메뉴 건너뛰기




Volumn 12, Issue 15, 2011, Pages 2297-2313

Investigational noncardiovascular uses of phosphodiesterase-5 inhibitors

Author keywords

Cancer; Cutaneous ulcerations; Cyclic guanosine monophosphate (cGMP); Diabetes; Genitourinary; Nitric oxide; Phosphodiesterase (PDE) 5; Surgery; Women's health

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; ALFUZOSIN; ARGININE; AVANAFIL; BOSENTAN; CYCLIC AMP; DOXORUBICIN; FLUOXETINE; GISADENAFIL; ICOSANOID; ILOPROST; LODENAFIL; MIRODENAFIL; NITRIC OXIDE; PAROXETINE; PENTOXIFYLLINE; PF 00489791; PHOSPHODIESTERASE V; PHOSPHODIESTERASE V INHIBITOR; PLACEBO; PROSTACYCLIN; PROSTAGLANDIN E1; ROLIPRAM; SILDENAFIL; TADALAFIL; TAMSULOSIN; UDENAFIL; UNCLASSIFIED DRUG; UNINDEXED DRUG; VARDENAFIL; VASCULOTROPIN;

EID: 80052884599     PISSN: 14656566     EISSN: 17447666     Source Type: Journal    
DOI: 10.1517/14656566.2011.600306     Document Type: Review
Times cited : (14)

References (117)
  • 1
    • 74049143429 scopus 로고    scopus 로고
    • Pharmacotherapy for erectile dysfunction
    • Eardley I, Donatucci C, Corbin J, et al. Pharmacotherapy for erectile dysfunction. J Sex Med 2010;7:524-40
    • (2010) J Sex Med , vol.7 , pp. 524-40
    • Eardley, I.1    Donatucci, C.2    Corbin, J.3
  • 2
    • 78549285356 scopus 로고    scopus 로고
    • An update on new oral PDE5 inhibitors for the treatment of erectile dysfunction
    • Palit V, Eardley I. An update on new oral PDE5 inhibitors for the treatment of erectile dysfunction. Nat Rev Urol 2010;7:603-9
    • (2010) Nat Rev Urol , vol.7 , pp. 603-9
    • Palit, V.1    Eardley, I.2
  • 3
    • 61449117843 scopus 로고    scopus 로고
    • Erectile dysfunction and cardiovascular disease: Efficacy and safety of phosphodiesterase type 5 inhibitors in men with both conditions
    • Nehra A. Erectile dysfunction and cardiovascular disease: efficacy and safety of phosphodiesterase type 5 inhibitors in men with both conditions. Mayo Clin Proc 2009;84:139-48
    • (2009) Mayo Clin Proc , vol.84 , pp. 139-48
    • Nehra, A.1
  • 7
    • 70449457458 scopus 로고    scopus 로고
    • PDE5 inhibitors in the treatment of LUTS
    • Speakman MJ. PDE5 inhibitors in the treatment of LUTS. Curr Pharm Des 2009;15:3502-5
    • (2009) Curr Pharm des , vol.15 , pp. 3502-5
    • Speakman, M.J.1
  • 8
    • 34247360867 scopus 로고    scopus 로고
    • Combination of Alfuzosin and Sildenafil is Superior to Monotherapy in Treating Lower Urinary Tract Symptoms and Erectile Dysfunction
    • DOI 10.1016/j.eururo.2007.01.033, PII S030228380700036X
    • Kaplan SA, Gonzalez RR, Te AE. Combination of alfuzosin and sildenafil is superior to monotherapy in treating lower urinary tract symptoms and erectile dysfunction. Eur Urol 2007;51:1717-23 (Pubitemid 46634750)
    • (2007) European Urology , vol.51 , Issue.6 , pp. 1717-1723
    • Kaplan, S.A.1    Gonzalez, R.R.2    Te, A.E.3
  • 9
    • 59349106827 scopus 로고    scopus 로고
    • Efficacy and safety of combined oral therapy with tadalafil and alfuzosin: An integrated approach to the management of patients with lower urinary tract symptoms and erectile dysfunction. Preliminary report
    • Liguori G, Trombetta C, De Giorgi G, et al. Efficacy and safety of combined oral therapy with tadalafil and alfuzosin: an integrated approach to the management of patients with lower urinary tract symptoms and erectile dysfunction. Preliminary report. J Sex Med 2009;6:544-52
    • (2009) J Sex Med , vol.6 , pp. 544-52
    • Liguori, G.1    Trombetta, C.2    De Giorgi, G.3
  • 10
    • 75849116360 scopus 로고    scopus 로고
    • Sildenafil citrate and tamsulosin combination is not superior to monotherapy in treating lower urinary tract symptoms and erectile dysfunction
    • Tuncel A, Nalcacioglu V, Ener K, et al. Sildenafil citrate and tamsulosin combination is not superior to monotherapy in treating lower urinary tract symptoms and erectile dysfunction. World J Urol 2010;28:17-22
    • (2010) World J Urol , vol.28 , pp. 17-22
    • Tuncel, A.1    Nalcacioglu, V.2    Ener, K.3
  • 11
    • 51349092065 scopus 로고    scopus 로고
    • Comparative efficacy assessment of tamsulosin vs. tamsulosin plus tadalafil in the treatment of LUTS/BPH. Pilot study
    • Bechara A, Romano S, Casabe A, et al. Comparative efficacy assessment of tamsulosin vs. tamsulosin plus tadalafil in the treatment of LUTS/BPH. Pilot study. J Sex Med 2008;5:2170-8
    • (2008) J Sex Med , vol.5 , pp. 2170-8
    • Bechara, A.1    Romano, S.2    Casabe, A.3
  • 12
    • 42749084255 scopus 로고    scopus 로고
    • A randomised, placebo-controlled study to assess the efficacy of twice-daily vardenafil in the treatment of lower urinary tract symptoms secondary to benign prostatic hyperplasia
    • Stief CG, Porst H, Neuser D, et al. A randomised, placebo-controlled study to assess the efficacy of twice-daily vardenafil in the treatment of lower urinary tract symptoms secondary to benign prostatic hyperplasia. Eur Urol 2008;53:1236-44
    • (2008) Eur Urol , vol.53 , pp. 1236-44
    • Stief, C.G.1    Porst, H.2    Neuser, D.3
  • 13
    • 76149134714 scopus 로고    scopus 로고
    • Changes in peak urinary flow and voiding efficiency in men with signs and symptoms of benign prostatic hyperplasia during once daily tadalafil treatment
    • Roehrborn CG, Kaminetsky JC, Auerbach SM, et al. Changes in peak urinary flow and voiding efficiency in men with signs and symptoms of benign prostatic hyperplasia during once daily tadalafil treatment. BJU Int 2010;105:502-7
    • (2010) BJU Int , vol.105 , pp. 502-507
    • Roehrborn, C.G.1    Kaminetsky, J.C.2    Auerbach, S.M.3
  • 14
    • 75849123577 scopus 로고    scopus 로고
    • Urodynamic effects of once daily tadalafil in men with lower urinary tract symptoms secondary to clinical benign prostatic hyperplasia: A randomized, placebo controlled 12-week clinical trial
    • Dmochowski R, Roehrborn C, Klise S, et al. Urodynamic effects of once daily tadalafil in men with lower urinary tract symptoms secondary to clinical benign prostatic hyperplasia: a randomized, placebo controlled 12-week clinical trial. J Urol 2010;183:1092-7
    • (2010) J Urol , vol.183 , pp. 1092-7
    • Dmochowski, R.1    Roehrborn, C.2    Klise, S.3
  • 15
    • 41149173029 scopus 로고    scopus 로고
    • Does sildenafil affect uroflowmetry values in men with lower urinary tract symptoms suggestive of benign prostatic enlargement?
