol. Chem. 273, 25529 (1998).
17. D. A. Kraut et al., PLoS Biol. 4, e99, (2006).
18. T. Alber et al., CIBA Found. Symp. 93, 4 (1982).
19. S. Hammes-Schiffer, S. J. Benkovic, Annu. Rev. Biochem. 75, 519 (2006).
20. K. A. Henzler-Wildman et al., Nature 450, 838 (2008).
21. We dedicate this paper to the memory of our good friend and long-time collaborator Jeremy R. Knowles.