Biodegradable poly(ester amine) based on glycerol dimethacrylate and polyethylenimine as a gene carrier

Journal of Gene Medicine

Volumn 10, Issue 11, 2008, Pages 1223-1235

  Arote, Rohidas B ^a,c   Hwang, Soon Kyung ^c   Yoo, Mi Kyong ^a   Jere, Dhananjay ^a   Jiang, Hu Lin ^a,c   Kim, You Kyoung ^a   Choi, Yun Jai ^a   Nah, Jae Woon ^b   Cho, Myung Haing ^c   Cho, Chong Su ^a,c  

^a Seoul National University   (South Korea)

^b Sunchon National University   (South Korea)

^c Seoul National University   (South Korea)

Author keywords

Degradable; Gene delivery; Glycerol; Osmotic effect; Poly(ester amine); Polyethlenimine; Proton sponge effect

Indexed keywords

ANHYDROUS METHANOL; BAFILOMYCIN A1; ENHANCED GREEN FLUORESCENT PROTEIN; GLYCEROL DIMETHACRYLATE; LIPOFECTAMINE; METHACRYLIC ACID; METHANOL; NANOPARTICLE; PLASMID DNA; POLYESTERAMINE; POLYETHYLENEIMINE; POLYMER; UNCLASSIFIED DRUG; BIOMATERIAL; DNA; DRUG CARRIER; GLYCEROL; MACROLIDE; METHACRYLIC ACID DERIVATIVE; POLY(CAPROLACTONE BLOCK ETHYLENEIMINE); POLY(CAPROLACTONE-BLOCK-ETHYLENEIMINE); POLYAMINE; POLYESTER;

AEROSOL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BAGG ALBINO MOUSE; BIODEGRADABILITY; CELL VOLUME; CONTROLLED STUDY; CYTOTOXICITY; DRUG DISTRIBUTION; DRUG HALF LIFE; FEMALE; GENE THERAPY; GENE TRANSFER; GENETIC TRANSFECTION; HEPATOBLASTOMA; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MOLECULAR WEIGHT; MOUSE; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; PRIORITY JOURNAL; REPORTER GENE; UTERINE CERVIX CARCINOMA; ZETA POTENTIAL; CELL LINE; CHEMISTRY; CONFOCAL MICROSCOPY; GENETICS; HELA CELL; METABOLISM;

PISUM SATIVUM;

BIOCOMPATIBLE MATERIALS; CELL LINE; DNA; DRUG CARRIERS; GENE TRANSFER TECHNIQUES; GLYCEROL; HELA CELLS; HUMANS; MACROLIDES; METHACRYLATES; MICROSCOPY, CONFOCAL; MOLECULAR WEIGHT; POLYAMINES; POLYESTERS; POLYETHYLENEIMINE; TRANSFECTION;

EID: 58149200165     PISSN: 1099498X     EISSN: 15212254     Source Type: Journal    
DOI: 10.1002/jgm.1252     Document Type: Article

References (36)