    • DOI 10.1159/000112611
    • Guler C, Tuzel E, Dogantekin E, Kiziltepe G. Does sildenafil affect uroflowmetry values in men with lower urinary tract symptoms suggestive of benign prostatic enlargement? Urol Int 2008;80:181-5 (Pubitemid 351440514)
    • (2008) Urologia Internationalis , vol.80 , Issue.2 , pp. 181-185
    • Guler, C.1    Tuzel, E.2    Dogantekin, E.3    Kiziltepe, G.4
  • 16
    • 77955896740 scopus 로고    scopus 로고
    • A placebo-controlled study investigating the efficacy and safety of the phosphodiesterase type 5 inhibitor UK-369,003 for the treatment of men with lower urinary tract symptoms associated with clinical benign prostatic hyperplasia
    • Tamimi NA, Mincik I, Haughie S, et al. A placebo-controlled study investigating the efficacy and safety of the phosphodiesterase type 5 inhibitor UK-369,003 for the treatment of men with lower urinary tract symptoms associated with clinical benign prostatic hyperplasia. BJU Int 2010;106:674-80
    • (2010) BJU Int , vol.106 , pp. 674-80
    • Tamimi, N.A.1    Mincik, I.2    Haughie, S.3
  • 17
    • 33846810223 scopus 로고    scopus 로고
    • Sildenafil citrate improves erectile function and urinary symptoms in men with erectile dysfunction and lower urinary tract symptoms associated with benign prostatic hyperplasia: A randomized, double-blind trial
    • DOI 10.1016/j.juro.2006.10.055, PII S0022534706027455
    • McVary K, Monnig W, Camps JL Jr, et al. Sildenafil citrate improves erectile function and urinary symptoms in men with erectile dysfunction and lower urinary tract symptoms associated with benign prostatic hyperplasia: a randomized, double-blind trial. J Urol 2007;177:1071-7 (Pubitemid 46216352)
    • (2007) Journal of Urology , vol.177 , Issue.3 , pp. 1071-1077
    • McVary, K.T.1    Monnig, W.2    Camps Jr., J.L.3    Young, J.M.4    Tseng, L.-J.5    Van Den Ende, G.6
  • 18
    • 50249148303 scopus 로고    scopus 로고
    • Sildenafil citrate improves erectile function and lower urinary tract symptoms independent of baseline body mass index or LUTS severity
    • McVary KT, Siegel RL, Carlsson M. Sildenafil citrate improves erectile function and lower urinary tract symptoms independent of baseline body mass index or LUTS severity. Urology 2008;72:575-9
    • (2008) Urology , vol.72 , pp. 575-9
    • McVary, K.T.1    Siegel, R.L.2    Carlsson, M.3
  • 19
    • 33745259309 scopus 로고    scopus 로고
    • Assessment of the impact of sildenafil citrate on lower urinary tract symptoms in men with erectile dysfunction
    • Mulhall JP, Guhring P, Parker M, Hopps C. Assessment of the impact of sildenafil citrate on lower urinary tract symptoms in men with erectile dysfunction. J Sex Med 2006;3:662-7
    • (2006) J Sex Med , vol.3 , pp. 662-7
    • Mulhall, J.P.1    Guhring, P.2    Parker, M.3    Hopps, C.4
  • 20
    • 77955887651 scopus 로고    scopus 로고
    • A placebo-controlled exploratory study investigating the efficacy and safety of the phosphodiesterase type 5 inhibitor UK-369,003 for the treatment of men with storage lower urinary tract symptoms associated with a clinical diagnosis of overactive bladder
    • Giuliano FA, Lamb J, Crossland A, et al. A placebo-controlled exploratory study investigating the efficacy and safety of the phosphodiesterase type 5 inhibitor UK-369,003 for the treatment of men with storage lower urinary tract symptoms associated with a clinical diagnosis of overactive bladder. BJU Int 2010;106:666-73
    • (2010) BJU Int , vol.106 , pp. 666-73
    • Giuliano, F.A.1    Lamb, J.2    Crossland, A.3
  • 21
    • 77951022374 scopus 로고    scopus 로고
    • Treatment of Peyronies disease with PDE5 inhibitors: An antifibrotic strategy
    • Gonzalez-Cadavid NF, Rajfer J. Treatment of Peyronies disease with PDE5 inhibitors: an antifibrotic strategy. Nat Rev Urol 2010;7:215-21
    • (2010) Nat Rev Urol , vol.7 , pp. 215-21
    • Gonzalez-Cadavid, N.F.1    Rajfer, J.2
  • 22
    • 0037362999 scopus 로고    scopus 로고
    • Corporoplasty for advanced peyronie's disease using venous and/or dermis patch grafting: New surgical technique and long-term patient satisfaction
    • DOI 10.1097/01.ju.0000052403.11923.51
    • Backhaus BO, Muller SC, Albers P. Corporoplasty for advanced Peyronies disease using venous and/or dermis patch grafting: new surgical technique and long-term patient satisfaction. J Urol 2003;169:981-4 (Pubitemid 36188139)
    • (2003) Journal of Urology , vol.169 , Issue.3 , pp. 981-984
    • Backhaus, B.O.1    Muller, S.C.2    Albers, P.3
  • 23
    • 54949099591 scopus 로고    scopus 로고
    • Experience with plaque excision and dermal grafting in the surgical treatment of Peyronies disease
    • Goyal NK, Kumar A, Das SK, et al. Experience with plaque excision and dermal grafting in the surgical treatment of Peyronies disease. Singapore Med J 2008;49:805-8
    • (2008) Singapore Med J , vol.49 , pp. 805-8
    • Goyal, N.K.1    Kumar, A.2    Das, S.K.3
  • 24
    • 0346275126 scopus 로고    scopus 로고
    • Penile corporoplasty using tunica albuginea free graft from proximal corpus cavernosum: A new technique for treatment of penile curvature in peyronie's disease
    • DOI 10.1016/S0302-2838(03)00378-6
    • Schwarzer JU, Muhlen B, Schukai O. Penile corporoplasty using tunica albuginea free graft from proximal corpus cavernosum: a new technique for treatment of penile curvature in Peyronies disease. Eur Urol 2003;44:720-3 (Pubitemid 37542931)
    • (2003) European Urology , vol.44 , Issue.6 , pp. 720-723
    • Schwarzer, J.U.1    Muhlen, B.2    Schukai, O.3
  • 25
    • 16344362835 scopus 로고    scopus 로고
    • Erectile dysfunction following surgical correction of peyronie's disease and a pilot study of the use of sildenafil citrate rehabilitation for postoperative erectile dysfunction
    • DOI 10.1111/j.1743-6109.2005.20234.x
    • Levine LA, Greenfield JM, Estrada CR. Erectile dysfunction following surgical correction of Peyronies disease and a pilot study of the use of sildenafil citrate rehabilitation for postoperative erectile dysfunction. J Sex Med 2005;2:241-7 (Pubitemid 40468180)
    • (2005) Journal of Sexual Medicine , vol.2 , Issue.2 , pp. 241-247
    • Levine, L.A.1    Greenfield, J.M.2    Estrada, C.R.3
  • 26
    • 0036940526 scopus 로고    scopus 로고
    • Treatment of erectile dysfunction in patients with Peyronie's disease using sildenafil citrate
    • DOI 10.1038/sj.ijir.3900912
    • Levine LA, Latchamsetty KC. Treatment of erectile dysfunction in patients with Peyronies disease using sildenafil citrate. Int J Impot Res 2002;14:478-82 (Pubitemid 36068424)
    • (2002) International Journal of Impotence Research , vol.14 , Issue.6 , pp. 478-482
    • Levine, L.A.1    Latchamsetty, K.C.2
  • 27
    • 33644991137 scopus 로고    scopus 로고
    • Effects of long-term vardenafil treatment on the development of fibrotic plaques in a rat model of Peyronies disease
    • Ferrini MG, Kovanecz I, Nolazco G, et al. Effects of long-term vardenafil treatment on the development of fibrotic plaques in a rat model of Peyronies disease. BJU Int 2006;97:625-33
