Bioactivities and secondary structures of constrained analogues of human parathyroid hormone: Cyclic lactams of the receptor binding region

Journal of Medicinal Chemistry

Volumn 40, Issue 9, 1997, Pages 1373-1380

  Barbier, Jean René ^a   Neugebauer, Witold ^a,b   Morley, Paul ^a   Ross, Virginia ^a   Soska, Mark ^a   Whitfield, James F ^a   Willick, Gordon ^a  

^a NATIONAL RESEARCH COUNCIL CANADA   (Canada)

^b UNIVERSITY OF SHERBROOKE   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

PARATHYROID HORMONE DERIVATIVE; PARATHYROID HORMONE[1-31]AMIDE; PARATHYROID HORMONE[1-31]AMIDE[LEUCINE 27]; PARATHYROID HORMONE[1-31]AMIDE[LEUCINE 27][CYCLO(GLUTAMIC ACID 22 LYSINE 26)]; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CIRCULAR DICHROISM; CONFORMATIONAL TRANSITION; DRUG BIOAVAILABILITY; DRUG CONFORMATION; DRUG EFFECT; DRUG POTENCY; DRUG UPTAKE; ENZYME ACTIVATION; ENZYME ACTIVITY; FEMALE; HYPOTENSION; INTRAVENOUS DRUG ADMINISTRATION; NONHUMAN; OSTEOSARCOMA CELL; RAT; STRUCTURE ACTIVITY RELATION; SUBCUTANEOUS DRUG ADMINISTRATION;

ADENYLATE CYCLASE; AMINO ACID SEQUENCE; AMINO ACIDS; ANIMALS; ANTIHYPERTENSIVE AGENTS; BLOOD PRESSURE; CIRCULAR DICHROISM; ENZYME ACTIVATION; HUMANS; LACTAMS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; OSTEOBLASTS; PARATHYROID HORMONE; PEPTIDE FRAGMENTS; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY; RATS; RECEPTORS, PARATHYROID HORMONE; TUMOR CELLS, CULTURED;

EID: 0030977984     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm960743o     Document Type: Article

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