1. Pouton CW, Seymour LW. Key issues in non-viral gene delivery. Adv Drug Deliv Rev 2001; 46: 187-203.
2. McTaggart S, Al-Rubeai M. Retroviral vectors for viral gene delivery. Biotechnol Adv 2002; 20: 1-31.
3. Hughes RM. Strategies for cancer gene therapy. J Surg Oncol 2004; 85: 28-35.
4. Han S, Mahato RI, Sung YK, Kim SW. Development of biomaterials for gene therapy. Mol Therapy 2000; 2: 302-317.
5. Luo D, Saltzman WM. Synthetic DNA delivery systems. Nat Biotechnol 2000; 18: 33-37.
6. Wagner E, Orgis M, Zauner W. Polylysine-based transfection systems utilizing receptor-mediated delivery. Adv Drug Deliv Rev 1998; 30: 98-113.
7. Kircheis RL, Wightman EW. Design and gene delivery activity of modified polyethylenimines. Adv Drug Deliv Rev 2001; 53: 341-358.
8. Bielinska AU, Chen C, Johnson J, Baker JR Jr. DNA complexing with polyamidoamine dendrimers: implications for transfection. Bioconjug Chem 1999; 10: 843-850.
9. Miller AD. Cationic liposomes for gene therapy. Angewandte Chem Int Edn 1998; 37: 1768-1785.
10. Godbey WT, Wu KK, Mikos AG. Poly (ethylenimine) and its role in gene delivery. J Control Release 1999; 60: 149-160.
11. Gosselin MA, Guo W, Lee RJ. Efficient gene transfer using reversibly cross-linked low molecular weight polyethyleneimine. Bioconjug Chem 2001; 12: 989-994.
12. Read ML, Singh S, Ahmed Z, et al. A versatile reducible polycation-based system for efficient delivery of a broad range of nucleic acids. Nucleic Acids Res 2005; 33: E86.
13. de Wolf HK, Luten J, Snel CJ, Oussoren C, Hennik WE, Storm G. In vivo tumor transfection mediated by polyplexes based on biodegradable poly(DMAEA)-phosphazene. J Control Release 2005; 109: 275-287.
14. Lynn DM, Langer R. Degradable poly (β-amino esters): synthesis, characterization and self assembly with plasmid DNA. J Am Chem Soc 2000; 122: 10761-10768.
15. Anderson DG, Akinc A, Hossain N, Langer R. Structure/property studies of polymeric gene delivery using a library of poly (β-amino esters). Mol Therapy 2005; 11: 426-434.
16. Lim YB, Kim SM, Suh H, Park JS. Biodegradable, endosome disruptive and cationic network-type polymer as a highly efficient and nontoxic gene delivery carrier. Bioconjug Chem 2002; 13: 952-957.
17. Zhao Z,Wang J, Mao HQ, Leong KW. Polyphosphoesters in drug and gene delivery. Adv Drug Deliv Rev 2003; 55: 483-499.
18. Park MR, Han KO, Han IK, et al. Degradable polyethyleniminealt-poly (ethylene glycol) copolymers as novel gene carriers. J Control Release 2005; 105: 367-380.
19. Lim YB, Choi YH, Park JS. A self-destroying polycationic polymer: biodegradable poly(4-hydroxy-L-proline ester). J Am Chem Soc 1999; 121: 5633-5639.
20. Kim TI, Seo HJ, Choi JS, et al. Synthesis of biodegradable cross-linked poly (beta-amino ester) for gene delivery and its modification, inducing enhanced transfection efficiency and stepwise degradation. Bioconjug Chem 2005; 16: 1140-1148.
21. Arote R, Kim TH, Kim YK, et al. A biodegradable poly (ester amine) based on polycaprolactone and polyethylenimine as a gene carrier. Biomaterials 2007; 28: 735-744.
22. Kim TH, Cook SE, Arote RB, et al. A degradable hyperbranched poly (ester amine) based on poloxamer diacrylate and polyethylenimine as a gene carrier. Macromol Biosci 2007; 7: 611-619.
23. Jere D, Yoo MK, Arote R, et al. Poly (amino ester) Composed of poly (ethylene glycol) and aminosilane prepared by combinatorial chemistry as a gene carrier. Pharm Res 2007; 25: 875-885.
24. Zauner W, Kichler A, Schmidt W, Mechler K, Wagner E. Glycerol and polylysine synergize in their ability to rupture vesicular membranes: a mechanism for increased transferrin-polylysine-mediated gene transfer. Exp Cell Res 1997; 232: 137-145.
25. Anderson DG, Akinc A, Hossain N, Langer R. Structure/property studies of polymeric gene delivery using a library of poly(beta-amino esters). Mol Ther 2005; 11: 426-434.
26. Arote R, Kim TH, Kim YK, et al. Novel poly(ester amine) based on polycaprolactone and polyethylenimine as a gene carrier: effect of hydrophobicity on transfection efficiency and cytotoxicity. Key Eng Mater 2007; 342/343: 453-456.
27. Lynn DM, Anderson DG, Putnam D, Langer R. Accelerated discovery of synthetic transfection vectors: parallel synthesis and screening of a degradable polymer library. J Am Chem Soc 2001; 123: 8155-8156.
28. Fischer D, Bieber T, Li Y, Elsasser HP, Kissel T. A novel non-viral vector for DNA delivery based on low molecular weight, branched polyethylenimine: effect of molecular weight on transfection efficiency and cytotoxicity. Pharm Res 1999; 16: 1273-1279.
29. Dubruel P, Dekie L, Christiaens B, et al. Poly l-glutamic acid derivatives as multifunctional vectors for gene delivery. Part B. Biological evaluation. Biomacromolecules 2003; 4: 1177-1183.
30. Bieber T, Elsasser HP. Preparation of a low molecular weight polyethylenimine for efficient cell transfection. Biotechniques 2001; 30: 74-81.
31. Godbey WT, Wu KK, Mikos AG. Size matters: molecular weight affects the efficiency of poly (ethylenimine) as a gene delivery vehicle. J Biomed Mater Res 1999; 45: 268-275.
32. Boussif O, Lenzoualc'h F, Zanta MA, et al. A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine. Proc Natl Acad Sci USA 1995; 92: 7297-7301.
33. Grosjean F, Bertschinger M, Hacker DL, Wurm FM. Multiple glycerol shocks increase the calcium phosphate transfection of non-synchronized CHO cells. Biotechnol Lett 2006; 28: 1827-1833.
34. Wilson SP, Smith LA. Addition of glycerol during DNA exposure enhances calcium phosphate transfection. Anal Biochem 1997; 246: 148-150.
35. Rudolph C, Schillinger U, Ortiz A, et al. Aerosolized nanogram quantities of plasmid DNA mediate highly efficient gene delivery to mouse airway epithelium. Mol Therapy 2005; 12: 493-501.
36. Koshkina NV, Agoulnik IY, Melton SL, Densmore CL, Knight V. Biodistribution and pharmacokinetics of aerosol and intravenously administered DNA-polyethyleneimine complexes: optimization of pulmonary delivery and retention. Mol Therapy 2003; 8: 249-254.