    • (2006) BJU Int , vol.97 , pp. 625-33
    • Ferrini, M.G.1    Kovanecz, I.2    Nolazco, G.3
  • 28
    • 1542351289 scopus 로고    scopus 로고
    • L-Arginine and phosphodiesterase (PDE) inhibitors counteract fibrosis in the Peyronie's fibrotic plaque and related fibroblast cultures
    • DOI 10.1016/j.niox.2003.12.002, PII S1089860303001101
    • Valente EG, Vernet D, Ferrini MG, et al. L-Arginine and phosphodiesterase (PDE) inhibitors counteract fibrosis in the Peyronies fibrotic plaque and related fibroblast cultures. Nitric Oxide 2003;9:229-44 (Pubitemid 38294362)
    • (2003) Nitric Oxide -Biology and Chemistry , vol.9 , Issue.4 , pp. 229-244
    • Valente, E.G.A.1    Vernet, D.2    Ferrini, M.G.3    Qian, A.4    Rajfer, J.5    Gonzalez-Cadavid, N.F.6
  • 29
    • 72449123274 scopus 로고    scopus 로고
    • Safety of sildenafil citrate: Review of 67 double-blind placebo-controlled trials and the postmarketing safety database
    • Giuliano F, Jackson G, Montorsi F, et al. Safety of sildenafil citrate: review of 67 double-blind placebo-controlled trials and the postmarketing safety database. Int J Clin Pract 2010;64:240-55
    • (2010) Int J Clin Pract , vol.64 , pp. 240-55
    • Giuliano, F.1    Jackson, G.2    Montorsi, F.3
  • 30
    • 80052892523 scopus 로고    scopus 로고
    • Words of wisdom. Re: Feasibility of the use of phosphodiesterase type 5 inhibitors in a pharmacologic prevention program for recurrent priapism
    • Lue TF, Bella AJ. Words of wisdom. Re: feasibility of the use of phosphodiesterase type 5 inhibitors in a pharmacologic prevention program for recurrent priapism. Eur Urol 2007;52:918-19
    • (2007) Eur Urol , vol.52 , pp. 918-19
    • Lue, T.F.1    Bella, A.J.2
  • 31
    • 33750473708 scopus 로고    scopus 로고
    • Feasibility of the use of phosphodiesterase type 5 Inhibitors in a pharmacologic prevention program for recurrent priapism
    • DOI 10.1111/j.1743-6109.2006.00333.x
    • Burnett AL, Bivalacqua TJ, Champion HC, Musicki B. Feasibility of the use of phosphodiesterase type 5 inhibitors in a pharmacologic prevention program for recurrent priapism. J Sex Med 2006;3:1077-84 (Pubitemid 44644720)
    • (2006) Journal of Sexual Medicine , vol.3 , Issue.6 , pp. 1077-1084
    • Burnett, A.L.1    Bivalacqua, T.J.2    Champion, H.C.3    Musicki, B.4
  • 32
    • 33645743465 scopus 로고    scopus 로고
    • Case report: Avoidance of palpable corporal fibrosis due to priapism with upregulators of nitric oxide
    • Rajfer J, Gore JL, Kaufman J, Gonzalez-Cadavid N. Case report: avoidance of palpable corporal fibrosis due to priapism with upregulators of nitric oxide. J Sex Med 2006;3:173-6
    • (2006) J Sex Med , vol.3 , pp. 173-6
    • Rajfer, J.1    Gore, J.L.2    Kaufman, J.3    Gonzalez-Cadavid, N.4
  • 33
    • 33745712565 scopus 로고    scopus 로고
    • Efficacy of type-5 phosphodiesterase inhibitors in the drug treatment of premature ejaculation: A systematic review
    • McMahon CG, McMahon CN, Leow LJ, Winestock CG. Efficacy of type-5 phosphodiesterase inhibitors in the drug treatment of premature ejaculation: a systematic review. BJU Int 2006;98:259-72
    • (2006) BJU Int , vol.98 , pp. 259-72
    • McMahon, C.G.1    McMahon, C.N.2    Leow, L.J.3    Winestock, C.G.4
  • 34
    • 41149130086 scopus 로고    scopus 로고
    • Tadalafil and fluoxetine in premature ejaculation: Prospective, randomized, double-blind, placebo-controlled study
    • DOI 10.1159/000112607
    • Mattos RM, Marmo Lucon A, Srougi M. Tadalafil and fluoxetine in premature ejaculation: prospective, randomized, double-blind, placebo-controlled study. Urol Int 2008;80:162-5 (Pubitemid 351440510)
    • (2008) Urologia Internationalis , vol.80 , Issue.2 , pp. 162-165
    • Mattos, R.M.1    Marmo Lucon, A.2    Srougi, M.3
  • 35
    • 34447334181 scopus 로고    scopus 로고
    • Effect of fluoxetine alone and in combination with sildenafil in patients with premature ejaculation
    • DOI 10.1159/000102909
    • Hosseini MM, Yarmohammadi H. Effect of fluoxetine alone and in combination with sildenafil in patients with premature ejaculation. Urol Int 2007;79:28-32 (Pubitemid 47051814)
    • (2007) Urologia Internationalis , vol.79 , Issue.1 , pp. 28-32
    • Hosseini, M.M.1    Yarmohammadi, H.2
  • 36
    • 68149148161 scopus 로고    scopus 로고
    • Effects of vardenafil administration on intravaginal ejaculatory latency time in men with lifelong premature ejaculation
    • Aversa A, Pili M, Francomano D, et al. Effects of vardenafil administration on intravaginal ejaculatory latency time in men with lifelong premature ejaculation. Int J Impot Res 2009;21:221-7
    • (2009) Int J Impot Res , vol.21 , pp. 221-7
    • Aversa, A.1    Pili, M.2    Francomano, D.3
  • 37
    • 34247578775 scopus 로고    scopus 로고
    • Can sildenafil treat primary premature ejaculation? A prospective clinical study
    • DOI 10.1111/j.1442-2042.2007.01606.x
    • Wang WF, Wang Y, Minhas S, Ralph DJ. Can sildenafil treat primary premature ejaculation? A prospective clinical study. Int J Urol 2007;14:331-5 (Pubitemid 46669039)
    • (2007) International Journal of Urology , vol.14 , Issue.4 , pp. 331-335
    • Wang, W.-F.1    Wang, Y.2    Minhas, S.3    Ralph, D.J.4
  • 38
    • 65349133562 scopus 로고    scopus 로고
    • Safety and efficacy of vardenafil versus sertraline in the treatment of premature ejaculation: A randomised, prospective and crossover study
    • Mathers MJ, Klotz T, Roth S, et al. Safety and efficacy of vardenafil versus sertraline in the treatment of premature ejaculation: a randomised, prospective and crossover study. Andrologia 2009;41:169-75
    • (2009) Andrologia , vol.41 , pp. 169-75
    • Mathers, M.J.1    Klotz, T.2    Roth, S.3
  • 40
    • 77957583427 scopus 로고    scopus 로고
    • Effects of phosphodiesterase-5 inhibitors on Leydig cell secretory function in oligoasthenospermic infertile men: A randomized trial
    • Dimitriadis F, Tsambalas S, Tsounapi P, et al. Effects of phosphodiesterase-5 inhibitors on Leydig cell secretory function in oligoasthenospermic infertile men: a randomized trial. BJU Int 2010;106:1181-5
    • (2010) BJU Int , vol.106 , pp. 1181-5
    • Dimitriadis, F.1    Tsambalas, S.2    Tsounapi, P.3
  • 41
    • 34247499476 scopus 로고    scopus 로고
    • Sildenafil citrate improves sperm motility but causes a premature acrosome reaction in vitro
    • DOI 10.1016/j.fertnstert.2006.11.017, PII S0015028206043871
    • Glenn DR, McVicar CM, McClure N, Lewis SE. Sildenafil citrate improves sperm motility but causes a premature acrosome reaction in vitro. Fertil Steril 2007;87:1064-70 (Pubitemid 46659924)
    • (2007) Fertility and Sterility , vol.87 , Issue.5 , pp. 1064-1070
    • Glenn, D.R.J.1    McVicar, C.M.2    McClure, N.3    Lewis, S.E.M.4
  • 42
    • 30744438097 scopus 로고    scopus 로고
    • Phosphodiesterase 11 (PDE11): Is it a player in human testicular function?
