Spatial approximation between secretin residue five and the third extracellular loop of its receptor provides new insight into the molecular basis of natural agonist binding

Molecular Pharmacology

Volumn 74, Issue 2, 2008, Pages 413-422

  Dong, Maoqing ^a   Lam, Polo C H ^b   Pinon, Delia I ^a   Sexton, Patrick M ^c   Abagyan, Ruben ^b   Miller, Laurence J ^a,d  

^a MAYO GRADUATE SCHOOL   (United States)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

^c MONASH UNIVERSITY   (Australia)

^d MAYO CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYANOGEN BROMIDE; G PROTEIN COUPLED RECEPTOR; LIGAND; MUTANT PROTEIN; PEPTIDE; SECRETIN;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; DEGLYCOSYLATION; FEMALE; INTROSPECTION; LIGAND BINDING; MODEL; NONHUMAN; PHOTOAFFINITY LABELING; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN PURIFICATION; SEQUENCE ANALYSIS; WILD TYPE;

AMINO ACID SEQUENCE; ANIMALS; CERCOPITHECUS AETHIOPS; CHO CELLS; COS CELLS; CRICETINAE; CRICETULUS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PHOTOAFFINITY LABELS; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; RATS; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, GASTROINTESTINAL HORMONE; SECRETIN; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 47949116776     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.108.047209     Document Type: Article

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