Poly (amino ester) composed of poly (ethylene glycol) and aminosilane prepared by combinatorial chemistry as a gene carrier

Pharmaceutical Research

Volumn 25, Issue 4, 2008, Pages 875-885

  Jere, Dhananjay ^a   Yoo, Mi Kyong ^a   Arote, Rohidas ^a   Kim, Tae Hee ^a   Cho, Myung Haing ^a   Nah, Jae Woon ^b   Choi, Yun Jaie ^a   Cho, Chong Su ^a  

^a Seoul National University   (South Korea)

^b Sunchon National University   (South Korea)

Author keywords

Aminosilane; Combinatorial chemistry; Gene delivery; Non viral vector; Poly ( amino ester)

Indexed keywords

3 AMINOPROPYLTRIETHOXYSILANE; DNA; LIPOFECTAMINE; POLY(ETHYLENEGLYCOL)DIACRYLATE; POLYETHYLENEIMINE; POLYMER;

ARTICLE; CELL VIABILITY; COMBINATORIAL CHEMISTRY; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG DNA BINDING; DRUG SYNTHESIS; ENZYME ASSAY; FEMALE; GEL ELECTROPHORESIS; GEL PERMEATION CHROMATOGRAPHY; GENE DELIVERY SYSTEM; GENETIC TRANSFECTION; HELA CELL; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; IN VITRO STUDY; LIGHT SCATTERING; MICHAEL ADDITION; MOLECULAR WEIGHT; PARTICLE SIZE; POLYMERIZATION; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; SERUM;

CELL LINE; CELL NUCLEUS; CELL SURVIVAL; CHROMATOGRAPHY, GEL; COMBINATORIAL CHEMISTRY TECHNIQUES; DNA; ELECTROPHORESIS, AGAR GEL; GENES, REPORTER; HELA CELLS; HUMANS; LIGHT; LUCIFERASES; MAGNETIC RESONANCE SPECTROSCOPY; NUCLEIC ACID CONFORMATION; PARTICLE SIZE; POLYETHYLENE GLYCOLS; SCATTERING, RADIATION; SILANES; TRANSFECTION;

EID: 43549118193     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-007-9448-4     Document Type: Article

References (26)

