Rational design, conformational studies and bioactivity of highly potent conformationally constrained calcitonin analogues

European Journal of Biochemistry

Volumn 265, Issue 2, 1999, Pages 606-618

  Kapurniotu, Aphrodite ^b   Kayed, Rakez ^c   Taylor, John W ^a   Voelter, Wolfgang ^c  

^a RUTGERS UNIVERSITY   (United States)

^b UNIVERSITY OF TÜBINGEN   (Germany)

^c NONE

Author keywords

turn sheet stabilization; Calcitonin; Circular dichroism; Cyclization; Hypocalcemic potency

Indexed keywords

CALCITONIN DERIVATIVE;

AMINO ACID SEQUENCE; ANIMAL MODEL; ARTICLE; CIRCULAR DICHROISM; CONTROLLED STUDY; CYCLIZATION; DRUG ACTIVITY; DRUG CONFORMATION; DRUG POTENCY; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYPOCALCEMIA; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; CALCITONIN; CIRCULAR DICHROISM; FEMALE; HUMANS; HYPOCALCEMIA; MICE; MICE, INBRED BALB C; MOLECULAR STRUCTURE; OSTEOPOROSIS; PEPTIDES, CYCLIC; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY; SALMON;

ANIMALIA;

EID: 0000231437     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1432-1327.1999.00708.x     Document Type: Article

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