Hydrogen bond coupling in the ketosteroid isomerase active site

Biochemistry

Volumn 48, Issue 29, 2009, Pages 6932-6939

  Sigala, Paul A ^a   Caaveiro, Jose M M ^b,c   Ringe, Dagmar ^b   Petsko, Gregory A ^b   Herschlag, Daniel ^a  

^a STANFORD UNIVERSITY   (United States)

^b BRANDEIS UNIVERSITY   (United States)

^c UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; BIOLOGICAL STRUCTURES; COMPUTATIONAL EXPLORATION; COUPLED MOTIONS; CRYSTALLOGRAPHIC MODELS; DEUTERIUM ISOTOPE EFFECT; DYNAMICAL COUPLING; ENZYME ACTIVE SITES; EQUILIBRIUM STRUCTURES; HYDROGEN BOND NETWORKS; ISOMERASE; KEY ELEMENTS; LIMITED INFORMATION; OXYANION HOLE; PHYSICAL COUPLING; SITE DIRECTED MUTAGENESIS; STRUCTURAL REARRANGEMENT; X-RAY STRUCTURE;

BINDING SITES; DEUTERIUM; HYDROGEN; NUCLEAR MAGNETIC RESONANCE; PROTONS; SUPRAMOLECULAR CHEMISTRY; X RAY CRYSTALLOGRAPHY;

HYDROGEN BONDS;

DEUTERIUM; EQUILENIN; STEROID DELTA ISOMERASE;

ARTICLE; BINDING SITE; COMPLEX FORMATION; CONTROLLED STUDY; HYDROGEN BOND; NONHUMAN; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; SITE DIRECTED MUTAGENESIS; X RAY CRYSTALLOGRAPHY;

CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; HYDROGEN BONDING; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; STEROID ISOMERASES;

BACTERIA (MICROORGANISMS);

EID: 67651207451     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi900713j     Document Type: Article

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