    • DOI 10.1038/sj.ijir.3901377, PII 3901377
    • Francis SH. Phosphodiesterase 11 (PDE11): is it a player in human testicular function? Int J Impot Res 2005;17:467-8 (Pubitemid 43093252)
    • (2005) International Journal of Impotence Research , vol.17 , Issue.5 , pp. 467-468
    • Francis, S.H.1
  • 44
    • 33845972676 scopus 로고    scopus 로고
    • Tadalafil as an in vitro sperm motility stimulant
    • DOI 10.1111/j.1439-0272.2006.00752.x
    • Mostafa T. Tadalafil as an in vitro sperm motility stimulant. Andrologia 2007;39:12-15 (Pubitemid 46051348)
    • (2007) Andrologia , vol.39 , Issue.1 , pp. 12-15
    • Mostafa, T.1
  • 45
    • 66149148931 scopus 로고    scopus 로고
    • ERK phosphorylation mediates sildenafil-induced myocardial protection against ischemia-reperfusion injury in mice
    • Das A, Salloum FN, Xi L, et al. ERK phosphorylation mediates sildenafil-induced myocardial protection against ischemia-reperfusion injury in mice. Am J Physiol Heart Circ Physiol 2009;296:H1236-43
    • (2009) Am J Physiol Heart Circ Physiol , vol.296
    • Das, A.1    Salloum, F.N.2    Xi, L.3
  • 46
    • 67650266514 scopus 로고    scopus 로고
    • Phosphodiesterase 5 inhibitors: Are they cardioprotective?
    • Reffelmann T, Kloner RA. Phosphodiesterase 5 inhibitors: are they cardioprotective? Cardiovasc Res 2009;83:204-12
    • (2009) Cardiovasc Res , vol.83 , pp. 204-12
    • Reffelmann, T.1    Kloner, R.A.2
  • 47
    • 60249083033 scopus 로고    scopus 로고
    • Sildenafil attenuates renal injury in an experimental model of rat cisplatin-induced nephrotoxicity
    • Lee KW, Jeong JY, Lim BJ, et al. Sildenafil attenuates renal injury in an experimental model of rat cisplatin-induced nephrotoxicity. Toxicology 2009;257:137-43
    • (2009) Toxicology , vol.257 , pp. 137-43
    • Lee, K.W.1    Jeong, J.Y.2    Lim, B.J.3
  • 48
    • 17144405644 scopus 로고    scopus 로고
    • Phosphodiesterase-5 inhibition with sildenafil attenuates cardiomyocyte apoptosis and left ventricular dysfunction in a chronic model of doxorubicin cardiotoxicity
    • DOI 10.1161/01.CIR.0000160359.49478.C2
    • Fisher PW, Salloum F, Das A, et al. Phosphodiesterase-5 inhibition with sildenafil attenuates cardiomyocyte apoptosis and left ventricular dysfunction in a chronic model of doxorubicin cardiotoxicity. Circulation 2005;111:1601-10 (Pubitemid 40525159)
    • (2005) Circulation , vol.111 , Issue.13 , pp. 1601-1610
    • Fisher, P.W.1    Salloum, F.2    Das, A.3    Hyder, H.4    Kukreja, R.C.5
  • 50
    • 70350217422 scopus 로고    scopus 로고
    • Sildenafil, an inhibitor of phosphodiesterase subtype 5, prevents indomethacin-induced small-intestinal ulceration in rats via a NO/cGMP-dependent mechanism
    • Kato N, Mashita Y, Kato S, et al. Sildenafil, an inhibitor of phosphodiesterase subtype 5, prevents indomethacin-induced small-intestinal ulceration in rats via a NO/cGMP-dependent mechanism. Dig Dis Sci 2009;54:2346-56
    • (2009) Dig Dis Sci , vol.54 , pp. 2346-56
    • Kato, N.1    Mashita, Y.2    Kato, S.3
  • 51
    • 65049090531 scopus 로고    scopus 로고
    • The effects of sildenafil on the functional and structural changes of ileum induced by intestinal ischemia-reperfusion in rats
    • Soydan G, Sokmensuer C, Kilinc K, Tuncer M. The effects of sildenafil on the functional and structural changes of ileum induced by intestinal ischemia-reperfusion in rats. Eur J Pharmacol 2009;610:87-92
    • (2009) Eur J Pharmacol , vol.610 , pp. 87-92
    • Soydan, G.1    Sokmensuer, C.2    Kilinc, K.3    Tuncer, M.4
  • 52
    • 0037284444 scopus 로고    scopus 로고
    • Treatment with sildenafil for the healing of refractory skin ulcerations in the antiphospholipid syndrome
    • DOI 10.1191/0961203303lu257cr
    • Gertner E. Treatment with sildenafil for the healing of refractory skin ulcerations in the antiphospholipid syndrome. Lupus 2003;12:133-5 (Pubitemid 36240847)
    • (2003) Lupus , vol.12 , Issue.2 , pp. 133-135
    • Gertner, E.1
  • 53
    • 28844442746 scopus 로고    scopus 로고
    • Severe refractory fingertip ulcerations in a patient with scleroderma: Successful treatment with sildenafil
    • Colglazier CL, Sutej PG, ORourke KS. Severe refractory fingertip ulcerations in a patient with scleroderma: successful treatment with sildenafil. J Rheumatol 2005;32:2440-2 (Pubitemid 41780663)
    • (2005) Journal of Rheumatology , vol.32 , Issue.12 , pp. 2440-2442
    • Colglazier, C.L.1    Sutej, P.G.2    O'Rourke, K.S.3
  • 55
    • 27744564115 scopus 로고    scopus 로고
    • Sildenafil in the treatment of Raynaud's phenomenon resistant to vasodilatory therapy
    • DOI 10.1161/CIRCULATIONAHA.104.523324
    • Fries R, Shariat K, von Wilmowsky H, Bohm M. Sildenafil in the treatment of Raynauds phenomenon resistant to vasodilatory therapy. Circulation 2005;112:2980-5 (Pubitemid 41612301)
    • (2005) Circulation , vol.112 , Issue.19 , pp. 2980-2985
    • Fries, R.1    Shariat, K.2    Von Wilmowsky, H.3    Bohm, M.4
  • 56
    • 77955460984 scopus 로고    scopus 로고
    • Effect of sildenafil on digital ulcers in systemic sclerosis: Analysis from a single centre pilot study
    • Brueckner CS, Becker MO, Kroencke T, et al. Effect of sildenafil on digital ulcers in systemic sclerosis: analysis from a single centre pilot study. Ann Rheum Dis 2010;69:1475-8
    • (2010) Ann Rheum Dis , vol.69 , pp. 1475-8
    • Brueckner, C.S.1    Becker, M.O.2    Kroencke, T.3
  • 57
    • 0033958037 scopus 로고    scopus 로고
    • Effects of sildenafil on esophageal motility of patients with idiopathic achalasia
    • Bortolotti M, Mari C, Lopilato C, et al. Effects of sildenafil on esophageal motility of patients with idiopathic achalasia. Gastroenterology 2000;118:253-7 (Pubitemid 30067497)
    • (2000) Gastroenterology , vol.118 , Issue.2 , pp. 253-257
    • Bortolotti, M.1    Mari, C.2    Lopilato, C.3    Porrazzo, G.4    Miglioli, M.5
  • 58
    • 0036103111 scopus 로고    scopus 로고
    • Effect of sildenafil on oesophageal motor function in healthy subjects and patients with oesophageal motor disorders
    • DOI 10.1136/gut.50.6.758
    • Eherer AJ, Schwetz I, Hammer HF, et al. Effect of sildenafil on oesophageal motor function in healthy subjects and patients with oesophageal motor disorders. Gut 2002;50:758-64 (Pubitemid 34539035)
    • (2002) Gut , vol.50 , Issue.6 , pp. 758-764
    • Eherer, A.J.1    Schwetz, I.2    Hammer, H.F.3    Petnehazy, T.4    Scheidl, S.J.5    Weber, K.6    Krejs, G.J.7
  • 59
    • 70449366624 scopus 로고    scopus 로고
