Conformationally constrained human calcitonin (hCt) analogues reveal a critical role of sequence 17-21 for the oligomerization state and bioactivity of hCt

European Journal of Biochemistry

Volumn 269, Issue 3, 2002, Pages 780-791

  Kazantzis, Athanasios ^a   Waldner, Michaela ^a   Taylor, John W ^b   Kapurniotu, Aphrodite ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b RUTGERS UNIVERSITY   (United States)

Author keywords

turn sheet conformation; Dimerization; Human calcitonin; Hypocalcemic activity; Receptor binding

Indexed keywords

CALCITONIN; CALCITONIN DERIVATIVE; CALCITONIN RECEPTOR; CYCLO 17,21 CALCITONIN[17 ASPARTIC ACID 18 (2 AMINOISOBUTYRIC ACID) 21 LYSINE]; CYCLO 17,21 CALCITONIN[17 ASPARTIC ACID 18 DEXTRO LYSINE 21 LYSINE]; CYCLO 17,21 CALCITONIN[17 ASPARTIC ACID 19 DEXTRO PHENYLALANINE 21 LYSINE]; CYCLO 17,21 CALCITONIN[17 ASPARTIC ACID 21 LYSINE]; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; BETA SHEET; BINDING AFFINITY; BONE DISEASE; CONTROLLED STUDY; DENATURATION; DRUG ACTIVITY; DRUG CONFORMATION; DRUG DESIGN; DRUG EFFECT; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; HUMAN; HUMAN CELL; OLIGOMERIZATION; OSTEOPOROSIS; PRIORITY JOURNAL; SEQUENCE HOMOLOGY; STRUCTURE ACTIVITY RELATION;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMALS; BUFFERS; CALCITONIN; CIRCULAR DICHROISM; ELECTROPHORESIS, POLYACRYLAMIDE GEL; HUMANS; HYDROGEN-ION CONCENTRATION; HYPOCALCEMIA; MICE; MOLECULAR SEQUENCE DATA; PEPTIDES, CYCLIC; PROTEIN CONFORMATION; RECEPTORS, CALCITONIN; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0036183529     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.0014-2956.2001.02689.x     Document Type: Article

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