1. L. H. M.-C. H. E. Wagner. Nonviral Vectors for Gene Delivery, Academic Press, New York, 1999.
2. Y. Liu, D. Wu, Y. Ma, G. Tang, S. Wang, C. He, T. Chung, and S. Goh. Novel poly(amino ester)s obtained from Michael addition polymerizations of trifunctional amine monomers with diacrylates: safe and efficient DNA carriers. Chem. Commun. 2630-2631 (2003).
3. A. Akinc, D. M. Lynn, D. G. Anderson, and R. Langer. Parallel synthesis and biophysical characterization of a degradable polymer library for gene delivery. J. Am. Chem. Soc. 125:5316-5323 (2003).
4. J. H. Lee, Y. B. Lim, J. S. Choi, Y. Lee, T. I. Kim, H. J. Kim, J. K. Yoon, K. Kim, and J. S. Park. Polyplexes assembled with internally quaternized PAMAM-OH dendrimer and plasmid DNA have a neutral surface and gene delivery potency. Bioconjug. Chem. 14:1214-1221 (2003).
5. O. Boussif, F. Lezoualc'h, M. A. Zanta, M. D. Mergny, D. Scherman, B. Demeneix, and J. P. Behr. A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine. Proc. Natl. Acad. Sci. U. S. A. 92:7297-7301 (1995).
6. D. W. Pack, A. S. Hoffman, S. Pun, and P. S. Stayton. Design and development of polymers for gene delivery. Nat. Rev. Drug Discov. 4:581-593 (2005).
7. K. C. Cho, S. H. Kim, J. H. Jeong, and T. G. Park. Folate receptor-mediated gene delivery using folate-poly(ethylene glycol)-poly(L- lysine) conjugate. Macromol. Biosci. 5:512-519 (2005).
8. E. M. Kim, H. J. Jeong, I. K. Park, C. S. Cho, H. S. Bom, and C. G. Kim. Monitoring the effect of PEGylation on polyethylenimine in vivo using nuclear imaging technique. Nucl. Med. Biol. 31:781-784 (2004).
9. Y. H. Choi, F. Liu, J. S. Park, and S. W. Kim. Lactose-poly(ethylene glycol)-grafted poly-L-lysine as hepatoma cell-targeted gene carrier. Bioconjug. Chem. 9:708-718 (1998).
10. C. Kneuer, M. Sameti, E. G. Haltner, T. Schiestel, H. Schirra, H. Schmidt, and C. M. Lehr. Silica nanoparticles modified with aminosilanes as carriers for plasmid DNA. Int. J. Pharm. 196:257-261 (2000).
11. Z. Li, S. Zhu, K. Gan, Q. Zhang, Z. Zeng, Y. Zhou, H. Liu, W. Xiong, X. Li, and G. Li. Poly-L-lysine-modified silica nanoparticles: a potential oral gene delivery system. J. Nanosci. Nanotechnol. 5:1199-1203 (2005).
12. M. Sameti, G. Bohr, M. N. Ravi Kumar, C. Kneuer, U. Bakowsky, M. Nacken, H. Schmidt, and C. M. Lehr. Stabilisation by freeze-drying of cationically modified silica nanoparticles for gene delivery. Int. J. Pharm. 266:51-60 (2003).
13. D. Luoand, and W. M. Saltzman. Enhancement of transfection by physical concentration of DNA at the cell surface. Nat. Biotechnol. 18:893-895 (2000).
14. M. Thomasand and A. M. Klibanov. Conjugation to gold nanoparticles enhances polyethylenimine's transfer of plasmid DNA into mammalian cells. Proc. Natl. Acad. Sci. U. S. A. 100:9138-9143 (2003).
15. E. H. Chowdhury, M. Kunou, M. Nagaoka, A. K. Kundu, T. Hoshiba, and T. Akaike. High-efficiency gene delivery for expression in mammalian cells by nanoprecipitates of Ca-Mg phosphate. Gene 341:77-82 (2004).
16. D. J. Bharali, I. Klejbor, E. K. Stachowiak, P. Dutta, I. Roy, N. Kaur, E. J. Bergey, P. N. Prasad, and M. K. Stachowiak. Organically modified silica nanoparticles: a nonviral vector for in vivo gene delivery and expression in the brain. Proc. Natl. Acad. Sci. U. S. A. 102:11539-11544 (2005).
17. D. Luo, E. Han, N. Belcheva, and W. M. Saltzman. A self-assembled, modular DNA delivery system mediated by silica nanoparticles. J. Control. Release 95:333-341 (2004).
18. B. D. Mather, K. Viswanathan, K. M. Miller, and T. E. Long. Michael addition reactions in macromolecular design for emerging technologies. Prog. Polym. Sci. 31:487-531 (2006).
19. D. Jere, R. Arote, H. Jiang, J. W. Nah, M. H. Cho, and C. S. Cho. A poly(β-amino ester) of spermine and poly(ethylene glycol) diacrylate as a gene carrier. Key Eng. Mater. 342-343:425-428 (2007).
20. T. H. Kim, S. E. Cook, R. Arote, M. H. Cho, J. W. Nah, Y. J. Choi, and C. S. Cho. A degradable hyperbranched poly(ester amine) based on poloxamer diacrylate and polyethylenimine as a gene carrier. Macromol. Biosci. 7:611-619 (2007).
21. R. Arote, T. H. Kim, Y. K. Kim, S. K. Hwang, H. L. Jiang, H. H. Song, J. W. Nah, M. H. Cho, and C. S. Cho. A biodegradable poly(ester amine) based on polycaprolactone and polyethylenimine as a gene carrier. Biomaterials 28:735-744 (2007).
22. N. D. Sonawane, F. C. Szoka, Jr., and A. S. Verkman. Chloride accumulation and swelling in endosomes enhances DNA transfer by polyamine-DNA polyplexes. J. Biol. Chem. 278:44826-44831 (2003).
23. M. R. Park, K. O. Han, I. K. Han, M. H. Cho, J. W. Nah, Y. J. Choi, and C. S. Cho. Degradable polyethylenimine-alt-poly(ethylene glycol) copolymers as novel gene carriers. J. Control. Release 105:367-380 (2005).
24. D. G. Anderson, A. Akinc, N. Hossain, and R. Langer. Structure/property studies of polymeric gene delivery using a library of poly(beta-amino esters). Molec. Ther. 11:426-434 (2005).
25. F. Meng, G. H. Engbers, and J. Feijen. Polyethylene glycol-grafted polystyrene particles. J. Biomed. Mater. Res. A. 70:49-58 (2004).
26. A. Akinc, D. G. Anderson, D. M. Lynn, and R. Langer. Synthesis of poly(beta-amino ester)s optimized for highly effective gene delivery. Bioconjug. Chem. 14:979-988 (2003).