    • Mechanisms of exercise limitation and pulmonary rehabilitation for patients with neuromuscular disease
    • Aboussouan LS. Mechanisms of exercise limitation and pulmonary rehabilitation for patients with neuromuscular disease. Chron Respir Dis 2009;6:231-49
    • (2009) Chron Respir Dis , vol.6 , pp. 231-49
    • Aboussouan, L.S.1
  • 60
    • 0036843061 scopus 로고    scopus 로고
    • Sildenafil (Viagra) induces neurogenesis and promotes functional recovery after stroke in rats
    • DOI 10.1161/01.STR.0000034399.95249.59
    • Zhang R, Wang Y, Zhang L, et al. Sildenafil (Viagra) induces neurogenesis and promotes functional recovery after stroke in rats. Stroke 2002;33:2675-80 (Pubitemid 35266440)
    • (2002) Stroke , vol.33 , Issue.11 , pp. 2675-2680
    • Zhang, R.1    Wang, Y.2    Zhang, L.3    Zhang, Z.4    Tsang, W.5    Lu, M.6    Zhang, L.7    Chopp, M.8
  • 61
    • 33750317276 scopus 로고    scopus 로고
    • Tadalafil, a long-acting type 5 phosphodiesterase isoenzyme inhibitor, improves neurological functional recovery in a rat model of embolic stroke
    • DOI 10.1016/j.brainres.2006.08.028, PII S000689930602378X
    • Zhang L, Zhang Z, Zhang RL, et al. Tadalafil, a long-acting type 5 phosphodiesterase isoenzyme inhibitor, improves neurological functional recovery in a rat model of embolic stroke. Brain Res 2006;1118:192-8 (Pubitemid 44633866)
    • (2006) Brain Research , vol.1118 , Issue.1 , pp. 192-198
    • Zhang, L.1    Zhang, Z.2    Zhang, R.L.3    Cui, Y.4    LaPointe, M.C.5    Silver, B.6    Chopp, M.7
  • 62
    • 33646365892 scopus 로고    scopus 로고
    • Delayed treatment with sildenafil enhances neurogenesis and improves functional recovery in aged rats after focal cerebral ischemia
    • DOI 10.1002/jnr.20813
    • Zhang RL, Zhang Z, Zhang L, et al. Delayed treatment with sildenafil enhances neurogenesis and improves functional recovery in aged rats after focal cerebral ischemia. J Neurosci Res 2006;83:1213-19 (Pubitemid 43668004)
    • (2006) Journal of Neuroscience Research , vol.83 , Issue.7 , pp. 1213-1219
    • Rui, L.Z.1    Zhang, Z.2    Zhang, L.3    Wang, Y.4    Zhang, C.5    Chopp, M.6
  • 63
    • 48749112427 scopus 로고    scopus 로고
    • Magnetic resonance imaging investigation of axonal remodeling and angiogenesis after embolic stroke in sildenafil-treated rats
    • Ding G, Jiang Q, Li L, et al. Magnetic resonance imaging investigation of axonal remodeling and angiogenesis after embolic stroke in sildenafil-treated rats. J Cereb Blood Flow Metab 2008;28:1440-8
    • (2008) J Cereb Blood Flow Metab , vol.28 , pp. 1440-8
    • Ding, G.1    Jiang, Q.2    Li, L.3
  • 64
    • 69149103302 scopus 로고    scopus 로고
    • Sildenafil treatment of subacute ischemic stroke: A safety study at 25-mg daily for 2 weeks
    • Silver B, McCarthy S, Lu M, et al. Sildenafil treatment of subacute ischemic stroke: a safety study at 25-mg daily for 2 weeks. J Stroke Cerebrovasc Dis 2009;18:381-3
    • (2009) J Stroke Cerebrovasc Dis , vol.18 , pp. 381-3
    • Silver, B.1    McCarthy, S.2    Lu, M.3
  • 66
    • 67649342620 scopus 로고    scopus 로고
    • Phosphodiesterase 5 inhibition improves synaptic function, memory, and amyloid-beta load in an Alzheimers disease mouse model
    • Puzzo D, Staniszewski A, Deng SX, et al. Phosphodiesterase 5 inhibition improves synaptic function, memory, and amyloid-beta load in an Alzheimers disease mouse model. J Neurosci 2009;29:8075-86
    • (2009) J Neurosci , vol.29 , pp. 8075-86
    • Puzzo, D.1    Staniszewski, A.2    Deng, S.X.3
  • 67
    • 78149249616 scopus 로고    scopus 로고
    • Phoshphodiesterase-5 inhibitors: Novel weapons against Alzheimers disease?
    • Sabayan B, Zamiri N, Farshchizarabi S. Phoshphodiesterase-5 inhibitors: novel weapons against Alzheimers disease? Int J Neurosci 2010;120:746-51
    • (2010) Int J Neurosci , vol.120 , pp. 746-51
    • Sabayan, B.1    Zamiri, N.2    Farshchizarabi, S.3
  • 68
    • 59449098930 scopus 로고    scopus 로고
    • A placebo-controlled study of sildenafil effects on cognition in schizophrenia
    • Goff DC, Cather C, Freudenreich O, et al. A placebo-controlled study of sildenafil effects on cognition in schizophrenia. Psychopharmacology (Berl) 2009;202:411-17
    • (2009) Psychopharmacology (Berl) , vol.202 , pp. 411-17
    • Goff, D.C.1    Cather, C.2    Freudenreich, O.3
  • 69
    • 43049118254 scopus 로고    scopus 로고
    • Selective PDE inhibitors rolipram and sildenafil improve object retrieval performance in adult cynomolgus macaques
    • Rutten K, Basile JL, Prickaerts J, et al. Selective PDE inhibitors rolipram and sildenafil improve object retrieval performance in adult cynomolgus macaques. Psychopharmacology (Berl) 2008;196:643-8
    • (2008) Psychopharmacology (Berl) , vol.196 , pp. 643-8
    • Rutten, K.1    Basile, J.L.2    Prickaerts, J.3
  • 70
    • 77957354074 scopus 로고    scopus 로고
    • Inhibition of phosphodiesterase-4 reverses memory deficits produced by Abeta25-35 or Abeta1-40 peptide in rats
    • Cheng YF, Wang C, Lin HB, et al. Inhibition of phosphodiesterase-4 reverses memory deficits produced by Abeta25-35 or Abeta1-40 peptide in rats. Psychopharmacology (Berl) 2010;212:181-91
    • (2010) Psychopharmacology (Berl) , vol.212 , pp. 181-91
    • Cheng, Y.F.1    Wang, C.2    Lin, H.B.3
  • 71
    • 77951206366 scopus 로고    scopus 로고
    • Etazolate improves performance in a foraging and homing task in aged rats
    • Drott J, Desire L, Drouin D, et al. Etazolate improves performance in a foraging and homing task in aged rats. Eur J Pharmacol 2010;634:95-100
    • (2010) Eur J Pharmacol , vol.634 , pp. 95-100
    • Drott, J.1    Desire, L.2    Drouin, D.3
  • 72
    • 78650474571 scopus 로고    scopus 로고
    • Sildenafil reverses cardiac dysfunction in the mdx mouse model of Duchenne muscular dystrophy
    • Adamo CM, Dai DF, Percival JM, et al. Sildenafil reverses cardiac dysfunction in the mdx mouse model of Duchenne muscular dystrophy. Proc Natl Acad Sci USA 2010;107:19079-83
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 19079-83
    • Adamo, C.M.1    Dai, D.F.2    Percival, J.M.3
  • 73
    • 5644304230 scopus 로고    scopus 로고
    • Modulatory effect of the PDE-5 inhibitor sildenafil in diabetic neuropathy
    • DOI 10.1159/000080104
    • Patil CS, Singh VP, Singh S, Kulkarni SK. Modulatory effect of the PDE-5 inhibitor sildenafil in diabetic neuropathy. Pharmacology 2004;72:190-5 (Pubitemid 39370248)
    • (2004) Pharmacology , vol.72 , Issue.3 , pp. 190-195
