Lactam constraints provide insights into the receptor-bound conformation of secretin and stabilize a receptor antagonist

Biochemistry

Volumn 50, Issue 38, 2011, Pages 8181-8192

  Dong, Maoqing ^a   Te, Jerez A ^b   Xu, Xiequn ^b   Wang, Jinhui ^c   Pinon, Delia I ^a   Storjohann, Laura ^a   Bordner, Andrew J ^a   Miller, Laurence J ^a  

^a MAYO GRADUATE SCHOOL   (United States)

^b PEKING UNION MEDICAL COLLEGE HOSPITAL   (China)

^c High School   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO-TERMINAL DOMAIN; AMINO-TERMINAL REGION; AMPHIPATHIC HELICAL CONFORMATIONS; BINDING AFFINITIES; CARBOXYL-TERMINAL; G PROTEIN COUPLED RECEPTORS; HELICAL CONFORMATION; HOMOLOGY MODELING; LACTAM BRIDGES; LIGAND BINDING; LINEAR PEPTIDES; MOLECULAR DYNAMICS SIMULATIONS; NATURAL LIGANDS; PHARMACOPHORES; RECEPTOR ANTAGONISTS;

BINDING ENERGY; BIOACTIVITY; CONFORMATIONS; LIGANDS; MOLECULAR DYNAMICS; MOLECULAR ORIENTATION; POLYPEPTIDES;

PEPTIDES;

LACTAM; SECRETIN;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; BIOLOGICAL ACTIVITY; HUMAN; LIGAND BINDING; MOLECULAR DYNAMICS; MOLECULAR MECHANICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; SEQUENCE HOMOLOGY;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CHO CELLS; CRICETINAE; CRICETULUS; HUMANS; LACTAMS; LIGANDS; MODELS, MOLECULAR; MOLECULAR DYNAMICS SIMULATION; MOLECULAR SEQUENCE DATA; MULTIPROTEIN COMPLEXES; PEPTIDES; PROTEIN CONFORMATION; PROTEIN STABILITY; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, GASTROINTESTINAL HORMONE; RECOMBINANT PROTEINS; SECRETIN;

EID: 80053016932     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi2008036     Document Type: Article

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