    • Patil, C.S.1    Singh, V.P.2    Singh, S.3    Kulkarni, S.K.4
  • 74
    • 0036673903 scopus 로고    scopus 로고
    • Acute and prolonged effects of sildenafil on brachial artery flow-mediated dilatation in type 2 diabetes
    • DOI 10.2337/diacare.25.8.1336
    • Desouza C, Parulkar A, Lumpkin D, et al. Acute and prolonged effects of sildenafil on brachial artery flow-mediated dilatation in type 2 diabetes. Diabetes Care 2002;25:1336-9 (Pubitemid 41071142)
    • (2002) Diabetes Care , vol.25 , Issue.8 , pp. 1336-1339
    • Desouza, C.1    Parulkar, A.2    Lumpkin, D.3    Akers, D.4    Fonseca, V.A.5
  • 75
    • 38049187090 scopus 로고    scopus 로고
    • Chronic administration of sildenafil improves markers of endothelial function in men with type 2 diabetes
    • Aversa A, Vitale C, Volterrani M, et al. Chronic administration of sildenafil improves markers of endothelial function in men with type 2 diabetes. Diabet Med 2008;25:37-44
    • (2008) Diabet Med , vol.25 , pp. 37-44
    • Aversa, A.1    Vitale, C.2    Volterrani, M.3
  • 76
    • 65549092581 scopus 로고    scopus 로고
    • Acute effects of sildenafil on flow mediated dilatation and cardiovascular autonomic nerve function in type 2 diabetic patients
    • Stirban A, Laude D, Elghozi JL, et al. Acute effects of sildenafil on flow mediated dilatation and cardiovascular autonomic nerve function in type 2 diabetic patients. Diabetes Metab Res Rev 2009;25:136-43
    • (2009) Diabetes Metab Res Rev , vol.25 , pp. 136-43
    • Stirban, A.1    Laude, D.2    Elghozi, J.L.3
  • 77
    • 34548443810 scopus 로고    scopus 로고
    • Sildenafil citrate diminishes microalbuminuria and the percentage of A1c in male patients with type 2 diabetes
    • DOI 10.1016/j.diabres.2007.02.006, PII S0168822707001131
    • Grover-Paez F, Villegas Rivera G, Guillen Ortiz R. Sildenafil citrate diminishes microalbuminuria and the percentage of A1c in male patients with type 2 diabetes. Diabetes Res Clin Pract 2007;78:136-40 (Pubitemid 47351245)
    • (2007) Diabetes Research and Clinical Practice , vol.78 , Issue.1 , pp. 136-140
    • Grover-Paez, F.1    Villegas Rivera, G.2    Guillen Ortiz, R.3
  • 78
    • 70450189512 scopus 로고    scopus 로고
    • Metabolic syndrome racial differences in adolescents
    • Hoffman RP. Metabolic syndrome racial differences in adolescents. Curr Diabetes Rev 2009;5:259-65
    • (2009) Curr Diabetes Rev , vol.5 , pp. 259-65
    • Hoffman, R.P.1
  • 79
    • 33847362727 scopus 로고    scopus 로고
    • Relationship between chronic tadalafil administration and improvement of endothelial function in men with erectile dysfunction: A pilot study
    • DOI 10.1038/sj.ijir.3901513, PII 3901513
    • Aversa A, Greco E, Bruzziches R, et al. Relationship between chronic tadalafil administration and improvement of endothelial function in men with erectile dysfunction: a pilot study. Int J Impot Res 2007;19:200-7 (Pubitemid 46340840)
    • (2007) International Journal of Impotence Research , vol.19 , Issue.2 , pp. 200-207
    • Aversa, A.1    Greco, E.2    Bruzziches, R.3    Pili, M.4    Rosano, G.5    Spera, G.6
  • 80
    • 12344288164 scopus 로고    scopus 로고
    • Chronic treatment with tadalafil improves endothelial function in men with increased cardiovascular risk
    • discussion 20-22
    • Rosano GM, Aversa A, Vitale C, et al. Chronic treatment with tadalafil improves endothelial function in men with increased cardiovascular risk. Eur Urol 2005;47:214-20. discussion 20-22
    • (2005) Eur Urol , vol.47 , pp. 214-20
    • Rosano, G.M.1    Aversa, A.2    Vitale, C.3
  • 81
    • 33748319486 scopus 로고    scopus 로고
    • The effect of vardenafil on endothelial function of brachial and cavernous arteries
    • DOI 10.1038/sj.ijir.3901454, PII 3901454
    • Mazo E, Gamidov S, Iremashvili V. The effect of vardenafil on endothelial function of brachial and cavernous arteries. Int J Impot Res 2006;18:464-9 (Pubitemid 44330297)
    • (2006) International Journal of Impotence Research , vol.18 , Issue.5 , pp. 464-469
    • Mazo, E.1    Gamidov, S.2    Iremashvili, V.3
  • 82
    • 33749166044 scopus 로고    scopus 로고
    • A new indication of sildenafil in medicine: Hypoxic cell sensitizer for penile cancer
    • Huilgol NG, Jain A. A new indication of sildenafil in medicine: hypoxic cell sensitizer for penile cancer. J Cancer Res Ther 2006;2:132-5 (Pubitemid 44477535)
    • (2006) Journal of Cancer Research and Therapeutics , vol.2 , Issue.3 , pp. 132-135
    • Huilgol, N.G.1    Jain, A.2
  • 83
    • 54049086905 scopus 로고    scopus 로고
    • PDE5 inhibitors enhance tumor permeability and efficacy of chemotherapy in a rat brain tumor model
    • Black KL, Yin D, Ong JM, et al. PDE5 inhibitors enhance tumor permeability and efficacy of chemotherapy in a rat brain tumor model. Brain Res 2008;1230:290-302
    • (2008) Brain Res , vol.1230 , pp. 290-302
    • Black, K.L.1    Yin, D.2    Ong, J.M.3
  • 84
    • 77956326618 scopus 로고    scopus 로고
    • Phosphodiesterase type 5 inhibitors increase Herceptin transport and treatment efficacy in mouse metastatic brain tumor models
    • Hu J, Ljubimova JY, Inoue S, et al. Phosphodiesterase type 5 inhibitors increase Herceptin transport and treatment efficacy in mouse metastatic brain tumor models. PLoS One 2010;5:e10108
    • (2010) PLoS One , vol.5
    • Hu, J.1    Ljubimova, J.Y.2    Inoue, S.3
  • 85
    • 78649329704 scopus 로고    scopus 로고
    • Influence of the phosphodiesterase-5 inhibitor, sildenafil, on sensitivity to chemotherapy in breast tumor cells
    • Di X, Gennings C, Bear HD, et al. Influence of the phosphodiesterase-5 inhibitor, sildenafil, on sensitivity to chemotherapy in breast tumor cells. Breast Cancer Res Treat 2010;124:349-60
    • (2010) Breast Cancer Res Treat , vol.124 , pp. 349-60
    • Di Gennings X, C.1    Bear, H.D.2
  • 87
    • 67649114159 scopus 로고    scopus 로고
    • Acute hemodynamic effects of intravenous sildenafil citrate in congestive heart failure: Comparison of phosphodiesterase type-3 and -5 inhibition
    • Botha P, Parry G, Dark JH, Macgowan GA. Acute hemodynamic effects of intravenous sildenafil citrate in congestive heart failure: comparison of phosphodiesterase type-3 and -5 inhibition. J Heart Lung Transplant 2009;28:676-82
    • (2009) J Heart Lung Transplant , vol.28 , pp. 676-82
    • Botha, P.1    Parry, G.2    Dark, J.H.3    MacGowan, G.A.4
  • 88
    • 36049002524 scopus 로고    scopus 로고
    • Use of sildenafil in heart transplant recipients with pulmonary hypertension may prevent right heart failure
    • DOI 10.1016/j.transproceed.2007.08.077, PII S0041134507010664
    • Maruszewski M, Zakliczynski M, Przybylski R, et al. Use of sildenafil in heart transplant recipients with pulmonary hypertension may prevent right heart failure. Transplant Proc 2007;39:2850-2 (Pubitemid 350088106)
    • (2007) Transplantation Proceedings , vol.39 , Issue.9 , pp. 2850-2852
    • Maruszewski, M.1    Zakliczynski, M.2    Przybylski, R.3    Kucewicz-Czech, E.4    Zembala, M.5
  • 89
    • 48049114444 scopus 로고    scopus 로고
    • Role of sildenafil in acute posttransplant right ventricular dysfunction: Successful experience in 13 consecutive patients
    • De Santo LS, Mastroianni C, Romano G, et al. Role of sildenafil in acute posttransplant right ventricular dysfunction: successful experience in 13 consecutive patients. Transplant Proc 2008;40:2015-18
    • (2008) Transplant Proc , vol.40 , pp. 2015-18
    • De Santo, L.S.1    Mastroianni, C.2    Romano, G.3
  • 91
    • 67650555952 scopus 로고    scopus 로고
    • The use of sildenafil to treat portopulmonary hypertension prior to liver transplantation
    • Cadden IS, Greanya ED, Erb SR, et al. The use of sildenafil to treat portopulmonary hypertension prior to liver transplantation. Ann Hepatol 2009;8:158-61
    • (2009) Ann Hepatol , vol.8 , pp. 158-61
    • Cadden, I.S.1    Greanya, E.D.2    Erb, S.R.3
  • 92
    • 3242762283 scopus 로고    scopus 로고
    • Sildenafil for portopulmonary hypertension in a patient undergoing liver transplantation
    • DOI 10.1002/lt.20153
    • Makisalo H, Koivusalo A, Vakkuri A, Hockerstedt K. Sildenafil for portopulmonary hypertension in a patient undergoing liver transplantation. Liver Transpl 2004;10:945-50 (Pubitemid 38979269)
    • (2004) Liver Transplantation , vol.10 , Issue.7 , pp. 945-950
    • Makisalo, H.1    Koivusalo, A.2    Vakkuri, A.3    Hockerstedt, K.4
  • 93
    • 64049084092 scopus 로고    scopus 로고
    • Sildenafil therapy is associated with improved hemodynamics in liver transplantation candidates with pulmonary arterial hypertension
    • Gough MS, White RJ. Sildenafil therapy is associated with improved hemodynamics in liver transplantation candidates with pulmonary arterial hypertension. Liver Transpl 2009;15:30-6
    • (2009) Liver Transpl , vol.15 , pp. 30-6
    • Gough, M.S.1    White, R.J.2
  • 94
    • 64049112788 scopus 로고    scopus 로고
    • Sildenafil monotherapy in portopulmonary hypertension can facilitate liver transplantation
    • Hemnes AR, Robbins IM. Sildenafil monotherapy in portopulmonary hypertension can facilitate liver transplantation. Liver Transpl 2009;15:15-19
    • (2009) Liver Transpl , vol.15 , pp. 15-19
    • Hemnes, A.R.1    Robbins, I.M.2
  • 95
    • 68149149879 scopus 로고    scopus 로고
    • Sildenafil as a protecting drug for warm ischemic kidney transplants: Experimental results
    • Lledo-Garcia E, Subira-Rios D, Rodriguez-Martinez D, et al. Sildenafil as a protecting drug for warm ischemic kidney transplants: experimental results. J Urol 2009;182:1222-5
    • (2009) J Urol , vol.182 , pp. 1222-5
    • Lledo-Garcia, E.1    Subira-Rios, D.2    Rodriguez-Martinez, D.3
  • 97
    • 64749091902 scopus 로고    scopus 로고
    • Improvement of pulmonary microcirculation after lung transplantation using phosphodiesterase-5 inhibitor modified preservation solution
    • Pizanis N, Heckmann J, Wendt D, et al. Improvement of pulmonary microcirculation after lung transplantation using phosphodiesterase-5 inhibitor modified preservation solution. Eur J Cardiothorac Surg 2009;35:801-6
    • (2009) Eur J Cardiothorac Surg , vol.35 , pp. 801-6
    • Pizanis, N.1    Heckmann, J.2    Wendt, D.3
  • 98
    • 46849119814 scopus 로고    scopus 로고
    • Evaluation of the effect of sildenafil and vascular endothelium growth factor combination treatment on skin flap survival in rats
    • Tsai JW, Ayubi FS, Hart KL, et al. Evaluation of the effect of sildenafil and vascular endothelium growth factor combination treatment on skin flap survival in rats. Aesthetic Plast Surg 2008;32:624-31
    • (2008) Aesthetic Plast Surg , vol.32 , pp. 624-31
    • Tsai, J.W.1    Ayubi, F.S.2    Hart, K.L.3
  • 99
    • 0242692555 scopus 로고    scopus 로고
    • Safety and efficacy of sildenafil citrate for the treatment of female sexual arousal disorder: A double-blind, placebo controlled study
    • DOI 10.1097/01.ju.0000090966.74607.34
    • Berman JR, Berman LA, Toler SM, et al. Safety and efficacy of sildenafil citrate for the treatment of female sexual arousal disorder: a double-blind, placebo controlled study. J Urol 2003;170:2333-8 (Pubitemid 37413990)
    • (2003) Journal of Urology , vol.170 , Issue.I6 , pp. 2333-2338
    • Berman, J.R.1    Berman, L.A.2    Toler, S.M.3    Gill, J.4    Haughie, S.5
  • 100
    • 62249137799 scopus 로고    scopus 로고
    • A literature review and case reports series on the use of phosphodiesterase inhibitors in the treatment of female sexual dysfunction
    • Foster R, Mears A, Goldmeier D. A literature review and case reports series on the use of phosphodiesterase inhibitors in the treatment of female sexual dysfunction. Int J STD AIDS 2009;20:152-7
    • (2009) Int J STD AIDS , vol.20 , pp. 152-7
    • Foster, R.1    Mears, A.2    Goldmeier, D.3
  • 101
    • 61549119473 scopus 로고    scopus 로고
    • The influence of testosterone combined with a PDE5-inhibitor on cognitive, affective, and physiological sexual functioning in women suffering from sexual dysfunction
    • van der Made F, Bloemers J, Yassem WE, et al. The influence of testosterone combined with a PDE5-inhibitor on cognitive, affective, and physiological sexual functioning in women suffering from sexual dysfunction. J Sex Med 2009;6:777-90
    • (2009) J Sex Med , vol.6 , pp. 777-90
    • Van Der Made, F.1    Bloemers, J.2    Yassem, W.E.3
  • 102
    • 1542327756 scopus 로고    scopus 로고
    • Efficacy of sildenafil in the treatment of female sexual dysfunction due to multiple sclerosis
    • DOI 10.1097/01.ju.0000113145.43174.24
    • DasGupta R, Wiseman OJ, Kanabar G, et al. Efficacy of sildenafil in the treatment of female sexual dysfunction due to multiple sclerosis. J Urol 2004;171:1189-93; discussion 93 (Pubitemid 38327555)
    • (2004) Journal of Urology , vol.171 , Issue.3 , pp. 1189-1193
    • DasGupta, R.1    Wiseman, O.J.2    Kanabar, G.3    Fowler, C.J.4
  • 103
    • 67651100816 scopus 로고    scopus 로고
    • Assessing the clinical efficacy of sildenafil for the treatment of female sexual dysfunction
    • Brown DA, Kyle JA, Ferrill MJ. Assessing the clinical efficacy of sildenafil for the treatment of female sexual dysfunction. Ann Pharmacother 2009;43:1275-85
    • (2009) Ann Pharmacother , vol.43 , pp. 1275-85
    • Brown, D.A.1    Kyle, J.A.2    Ferrill, M.J.3
  • 104
    • 33646097702 scopus 로고    scopus 로고
    • Sildenafil improves sexual functioning in premenopausal women with type 1 diabetes who are affected by sexual arousal disorder: A double-blind, crossover, placebo-controlled pilot study
    • Caruso S, Rugolo S, Agnello C, et al. Sildenafil improves sexual functioning in premenopausal women with type 1 diabetes who are affected by sexual arousal disorder: a double-blind, crossover, placebo-controlled pilot study. Fertil Steril 2006;85:1496-501
    • (2006) Fertil Steril , vol.85 , pp. 1496-501
    • Caruso, S.1    Rugolo, S.2    Agnello, C.3
  • 106
    • 33746881793 scopus 로고    scopus 로고
    • Modeling and simulation of sexual activity daily diary data of patients with female sexual arousal disorder treated with sildenafil citrate (Viagra®)
    • DOI 10.1007/s11095-006-9007-4
    • Claret L, Cox EH, McFadyen L, et al. Modeling and simulation of sexual activity daily diary data of patients with female sexual arousal disorder treated with sildenafil citrate (Viagra). Pharm Res 2006;23:1756-64 (Pubitemid 44200539)
    • (2006) Pharmaceutical Research , vol.23 , Issue.8 , pp. 1756-1764
    • Claret, L.1    Cox, E.H.2    McFadyen, L.3    Pidgen, A.4    Johnson, P.J.5    Haughie, S.6    Boolell, M.7    Bruno, R.8
  • 108
    • 77949918332 scopus 로고    scopus 로고
    • Endometrial growth and uterine blood flow: A pilot study for improving endometrial thickness in the patients with a thin endometrium
    • Takasaki A, Tamura H, Miwa I, et al. Endometrial growth and uterine blood flow: a pilot study for improving endometrial thickness in the patients with a thin endometrium. Fertil Steril 2010;93:1851-8
    • (2010) Fertil Steril , vol.93 , pp. 1851-8
    • Takasaki, A.1    Tamura, H.2    Miwa, I.3
  • 109
  • 110
    • 55149093198 scopus 로고    scopus 로고
    • Sildenafil citrate decreased natural killer cell activity and enhanced chance of successful pregnancy in women with a history of recurrent miscarriage
    • Jerzak M, Kniotek M, Mrozek J, et al. Sildenafil citrate decreased natural killer cell activity and enhanced chance of successful pregnancy in women with a history of recurrent miscarriage. Fertil Steril 2008;90:1848-53
    • (2008) Fertil Steril , vol.90 , pp. 1848-53
    • Jerzak, M.1    Kniotek, M.2    Mrozek, J.3
  • 111
    • 73349102184 scopus 로고    scopus 로고
    • Biochemical role of intravaginal sildenafil citrate as a novel antiabortive agent in unexplained recurrent spontaneous miscarriage: First clinical study of four case reports from Egypt
    • El-Far M, El-Motwally Ael G, Hashem IA, Bakry N. Biochemical role of intravaginal sildenafil citrate as a novel antiabortive agent in unexplained recurrent spontaneous miscarriage: first clinical study of four case reports from Egypt. Clin Chem Lab Med 2009;47:1433-8
    • (2009) Clin Chem Lab Med , vol.47 , pp. 1433-8
    • El-Far, M.1    El-Motwally Ael, G.2    Hashem, I.A.3    Bakry, N.4
  • 112
    • 0034027145 scopus 로고    scopus 로고
    • Vaginal sildenafil (Viagra): A preliminary report of a novel method to improve uterine artery blood flow and endometrial development in patients undergoing IVF
    • Sher G, Fisch JD. Vaginal sildenafil (Viagra): a preliminary report of a novel method to improve uterine artery blood flow and endometrial development in patients undergoing IVF. Hum Reprod 2000;15:806-9 (Pubitemid 30192727)
    • (2000) Human Reproduction , vol.15 , Issue.4 , pp. 806-809
    • Sher, G.1    Jeffrey, D.F.2
  • 113
    • 0036842412 scopus 로고    scopus 로고
    • Effect of vaginal sildenafil on the outcome of in vitro fertilization (IVF) after multiple IVF failures attributed to poor endometrial development
    • DOI 10.1016/S0015-0282(02)03375-7, PII S0015028202033757
    • Sher G, Fisch JD. Effect of vaginal sildenafil on the outcome of in vitro fertilization (IVF) after multiple IVF failures attributed to poor endometrial development. Fertil Steril 2002;78:1073-6 (Pubitemid 35292511)
    • (2002) Fertility and Sterility , vol.78 , Issue.5 , pp. 1073-1076
    • Sher, G.1    Fisch, J.D.2
  • 114
    • 47549092919 scopus 로고    scopus 로고
    • The effect of sildenafil on the altered thoracic aorta smooth muscle responses in rat pre-eclampsia model
    • Turgut NH, Temiz TK, Bagcivan I, et al. The effect of sildenafil on the altered thoracic aorta smooth muscle responses in rat pre-eclampsia model. Eur J Pharmacol 2008;589:180-7
    • (2008) Eur J Pharmacol , vol.589 , pp. 180-7
    • Turgut, N.H.1    Temiz, T.K.2    Bagcivan, I.3
  • 115
    • 70350311152 scopus 로고    scopus 로고
    • A randomised, double-blinded, placebo-controlled study of the phosphodiesterase type 5 inhibitor sildenafil for the treatment of preeclampsia
    • Samangaya RA, Mires G, Shennan A, et al. A randomised, double-blinded, placebo-controlled study of the phosphodiesterase type 5 inhibitor sildenafil for the treatment of preeclampsia. Hypertens Pregnancy 2009;28:369-82
    • (2009) Hypertens Pregnancy , vol.28 , pp. 369-82
    • Samangaya, R.A.1    Mires, G.2    Shennan, A.3
  • 116
    • 58049166419 scopus 로고    scopus 로고
    • The effects of sildenafil citrate (Viagra) on uterine blood flow and well being in the intrauterine growth-restricted fetus
    • Miller SL, Loose JM, Jenkin G, Wallace EM. The effects of sildenafil citrate (Viagra) on uterine blood flow and well being in the intrauterine growth-restricted fetus. Am J Obstet Gynecol 2009;200:102 e1-7
    • (2009) Am J Obstet Gynecol , vol.200
    • Miller, S.L.1    Loose, J.M.2    Jenkin, G.3    Wallace, E.M.4
  • 117
    • 74949087697 scopus 로고    scopus 로고
    • Sildenafil citrate treatment enhances amino acid availability in the conceptus and fetal growth in an ovine model of intrauterine growth restriction
    • Satterfield MC, Bazer FW, Spencer TE, Wu G. Sildenafil citrate treatment enhances amino acid availability in the conceptus and fetal growth in an ovine model of intrauterine growth restriction. J Nutr 2010;140:251-8
    • (2010) J Nutr , vol.140 , pp. 251-8
    • Satterfield, M.C.1    Bazer, F.W.2    Spencer, T.E.3    Wu, G.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.